Core-Shell Magnetic Gold Nanoparticles for Magnetic Field-Enhanced Radio-Photothermal Therapy in Cervical Cancer
Identifieur interne : 000670 ( Main/Exploration ); précédent : 000669; suivant : 000671Core-Shell Magnetic Gold Nanoparticles for Magnetic Field-Enhanced Radio-Photothermal Therapy in Cervical Cancer
Auteurs : Rui Hu [République populaire de Chine] ; Minxue Zheng ; Jinchang Wu ; Cheng Li ; Danqing Shen ; Dian Yang [République populaire de Chine] ; Li Li ; Mingfeng Ge ; Zhimin Chang ; Wenfei DongSource :
- Nanomaterials [ 2079-4991 ] ; 2017.
Abstract
The combination of radiotherapy (RT) and photothermal therapy (PTT) has been considered an attractive strategy in cervical cancer treatment. However, it remains a challenge to simultaneously enhance the radio-sensitivity of tumor tissue, develop tumor tissue-focused radiation therapies and combine dual therapeutic modalities. In this study, core-shell type magnetic gold (Fe3O4@Au) nanoparticles are exploited to achieve the synergistic efficacy of radio-photothermal therapy in cervical cancer. Fe3O4@Au nanoparticles (NPs) with uniform morphology exhibited superior surface plasmon resonance properties, excellent superparamagnetic properties, good biocompatibility and high photothermal conversion efficiency. For the in vitro tests, a low concentration of Fe3O4@Au NPs after a short period of near-infrared irradiation lead to the time-dependent death of cervical cancer cells. Further, the combination of RT and PTT induced synergistic anti-cancer effects in vitro. More importantly, an external magnetic field could significantly enhance the synergistic efficacy of Fe3O4@Au NPs by improving their internalization. Hence, the reported Fe3O4@Au NPs have the potential to be good nanoagents with excellent magnetic targeting ability for cervical cancer radio-photothermal treatment.
Url:
DOI: 10.3390/nano7050111
PubMed: 28492507
PubMed Central: 5449992
Affiliations:
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Sciences, Beijing 100049</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation><nlm:aff id="af3-nanomaterials-07-00111">Department of Radiation Oncology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, No. 26 Daoqian RD, Suzhou 215000, China;<email>wjinchang@sina.com</email> (J.W.);<email>chengli1981116@163.com</email> (C.L.);<email>tuzi.go@163.com</email> (D.S.)</nlm:aff></affiliation></author><author><name sortKey="Zheng, Minxue" sort="Zheng, Minxue" uniqKey="Zheng M" first="Minxue" last="Zheng">Minxue Zheng</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> 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(L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation></author><author><name sortKey="Ge, Mingfeng" sort="Ge, Mingfeng" uniqKey="Ge M" first="Mingfeng" last="Ge">Mingfeng Ge</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> (L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation></author><author><name sortKey="Chang, Zhimin" sort="Chang, Zhimin" uniqKey="Chang Z" first="Zhimin" last="Chang">Zhimin Chang</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> (L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation></author><author><name sortKey="Dong, Wenfei" sort="Dong, Wenfei" uniqKey="Dong W" first="Wenfei" last="Dong">Wenfei Dong</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> (L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28492507</idno><idno type="pmc">5449992</idno><idno 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type="main">Core-Shell Magnetic Gold Nanoparticles for Magnetic Field-Enhanced Radio-Photothermal Therapy in Cervical Cancer</title><author><name sortKey="Hu, Rui" sort="Hu, Rui" uniqKey="Hu R" first="Rui" last="Hu">Rui Hu</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> (L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-nanomaterials-07-00111">University of Chinese Academy of Sciences, Beijing 100049, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>University of Chinese Academy of Sciences, Beijing 100049</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation><nlm:aff id="af3-nanomaterials-07-00111">Department of Radiation Oncology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, No. 26 Daoqian RD, Suzhou 215000, China;<email>wjinchang@sina.com</email> (J.W.);<email>chengli1981116@163.com</email> (C.L.);<email>tuzi.go@163.com</email> (D.S.)</nlm:aff></affiliation></author><author><name sortKey="Zheng, Minxue" sort="Zheng, Minxue" uniqKey="Zheng M" first="Minxue" last="Zheng">Minxue Zheng</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> (L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation></author><author><name sortKey="Wu, Jinchang" sort="Wu, Jinchang" uniqKey="Wu J" first="Jinchang" last="Wu">Jinchang Wu</name><affiliation><nlm:aff id="af3-nanomaterials-07-00111">Department of Radiation Oncology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, No. 26 Daoqian RD, Suzhou 215000, China;<email>wjinchang@sina.com</email> (J.W.);<email>chengli1981116@163.com</email> (C.L.);<email>tuzi.go@163.com</email> (D.S.)</nlm:aff></affiliation></author><author><name sortKey="Li, Cheng" sort="Li, Cheng" uniqKey="Li C" first="Cheng" last="Li">Cheng Li</name><affiliation><nlm:aff id="af3-nanomaterials-07-00111">Department of Radiation Oncology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, No. 26 Daoqian RD, Suzhou 215000, China;<email>wjinchang@sina.com</email> (J.W.);<email>chengli1981116@163.com</email> (C.L.);<email>tuzi.go@163.com</email> (D.S.)</nlm:aff></affiliation></author><author><name sortKey="Shen, Danqing" sort="Shen, Danqing" uniqKey="Shen D" first="Danqing" last="Shen">Danqing Shen</name><affiliation><nlm:aff id="af3-nanomaterials-07-00111">Department of Radiation Oncology, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, No. 26 Daoqian RD, Suzhou 215000, China;<email>wjinchang@sina.com</email> (J.W.);<email>chengli1981116@163.com</email> (C.L.);<email>tuzi.go@163.com</email> (D.S.)</nlm:aff></affiliation></author><author><name sortKey="Yang, Dian" sort="Yang, Dian" uniqKey="Yang D" first="Dian" last="Yang">Dian Yang</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> (L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-nanomaterials-07-00111">University of Chinese Academy of Sciences, Beijing 100049, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>University of Chinese Academy of Sciences, Beijing 100049</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> (L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation></author><author><name sortKey="Ge, Mingfeng" sort="Ge, Mingfeng" uniqKey="Ge M" first="Mingfeng" last="Ge">Mingfeng Ge</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> (L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation></author><author><name sortKey="Chang, Zhimin" sort="Chang, Zhimin" uniqKey="Chang Z" first="Zhimin" last="Chang">Zhimin Chang</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> (L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation></author><author><name sortKey="Dong, Wenfei" sort="Dong, Wenfei" uniqKey="Dong W" first="Wenfei" last="Dong">Wenfei Dong</name><affiliation><nlm:aff id="af1-nanomaterials-07-00111">CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, No. 88 Keling Road, Suzhou 215163, China;<email>huuno@sohu.com</email> (R.H.);<email>minxue.zheng@sibet.ac.cn</email> (M.Z.);<email>15251855931@163.com</email> (D.Y.);<email>jlu_li@163.com</email> (L.L.);<email>gemf@sibet.ac.cn</email> (M.G.)</nlm:aff></affiliation></author></analytic><series><title level="j">Nanomaterials</title><idno type="eISSN">2079-4991</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The combination of radiotherapy (RT) and photothermal therapy (PTT) has been considered an attractive strategy in cervical cancer treatment. However, it remains a challenge to simultaneously enhance the radio-sensitivity of tumor tissue, develop tumor tissue-focused radiation therapies and combine dual therapeutic modalities. In this study, core-shell type magnetic gold (Fe<sub>3</sub>O<sub>4</sub>@Au) nanoparticles are exploited to achieve the synergistic efficacy of radio-photothermal therapy in cervical cancer. Fe<sub>3</sub>O<sub>4</sub>@Au nanoparticles (NPs) with uniform morphology exhibited superior surface plasmon resonance properties, excellent superparamagnetic properties, good biocompatibility and high photothermal conversion efficiency. For the in vitro tests, a low concentration of Fe<sub>3</sub>O<sub>4</sub>@Au NPs after a short period of near-infrared irradiation lead to the time-dependent death of cervical cancer cells. Further, the combination of RT and PTT induced synergistic anti-cancer effects in vitro. More importantly, an external magnetic field could significantly enhance the synergistic efficacy of Fe<sub>3</sub>O<sub>4</sub>@Au NPs by improving their internalization. Hence, the reported Fe<sub>3</sub>O<sub>4</sub>@Au NPs have the potential to be good nanoagents with excellent magnetic targeting ability for cervical cancer radio-photothermal treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Maluccio, M" uniqKey="Maluccio M">M. Maluccio</name></author><author><name sortKey="Covey, A" uniqKey="Covey A">A. Covey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, F X" uniqKey="Bosch F">F.X. Bosch</name></author><author><name sortKey="De Sanjose, S" uniqKey="De Sanjose S">S. De Sanjosé</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siegel, R" uniqKey="Siegel R">R. 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