The mitotic spindle: linking teratogenic effects of Zika virus with human genetics?
Identifieur interne : 000A02 ( Main/Exploration ); précédent : 000A01; suivant : 000A03The mitotic spindle: linking teratogenic effects of Zika virus with human genetics?
Auteurs : Joern Bullerdiek [Allemagne] ; Andreas Dotzauer [Allemagne] ; Ingrid Bauer [Allemagne]Source :
- Molecular Cytogenetics [ 1755-8166 ] ; 2016.
Abstract
Recently, an association between Zika virus infection and microcephaly/ocular findings was found to be reasonable e.g. because of the demonstration that the virus was found in the brain of a fetus after presumed maternal infection. Although there is no proof yet for a causal relationship, for an appropriate risk calculation efforts are urgently needed to either establish or disprove this assumption.
On the basis of inherited syndromes combining microcephaly with ocular findings similar to those associated with Zika infections, we have hypothesized that the impairment of the proper function of the mitotic apparatus is a possible mechanism by which Zika can exert teratogenic effects.
A bundle of well-known cytogenetic and molecular-cytogenetic methods (e.g. formation of micronuclei, chromosomal lagging, immunofluorescence of centrosomes) to evaluate proper function, maintenance, and establishment of the mitotic spindle poles can be applied on infected cells. Also, the viral proteins can be tested for their possible interaction with proteins encoded by genes involved in inherited syndromes with microcephaly and ocular findings resembling those in presumed cases of intrauterine ZIKV infection.
Once proved, this hypothesis allows for a targeted approach into mechanisms of possible relevance as e.g. if different strains of the virus are implicated in the teratogenic effects to the same or a different extent.
Url:
DOI: 10.1186/s13039-016-0240-1
PubMed: 27099632
PubMed Central: 4837584
Affiliations:
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ZHG, D-28359 Bremen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Centre for Human Genetics, University of Bremen, Leobener Str. ZHG, D-28359 Bremen</wicri:regionArea><placeName><region type="land" nuts="3">Brême (Land)</region><settlement type="city">Brême</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute of Medical Genetics, University Rostock Medical Center, Ernst-Heydemann-Strasse 8, D-18057 Rostock, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Genetics, University Rostock Medical Center, Ernst-Heydemann-Strasse 8, D-18057 Rostock</wicri:regionArea><wicri:noRegion>18057 Rostock</wicri:noRegion><wicri:noRegion>18057 Rostock</wicri:noRegion><wicri:noRegion>D-18057 Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Dotzauer, Andreas" sort="Dotzauer, Andreas" uniqKey="Dotzauer A" first="Andreas" last="Dotzauer">Andreas Dotzauer</name><affiliation wicri:level="3"><nlm:aff id="Aff3">Laboratory of Virus Research, University of Bremen, Leobener Straße/UFT, 28359, D-28359 Bremen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Laboratory of Virus Research, University of Bremen, Leobener Straße/UFT, 28359, D-28359 Bremen</wicri:regionArea><placeName><region type="land" nuts="3">Brême (Land)</region><settlement type="city">Brême</settlement></placeName></affiliation></author><author><name sortKey="Bauer, Ingrid" sort="Bauer, Ingrid" uniqKey="Bauer I" first="Ingrid" last="Bauer">Ingrid Bauer</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Institute of Medical Genetics, University Rostock Medical Center, Ernst-Heydemann-Strasse 8, D-18057 Rostock, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Genetics, University Rostock Medical Center, Ernst-Heydemann-Strasse 8, D-18057 Rostock</wicri:regionArea><wicri:noRegion>18057 Rostock</wicri:noRegion><wicri:noRegion>18057 Rostock</wicri:noRegion><wicri:noRegion>D-18057 Rostock</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Cytogenetics</title><idno type="eISSN">1755-8166</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Recently, an association between Zika virus infection and microcephaly/ocular findings was found to be reasonable e.g. because of the demonstration that the virus was found in the brain of a fetus after presumed maternal infection. Although there is no proof yet for a causal relationship, for an appropriate risk calculation efforts are urgently needed to either establish or disprove this assumption.</p></sec><sec><title>Presentation of the hypothesis</title><p>On the basis of inherited syndromes combining microcephaly with ocular findings similar to those associated with Zika infections, we have hypothesized that the impairment of the proper function of the mitotic apparatus is a possible mechanism by which Zika can exert teratogenic effects.</p></sec><sec><title>Testing the hypothesis</title><p>A bundle of well-known cytogenetic and molecular-cytogenetic methods (e.g. formation of micronuclei, chromosomal lagging, immunofluorescence of centrosomes) to evaluate proper function, maintenance, and establishment of the mitotic spindle poles can be applied on infected cells. Also, the viral proteins can be tested for their possible interaction with proteins encoded by genes involved in inherited syndromes with microcephaly and ocular findings resembling those in presumed cases of intrauterine ZIKV infection.</p></sec><sec><title>Implications of the hypothesis</title><p>Once proved, this hypothesis allows for a targeted approach into mechanisms of possible relevance as e.g. if different strains of the virus are implicated in the teratogenic effects to the same or a different extent.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schuler Faccini, L" uniqKey="Schuler Faccini L">L Schuler-Faccini</name></author><author><name sortKey="Ribeiro, Em" uniqKey="Ribeiro E">EM Ribeiro</name></author><author><name sortKey="Feitosa, Iml" uniqKey="Feitosa I">IML Feitosa</name></author><author><name sortKey="Horovitz, Ddg" uniqKey="Horovitz D">DDG Horovitz</name></author><author><name sortKey="Cavalcanti, Dp" uniqKey="Cavalcanti D">DP Cavalcanti</name></author><author><name sortKey="Pessoa, A" uniqKey="Pessoa A">A Pessoa</name></author><author><name sortKey="Doriqui, Mjr" uniqKey="Doriqui M">MJR Doriqui</name></author><author><name sortKey="Neri, Ji" uniqKey="Neri J">JI Neri</name></author><author><name sortKey="De P Neto, Jm" uniqKey="De P Neto J">JM de P Neto</name></author><author><name sortKey="Wanderley, Hyc" uniqKey="Wanderley H">HYC Wanderley</name></author><author><name sortKey="Cernach, M" uniqKey="Cernach M">M Cernach</name></author><author><name sortKey="El Husny, As" uniqKey="El Husny A">AS El-Husny</name></author><author><name sortKey="Pone, Mvs" uniqKey="Pone M">MVS Pone</name></author><author><name sortKey="Serao, Clc" uniqKey="Serao C">CLC Serao</name></author><author><name sortKey="Sanseverino, Mt" uniqKey="Sanseverino M">MT Sanseverino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ventura, Cv" uniqKey="Ventura C">CV Ventura</name></author><author><name sortKey="Maia, M" uniqKey="Maia M">M Maia</name></author><author><name sortKey="Ventura, Bv" uniqKey="Ventura B">BV Ventura</name></author><author><name sortKey="Van Der Linden, V" uniqKey="Van Der Linden V">V Van Der Linden</name></author><author><name sortKey="Araujo, Eb" uniqKey="Araujo E">EB Araújo</name></author><author><name sortKey="Ramos, Rc" uniqKey="Ramos R">RC Ramos</name></author><author><name sortKey="Rocha, Maw" uniqKey="Rocha M">MAW Rocha</name></author><author><name sortKey="Carvalho, Mdcg" uniqKey="Carvalho M">MDCG Carvalho</name></author><author><name sortKey="Belfort, R" uniqKey="Belfort R">R Belfort</name></author><author><name sortKey="Ventura, Lo" uniqKey="Ventura L">LO Ventura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ventura, Cv" uniqKey="Ventura C">CV Ventura</name></author><author><name sortKey="Maia, M" uniqKey="Maia M">M Maia</name></author><author><name sortKey="Bravo Filho, V" uniqKey="Bravo Filho V">V Bravo-Filho</name></author><author><name sortKey="G Is, Al" uniqKey="G Is A">AL Góis</name></author><author><name sortKey="Belfort, R" uniqKey="Belfort R">R Belfort</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mlakar, J" uniqKey="Mlakar J">J Mlakar</name></author><author><name sortKey="Korva, M" uniqKey="Korva M">M Korva</name></author><author><name sortKey="Tul, N" uniqKey="Tul N">N Tul</name></author><author><name sortKey="Popovi, M" uniqKey="Popovi M">M Popović</name></author><author><name sortKey="Poljsak Prijatelj, M" uniqKey="Poljsak Prijatelj M">M Poljšak-Prijatelj</name></author><author><name sortKey="Mraz, J" uniqKey="Mraz J">J Mraz</name></author><author><name sortKey="Kolenc, M" uniqKey="Kolenc M">M Kolenc</name></author><author><name sortKey="Resman Rus, K" uniqKey="Resman Rus K">K Resman Rus</name></author><author><name sortKey="Vesnaver Vipotnik, T" uniqKey="Vesnaver Vipotnik T">T Vesnaver Vipotnik</name></author><author><name sortKey="Fabjan Vodusek, V" uniqKey="Fabjan Vodusek V">V Fabjan Vodušek</name></author><author><name sortKey="Vizjak, A" uniqKey="Vizjak A">A Vizjak</name></author><author><name sortKey="Pizem, J" uniqKey="Pizem J">J Pižem</name></author><author><name sortKey="Petrovec, M" uniqKey="Petrovec M">M Petrovec</name></author><author><name sortKey="Avsi Upanc, T" uniqKey="Avsi Upanc T">T AvšičŽupanc</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oliveira Melo, As" uniqKey="Oliveira Melo A">AS Oliveira Melo</name></author><author><name sortKey="Malinger, G" uniqKey="Malinger G">G Malinger</name></author><author><name sortKey="Ximenes, R" uniqKey="Ximenes R">R Ximenes</name></author><author><name sortKey="Szejnfeld, Po" uniqKey="Szejnfeld P">PO Szejnfeld</name></author><author><name sortKey="Alves Sampaio, S" uniqKey="Alves Sampaio S">S Alves Sampaio</name></author><author><name sortKey="Bispo De Filippis, Am" uniqKey="Bispo De Filippis A">AM Bispo de Filippis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tetro, Ja" uniqKey="Tetro J">JA Tetro</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gilmore, Ec" uniqKey="Gilmore E">EC Gilmore</name></author><author><name sortKey="Walsh, Ca" uniqKey="Walsh C">CA Walsh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fryns, Jp" uniqKey="Fryns J">JP Fryns</name></author><author><name sortKey="Smeets, E" uniqKey="Smeets E">E Smeets</name></author><author><name sortKey="Van Den Berghe, H" uniqKey="Van Den Berghe H">H Van den Berghe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ostergaard, P" uniqKey="Ostergaard P">P Ostergaard</name></author><author><name sortKey="Simpson, Ma" uniqKey="Simpson M">MA Simpson</name></author><author><name sortKey="Mendola, A" uniqKey="Mendola A">A Mendola</name></author><author><name sortKey="Vasudevan, P" uniqKey="Vasudevan P">P Vasudevan</name></author><author><name sortKey="Connell, Fc" uniqKey="Connell F">FC Connell</name></author><author><name sortKey="Van Impel, A" uniqKey="Van Impel A">A van Impel</name></author><author><name sortKey="Moore, At" uniqKey="Moore A">AT Moore</name></author><author><name sortKey="Loeys, Bl" uniqKey="Loeys B">BL Loeys</name></author><author><name sortKey="Ghalamkarpour, A" uniqKey="Ghalamkarpour A">A Ghalamkarpour</name></author><author><name sortKey="Onoufriadis, A" uniqKey="Onoufriadis A">A Onoufriadis</name></author><author><name sortKey="Martinez Corral, I" uniqKey="Martinez Corral I">I Martinez-Corral</name></author><author><name sortKey="Devery, S" uniqKey="Devery S">S Devery</name></author><author><name sortKey="Leroy, Jg" uniqKey="Leroy J">JG Leroy</name></author><author><name sortKey="Van Laer, L" uniqKey="Van Laer L">L van Laer</name></author><author><name sortKey="Singer, A" uniqKey="Singer A">A Singer</name></author><author><name sortKey="Bialer, Mg" uniqKey="Bialer M">MG Bialer</name></author><author><name sortKey="Mcentagart, M" uniqKey="Mcentagart M">M McEntagart</name></author><author><name sortKey="Quarrell, O" uniqKey="Quarrell O">O Quarrell</name></author><author><name sortKey="Brice, G" uniqKey="Brice G">G Brice</name></author><author><name sortKey="Trembath, Rc" uniqKey="Trembath R">RC Trembath</name></author><author><name sortKey="Schulte Merker, S" uniqKey="Schulte Merker S">S Schulte-Merker</name></author><author><name sortKey="Makinen, T" uniqKey="Makinen T">T Makinen</name></author><author><name sortKey="Vikkula, M" uniqKey="Vikkula M">M Vikkula</name></author><author><name sortKey="Mortimer, Ps" uniqKey="Mortimer P">PS Mortimer</name></author><author><name sortKey="Mansour, S" uniqKey="Mansour S">S Mansour</name></author><author><name sortKey="Jeffery, S" uniqKey="Jeffery S">S Jeffery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mirzaa, Gm" uniqKey="Mirzaa G">GM Mirzaa</name></author><author><name sortKey="Enyedi, L" uniqKey="Enyedi L">L Enyedi</name></author><author><name sortKey="Parsons, G" uniqKey="Parsons G">G Parsons</name></author><author><name sortKey="Collins, S" uniqKey="Collins S">S Collins</name></author><author><name sortKey="Medne, L" uniqKey="Medne L">L Medne</name></author><author><name sortKey="Adams, C" uniqKey="Adams C">C Adams</name></author><author><name sortKey="Ward, T" uniqKey="Ward T">T Ward</name></author><author><name sortKey="Davitt, B" uniqKey="Davitt B">B Davitt</name></author><author><name sortKey="Bicknese, A" uniqKey="Bicknese A">A Bicknese</name></author><author><name sortKey="Zackai, E" uniqKey="Zackai E">E Zackai</name></author><author><name sortKey="Toriello, H" uniqKey="Toriello H">H Toriello</name></author><author><name sortKey="Dobyns, Wb" uniqKey="Dobyns W">WB Dobyns</name></author><author><name sortKey="Christian, S" uniqKey="Christian S">S Christian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valentine, Mt" uniqKey="Valentine M">MT Valentine</name></author><author><name sortKey="Fordyce, Pm" uniqKey="Fordyce P">PM Fordyce</name></author><author><name sortKey="Krzysiak, Tc" uniqKey="Krzysiak T">TC Krzysiak</name></author><author><name sortKey="Gilbert, Sp" uniqKey="Gilbert S">SP Gilbert</name></author><author><name sortKey="Block, Sm" uniqKey="Block S">SM Block</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kapitein, Lc" uniqKey="Kapitein L">LC Kapitein</name></author><author><name sortKey="Peterman, Ejg" uniqKey="Peterman E">EJG Peterman</name></author><author><name sortKey="Kwok, Bh" uniqKey="Kwok B">BH Kwok</name></author><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author><author><name sortKey="Kapoor, Tm" uniqKey="Kapoor T">TM Kapoor</name></author><author><name sortKey="Schmidt, Cf" uniqKey="Schmidt C">CF Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lecland, N" uniqKey="Lecland N">N Lecland</name></author><author><name sortKey="Luders, J" uniqKey="Luders J">J Lüders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferhat, L" uniqKey="Ferhat L">L Ferhat</name></author><author><name sortKey="Cook, C" uniqKey="Cook C">C Cook</name></author><author><name sortKey="Chauviere, M" uniqKey="Chauviere M">M Chauviere</name></author><author><name sortKey="Harper, M" uniqKey="Harper M">M Harper</name></author><author><name sortKey="Kress, M" uniqKey="Kress M">M Kress</name></author><author><name sortKey="Lyons, Ge" uniqKey="Lyons G">GE Lyons</name></author><author><name sortKey="Baas, Pw" uniqKey="Baas P">PW Baas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author><author><name sortKey="Li, D" uniqKey="Li D">D Li</name></author><author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name></author><author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name></author><author><name sortKey="Sun, X" uniqKey="Sun X">X Sun</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Huo, L" uniqKey="Huo L">L Huo</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, C A" uniqKey="Martin C">C-A Martin</name></author><author><name sortKey="Ahmad, I" uniqKey="Ahmad I">I Ahmad</name></author><author><name sortKey="Klingseisen, A" uniqKey="Klingseisen A">A Klingseisen</name></author><author><name sortKey="Hussain, Ms" uniqKey="Hussain M">MS Hussain</name></author><author><name sortKey="Bicknell, Ls" uniqKey="Bicknell L">LS Bicknell</name></author><author><name sortKey="Leitch, A" uniqKey="Leitch A">A Leitch</name></author><author><name sortKey="Nurnberg, G" uniqKey="Nurnberg G">G Nürnberg</name></author><author><name sortKey="Toliat, Mr" uniqKey="Toliat M">MR Toliat</name></author><author><name sortKey="Murray, Je" uniqKey="Murray J">JE Murray</name></author><author><name sortKey="Hunt, D" uniqKey="Hunt D">D Hunt</name></author><author><name sortKey="Khan, F" uniqKey="Khan F">F Khan</name></author><author><name sortKey="Ali, Z" uniqKey="Ali Z">Z Ali</name></author><author><name sortKey="Tinschert, S" uniqKey="Tinschert S">S Tinschert</name></author><author><name sortKey="Ding, J" uniqKey="Ding J">J Ding</name></author><author><name sortKey="Keith, C" uniqKey="Keith C">C Keith</name></author><author><name sortKey="Harley, Me" uniqKey="Harley M">ME Harley</name></author><author><name sortKey="Heyn, P" uniqKey="Heyn P">P Heyn</name></author><author><name sortKey="Muller, R" uniqKey="Muller R">R Müller</name></author><author><name sortKey="Hoffmann, I" uniqKey="Hoffmann I">I Hoffmann</name></author><author><name sortKey="Daire, Vc" uniqKey="Daire V">VC Daire</name></author><author><name sortKey="Dollfus, H" uniqKey="Dollfus H">H Dollfus</name></author><author><name sortKey="Dupuis, L" uniqKey="Dupuis L">L Dupuis</name></author><author><name sortKey="Bashamboo, A" uniqKey="Bashamboo A">A Bashamboo</name></author><author><name sortKey="Mcelreavey, K" uniqKey="Mcelreavey K">K McElreavey</name></author><author><name sortKey="Kariminejad, A" uniqKey="Kariminejad A">A Kariminejad</name></author><author><name sortKey="Mendoza Londono, R" uniqKey="Mendoza Londono R">R Mendoza-Londono</name></author><author><name sortKey="Moore, At" uniqKey="Moore A">AT Moore</name></author><author><name sortKey="Saggar, A" uniqKey="Saggar A">A Saggar</name></author><author><name sortKey="Schlechter, C" uniqKey="Schlechter C">C Schlechter</name></author><author><name sortKey="Weleber, R" uniqKey="Weleber R">R Weleber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scheidecker, S" uniqKey="Scheidecker S">S Scheidecker</name></author><author><name sortKey="Etard, C" uniqKey="Etard C">C Etard</name></author><author><name sortKey="Haren, L" uniqKey="Haren L">L Haren</name></author><author><name sortKey="Stoetzel, C" uniqKey="Stoetzel C">C Stoetzel</name></author><author><name sortKey="Hull, S" uniqKey="Hull S">S Hull</name></author><author><name sortKey="Arno, G" uniqKey="Arno G">G Arno</name></author><author><name sortKey="Plagnol, V" uniqKey="Plagnol V">V Plagnol</name></author><author><name sortKey="Drunat, S" uniqKey="Drunat S">S Drunat</name></author><author><name sortKey="Passemard, S" uniqKey="Passemard S">S Passemard</name></author><author><name sortKey="Toutain, A" uniqKey="Toutain A">A Toutain</name></author><author><name sortKey="Obringer, C" uniqKey="Obringer C">C Obringer</name></author><author><name sortKey="Koob, M" uniqKey="Koob M">M Koob</name></author><author><name sortKey="Geoffroy, V" uniqKey="Geoffroy V">V Geoffroy</name></author><author><name sortKey="Marion, V" uniqKey="Marion V">V Marion</name></author><author><name sortKey="Str Hle, U" uniqKey="Str Hle U">U Strähle</name></author><author><name sortKey="Ostergaard, P" uniqKey="Ostergaard P">P Ostergaard</name></author><author><name sortKey="Verloes, A" uniqKey="Verloes A">A Verloes</name></author><author><name sortKey="Merdes, A" uniqKey="Merdes A">A Merdes</name></author><author><name sortKey="Moore, At" uniqKey="Moore A">AT Moore</name></author><author><name sortKey="Dollfus, H" uniqKey="Dollfus H">H Dollfus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forgues, M" uniqKey="Forgues M">M Forgues</name></author><author><name sortKey="Difilippantonio, Mj" uniqKey="Difilippantonio M">MJ Difilippantonio</name></author><author><name sortKey="Linke, Sp" uniqKey="Linke S">SP Linke</name></author><author><name sortKey="Ried, T" uniqKey="Ried T">T Ried</name></author><author><name sortKey="Nagashima, K" uniqKey="Nagashima K">K Nagashima</name></author><author><name sortKey="Feden, J" uniqKey="Feden J">J Feden</name></author><author><name sortKey="Valerie, K" uniqKey="Valerie K">K Valerie</name></author><author><name sortKey="Fukasawa, K" uniqKey="Fukasawa K">K Fukasawa</name></author><author><name sortKey="Wang, Xw" uniqKey="Wang X">XW Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Jt" uniqKey="Thomas J">JT Thomas</name></author><author><name sortKey="Laimins, La" uniqKey="Laimins L">LA Laimins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buckley, A" uniqKey="Buckley A">A Buckley</name></author><author><name sortKey="Gould, Ea" uniqKey="Gould E">EA Gould</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamel, R" uniqKey="Hamel R">R Hamel</name></author><author><name sortKey="Dejarnac, O" uniqKey="Dejarnac O">O Dejarnac</name></author><author><name sortKey="Wichit, S" uniqKey="Wichit S">S Wichit</name></author><author><name sortKey="Ekchariyawat, P" uniqKey="Ekchariyawat P">P Ekchariyawat</name></author><author><name sortKey="Neyret, A" uniqKey="Neyret A">A Neyret</name></author><author><name sortKey="Luplertlop, N" uniqKey="Luplertlop N">N Luplertlop</name></author><author><name sortKey="Perera Lecoin, M" uniqKey="Perera Lecoin M">M Perera-Lecoin</name></author><author><name sortKey="Surasombatpattana, P" uniqKey="Surasombatpattana P">P Surasombatpattana</name></author><author><name sortKey="Talignani, L" uniqKey="Talignani L">L Talignani</name></author><author><name sortKey="Thomas, F" uniqKey="Thomas F">F Thomas</name></author><author><name sortKey="Cao Lormeau, V M" uniqKey="Cao Lormeau V">V-M Cao-Lormeau</name></author><author><name sortKey="Choumet, V" uniqKey="Choumet V">V Choumet</name></author><author><name sortKey="Briant, L" uniqKey="Briant L">L Briant</name></author><author><name sortKey="Despres, P" uniqKey="Despres P">P Desprès</name></author><author><name sortKey="Amara, A" uniqKey="Amara A">A Amara</name></author><author><name sortKey="Yssel, H" uniqKey="Yssel H">H Yssel</name></author><author><name sortKey="Misse, D" uniqKey="Misse D">D Missé</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Brême (Land)</li></region><settlement><li>Brême</li></settlement></list><tree><country name="Allemagne"><region name="Brême (Land)"><name sortKey="Bullerdiek, Joern" sort="Bullerdiek, Joern" uniqKey="Bullerdiek J" first="Joern" last="Bullerdiek">Joern Bullerdiek</name></region><name sortKey="Bauer, Ingrid" sort="Bauer, Ingrid" uniqKey="Bauer I" first="Ingrid" last="Bauer">Ingrid Bauer</name><name sortKey="Bullerdiek, Joern" sort="Bullerdiek, Joern" uniqKey="Bullerdiek J" first="Joern" last="Bullerdiek">Joern Bullerdiek</name><name sortKey="Dotzauer, Andreas" sort="Dotzauer, Andreas" uniqKey="Dotzauer A" first="Andreas" last="Dotzauer">Andreas Dotzauer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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