The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases.
Identifieur interne : 000A31 ( Main/Exploration ); précédent : 000A30; suivant : 000A32The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases.
Auteurs : Peter Mubanga Cheuka [Afrique du Sud] ; Godfrey Mayoka [Afrique du Sud] ; Peggoty Mutai [Kenya] ; Kelly Chibale [Afrique du Sud]Source :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2016.
Descripteurs français
- KwdFr :
- Antiprotozoaires (usage thérapeutique), Découverte de médicament (), Filariose lymphatique (traitement médicamenteux), Humains, Leishmaniose (traitement médicamenteux), Maladie du sommeil (traitement médicamenteux), Maladies négligées (traitement médicamenteux), Phytothérapie (), Produits biologiques (usage thérapeutique), Préparations à base de plantes (usage thérapeutique), Schistosomiase (traitement médicamenteux).
- MESH :
- traitement médicamenteux : Filariose lymphatique, Leishmaniose, Maladie du sommeil, Maladies négligées, Schistosomiase.
- usage thérapeutique : Antiprotozoaires, Produits biologiques, Préparations à base de plantes.
- Découverte de médicament, Humains, Phytothérapie.
English descriptors
- KwdEn :
- Antiprotozoal Agents (therapeutic use), Biological Products (therapeutic use), Drug Discovery (methods), Elephantiasis, Filarial (drug therapy), Humans, Leishmaniasis (drug therapy), Neglected Diseases (drug therapy), Phytotherapy (methods), Plant Preparations (therapeutic use), Schistosomiasis (drug therapy), Trypanosomiasis, African (drug therapy).
- MESH :
- chemical , therapeutic use : Antiprotozoal Agents, Biological Products, Plant Preparations.
- drug therapy : Elephantiasis, Filarial, Leishmaniasis, Neglected Diseases, Schistosomiasis, Trypanosomiasis, African.
- methods : Drug Discovery, Phytotherapy.
- Humans.
Abstract
Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures. Natural products have been a valuable source of drug regimens that form the cornerstone of modern pharmaceutical care. In this review, we highlight the potential that remains untapped in natural products as drug leads for NTDs. We cover natural products from plant, marine, and microbial sources including natural-product-inspired semi-synthetic derivatives which have been evaluated against the various causative agents of NTDs. Our coverage is limited to four major NTDs which include human African trypanosomiasis (sleeping sickness), leishmaniasis, schistosomiasis and lymphatic filariasis.
DOI: 10.3390/molecules22010058
PubMed: 28042865
Affiliations:
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These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures. Natural products have been a valuable source of drug regimens that form the cornerstone of modern pharmaceutical care. In this review, we highlight the potential that remains untapped in natural products as drug leads for NTDs. We cover natural products from plant, marine, and microbial sources including natural-product-inspired semi-synthetic derivatives which have been evaluated against the various causative agents of NTDs. Our coverage is limited to four major NTDs which include human African trypanosomiasis (sleeping sickness), leishmaniasis, schistosomiasis and lymphatic filariasis.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Kenya</li></country></list><tree><country name="Afrique du Sud"><noRegion><name sortKey="Cheuka, Peter Mubanga" sort="Cheuka, Peter Mubanga" uniqKey="Cheuka P" first="Peter Mubanga" last="Cheuka">Peter Mubanga Cheuka</name></noRegion><name sortKey="Chibale, Kelly" sort="Chibale, Kelly" uniqKey="Chibale K" first="Kelly" last="Chibale">Kelly Chibale</name><name sortKey="Mayoka, Godfrey" sort="Mayoka, Godfrey" uniqKey="Mayoka G" first="Godfrey" last="Mayoka">Godfrey Mayoka</name></country><country name="Kenya"><noRegion><name sortKey="Mutai, Peggoty" sort="Mutai, Peggoty" uniqKey="Mutai P" first="Peggoty" last="Mutai">Peggoty Mutai</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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