SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development
Identifieur interne : 000B45 ( Main/Exploration ); précédent : 000B44; suivant : 000B46SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development
Auteurs : Sara Cuvertino [Royaume-Uni] ; Georges Lacaud [Royaume-Uni] ; Valerie Kouskoff [Royaume-Uni]Source :
- Open Biology [ 2046-2441 ] ; 2016.
Abstract
During embryogenesis, the three SOXF transcription factors, SOX7, SOX17 and SOX18, regulate the specification of the cardiovascular system and are also involved in the development of haematopoiesis. The ectopic expression of SOX17 in both embryonic and adult blood cells enhances self-renewal. Likewise, the enforced expression of SOX7 during embryonic development promotes the proliferation of early blood progenitors and blocks lineage commitment. However, whether SOX7 expression can also affect the self-renewal of adult blood progenitors has never been explored. In this study, we demonstrate using an inducible transgenic mouse model that the enforced expression of
Url:
DOI: 10.1098/rsob.160070
PubMed: 27411892
PubMed Central: 4967825
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development</title><author><name sortKey="Cuvertino, Sara" sort="Cuvertino, Sara" uniqKey="Cuvertino S" first="Sara" last="Cuvertino">Sara Cuvertino</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cell Hematopoiesis Group</addr-line>,<institution>Cancer Research UK Manchester Institute, University of Manchester</institution>,<addr-line>Wilmslow Road, Manchester M20 4BX</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lacaud, Georges" sort="Lacaud, Georges" uniqKey="Lacaud G" first="Georges" last="Lacaud">Georges Lacaud</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Stem Cell Biology Group</addr-line>,<institution>Cancer Research UK Manchester Institute, University of Manchester</institution>,<addr-line>Wilmslow Road, Manchester M20 4BX</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kouskoff, Valerie" sort="Kouskoff, Valerie" uniqKey="Kouskoff V" first="Valerie" last="Kouskoff">Valerie Kouskoff</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cell Hematopoiesis Group</addr-line>,<institution>Cancer Research UK Manchester Institute, University of Manchester</institution>,<addr-line>Wilmslow Road, Manchester M20 4BX</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27411892</idno><idno type="pmc">4967825</idno><idno 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type="main">SOX7-enforced expression promotes the expansion of adult blood progenitors and blocks B-cell development</title><author><name sortKey="Cuvertino, Sara" sort="Cuvertino, Sara" uniqKey="Cuvertino S" first="Sara" last="Cuvertino">Sara Cuvertino</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cell Hematopoiesis Group</addr-line>,<institution>Cancer Research UK Manchester Institute, University of Manchester</institution>,<addr-line>Wilmslow Road, Manchester M20 4BX</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lacaud, Georges" sort="Lacaud, Georges" uniqKey="Lacaud G" first="Georges" last="Lacaud">Georges Lacaud</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Stem Cell Biology Group</addr-line>,<institution>Cancer Research UK Manchester Institute, University of Manchester</institution>,<addr-line>Wilmslow Road, Manchester M20 4BX</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kouskoff, Valerie" sort="Kouskoff, Valerie" uniqKey="Kouskoff V" first="Valerie" last="Kouskoff">Valerie Kouskoff</name><affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Stem Cell Hematopoiesis Group</addr-line>,<institution>Cancer Research UK Manchester Institute, University of Manchester</institution>,<addr-line>Wilmslow Road, Manchester M20 4BX</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Open Biology</title><idno type="eISSN">2046-2441</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>During embryogenesis, the three SOXF transcription factors, SOX7, SOX17 and SOX18, regulate the specification of the cardiovascular system and are also involved in the development of haematopoiesis. The ectopic expression of SOX17 in both embryonic and adult blood cells enhances self-renewal. Likewise, the enforced expression of SOX7 during embryonic development promotes the proliferation of early blood progenitors and blocks lineage commitment. However, whether SOX7 expression can also affect the self-renewal of adult blood progenitors has never been explored. In this study, we demonstrate using an inducible transgenic mouse model that the enforced expression of <italic>Sox7 ex vivo</italic> in bone marrow/stroma cell co-culture promotes the proliferation of blood progenitors which retain multi-lineage short-term engrafting capacity. Furthermore, SOX7 expression induces a profound block in the generation of B lymphocytes. Correspondingly, the ectopic expression of SOX7 <italic>in vivo</italic> results in dramatic alterations of the haematopoietic system, inducing the proliferation of blood progenitors in the bone marrow while blocking B lymphopoiesis. In addition, SOX7 expression induces extra-medullary haematopoiesis in the spleen and liver. Together, these data demonstrate that the uncontrolled expression of the transcription factor SOX7 in adult haematopoietic cells has dramatic consequences on blood homeostasis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schepers, Ge" uniqKey="Schepers G">GE Schepers</name></author><author><name sortKey="Teasdale, Rd" uniqKey="Teasdale R">RD Teasdale</name></author><author><name sortKey="Koopman, P" uniqKey="Koopman P">P Koopman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamachi, Y" uniqKey="Kamachi Y">Y Kamachi</name></author><author><name sortKey="Kondoh, H" uniqKey="Kondoh H">H Kondoh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarkar, A" uniqKey="Sarkar A">A Sarkar</name></author><author><name sortKey="Hochedlinger, K" uniqKey="Hochedlinger K">K Hochedlinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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Vikkula</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Man, Ch" uniqKey="Man C">CH Man</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cumano, A" uniqKey="Cumano A">A Cumano</name></author><author><name sortKey="Paige, Cj" uniqKey="Paige C">CJ Paige</name></author><author><name sortKey="Iscove, Nn" uniqKey="Iscove N">NN Iscove</name></author><author><name sortKey="Brady, G" uniqKey="Brady G">G Brady</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lacaud, G" uniqKey="Lacaud G">G Lacaud</name></author><author><name sortKey="Carlsson, L" uniqKey="Carlsson L">L Carlsson</name></author><author><name sortKey="Keller, G" uniqKey="Keller G">G Keller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Q" uniqKey="Yu Q">Q Yu</name></author><author><name sortKey="Quinn, Wj" uniqKey="Quinn W">WJ Quinn</name></author><author><name sortKey="Salay, T" uniqKey="Salay T">T Salay</name></author><author><name sortKey="Crowley, Je" uniqKey="Crowley J">JE Crowley</name></author><author><name sortKey="Cancro, Mp" uniqKey="Cancro M">MP Cancro</name></author><author><name sortKey="Sen, Jm" uniqKey="Sen J">JM Sen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Cuvertino, Sara" sort="Cuvertino, Sara" uniqKey="Cuvertino S" first="Sara" last="Cuvertino">Sara Cuvertino</name></noRegion><name sortKey="Kouskoff, Valerie" sort="Kouskoff, Valerie" uniqKey="Kouskoff V" first="Valerie" last="Kouskoff">Valerie Kouskoff</name><name sortKey="Lacaud, Georges" sort="Lacaud, Georges" uniqKey="Lacaud G" first="Georges" last="Lacaud">Georges Lacaud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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