Efficacy, Safety, and Overall Quality of Life of Endoscopic Submucosal Dissection for Early Colorectal Cancer in Elderly Patients
Identifieur interne : 000597 ( Main/Exploration ); précédent : 000596; suivant : 000598Efficacy, Safety, and Overall Quality of Life of Endoscopic Submucosal Dissection for Early Colorectal Cancer in Elderly Patients
Auteurs : Liang Liu [République populaire de Chine] ; Xingjie Shen [République populaire de Chine] ; Jingyu Zhu [République populaire de Chine]Source :
- Gastroenterology Research and Practice [ 1687-6121 ] ; 2017.
Abstract
Studies reporting the treatment of early colorectal cancer (ECC) by endoscopic submucosal dissection (ESD) in elderly patients are lacking in China. The aim was to evaluate the efficacy, safety and overall quality of life of elderly patients with ECC who undergoing ESD.
Three hundred and seventy-nine patients with 401 colorectal lesions entered into our study from March 2013 to March 2016 (Patients with an age 70 years old or older were divided into the elderly group and those who were less than 70-year-old entered the non-elderly group).
No significant differences were found in sex ratio, body mass index, location, endoscopic classification, pathological pattern, lesion size, mean procedure time, hospitalization days, complete excision, and en bloc resection rate between the two groups (
ESD was relatively safe and effective for elderly patients with ECC, and it may be an recommended first-line treatment.
Url:
DOI: 10.1155/2017/2386291
PubMed: 28757866
PubMed Central: 5512118
Affiliations:
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University, Ji'nan 250012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan 250012</wicri:regionArea><wicri:noRegion>Ji'nan 250012</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Jingyu" sort="Zhu, Jingyu" uniqKey="Zhu J" first="Jingyu" last="Zhu">Jingyu Zhu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan 250012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan 250012</wicri:regionArea><wicri:noRegion>Ji'nan 250012</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28757866</idno><idno 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type="wicri:Area/Main/Exploration">000597</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy, Safety, and Overall Quality of Life of Endoscopic Submucosal Dissection for Early Colorectal Cancer in Elderly Patients</title><author><name sortKey="Liu, Liang" sort="Liu, Liang" uniqKey="Liu L" first="Liang" last="Liu">Liang Liu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan 250012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan 250012</wicri:regionArea><wicri:noRegion>Ji'nan 250012</wicri:noRegion></affiliation></author><author><name sortKey="Shen, Xingjie" sort="Shen, Xingjie" uniqKey="Shen X" first="Xingjie" last="Shen">Xingjie Shen</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan 250012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan 250012</wicri:regionArea><wicri:noRegion>Ji'nan 250012</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Jingyu" sort="Zhu, Jingyu" uniqKey="Zhu J" first="Jingyu" last="Zhu">Jingyu Zhu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan 250012, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gastroenterology, Ji'nan Central Hospital Affiliated to Shandong University, Ji'nan 250012</wicri:regionArea><wicri:noRegion>Ji'nan 250012</wicri:noRegion></affiliation></author></analytic><series><title level="j">Gastroenterology Research and Practice</title><idno type="ISSN">1687-6121</idno><idno type="eISSN">1687-630X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p> Studies reporting the treatment of early colorectal cancer (ECC) by endoscopic submucosal dissection (ESD) in elderly patients are lacking in China. The aim was to evaluate the efficacy, safety and overall quality of life of elderly patients with ECC who undergoing ESD. </p></sec><sec><title>Methods</title><p> Three hundred and seventy-nine patients with 401 colorectal lesions entered into our study from March 2013 to March 2016 (Patients with an age 70 years old or older were divided into the elderly group and those who were less than 70-year-old entered the non-elderly group). </p></sec><sec><title>Results</title><p> No significant differences were found in sex ratio, body mass index, location, endoscopic classification, pathological pattern, lesion size, mean procedure time, hospitalization days, complete excision, and en bloc resection rate between the two groups (<italic>P</italic> > 0.05). No significant differences were observed between the groups in terms of complications during and after ESD procedure (<italic>P</italic> > 0.05). There were no statistical differences between two groups in Quality of life index (QL-Index) and European Organization for Research and Treatment quality of life version 3.0 questionnaire (EORTC QLQ-C30) scores (<italic>P</italic> > 0.05). </p></sec><sec><title>Conclusion</title><p> ESD was relatively safe and effective for elderly patients with ECC, and it may be an recommended first-line treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, W Q" uniqKey="Chen W">W. Q. Chen</name></author><author><name sortKey="Zheng, R S" uniqKey="Zheng R">R. S. Zheng</name></author><author><name sortKey="Zeng, H M" uniqKey="Zeng H">H. M. Zeng</name></author><author><name sortKey="Zhang, S W" uniqKey="Zhang S">S. W. Zhang</name></author><author><name sortKey="He, J" uniqKey="He J">J. He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, J W" uniqKey="Wang J">J. W. 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Watari</name></author><author><name sortKey="Tomita, T" uniqKey="Tomita T">T. Tomita</name></author><author><name sortKey="Toyoshima, F" uniqKey="Toyoshima F">F. Toyoshima</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Liang" sort="Liu, Liang" uniqKey="Liu L" first="Liang" last="Liu">Liang Liu</name></noRegion><name sortKey="Shen, Xingjie" sort="Shen, Xingjie" uniqKey="Shen X" first="Xingjie" last="Shen">Xingjie Shen</name><name sortKey="Zhu, Jingyu" sort="Zhu, Jingyu" uniqKey="Zhu J" first="Jingyu" last="Zhu">Jingyu Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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