New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network
Identifieur interne : 000D54 ( Main/Exploration ); précédent : 000D53; suivant : 000D55New concept for the prevention and treatment of metastatic lymph nodes using chemotherapy administered via the lymphatic network
Auteurs : Tetsuya Kodama [Japon] ; Daisuke Matsuki [Japon] ; Asuka Tada [Japon] ; Kazu Takeda [Japon] ; Shiro Mori [Japon]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
Intravenous chemotherapy has poor access to metastatic lymph nodes (LNs) and is limited by short-lived drug concentrations. Here, we describe the administration of chemotherapy via the lymphatic network as a new concept for the prevention and treatment of metastatic LNs. A metastatic LN can be treated by the injection of drugs into an upstream LN, either the sentinel LN (SLN) or another upstream LN. In a mouse model, tumor cells were inoculated into the subiliac LN (SiLN) to induce metastasis to the proper axillary LN (PALN). Two routes were used for drug delivery to the PALN, namely from the SiLN and from the accessory axillary LN (AALN). We found that tumor masses were formed in lymphatic vessels between the SiLN and PALN. The flow of fluorescent solution injected into the SiLN towards the PALN decreased with tumor mass formation. Delivery from the AALN (free of metastatic tumor cells) to the PALN was identified as an alternative route. Intranodal injection can deliver high concentrations of drugs to secondary metastatic LNs. The study advocates a new concept for the prevention and treatment of metastatic lymph nodes whereby drugs injected into upstream lymph nodes can reach metastatic lymph nodes via the lymphatic network.
Url:
DOI: 10.1038/srep32506
PubMed: 27581921
PubMed Central: 5007471
Affiliations:
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xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Matsuki, Daisuke" sort="Matsuki, Daisuke" uniqKey="Matsuki D" first="Daisuke" last="Matsuki">Daisuke Matsuki</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Laboratory of Biomedical Engineering for Cancer, Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University</institution>, 4-1 Seiryo, Aoba, Sendai, Miyagi, 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tada, Asuka" sort="Tada, Asuka" uniqKey="Tada A" first="Asuka" last="Tada">Asuka Tada</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Laboratory of Biomedical Engineering for Cancer, Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University</institution>, 4-1 Seiryo, Aoba, Sendai, Miyagi, 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Graduate School of Engineering, Tohoku University</institution>, 6-6-05 Aramaki-aza-Aoba, Aoba, Sendai 980-8579,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Takeda, Kazu" sort="Takeda, Kazu" uniqKey="Takeda K" first="Kazu" last="Takeda">Kazu Takeda</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Laboratory of Biomedical Engineering for Cancer, Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University</institution>, 4-1 Seiryo, Aoba, Sendai, Miyagi, 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mori, Shiro" sort="Mori, Shiro" uniqKey="Mori S" first="Shiro" last="Mori">Shiro Mori</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Oral and Maxillofacial Surgery, Tohoku University Hospital</institution>, 1-1 Seiryo, Aoba, Sendai 980-8575,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Intravenous chemotherapy has poor access to metastatic lymph nodes (LNs) and is limited by short-lived drug concentrations. Here, we describe the administration of chemotherapy via the lymphatic network as a new concept for the prevention and treatment of metastatic LNs. A metastatic LN can be treated by the injection of drugs into an upstream LN, either the sentinel LN (SLN) or another upstream LN. In a mouse model, tumor cells were inoculated into the subiliac LN (SiLN) to induce metastasis to the proper axillary LN (PALN). Two routes were used for drug delivery to the PALN, namely from the SiLN and from the accessory axillary LN (AALN). We found that tumor masses were formed in lymphatic vessels between the SiLN and PALN. The flow of fluorescent solution injected into the SiLN towards the PALN decreased with tumor mass formation. Delivery from the AALN (free of metastatic tumor cells) to the PALN was identified as an alternative route. Intranodal injection can deliver high concentrations of drugs to secondary metastatic LNs. The study advocates a new concept for the prevention and treatment of metastatic lymph nodes whereby drugs injected into upstream lymph nodes can reach metastatic lymph nodes via the lymphatic network.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mehlen, P" uniqKey="Mehlen P">P. Mehlen</name></author><author><name sortKey="Puisieux, A" uniqKey="Puisieux A">A. Puisieux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamamoto, H" uniqKey="Yamamoto H">H. Yamamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sato, T" uniqKey="Sato T">T. Sato</name></author><author><name sortKey="Mori, S" uniqKey="Mori S">S. Mori</name></author><author><name sortKey="Arai, Y" uniqKey="Arai Y">Y. Arai</name></author><author><name sortKey="Kodama, T" uniqKey="Kodama T">T. 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Sakamoto</name></author><author><name sortKey="Takahashi, S" uniqKey="Takahashi S">S. Takahashi</name></author><author><name sortKey="Kodama, T" uniqKey="Kodama T">T. Kodama</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Kodama, Tetsuya" sort="Kodama, Tetsuya" uniqKey="Kodama T" first="Tetsuya" last="Kodama">Tetsuya Kodama</name></noRegion><name sortKey="Matsuki, Daisuke" sort="Matsuki, Daisuke" uniqKey="Matsuki D" first="Daisuke" last="Matsuki">Daisuke Matsuki</name><name sortKey="Mori, Shiro" sort="Mori, Shiro" uniqKey="Mori S" first="Shiro" last="Mori">Shiro Mori</name><name sortKey="Tada, Asuka" sort="Tada, Asuka" uniqKey="Tada A" first="Asuka" last="Tada">Asuka Tada</name><name sortKey="Tada, Asuka" sort="Tada, Asuka" uniqKey="Tada A" first="Asuka" last="Tada">Asuka Tada</name><name sortKey="Takeda, Kazu" sort="Takeda, Kazu" uniqKey="Takeda K" first="Kazu" last="Takeda">Kazu Takeda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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