Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy
Identifieur interne : 000762 ( Main/Exploration ); précédent : 000761; suivant : 000763Association of One-Step Nucleic Acid Amplification Detected Micrometastases with Tumour Biology and Adjuvant Chemotherapy
Auteurs : Ghaleb Goussous [Royaume-Uni] ; Sadaf Jafferbhoy [Royaume-Uni] ; Niamh Smyth [Royaume-Uni] ; Lisette Hammond [Royaume-Uni] ; Sankaran Narayanan [Royaume-Uni] ; Robert Mark Kirby [Royaume-Uni] ; Soni Soumian [Royaume-Uni]Source :
- International Journal of Breast Cancer [ 2090-3170 ] ; 2017.
Abstract
One-step nucleic acid amplification (OSNA) is an intraoperative technique with a high sensitivity and specificity for sentinel node assessment. The aim of this study was to assess the impact of OSNA on micrometastases detection rates and use of adjuvant chemotherapy. A retrospective review of patients with sentinel node micrometastases over a five-year period was carried out and a comparison of micrometastases detection using OSNA and H&E techniques was made. Out of 1285 patients who underwent sentinel node (SLN) biopsy, 76 patients had micrometastases. Using H&E staining, 36 patients were detected with SLN micrometastases (9/year) in contrast to 40 patients in the OSNA year (40/year) (
Url:
DOI: 10.1155/2017/4971096
PubMed: 28695012
PubMed Central: 5485356
Affiliations:
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Narayanan</name><affiliation wicri:level="1"><nlm:aff id="I1">University Hospitals of North Midlands, Newcastle Road, Stoke-on-Trent, Staffordshire ST4 6QG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Hospitals of North Midlands, Newcastle Road, Stoke-on-Trent, Staffordshire ST4 6QG</wicri:regionArea><wicri:noRegion>Staffordshire ST4 6QG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">School of Medicine, Keele University, David Weatherall Building, Stoke-on-Trent, Staffordshire ST5 5BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Medicine, Keele University, David Weatherall Building, Stoke-on-Trent, Staffordshire ST5 5BG</wicri:regionArea><wicri:noRegion>Staffordshire ST5 5BG</wicri:noRegion></affiliation></author><author><name sortKey="Kirby, Robert Mark" sort="Kirby, Robert Mark" uniqKey="Kirby R" first="Robert Mark" last="Kirby">Robert Mark Kirby</name><affiliation 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North Midlands, Newcastle Road, Stoke-on-Trent, Staffordshire ST4 6QG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University Hospitals of North Midlands, Newcastle Road, Stoke-on-Trent, Staffordshire ST4 6QG</wicri:regionArea><wicri:noRegion>Staffordshire ST4 6QG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">School of Medicine, Keele University, David Weatherall Building, Stoke-on-Trent, Staffordshire ST5 5BG, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Medicine, Keele University, David Weatherall Building, Stoke-on-Trent, Staffordshire ST5 5BG</wicri:regionArea><wicri:noRegion>Staffordshire ST5 5BG</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Breast Cancer</title><idno type="ISSN">2090-3170</idno><idno type="eISSN">2090-3189</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>One-step nucleic acid amplification (OSNA) is an intraoperative technique with a high sensitivity and specificity for sentinel node assessment. The aim of this study was to assess the impact of OSNA on micrometastases detection rates and use of adjuvant chemotherapy. A retrospective review of patients with sentinel node micrometastases over a five-year period was carried out and a comparison of micrometastases detection using OSNA and H&E techniques was made. Out of 1285 patients who underwent sentinel node (SLN) biopsy, 76 patients had micrometastases. Using H&E staining, 36 patients were detected with SLN micrometastases (9/year) in contrast to 40 patients in the OSNA year (40/year) (<italic>p</italic> < 0.0001), demonstrating a fourfold increase with the use of OSNA. In the OSNA group, there was also a proportional increase in Grade III, triple-negative, ER-negative, and HER-2-positive tumours being diagnosed with micrometastases. Also on interactive PREDICT tool, the number of patients with a predicted 10-year survival benefit of more than 3% with adjuvant chemotherapy increased from 52 to 70 percent. OSNA has resulted in an increased detection rate of micrometastases especially in patients with aggressive tumour biology. This increased the number of patients who had a predicted survival benefit from adjuvant chemotherapy. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Giuliano, A E" uniqKey="Giuliano A">A. E. Giuliano</name></author><author><name sortKey="Jones, R C" uniqKey="Jones R">R. C. Jones</name></author><author><name sortKey="Brennan, M" uniqKey="Brennan M">M. Brennan</name></author><author><name sortKey="Statman, R" uniqKey="Statman R">R. Statman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krag, D N" uniqKey="Krag D">D. N. Krag</name></author><author><name sortKey="Anderson, S J" uniqKey="Anderson S">S. J. Anderson</name></author><author><name sortKey="Julian, T B" uniqKey="Julian T">T. B. 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Rausei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Engelhardt, E G" uniqKey="Engelhardt E">E. G. Engelhardt</name></author><author><name sortKey="Van Den Broek, A J" uniqKey="Van Den Broek A">A. J. van den Broek</name></author><author><name sortKey="Linn, S C" uniqKey="Linn S">S. C. Linn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Glas, N A" uniqKey="De Glas N">N. A. De Glas</name></author><author><name sortKey="Bastiaannet, E" uniqKey="Bastiaannet E">E. Bastiaannet</name></author><author><name sortKey="Engels, C C" uniqKey="Engels C">C. C. Engels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huxley, N" uniqKey="Huxley N">N. Huxley</name></author><author><name sortKey="Jones Hughes, T" uniqKey="Jones Hughes T">T. Jones-Hughes</name></author><author><name sortKey="Coelho, H" uniqKey="Coelho H">H. Coelho</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Goussous, Ghaleb" sort="Goussous, Ghaleb" uniqKey="Goussous G" first="Ghaleb" last="Goussous">Ghaleb Goussous</name></noRegion><name sortKey="Hammond, Lisette" sort="Hammond, Lisette" uniqKey="Hammond L" first="Lisette" last="Hammond">Lisette Hammond</name><name sortKey="Jafferbhoy, Sadaf" sort="Jafferbhoy, Sadaf" uniqKey="Jafferbhoy S" first="Sadaf" last="Jafferbhoy">Sadaf Jafferbhoy</name><name sortKey="Kirby, Robert Mark" sort="Kirby, Robert Mark" uniqKey="Kirby R" first="Robert Mark" last="Kirby">Robert Mark Kirby</name><name sortKey="Kirby, Robert Mark" sort="Kirby, Robert Mark" uniqKey="Kirby R" first="Robert Mark" last="Kirby">Robert Mark Kirby</name><name sortKey="Narayanan, Sankaran" sort="Narayanan, Sankaran" uniqKey="Narayanan S" first="Sankaran" last="Narayanan">Sankaran Narayanan</name><name sortKey="Narayanan, Sankaran" sort="Narayanan, Sankaran" uniqKey="Narayanan S" first="Sankaran" last="Narayanan">Sankaran Narayanan</name><name sortKey="Smyth, Niamh" sort="Smyth, Niamh" uniqKey="Smyth N" first="Niamh" last="Smyth">Niamh Smyth</name><name sortKey="Soumian, Soni" sort="Soumian, Soni" uniqKey="Soumian S" first="Soni" last="Soumian">Soni Soumian</name><name sortKey="Soumian, Soni" sort="Soumian, Soni" uniqKey="Soumian S" first="Soni" last="Soumian">Soni Soumian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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