MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
Identifieur interne : 000E32 ( Main/Exploration ); précédent : 000E31; suivant : 000E33MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis
Auteurs : Hoi Leong Xavier Wong [République populaire de Chine] ; Guoxiang Jin [République populaire de Chine] ; Renhai Cao [Suède] ; Shuo Zhang [République populaire de Chine] ; Yihai Cao [Suède] ; Zhongjun Zhou [République populaire de Chine]Source :
- Nature Communications [ 2041-1723 ] ; 2016.
Abstract
Lymphangiogensis is involved in various pathological conditions, such as arthritis and cancer metastasis. Although many factors have been identified to stimulate lymphatic vessel growth, little is known about lymphangiogenesis inhibitors. Here we report that membrane type 1-matrix metalloproteinase (MT1-MMP) is an endogenous suppressor of lymphatic vessel growth. MT1-MMP-deficient mice exhibit spontaneous corneal lymphangiogenesis without concomitant changes in angiogenesis. Mice lacking MT1-MMP in either lymphatic endothelial cells or macrophages recapitulate corneal lymphangiogenic phenotypes observed in
Url:
DOI: 10.1038/ncomms10824
PubMed: 26926389
PubMed Central: 4773521
Affiliations:
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country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Guoxiang" sort="Jin, Guoxiang" uniqKey="Jin G" first="Guoxiang" last="Jin">Guoxiang Jin</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, University of Hong Kong</institution>, 21 Sassoon Road, Hong Kong,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cao, Renhai" sort="Cao, Renhai" uniqKey="Cao R" first="Renhai" last="Cao">Renhai Cao</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Microbiology and Tumor Center, Karolinska Institute</institution>, Stockholm 171 77,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Shuo" sort="Zhang, Shuo" uniqKey="Zhang S" first="Shuo" last="Zhang">Shuo Zhang</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Shenzhen Institute of Research and Innovation, University of Hong Kong</institution>, Shenzhen 518057,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, University of Hong Kong</institution>, 21 Sassoon Road, Hong Kong,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of 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Kong</institution>, 21 Sassoon Road, Hong Kong,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jin, Guoxiang" sort="Jin, Guoxiang" uniqKey="Jin G" first="Guoxiang" last="Jin">Guoxiang Jin</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, University of Hong Kong</institution>, 21 Sassoon Road, Hong Kong,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cao, Renhai" sort="Cao, Renhai" uniqKey="Cao R" first="Renhai" last="Cao">Renhai Cao</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Microbiology and Tumor Center, Karolinska Institute</institution>, Stockholm 171 77,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Shuo" sort="Zhang, Shuo" uniqKey="Zhang S" first="Shuo" last="Zhang">Shuo Zhang</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Shenzhen Institute of Research and Innovation, University of Hong Kong</institution>, Shenzhen 518057,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, University of Hong Kong</institution>, 21 Sassoon Road, Hong Kong,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Microbiology and Tumor Center, Karolinska Institute</institution>, Stockholm 171 77,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Zhongjun" sort="Zhou, Zhongjun" uniqKey="Zhou Z" first="Zhongjun" last="Zhou">Zhongjun Zhou</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Shenzhen Institute of Research and Innovation, University of Hong Kong</institution>, Shenzhen 518057,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, University of Hong Kong</institution>, 21 Sassoon Road, Hong Kong,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphangiogensis is involved in various pathological conditions, such as arthritis and cancer metastasis. Although many factors have been identified to stimulate lymphatic vessel growth, little is known about lymphangiogenesis inhibitors. Here we report that membrane type 1-matrix metalloproteinase (MT1-MMP) is an endogenous suppressor of lymphatic vessel growth. MT1-MMP-deficient mice exhibit spontaneous corneal lymphangiogenesis without concomitant changes in angiogenesis. Mice lacking MT1-MMP in either lymphatic endothelial cells or macrophages recapitulate corneal lymphangiogenic phenotypes observed in <italic>Mmp14</italic><sup>−/−</sup> mice, suggesting that the spontaneous lymphangiogenesis is both lymphatic endothelial cells autonomous and macrophage associated. Mechanistically, MT1-MMP directly cleaves LYVE-1 on lymphatic endothelial cells to inhibit LYVE-1-mediated lymphangiogenic responses. In addition, MT1-MMP-mediated PI3Kδ signalling restrains the production of VEGF-C from prolymphangiogenic macrophages through repressing the activation of NF-κB signalling. 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Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pitulescu, M E" uniqKey="Pitulescu M">M. E. Pitulescu</name></author><author><name sortKey="Schmidt, I" uniqKey="Schmidt I">I. Schmidt</name></author><author><name sortKey="Benedito, R" uniqKey="Benedito R">R. Benedito</name></author><author><name sortKey="Adams, R H" uniqKey="Adams R">R. H. Adams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krishnan, V" uniqKey="Krishnan V">V. Krishnan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>Suède</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wong, Hoi Leong Xavier" sort="Wong, Hoi Leong Xavier" uniqKey="Wong H" first="Hoi Leong Xavier" last="Wong">Hoi Leong Xavier Wong</name></noRegion><name sortKey="Jin, Guoxiang" sort="Jin, Guoxiang" uniqKey="Jin G" first="Guoxiang" last="Jin">Guoxiang Jin</name><name sortKey="Wong, Hoi Leong Xavier" sort="Wong, Hoi Leong Xavier" uniqKey="Wong H" first="Hoi Leong Xavier" last="Wong">Hoi Leong Xavier Wong</name><name sortKey="Zhang, Shuo" sort="Zhang, Shuo" uniqKey="Zhang S" first="Shuo" last="Zhang">Shuo Zhang</name><name sortKey="Zhang, Shuo" sort="Zhang, Shuo" uniqKey="Zhang S" first="Shuo" last="Zhang">Shuo Zhang</name><name sortKey="Zhou, Zhongjun" sort="Zhou, Zhongjun" uniqKey="Zhou Z" first="Zhongjun" last="Zhou">Zhongjun Zhou</name><name sortKey="Zhou, Zhongjun" sort="Zhou, Zhongjun" uniqKey="Zhou Z" first="Zhongjun" last="Zhou">Zhongjun Zhou</name></country><country name="Suède"><noRegion><name sortKey="Cao, Renhai" sort="Cao, Renhai" uniqKey="Cao R" first="Renhai" last="Cao">Renhai Cao</name></noRegion><name sortKey="Cao, Yihai" sort="Cao, Yihai" uniqKey="Cao Y" first="Yihai" last="Cao">Yihai Cao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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