Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: a comparative study
Identifieur interne : 000266 ( Main/Exploration ); précédent : 000265; suivant : 000267Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: a comparative study
Auteurs : Ming Yin ; Wenge Wang ; Joseph J. Drabick ; Harvey A. HaroldSource :
- BMC Cancer [ 1471-2407 ] ; 2017.
Abstract
Breast angiosarcoma is a rare malignancy with limited publications confined to small retrospective case reviews and case reports. Knowledge of this disease is limited because information from previous studies is insufficient and inconsistent.
We obtained data from the Surveillance, Epidemiology, and End Results Program for non-metastatic primary and secondary breast angiosarcoma, and performed analysis to determine clinicopathological characteristics and estimate their associations with overall survival (OS).
Median age was 50–54 years in primary breast angiosarcoma and 70–74 years in secondary breast angiosarcoma, while median OS was 93 and 32 months, respectively. Age, tumor grade and tumor spread were associated with poor survival outcomes. Compared with primary breast angiosarcoma, patients with secondary breast angiosarcoma had a “nominal” increased death risk (HR = 1.89, 95% CI, 1.43–2.50,
There is a “nominal” increased death risk in secondary breast angiosarcoma due to advanced clinicopathological features. Both BCS and mastectomy are feasible in primary and secondary angiosarcoma if R0 can be achieved. Routine radiation in unselected breast angiosarcoma should be cautious because there is no survival benefit in primary AS and appeared to be associated with a worse OS in secondary AS.
The online version of this article (doi:10.1186/s12885-017-3292-7) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12885-017-3292-7
PubMed: 28449661
PubMed Central: 5408408
Affiliations:
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Harold</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28449661</idno><idno type="pmc">5408408</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408408</idno><idno type="RBID">PMC:5408408</idno><idno type="doi">10.1186/s12885-017-3292-7</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000C42</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C42</idno><idno type="wicri:Area/Pmc/Curation">000C41</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C41</idno><idno type="wicri:Area/Pmc/Checkpoint">000127</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000127</idno><idno type="wicri:Area/Ncbi/Merge">009006</idno><idno type="wicri:Area/Ncbi/Curation">009006</idno><idno type="wicri:Area/Ncbi/Checkpoint">009006</idno><idno type="wicri:Area/Main/Merge">000266</idno><idno type="wicri:Area/Main/Curation">000266</idno><idno type="wicri:Area/Main/Exploration">000266</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prognosis and treatment of non-metastatic primary and secondary breast angiosarcoma: a comparative study</title><author><name sortKey="Yin, Ming" sort="Yin, Ming" uniqKey="Yin M" first="Ming" last="Yin">Ming Yin</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Wang, Wenge" sort="Wang, Wenge" uniqKey="Wang W" first="Wenge" last="Wang">Wenge Wang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Drabick, Joseph J" sort="Drabick, Joseph J" uniqKey="Drabick J" first="Joseph J." last="Drabick">Joseph J. Drabick</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Harold, Harvey A" sort="Harold, Harvey A" uniqKey="Harold H" first="Harvey A." last="Harold">Harvey A. Harold</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">BMC Cancer</title><idno type="eISSN">1471-2407</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Breast angiosarcoma is a rare malignancy with limited publications confined to small retrospective case reviews and case reports. Knowledge of this disease is limited because information from previous studies is insufficient and inconsistent.</p></sec><sec><title>Methods</title><p>We obtained data from the Surveillance, Epidemiology, and End Results Program for non-metastatic primary and secondary breast angiosarcoma, and performed analysis to determine clinicopathological characteristics and estimate their associations with overall survival (OS).</p></sec><sec><title>Results</title><p>Median age was 50–54 years in primary breast angiosarcoma and 70–74 years in secondary breast angiosarcoma, while median OS was 93 and 32 months, respectively. Age, tumor grade and tumor spread were associated with poor survival outcomes. Compared with primary breast angiosarcoma, patients with secondary breast angiosarcoma had a “nominal” increased death risk (HR = 1.89, 95% CI, 1.43–2.50, <italic>p</italic> < 0.001), which was driven by older age and more aggressive tumor phenotype at presentation. Mastectomy was associated with worse OS compared with breast conservative surgery (BCS) (adjHR = 2.47, 95% CI, 1.29–4.74) in primary angiosarcoma patients. Adjuvant radiation was associated with worse OS in secondary angiosarcoma patients (adjHR =1.77, 95% CI, 1.01–3.12).</p></sec><sec><title>Conclusions</title><p>There is a “nominal” increased death risk in secondary breast angiosarcoma due to advanced clinicopathological features. Both BCS and mastectomy are feasible in primary and secondary angiosarcoma if R0 can be achieved. Routine radiation in unselected breast angiosarcoma should be cautious because there is no survival benefit in primary AS and appeared to be associated with a worse OS in secondary AS.</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (doi:10.1186/s12885-017-3292-7) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="May, Ds" uniqKey="May D">DS May</name></author><author><name sortKey="Stroup, Ne" uniqKey="Stroup N">NE Stroup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheth, Gr" uniqKey="Sheth G">GR Sheth</name></author><author><name sortKey="Cranmer, Ld" uniqKey="Cranmer L">LD Cranmer</name></author><author><name sortKey="Smith, Bd" uniqKey="Smith B">BD Smith</name></author><author><name sortKey="Grasso Lebeau, L" uniqKey="Grasso Lebeau L">L 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