Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway
Identifieur interne : 000C16 ( Main/Exploration ); précédent : 000C15; suivant : 000C17Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway
Auteurs : Noraziah Nordin [Malaisie] ; Mehran Fadaeinasab [Malaisie] ; Syam Mohan ; Najihah Mohd Hashim [Malaisie] ; Rozana Othman [Malaisie] ; Hamed Karimian [Malaisie] ; Venus Iman [Malaisie] ; Noorlela Ramli [Malaisie] ; Hapipah Mohd Ali [Malaisie] ; Nazia Abdul Majid [Malaisie]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
Drug resistance presents a challenge in chemotherapy and has attracted research interest worldwide and particular attention has been given to natural compounds to overcome this difficulty. Pulchrin A, a new compound isolated from natural products has demonstrated novel potential for development as a drug. The identification of pulchrin A was conducted using several spectroscopic techniques such as nuclear magnetic resonance, liquid chromatography mass spectrometer, infrared and ultraviolet spectrometry. The cytotoxicity effects on CAOV-3 cells indicates that pulchrin A is more active than cisplatin, which has an IC50 of 22.3 μM. Significant changes in cell morphology were present, such as cell membrane blebbing and formation of apoptotic bodies. The involvement of phosphatidylserine (PS) in apoptosis was confirmed by Annexin V-FITC after a 24 h treatment. Apoptosis was activated through the intrinsic pathway by activation of procaspases 3 and 9 as well as cleaved caspases 3 and 9 and ended at the executioner pathway, with the occurrence of DNA laddering. Apoptosis was further confirmed via gene and protein expression levels, in which Bcl-2 protein was down-regulated and Bax protein was up-regulated. Furthermore, the CAOV-3 cell cycle was disrupted at the G0/G1 phase, leading to apoptosis. Molecular modeling of Bcl-2 proteins demonstrated a high- binding affinity, which inhibited the function of Bcl-2 proteins and led to cell death. Results of the current study can shed light on the development of new therapeutic agents, particularly, human ovarian cancer treatments.
Url:
DOI: 10.1371/journal.pone.0154023
PubMed: 27136097
PubMed Central: 4852948
Affiliations:
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Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Fadaeinasab, Mehran" sort="Fadaeinasab, Mehran" uniqKey="Fadaeinasab M" first="Mehran" last="Fadaeinasab">Mehran Fadaeinasab</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Mohan, Syam" sort="Mohan, Syam" uniqKey="Mohan S" first="Syam" last="Mohan">Syam Mohan</name><affiliation><nlm:aff id="aff003"><addr-line>Medical Research Center, Jazan University, Jazan, Kingdom of Saudi Arabia</addr-line></nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia</wicri:noCountry></affiliation></author><author><name sortKey="Mohd Hashim, Najihah" sort="Mohd Hashim, Najihah" uniqKey="Mohd Hashim N" first="Najihah" last="Mohd Hashim">Najihah Mohd Hashim</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Othman, Rozana" sort="Othman, Rozana" uniqKey="Othman R" first="Rozana" last="Othman">Rozana Othman</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Karimian, Hamed" sort="Karimian, Hamed" uniqKey="Karimian H" first="Hamed" last="Karimian">Hamed Karimian</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Iman, Venus" sort="Iman, Venus" uniqKey="Iman V" first="Venus" last="Iman">Venus Iman</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Ramli, Noorlela" sort="Ramli, Noorlela" uniqKey="Ramli N" first="Noorlela" last="Ramli">Noorlela Ramli</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Mohd Ali, Hapipah" sort="Mohd Ali, Hapipah" uniqKey="Mohd Ali H" first="Hapipah" last="Mohd Ali">Hapipah Mohd Ali</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Abdul Majid, Nazia" sort="Abdul Majid, Nazia" uniqKey="Abdul Majid N" first="Nazia" last="Abdul Majid">Nazia Abdul Majid</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Drug resistance presents a challenge in chemotherapy and has attracted research interest worldwide and particular attention has been given to natural compounds to overcome this difficulty. Pulchrin A, a new compound isolated from natural products has demonstrated novel potential for development as a drug. The identification of pulchrin A was conducted using several spectroscopic techniques such as nuclear magnetic resonance, liquid chromatography mass spectrometer, infrared and ultraviolet spectrometry. The cytotoxicity effects on CAOV-3 cells indicates that pulchrin A is more active than cisplatin, which has an IC<sub>50</sub> of 22.3 μM. Significant changes in cell morphology were present, such as cell membrane blebbing and formation of apoptotic bodies. The involvement of phosphatidylserine (PS) in apoptosis was confirmed by Annexin V-FITC after a 24 h treatment. Apoptosis was activated through the intrinsic pathway by activation of procaspases 3 and 9 as well as cleaved caspases 3 and 9 and ended at the executioner pathway, with the occurrence of DNA laddering. Apoptosis was further confirmed via gene and protein expression levels, in which Bcl-2 protein was down-regulated and Bax protein was up-regulated. Furthermore, the CAOV-3 cell cycle was disrupted at the G0/G1 phase, leading to apoptosis. Molecular modeling of Bcl-2 proteins demonstrated a high- binding affinity, which inhibited the function of Bcl-2 proteins and led to cell death. Results of the current study can shed light on the development of new therapeutic agents, particularly, human ovarian cancer treatments.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Syam, S" uniqKey="Syam S">S Syam</name></author><author><name sortKey="Abdul, Ab" uniqKey="Abdul A">AB Abdul</name></author><author><name sortKey="Sukari, Ma" uniqKey="Sukari M">MA Sukari</name></author><author><name sortKey="Mohan, S" uniqKey="Mohan S">S Mohan</name></author><author><name sortKey="Abdelwahab, Si" uniqKey="Abdelwahab S">SI Abdelwahab</name></author><author><name sortKey="Wah, Ts" uniqKey="Wah T">TS Wah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dellaire, G" uniqKey="Dellaire G">G Dellaire</name></author><author><name sortKey="Berman, Jn" uniqKey="Berman J">JN Berman</name></author><author><name sortKey="Arceci, Rj" uniqKey="Arceci R">RJ Arceci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zainal Ariffin, O" uniqKey="Zainal Ariffin O">O Zainal Ariffin</name></author><author><name sortKey="Nor Saleha, I" uniqKey="Nor Saleha I">I Nor Saleha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I Soerjomataram</name></author><author><name sortKey="Ervik, M" uniqKey="Ervik M">M Ervik</name></author><author><name sortKey="Dikshit, R" uniqKey="Dikshit R">R Dikshit</name></author><author><name sortKey="Eser, S" uniqKey="Eser S">S Eser</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siegel, R" uniqKey="Siegel R">R Siegel</name></author><author><name sortKey="Naishadham, D" uniqKey="Naishadham D">D Naishadham</name></author><author><name sortKey="Jemal, A" uniqKey="Jemal A">A Jemal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gentry Maharaj, A" uniqKey="Gentry Maharaj A">A Gentry-Maharaj</name></author><author><name sortKey="Menon, U" uniqKey="Menon U">U Menon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosary, Cl" uniqKey="Kosary C">CL Kosary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubin, Sc" uniqKey="Rubin S">SC Rubin</name></author><author><name sortKey="Randall, Tc" uniqKey="Randall T">TC Randall</name></author><author><name sortKey="Armstrong, Ka" uniqKey="Armstrong K">KA Armstrong</name></author><author><name sortKey="Chi, Ds" uniqKey="Chi D">DS Chi</name></author><author><name sortKey="Hoskins, Wj" uniqKey="Hoskins W">WJ Hoskins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mantovani, A" uniqKey="Mantovani A">A Mantovani</name></author><author><name sortKey="Allavena, P" uniqKey="Allavena P">P Allavena</name></author><author><name sortKey="Sica, A" uniqKey="Sica A">A Sica</name></author><author><name sortKey="Balkwill, F" uniqKey="Balkwill F">F Balkwill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egan, D" uniqKey="Egan D">D Egan</name></author><author><name sortKey="O Kennedy, R" uniqKey="O Kennedy R">R O'kennedy</name></author><author><name sortKey="Moran, E" uniqKey="Moran E">E Moran</name></author><author><name sortKey="Cox, D" uniqKey="Cox D">D Cox</name></author><author><name sortKey="Prosser, E" uniqKey="Prosser E">E Prosser</name></author><author><name sortKey="Thornes, Rd" uniqKey="Thornes R">RD Thornes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borges, F" uniqKey="Borges F">F Borges</name></author><author><name sortKey="Roleira, F" uniqKey="Roleira F">F Roleira</name></author><author><name sortKey="Milhazes, N" uniqKey="Milhazes N">N Milhazes</name></author><author><name sortKey="Santana, L" uniqKey="Santana L">L Santana</name></author><author><name sortKey="Uriarte, E" uniqKey="Uriarte E">E Uriarte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harvey, Rg" uniqKey="Harvey R">RG Harvey</name></author><author><name sortKey="Cortez, C" uniqKey="Cortez C">C Cortez</name></author><author><name sortKey="Ananthanarayan, T" uniqKey="Ananthanarayan T">T Ananthanarayan</name></author><author><name sortKey="Schmolka, S" uniqKey="Schmolka S">S Schmolka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kostova, I" uniqKey="Kostova I">I Kostova</name></author><author><name sortKey="Raleva, S" uniqKey="Raleva S">S Raleva</name></author><author><name sortKey="Genova, P" uniqKey="Genova P">P Genova</name></author><author><name sortKey="Argirova, R" uniqKey="Argirova R">R Argirova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moffett, Rb" uniqKey="Moffett R">RB Moffett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Haiza, M" uniqKey="Al Haiza M">M Al-Haiza</name></author><author><name sortKey="Mostafa, M" uniqKey="Mostafa M">M Mostafa</name></author><author><name sortKey="El Kady, M" uniqKey="El Kady M">M El-Kady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Musicki, B" uniqKey="Musicki B">B Musicki</name></author><author><name sortKey="Periers, A M" uniqKey="Periers A">A-M Periers</name></author><author><name sortKey="Laurin, P" uniqKey="Laurin P">P Laurin</name></author><author><name sortKey="Ferroud, D" uniqKey="Ferroud D">D Ferroud</name></author><author><name sortKey="Benedetti, Y" uniqKey="Benedetti Y">Y Benedetti</name></author><author><name sortKey="Lachaud, S" uniqKey="Lachaud S">S Lachaud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Ansary, L" uniqKey="El Ansary L">L El-Ansary</name></author><author><name sortKey="Aly, E" uniqKey="Aly E">E Aly</name></author><author><name sortKey="Halem, M" uniqKey="Halem M">M Halem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cacic, M" uniqKey="Cacic M">M Cacic</name></author><author><name sortKey="Trkovnik, M" uniqKey="Trkovnik M">M Trkovnik</name></author><author><name sortKey="Cacic, F" uniqKey="Cacic F">F Cacic</name></author><author><name sortKey="Has Schon, E" uniqKey="Has Schon E">E Has-Schon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fylaktakidou, Kc" uniqKey="Fylaktakidou K">KC Fylaktakidou</name></author><author><name sortKey="Hadjipavlou Litina, Dj" uniqKey="Hadjipavlou Litina D">DJ Hadjipavlou-Litina</name></author><author><name sortKey="Litinas, Ke" uniqKey="Litinas K">KE Litinas</name></author><author><name sortKey="Nicolaides, Dn" uniqKey="Nicolaides D">DN Nicolaides</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, J C" uniqKey="Jung J">J-C Jung</name></author><author><name sortKey="Kim, J C" uniqKey="Kim J">J-C Kim</name></author><author><name sortKey="Park, O S" uniqKey="Park O">O-S Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allah, Oa" uniqKey="Allah O">OA Allah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Z S" uniqKey="Wang Z">Z-S Wang</name></author><author><name sortKey="Hara, K" uniqKey="Hara K">K Hara</name></author><author><name sortKey="Dan Oh, Y" uniqKey="Dan Oh Y">Y Dan-oh</name></author><author><name sortKey="Kasada, C" uniqKey="Kasada C">C Kasada</name></author><author><name sortKey="Shinpo, A" uniqKey="Shinpo A">A Shinpo</name></author><author><name sortKey="Suga, S" uniqKey="Suga S">S Suga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casley Smith, Jr" uniqKey="Casley Smith J">JR Casley-Smith</name></author><author><name sortKey="Casley Smith, Jr" uniqKey="Casley Smith J">JR Casley-Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casley Smith, Jr" uniqKey="Casley Smith J">JR Casley-Smith</name></author><author><name sortKey="Morgan, Rg" uniqKey="Morgan R">RG Morgan</name></author><author><name sortKey="Piller, Nb" uniqKey="Piller N">NB Piller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cox, D" uniqKey="Cox D">D Cox</name></author><author><name sortKey="O Kennedy, R" uniqKey="O Kennedy R">R O'kennedy</name></author><author><name sortKey="Thornes, R" uniqKey="Thornes R">R Thornes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sahoo, Ss" uniqKey="Sahoo S">SS Sahoo</name></author><author><name sortKey="Shukla, S" uniqKey="Shukla S">S Shukla</name></author><author><name sortKey="Nandy, S" uniqKey="Nandy S">S Nandy</name></author><author><name sortKey="Sahoo, Hb" uniqKey="Sahoo H">HB Sahoo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nordin, N" uniqKey="Nordin N">N Nordin</name></author><author><name sortKey="Salama, Sm" uniqKey="Salama S">SM Salama</name></author><author><name sortKey="Golbabapour, S" uniqKey="Golbabapour S">S Golbabapour</name></author><author><name sortKey="Hajrezaie, M" uniqKey="Hajrezaie M">M Hajrezaie</name></author><author><name sortKey="Hassandarvish, P" uniqKey="Hassandarvish P">P Hassandarvish</name></author><author><name sortKey="Kamalidehghan, B" uniqKey="Kamalidehghan B">B Kamalidehghan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, M" uniqKey="Kim M">M Kim</name></author><author><name sortKey="Rooper, L" uniqKey="Rooper L">L Rooper</name></author><author><name sortKey="Xie, J" uniqKey="Xie J">J Xie</name></author><author><name sortKey="Rayahin, J" uniqKey="Rayahin J">J Rayahin</name></author><author><name sortKey="Burdette, Je" uniqKey="Burdette J">JE Burdette</name></author><author><name sortKey="Kajdacsy Balla, Aa" uniqKey="Kajdacsy Balla A">AA Kajdacsy-Balla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Ml" uniqKey="Wong M">ML Wong</name></author><author><name sortKey="Medrano, Jf" uniqKey="Medrano J">JF Medrano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toure, Bb" uniqKey="Toure B">BB Touré</name></author><author><name sortKey="Miller Moslin, K" uniqKey="Miller Moslin K">K Miller-Moslin</name></author><author><name sortKey="Yusuff, N" uniqKey="Yusuff N">N Yusuff</name></author><author><name sortKey="Perez, L" uniqKey="Perez L">L Perez</name></author><author><name sortKey="Dore, M" uniqKey="Dore M">M Doré</name></author><author><name sortKey="Joud, C" uniqKey="Joud C">C Joud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berman, Hm" uniqKey="Berman H">HM Berman</name></author><author><name sortKey="Westbrook, J" uniqKey="Westbrook J">J Westbrook</name></author><author><name sortKey="Feng, Z" uniqKey="Feng Z">Z Feng</name></author><author><name sortKey="Gilliland, G" uniqKey="Gilliland G">G Gilliland</name></author><author><name sortKey="Bhat, T" uniqKey="Bhat T">T Bhat</name></author><author><name sortKey="Weissig, H" uniqKey="Weissig H">H Weissig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deshpande, N" uniqKey="Deshpande N">N Deshpande</name></author><author><name sortKey="Addess, Kj" uniqKey="Addess K">KJ Addess</name></author><author><name sortKey="Bluhm, Wf" uniqKey="Bluhm W">WF Bluhm</name></author><author><name sortKey="Merino Ott, Jc" uniqKey="Merino Ott J">JC Merino-Ott</name></author><author><name sortKey="Townsend Merino, W" uniqKey="Townsend Merino W">W Townsend-Merino</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morris, Gm" uniqKey="Morris G">GM Morris</name></author><author><name sortKey="Goodsell, Ds" uniqKey="Goodsell D">DS Goodsell</name></author><author><name sortKey="Halliday, Rs" uniqKey="Halliday R">RS Halliday</name></author><author><name sortKey="Huey, R" uniqKey="Huey R">R Huey</name></author><author><name sortKey="Hart, We" uniqKey="Hart W">WE Hart</name></author><author><name sortKey="Belew, Rk" uniqKey="Belew R">RK Belew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patil, Po" uniqKey="Patil P">PO Patil</name></author><author><name sortKey="Bari, Sb" uniqKey="Bari S">SB Bari</name></author><author><name sortKey="Firke, Sd" uniqKey="Firke S">SD Firke</name></author><author><name sortKey="Deshmukh, Pk" uniqKey="Deshmukh P">PK Deshmukh</name></author><author><name sortKey="Donda, St" uniqKey="Donda S">ST Donda</name></author><author><name sortKey="Patil, Da" uniqKey="Patil D">DA Patil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sotaniemi, E" uniqKey="Sotaniemi E">E Sotaniemi</name></author><author><name sortKey="Rautio, A" uniqKey="Rautio A">A Rautio</name></author><author><name sortKey="Backstrom, M" uniqKey="Backstrom M">M Backstrom</name></author><author><name sortKey="Arvela, P" uniqKey="Arvela P">P Arvela</name></author><author><name sortKey="Pelkonen, O" uniqKey="Pelkonen O">O Pelkonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eliopoulos, Ag" uniqKey="Eliopoulos A">AG Eliopoulos</name></author><author><name sortKey="Kerr, Dj" uniqKey="Kerr D">DJ Kerr</name></author><author><name sortKey="Herod, J" uniqKey="Herod J">J Herod</name></author><author><name sortKey="Hodgkins, L" uniqKey="Hodgkins L">L Hodgkins</name></author><author><name sortKey="Krajewski, S" uniqKey="Krajewski S">S Krajewski</name></author><author><name sortKey="Reed, Jc" uniqKey="Reed J">JC Reed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name></author><author><name sortKey="Petit, P" uniqKey="Petit P">P Petit</name></author><author><name sortKey="Zamzami, N" uniqKey="Zamzami N">N Zamzami</name></author><author><name sortKey="Vayssiere, J" uniqKey="Vayssiere J">J Vayssiere</name></author><author><name sortKey="Mignotte, B" uniqKey="Mignotte B">B Mignotte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hockenbery, D" uniqKey="Hockenbery D">D Hockenbery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaux, D" uniqKey="Vaux D">D Vaux</name></author><author><name sortKey="Cory, S" uniqKey="Cory S">S Cory</name></author><author><name sortKey="Adams, J" uniqKey="Adams J">J Adams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kothakota, S" uniqKey="Kothakota S">S Kothakota</name></author><author><name sortKey="Azuma, T" uniqKey="Azuma T">T Azuma</name></author><author><name sortKey="Reinhard, C" uniqKey="Reinhard C">C Reinhard</name></author><author><name sortKey="Klippel, A" uniqKey="Klippel A">A Klippel</name></author><author><name sortKey="Tang, J" uniqKey="Tang J">J Tang</name></author><author><name sortKey="Chu, K" uniqKey="Chu K">K Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudel, T" uniqKey="Rudel T">T Rudel</name></author><author><name sortKey="Bokoch, Gm" uniqKey="Bokoch G">GM Bokoch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samali, A" uniqKey="Samali A">A Samali</name></author><author><name sortKey="Zhivotovsky, B" uniqKey="Zhivotovsky B">B Zhivotovsky</name></author><author><name sortKey="Jones, D" uniqKey="Jones D">D Jones</name></author><author><name sortKey="Nagata, S" uniqKey="Nagata S">S Nagata</name></author><author><name sortKey="Orrenius, S" uniqKey="Orrenius S">S Orrenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blagosklonny, M" uniqKey="Blagosklonny M">M Blagosklonny</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagata, S" uniqKey="Nagata S">S Nagata</name></author><author><name sortKey="Hanayama, R" uniqKey="Hanayama R">R Hanayama</name></author><author><name sortKey="Kawane, K" uniqKey="Kawane K">K Kawane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fadok, Va" uniqKey="Fadok V">VA Fadok</name></author><author><name sortKey="Voelker, Dr" uniqKey="Voelker D">DR Voelker</name></author><author><name sortKey="Campbell, Pa" uniqKey="Campbell P">PA Campbell</name></author><author><name sortKey="Cohen, Jj" uniqKey="Cohen J">JJ Cohen</name></author><author><name sortKey="Bratton, Dl" uniqKey="Bratton D">DL Bratton</name></author><author><name sortKey="Henson, Pm" uniqKey="Henson P">PM Henson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verhoven, B" uniqKey="Verhoven B">B Verhoven</name></author><author><name sortKey="Schlegel, R" uniqKey="Schlegel R">R Schlegel</name></author><author><name sortKey="Williamson, P" uniqKey="Williamson P">P Williamson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ravichandran, Ks" uniqKey="Ravichandran K">KS Ravichandran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buendia, B" uniqKey="Buendia B">B Buendia</name></author><author><name sortKey="Santa Maria, A" uniqKey="Santa Maria A">A Santa-Maria</name></author><author><name sortKey="Courvalin, J" uniqKey="Courvalin J">J Courvalin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lazebnik, Ya" uniqKey="Lazebnik Y">YA Lazebnik</name></author><author><name sortKey="Takahashi, A" uniqKey="Takahashi A">A Takahashi</name></author><author><name sortKey="Moir, Rd" uniqKey="Moir R">RD Moir</name></author><author><name sortKey="Goldman, Rd" uniqKey="Goldman R">RD Goldman</name></author><author><name sortKey="Poirier, Gg" uniqKey="Poirier G">GG Poirier</name></author><author><name sortKey="Kaufmann, Sh" uniqKey="Kaufmann S">SH Kaufmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, L" uniqKey="Rao L">L Rao</name></author><author><name sortKey="Perez, D" uniqKey="Perez D">D Perez</name></author><author><name sortKey="White, E" uniqKey="White E">E White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elmore, S" uniqKey="Elmore S">S Elmore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nordin, N" uniqKey="Nordin N">N Nordin</name></author><author><name sortKey="Majid, N" uniqKey="Majid N">N Majid</name></author><author><name sortKey="Hashim, Nm" uniqKey="Hashim N">NM Hashim</name></author><author><name sortKey="Rahman, Ma" uniqKey="Rahman M">MA Rahman</name></author><author><name sortKey="Hassan, Z" uniqKey="Hassan Z">Z Hassan</name></author><author><name sortKey="Ali, Hm" uniqKey="Ali H">HM Ali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decaudin, D" uniqKey="Decaudin D">D Decaudin</name></author><author><name sortKey="Marzo, I" uniqKey="Marzo I">I Marzo</name></author><author><name sortKey="Brenner, C" uniqKey="Brenner C">C Brenner</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Green, Dr" uniqKey="Green D">DR Green</name></author><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuler, M" uniqKey="Schuler M">M Schuler</name></author><author><name sortKey="Green, D" uniqKey="Green D">D Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ricci, J E" uniqKey="Ricci J">J-E Ricci</name></author><author><name sortKey="Mu Oz Pinedo, C" uniqKey="Mu Oz Pinedo C">C Muñoz-Pinedo</name></author><author><name sortKey="Fitzgerald, P" uniqKey="Fitzgerald P">P Fitzgerald</name></author><author><name sortKey="Bailly Maitre, B" uniqKey="Bailly Maitre B">B Bailly-Maitre</name></author><author><name sortKey="Perkins, Ga" uniqKey="Perkins G">GA Perkins</name></author><author><name sortKey="Yadava, N" uniqKey="Yadava N">N Yadava</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saelens, X" uniqKey="Saelens X">X Saelens</name></author><author><name sortKey="Festjens, N" uniqKey="Festjens N">N Festjens</name></author><author><name sortKey="Walle, Lv" uniqKey="Walle L">LV Walle</name></author><author><name sortKey="Van Gurp, M" uniqKey="Van Gurp M">M Van Gurp</name></author><author><name sortKey="Van Loo, G" uniqKey="Van Loo G">G van Loo</name></author><author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P Vandenabeele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moll, Um" uniqKey="Moll U">UM Moll</name></author><author><name sortKey="Wolff, S" uniqKey="Wolff S">S Wolff</name></author><author><name sortKey="Speidel, D" uniqKey="Speidel D">D Speidel</name></author><author><name sortKey="Deppert, W" uniqKey="Deppert W">W Deppert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stennicke, Hr" uniqKey="Stennicke H">HR Stennicke</name></author><author><name sortKey="Salvesen, Gs" uniqKey="Salvesen G">GS Salvesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Degterev, A" uniqKey="Degterev A">A Degterev</name></author><author><name sortKey="Boyce, M" uniqKey="Boyce M">M Boyce</name></author><author><name sortKey="Yuan, J" uniqKey="Yuan J">J Yuan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Wd" uniqKey="Thomas W">WD Thomas</name></author><author><name sortKey="Hersey, P" uniqKey="Hersey P">P Hersey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagata, S" uniqKey="Nagata S">S Nagata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wyllie, Ah" uniqKey="Wyllie A">AH Wyllie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ambrosini, G" uniqKey="Ambrosini G">G Ambrosini</name></author><author><name sortKey="Adida, C" uniqKey="Adida C">C Adida</name></author><author><name sortKey="Altieri, Dc" uniqKey="Altieri D">DC Altieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altieri, Dc" uniqKey="Altieri D">DC Altieri</name></author><author><name sortKey="Marchisio, P" uniqKey="Marchisio P">P Marchisio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salvesen, Gs" uniqKey="Salvesen G">GS Salvesen</name></author><author><name sortKey="Duckett, Cs" uniqKey="Duckett C">CS Duckett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deveraux, Ql" uniqKey="Deveraux Q">QL Deveraux</name></author><author><name sortKey="Reed, Jc" uniqKey="Reed J">JC Reed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheung, Hh" uniqKey="Cheung H">HH Cheung</name></author><author><name sortKey="Lacasse, Ec" uniqKey="Lacasse E">EC LaCasse</name></author><author><name sortKey="Korneluk, Rg" uniqKey="Korneluk R">RG Korneluk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hartwell, Lh" uniqKey="Hartwell L">LH Hartwell</name></author><author><name sortKey="Weinert, Ta" uniqKey="Weinert T">TA 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Livingstone</name></author><author><name sortKey="White, A" uniqKey="White A">A White</name></author><author><name sortKey="Sprouse, J" uniqKey="Sprouse J">J Sprouse</name></author><author><name sortKey="Livanos, E" uniqKey="Livanos E">E Livanos</name></author><author><name sortKey="Jacks, T" uniqKey="Jacks T">T Jacks</name></author><author><name sortKey="Tlsty, Td" uniqKey="Tlsty T">TD Tlsty</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Malaisie</li></country></list><tree><noCountry><name sortKey="Mohan, Syam" sort="Mohan, Syam" uniqKey="Mohan S" first="Syam" last="Mohan">Syam Mohan</name></noCountry><country name="Malaisie"><noRegion><name sortKey="Nordin, Noraziah" sort="Nordin, Noraziah" uniqKey="Nordin N" first="Noraziah" last="Nordin">Noraziah Nordin</name></noRegion><name sortKey="Abdul Majid, Nazia" sort="Abdul Majid, Nazia" uniqKey="Abdul Majid N" first="Nazia" last="Abdul Majid">Nazia Abdul Majid</name><name 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