Effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis: an in vivo and in vitro study
Identifieur interne : 000606 ( Main/Exploration ); précédent : 000605; suivant : 000607Effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis: an in vivo and in vitro study
Auteurs : Yi-Xun Liu [République populaire de Chine] ; Guo-Dong Wang [République populaire de Chine] ; Xiao Wang [République populaire de Chine] ; Yong-Le Zhang [République populaire de Chine] ; Tian-Lun Zhang [République populaire de Chine]Source :
- Oncotarget [ 1949-2553 ] ; 2017.
Abstract
The study aims to explore the effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis (OA). Degenerative knee OA and normal cartilage samples were collected from patients with degenerative knee OA receiving total knee arthroplasty and amputation. Expressions of TLR-2, NF-κB and MMP-13 were determined by qRT-PCR and immunochemistry. The chondrocytes were divided into control, IL-1β, IL-1β + anti-TLR-2 and IL-1β + PDTC groups. MTT assay and flow cytometry were performed to determine proliferation and apoptosis of the chondrocytes. Expressions of TLR-2, NF-κB and MMP-13 were measured by Western blotting. ELISA was conducted to detect the expressions of related inflammatory factors. The positive expressions of TLR, NF-κB and MMP13 were associated with body mass index (BMI), family history, exercise, and WOMAC scores of OA patients. Logistic regression analysis showed that OA influencing factors were TLR, NF-κB, MMP13, BMI, family history and exercise. Compared with normal chondrocytes, the expressions of TLR-2, NF-κB, MMP-13 and related inflammatory factors increased in degenerative knee OA. The chondrocytes in the IL-1β + anti-TLR-2 and IL-1β + PDTC groups showed lower apoptosis rates than those in the IL-1β group. Compared with the control group, increased expressions of TLR-2, NF-κB, phosphorylated-NF-κB (p-NF-κB), MMP-13, IL-1, IL-6 and TNF-α were found in the IL-1β group. In the IL-1β + anti-TLR-2 and IL-1β + PDTC groups, decreased expressions of NF-κB, p-NF-κB, MMP-13, IL-1, IL-6 and TNF-α were found compared with those in the IL-1β group. TLR-2/NF-κB signaling pathway contributes to the occurrence of degenerative knee OA.
Url:
DOI: 10.18632/oncotarget.16199
PubMed: 28418842
PubMed Central: 5503557
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis: an <italic>in vivo</italic> and <italic>in vitro</italic> study</title><author><name sortKey="Liu, Yi Xun" sort="Liu, Yi Xun" uniqKey="Liu Y" first="Yi-Xun" last="Liu">Yi-Xun Liu</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng</wicri:regionArea><wicri:noRegion>Kaifeng</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Guo Dong" sort="Wang, Guo Dong" uniqKey="Wang G" first="Guo-Dong" last="Wang">Guo-Dong Wang</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng</wicri:regionArea><wicri:noRegion>Kaifeng</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Xiao" sort="Wang, Xiao" uniqKey="Wang X" first="Xiao" last="Wang">Xiao Wang</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng</wicri:regionArea><wicri:noRegion>Kaifeng</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yong Le" sort="Zhang, Yong Le" uniqKey="Zhang Y" first="Yong-Le" last="Zhang">Yong-Le Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng</wicri:regionArea><wicri:noRegion>Kaifeng</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Tian Lun" sort="Zhang, Tian Lun" uniqKey="Zhang T" first="Tian-Lun" last="Zhang">Tian-Lun Zhang</name><affiliation wicri:level="1"><nlm:aff id="A2"> School of Aerospace Engineering, University of Electronic Science and Technology of China, Chengdu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> School of Aerospace Engineering, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28418842</idno><idno type="pmc">5503557</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503557</idno><idno type="RBID">PMC:5503557</idno><idno type="doi">10.18632/oncotarget.16199</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">004275</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004275</idno><idno type="wicri:Area/Pmc/Curation">004274</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004274</idno><idno type="wicri:Area/Pmc/Checkpoint">000307</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000307</idno><idno type="wicri:Area/Ncbi/Merge">008F80</idno><idno type="wicri:Area/Ncbi/Curation">008F80</idno><idno type="wicri:Area/Ncbi/Checkpoint">008F80</idno><idno type="wicri:Area/Main/Merge">000607</idno><idno type="wicri:Area/Main/Curation">000606</idno><idno type="wicri:Area/Main/Exploration">000606</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis: an <italic>in vivo</italic> and <italic>in vitro</italic> study</title><author><name sortKey="Liu, Yi Xun" sort="Liu, Yi Xun" uniqKey="Liu Y" first="Yi-Xun" last="Liu">Yi-Xun Liu</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng</wicri:regionArea><wicri:noRegion>Kaifeng</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Guo Dong" sort="Wang, Guo Dong" uniqKey="Wang G" first="Guo-Dong" last="Wang">Guo-Dong Wang</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng</wicri:regionArea><wicri:noRegion>Kaifeng</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Xiao" sort="Wang, Xiao" uniqKey="Wang X" first="Xiao" last="Wang">Xiao Wang</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng</wicri:regionArea><wicri:noRegion>Kaifeng</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yong Le" sort="Zhang, Yong Le" uniqKey="Zhang Y" first="Yong-Le" last="Zhang">Yong-Le Zhang</name><affiliation wicri:level="1"><nlm:aff id="A1"> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> Department of Orthopedic, Huaihe Hospital of Henan University, Kaifeng</wicri:regionArea><wicri:noRegion>Kaifeng</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Tian Lun" sort="Zhang, Tian Lun" uniqKey="Zhang T" first="Tian-Lun" last="Zhang">Tian-Lun Zhang</name><affiliation wicri:level="1"><nlm:aff id="A2"> School of Aerospace Engineering, University of Electronic Science and Technology of China, Chengdu, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea> School of Aerospace Engineering, University of Electronic Science and Technology of China, Chengdu</wicri:regionArea><wicri:noRegion>Chengdu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The study aims to explore the effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis (OA). Degenerative knee OA and normal cartilage samples were collected from patients with degenerative knee OA receiving total knee arthroplasty and amputation. Expressions of TLR-2, NF-κB and MMP-13 were determined by qRT-PCR and immunochemistry. The chondrocytes were divided into control, IL-1β, IL-1β + anti-TLR-2 and IL-1β + PDTC groups. MTT assay and flow cytometry were performed to determine proliferation and apoptosis of the chondrocytes. Expressions of TLR-2, NF-κB and MMP-13 were measured by Western blotting. ELISA was conducted to detect the expressions of related inflammatory factors. The positive expressions of TLR, NF-κB and MMP13 were associated with body mass index (BMI), family history, exercise, and WOMAC scores of OA patients. Logistic regression analysis showed that OA influencing factors were TLR, NF-κB, MMP13, BMI, family history and exercise. Compared with normal chondrocytes, the expressions of TLR-2, NF-κB, MMP-13 and related inflammatory factors increased in degenerative knee OA. The chondrocytes in the IL-1β + anti-TLR-2 and IL-1β + PDTC groups showed lower apoptosis rates than those in the IL-1β group. Compared with the control group, increased expressions of TLR-2, NF-κB, phosphorylated-NF-κB (p-NF-κB), MMP-13, IL-1, IL-6 and TNF-α were found in the IL-1β group. In the IL-1β + anti-TLR-2 and IL-1β + PDTC groups, decreased expressions of NF-κB, p-NF-κB, MMP-13, IL-1, IL-6 and TNF-α were found compared with those in the IL-1β group. TLR-2/NF-κB signaling pathway contributes to the occurrence of degenerative knee OA.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mobasheri, A" uniqKey="Mobasheri A">A Mobasheri</name></author><author><name sortKey="Csaki, C" uniqKey="Csaki C">C Csaki</name></author><author><name sortKey="Clutterbuck, Al" uniqKey="Clutterbuck A">AL Clutterbuck</name></author><author><name sortKey="Rahmanzadeh, M" uniqKey="Rahmanzadeh M">M Rahmanzadeh</name></author><author><name sortKey="Shakibaei, M" uniqKey="Shakibaei M">M Shakibaei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fransen, M" uniqKey="Fransen M">M Fransen</name></author><author><name sortKey="Bridgett, L" uniqKey="Bridgett L">L Bridgett</name></author><author><name sortKey="March, L" uniqKey="March L">L March</name></author><author><name sortKey="Hoy, D" uniqKey="Hoy D">D Hoy</name></author><author><name sortKey="Penserga, E" 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sortKey="Mankin, Hj" uniqKey="Mankin H">HJ Mankin</name></author><author><name sortKey="Johnson, Me" uniqKey="Johnson M">ME Johnson</name></author><author><name sortKey="Lippiello, L" uniqKey="Lippiello L">L Lippiello</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Yi Xun" sort="Liu, Yi Xun" uniqKey="Liu Y" first="Yi-Xun" last="Liu">Yi-Xun Liu</name></noRegion><name sortKey="Wang, Guo Dong" sort="Wang, Guo Dong" uniqKey="Wang G" first="Guo-Dong" last="Wang">Guo-Dong Wang</name><name sortKey="Wang, Xiao" sort="Wang, Xiao" uniqKey="Wang X" first="Xiao" last="Wang">Xiao Wang</name><name sortKey="Zhang, Tian Lun" sort="Zhang, Tian Lun" uniqKey="Zhang T" first="Tian-Lun" last="Zhang">Tian-Lun Zhang</name><name sortKey="Zhang, Yong Le" sort="Zhang, Yong Le" uniqKey="Zhang Y" first="Yong-Le" 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