Serveur d'exploration sur le lymphœdème

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Pump function curve shape for a model lymphatic vessel

Identifieur interne : 000C12 ( Main/Exploration ); précédent : 000C11; suivant : 000C13

Pump function curve shape for a model lymphatic vessel

Auteurs : C. D. Bertram ; C. Macaskill ; J. E. Moore

Source :

RBID : PMC:4893775

Abstract

The transport capacity of a contractile segment of lymphatic vessel is defined by its pump function curve relating mean flow-rate and adverse pressure difference. Numerous system characteristics affect curve shape and the magnitude of the generated flow-rates and pressures. Some cannot be varied experimentally, but their separate and interacting effects can be systematically revealed numerically. This paper explores variations in the rate of change of active tension and the form of the relation between active tension and muscle length, factors not known from experiment to functional precision. Whether the pump function curve bends toward or away from the origin depends partly on the curvature of the passive pressure-diameter relation near zero transmural pressure, but rather more on the form of the relation between active tension and muscle length. A pump function curve bending away from the origin defines a well-performing pump by maximum steady output power. This behaviour is favoured by a length/active-tension relationship which sustains tension at smaller lengths. Such a relationship also favours high peak mechanical efficiency, defined as output power divided by the input power obtained from the lymphangion diameter changes and active-tension time-course. The results highlight the need to pin down experimentally the form of the active tension/length relationship.


Url:
DOI: 10.1016/j.medengphy.2016.04.009
PubMed: 27185045
PubMed Central: 4893775


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Pump function curve shape for a model lymphatic vessel</title>
<author>
<name sortKey="Bertram, C D" sort="Bertram, C D" uniqKey="Bertram C" first="C. D." last="Bertram">C. D. Bertram</name>
<affiliation>
<nlm:aff id="A1">School of Mathematics and Statistics, University of Sydney, New South Wales, Australia 2006</nlm:aff>
<wicri:noCountry code="subfield">Australia 2006</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Macaskill, C" sort="Macaskill, C" uniqKey="Macaskill C" first="C." last="Macaskill">C. Macaskill</name>
<affiliation>
<nlm:aff id="A1">School of Mathematics and Statistics, University of Sydney, New South Wales, Australia 2006</nlm:aff>
<wicri:noCountry code="subfield">Australia 2006</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Moore, J E" sort="Moore, J E" uniqKey="Moore J" first="J. E." last="Moore">J. E. Moore</name>
<affiliation>
<nlm:aff id="A2">Department of Bioengineering, Imperial College, London, England SW7 2AZ</nlm:aff>
<wicri:noCountry code="subfield">England SW7 2AZ</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">27185045</idno>
<idno type="pmc">4893775</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893775</idno>
<idno type="RBID">PMC:4893775</idno>
<idno type="doi">10.1016/j.medengphy.2016.04.009</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">003991</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003991</idno>
<idno type="wicri:Area/Pmc/Curation">003990</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003990</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000657</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000657</idno>
<idno type="wicri:Area/Ncbi/Merge">008297</idno>
<idno type="wicri:Area/Ncbi/Curation">008297</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">008297</idno>
<idno type="wicri:doubleKey">1350-4533:2016:Bertram C:pump:function:curve</idno>
<idno type="wicri:Area/Main/Merge">000C13</idno>
<idno type="wicri:Area/Main/Curation">000C12</idno>
<idno type="wicri:Area/Main/Exploration">000C12</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Pump function curve shape for a model lymphatic vessel</title>
<author>
<name sortKey="Bertram, C D" sort="Bertram, C D" uniqKey="Bertram C" first="C. D." last="Bertram">C. D. Bertram</name>
<affiliation>
<nlm:aff id="A1">School of Mathematics and Statistics, University of Sydney, New South Wales, Australia 2006</nlm:aff>
<wicri:noCountry code="subfield">Australia 2006</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Macaskill, C" sort="Macaskill, C" uniqKey="Macaskill C" first="C." last="Macaskill">C. Macaskill</name>
<affiliation>
<nlm:aff id="A1">School of Mathematics and Statistics, University of Sydney, New South Wales, Australia 2006</nlm:aff>
<wicri:noCountry code="subfield">Australia 2006</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Moore, J E" sort="Moore, J E" uniqKey="Moore J" first="J. E." last="Moore">J. E. Moore</name>
<affiliation>
<nlm:aff id="A2">Department of Bioengineering, Imperial College, London, England SW7 2AZ</nlm:aff>
<wicri:noCountry code="subfield">England SW7 2AZ</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Medical engineering & physics</title>
<idno type="ISSN">1350-4533</idno>
<idno type="eISSN">1873-4030</idno>
<imprint>
<date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p id="P1">The transport capacity of a contractile segment of lymphatic vessel is defined by its pump function curve relating mean flow-rate and adverse pressure difference. Numerous system characteristics affect curve shape and the magnitude of the generated flow-rates and pressures. Some cannot be varied experimentally, but their separate and interacting effects can be systematically revealed numerically. This paper explores variations in the rate of change of active tension and the form of the relation between active tension and muscle length, factors not known from experiment to functional precision. Whether the pump function curve bends toward or away from the origin depends partly on the curvature of the passive pressure-diameter relation near zero transmural pressure, but rather more on the form of the relation between active tension and muscle length. A pump function curve bending away from the origin defines a well-performing pump by maximum steady output power. This behaviour is favoured by a length/active-tension relationship which sustains tension at smaller lengths. Such a relationship also favours high peak mechanical efficiency, defined as output power divided by the input power obtained from the lymphangion diameter changes and active-tension time-course. The results highlight the need to pin down experimentally the form of the active tension/length relationship.</p>
</div>
</front>
</TEI>
<affiliations>
<list></list>
<tree>
<noCountry>
<name sortKey="Bertram, C D" sort="Bertram, C D" uniqKey="Bertram C" first="C. D." last="Bertram">C. D. Bertram</name>
<name sortKey="Macaskill, C" sort="Macaskill, C" uniqKey="Macaskill C" first="C." last="Macaskill">C. Macaskill</name>
<name sortKey="Moore, J E" sort="Moore, J E" uniqKey="Moore J" first="J. E." last="Moore">J. E. Moore</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C12 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C12 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4893775
   |texte=   Pump function curve shape for a model lymphatic vessel
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27185045" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1 

Wicri

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024