LymphedemaV1, Main, Exploration, bibRecord, 000517

High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.

Identifieur interne : 000517 ( Main/Exploration ); précédent : 000516; suivant : 000518

High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.

Auteurs : Epameinondas Gousopoulos [Suisse] ; Sinem Karaman ; Steven T. Proulx ; Kristin Leu ; Dorina Buschle ; Michael Detmar

Source :

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes [ 1421-9921 ] ; 2017.

RBID : pubmed:28301852

Abstract

Lymphoedema represents the cardinal manifestation of lymphatic dysfunction and is associated with expansion of the adipose tissue in the affected limb. In mice, high-fat diet (HFD)-induced obesity was associated with impaired collecting lymphatic vessel function, and adiposity aggravated surgery-induced lymphoedema in a mouse model. The aim of the current study was to investigate whether adiposity is necessary to impair lymphatic function or whether increased lipid exposure alone might be sufficient in a surgical lymphoedema model.

DOI: 10.1159/000461579
PubMed: 28301852

Affiliations:

Suisse

Le document en format XML

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<front><div type="abstract" xml:lang="en">Lymphoedema represents the cardinal manifestation of lymphatic dysfunction and is associated with expansion of the adipose tissue in the affected limb. In mice, high-fat diet (HFD)-induced obesity was associated with impaired collecting lymphatic vessel function, and adiposity aggravated surgery-induced lymphoedema in a mouse model. The aim of the current study was to investigate whether adiposity is necessary to impair lymphatic function or whether increased lipid exposure alone might be sufficient in a surgical lymphoedema model.</div>
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Serveur d'exploration sur le lymphœdème

High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.

High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.

Source :

Abstract

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Le document en format XML

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