Adjunctive clindamycin for cellulitis: a clinical trial comparing flucloxacillin with or without clindamycin for the treatment of limb cellulitis
Identifieur interne : 000802 ( Main/Exploration ); précédent : 000801; suivant : 000803Adjunctive clindamycin for cellulitis: a clinical trial comparing flucloxacillin with or without clindamycin for the treatment of limb cellulitis
Auteurs : Richard Brindle [Royaume-Uni] ; O Martin Williams [Royaume-Uni] ; Paul Davies [Royaume-Uni] ; Tim Harris [Royaume-Uni] ; Heather Jarman [Royaume-Uni] ; Alastair D. Hay [Royaume-Uni] ; Peter Featherstone [Royaume-Uni]Source :
- BMJ Open [ 2044-6055 ] ; 2017.
Abstract
To compare flucloxacillin with clindamycin to flucloxacillin alone for the treatment of limb cellulitis.
Parallel, double-blinded, randomised controlled trial.
Emergency department attendances and general practice referrals within 20 hospitals in England.
Flucloxacillin, at a minimum of 500 mg 4 times per day for 5 days, with clindamycin 300 mg 4 times per day for 2 days given orally versus flucloxacillin given alone.
The primary outcome was improvement at day 5. This was defined as being afebrile with either a reduction in affected skin surface temperature or a reduction in the circumference of the affected area. Secondary outcomes included resolution of systemic features, resolution of inflammatory markers, recovery of renal function, reduction in the affected area, decrease in pain, return to work or normal activities and the absence of increased side effects.
410 patients were included in the trial. No significant difference was seen in improvement at day 5 for flucloxacillin with clindamycin (136/156, 87%) versus flucloxacillin alone (140/172, 81%)—OR 1.55 (95% CI 0.81 to 3.01), p=0.174. There was a significant difference in the number of patients with diarrhoea at day 5 in the flucloxacillin with clindamycin allocation (34/160, 22%) versus flucloxacillin alone (16/176, 9%)—OR 2.7 (95% CI 1.41 to 5.07), p=0.002. There was no clinically significant difference in any secondary outcome measures. There was no significant difference in the number of patients stating that they had returned to normal activities at the day 30 interview in the flucloxacillin with clindamycin allocation (99/121, 82%) versus flucloxacillin alone (104/129, 81%)—adjusted OR 0.90 (95% CI 0.44 to 1.84).
The addition of a short course of clindamycin to flucloxacillin early on in limb cellulitis does not improve outcome. The addition of clindamycin doubles the likelihood of diarrhoea within the first few days.
Url:
DOI: 10.1136/bmjopen-2016-013260
PubMed: 28314743
PubMed Central: 5372109
Affiliations:
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Hay</name><affiliation wicri:level="1"><nlm:aff id="af5"><addr-line>Centre for Academic Primary Care</addr-line>,<institution>University of Bristol</institution>,<addr-line>Bristol</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Featherstone, Peter" sort="Featherstone, Peter" uniqKey="Featherstone P" first="Peter" last="Featherstone">Peter Featherstone</name><affiliation wicri:level="1"><nlm:aff id="af6"><addr-line>Acute Medicine Unit</addr-line>,<institution>Queen Alexandra Hospital</institution>,<addr-line>Portsmouth</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMJ Open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To compare flucloxacillin with clindamycin to flucloxacillin alone for the treatment of limb cellulitis.</p></sec><sec><title>Design</title><p>Parallel, double-blinded, randomised controlled trial.</p></sec><sec><title>Setting</title><p>Emergency department attendances and general practice referrals within 20 hospitals in England.</p></sec><sec><title>Interventions</title><p>Flucloxacillin, at a minimum of 500 mg 4 times per day for 5 days, with clindamycin 300 mg 4 times per day for 2 days given orally versus flucloxacillin given alone.</p></sec><sec><title>Main outcome measures</title><p>The primary outcome was improvement at day 5. This was defined as being afebrile with either a reduction in affected skin surface temperature or a reduction in the circumference of the affected area. Secondary outcomes included resolution of systemic features, resolution of inflammatory markers, recovery of renal function, reduction in the affected area, decrease in pain, return to work or normal activities and the absence of increased side effects.</p></sec><sec><title>Results</title><p>410 patients were included in the trial. No significant difference was seen in improvement at day 5 for flucloxacillin with clindamycin (136/156, 87%) versus flucloxacillin alone (140/172, 81%)—OR 1.55 (95% CI 0.81 to 3.01), p=0.174. There was a significant difference in the number of patients with diarrhoea at day 5 in the flucloxacillin with clindamycin allocation (34/160, 22%) versus flucloxacillin alone (16/176, 9%)—OR 2.7 (95% CI 1.41 to 5.07), p=0.002. There was no clinically significant difference in any secondary outcome measures. There was no significant difference in the number of patients stating that they had returned to normal activities at the day 30 interview in the flucloxacillin with clindamycin allocation (99/121, 82%) versus flucloxacillin alone (104/129, 81%)—adjusted OR 0.90 (95% CI 0.44 to 1.84).</p></sec><sec><title>Conclusions</title><p>The addition of a short course of clindamycin to flucloxacillin early on in limb cellulitis does not improve outcome. The addition of clindamycin doubles the likelihood of diarrhoea within the first few days.</p></sec><sec><title>Trial registration number</title><p><ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT01876628">NCT01876628</ext-link>, Results.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hirschmann, Jv" uniqKey="Hirschmann J">JV Hirschmann</name></author><author><name sortKey="Raugi, Gj" uniqKey="Raugi G">GJ Raugi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bernard, P" uniqKey="Bernard P">P Bernard</name></author><author><name sortKey="Toty, L" uniqKey="Toty L">L Toty</name></author><author><name sortKey="Mounier, M" uniqKey="Mounier M">M Mounier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brook, I" uniqKey="Brook I">I Brook</name></author><author><name sortKey="Frazier, Eh" uniqKey="Frazier E">EH Frazier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Ke" uniqKey="Johnson K">KE Johnson</name></author><author><name sortKey="Kiyatkin, De" uniqKey="Kiyatkin D">DE Kiyatkin</name></author><author><name sortKey="An, At" uniqKey="An A">AT An</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karppelin, M" uniqKey="Karppelin M">M Karppelin</name></author><author><name sortKey="Siljander, T" uniqKey="Siljander T">T Siljander</name></author><author><name sortKey="Haapala, Am" uniqKey="Haapala A">AM Haapala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toleman, Ms" uniqKey="Toleman M">MS Toleman</name></author><author><name sortKey="Vipond, Ib" uniqKey="Vipond I">IB Vipond</name></author><author><name sortKey="Brindle, R" uniqKey="Brindle R">R Brindle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pallin, Dj" uniqKey="Pallin D">DJ Pallin</name></author><author><name sortKey="Binder, Wd" uniqKey="Binder W">WD Binder</name></author><author><name sortKey="Allen, Mb" uniqKey="Allen M">MB Allen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brindle, R" uniqKey="Brindle R">R Brindle</name></author><author><name sortKey="Williams, Om" uniqKey="Williams O">OM Williams</name></author><author><name sortKey="Bennett, C" uniqKey="Bennett C">C Bennett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sawai, J" uniqKey="Sawai J">J Sawai</name></author><author><name sortKey="Hasegawa, T" uniqKey="Hasegawa T">T Hasegawa</name></author><author><name sortKey="Kamimura, T" uniqKey="Kamimura T">T Kamimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gemmell, Cg" uniqKey="Gemmell C">CG Gemmell</name></author><author><name sortKey="Peterson, Pk" uniqKey="Peterson P">PK Peterson</name></author><author><name sortKey="Schmeling, D" uniqKey="Schmeling D">D Schmeling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bryant, Ae" uniqKey="Bryant A">AE Bryant</name></author><author><name sortKey="Stevens, Dl" uniqKey="Stevens D">DL Stevens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mulla, Zd" uniqKey="Mulla Z">ZD Mulla</name></author><author><name sortKey="Leaverton, Pe" uniqKey="Leaverton P">PE Leaverton</name></author><author><name sortKey="Wiersma, St" uniqKey="Wiersma S">ST Wiersma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehta, S" uniqKey="Mehta S">S Mehta</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name></author><author><name sortKey="Low, De" uniqKey="Low D">DE Low</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mascini, Em" uniqKey="Mascini E">EM Mascini</name></author><author><name sortKey="Jansze, M" uniqKey="Jansze M">M Jansze</name></author><author><name sortKey="Schouls, Lm" uniqKey="Schouls L">LM Schouls</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimbelman, J" uniqKey="Zimbelman J">J Zimbelman</name></author><author><name sortKey="Palmer, A" uniqKey="Palmer A">A Palmer</name></author><author><name sortKey="Todd, J" uniqKey="Todd J">J Todd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carapetis, Jr" uniqKey="Carapetis J">JR Carapetis</name></author><author><name sortKey="Jacoby, P" uniqKey="Jacoby P">P Jacoby</name></author><author><name sortKey="Carville, K" uniqKey="Carville K">K Carville</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Dong, Sl" uniqKey="Dong S">SL Dong</name></author><author><name sortKey="Kelly, Kd" uniqKey="Kelly K">KD Kelly</name></author><author><name 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uniqKey="Montalto M">M Montalto</name></author><author><name sortKey="Davies, F" uniqKey="Davies F">F Davies</name></author><author><name sortKey="Marijanovic, N" uniqKey="Marijanovic N">N Marijanovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bjornsd Ttir, S" uniqKey="Bjornsd Ttir S">S Björnsdóttir</name></author><author><name sortKey="Gottfredsson, M" uniqKey="Gottfredsson M">M Gottfredsson</name></author><author><name sortKey="Th Risd Ttir, As" uniqKey="Th Risd Ttir A">AS Thórisdóttir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leman, P" uniqKey="Leman P">P Leman</name></author><author><name sortKey="Mukherjee, D" uniqKey="Mukherjee D">D Mukherjee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carter, K" uniqKey="Carter K">K Carter</name></author><author><name sortKey="Kilburn, S" uniqKey="Kilburn S">S Kilburn</name></author><author><name sortKey="Featherstone, P" uniqKey="Featherstone P">P Featherstone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, Ks" uniqKey="Thomas K">KS Thomas</name></author><author><name sortKey="Cox, Nh" uniqKey="Cox N">NH Cox</name></author><author><name sortKey="Savelyich, Bs" uniqKey="Savelyich B">BS Savelyich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warrell, Da" uniqKey="Warrell D">DA Warrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leigh, Da" uniqKey="Leigh D">DA Leigh</name></author><author><name sortKey="Simmons, K" uniqKey="Simmons K">K Simmons</name></author><author><name sortKey="Williams, S" uniqKey="Williams S">S Williams</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Brindle, Richard" sort="Brindle, Richard" uniqKey="Brindle R" first="Richard" last="Brindle">Richard Brindle</name></noRegion><name sortKey="Davies, Paul" sort="Davies, Paul" uniqKey="Davies P" first="Paul" last="Davies">Paul Davies</name><name sortKey="Featherstone, Peter" sort="Featherstone, Peter" uniqKey="Featherstone P" first="Peter" last="Featherstone">Peter Featherstone</name><name sortKey="Harris, Tim" sort="Harris, Tim" uniqKey="Harris T" first="Tim" last="Harris">Tim Harris</name><name sortKey="Hay, Alastair D" sort="Hay, Alastair D" uniqKey="Hay A" first="Alastair D" last="Hay">Alastair D. Hay</name><name sortKey="Jarman, Heather" sort="Jarman, Heather" uniqKey="Jarman H" first="Heather" last="Jarman">Heather Jarman</name><name sortKey="Williams, O Martin" sort="Williams, O Martin" uniqKey="Williams O" first="O Martin" last="Williams">O Martin Williams</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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