Recurrent and Sustained Viral Infections in Primary Immunodeficiencies
Identifieur interne : 000234 ( Main/Exploration ); précédent : 000233; suivant : 000235Recurrent and Sustained Viral Infections in Primary Immunodeficiencies
Auteurs : Melanie A. Ruffner [États-Unis] ; Kathleen E. Sullivan [États-Unis] ; Sarah E. Henrickson [États-Unis]Source :
- Frontiers in Immunology [ 1664-3224 ] ; 2017.
Abstract
Viral infections are commonplace and often innocuous. Nevertheless, within the population of patients with primary immunodeficiencies (PIDDs), viral infections can be the feature that drives a diagnostic evaluation or can be the most significant morbidity for the patient. This review is focused on the viral complications of PIDDs. It will focus on respiratory viruses, the most common type of viral infection in the general population. Children and adults with an increased frequency or severity of respiratory viral infections are often referred for an immunologic evaluation. The classic teaching is to investigate humoral function in people with recurrent sinopulmonary infections, but this is often interpreted to mean recurrent bacterial infections. Recurrent or very severe viral infections may also be a harbinger of a primary immunodeficiency as well. This review will also cover persistent cutaneous viral infections, systemic infections, central nervous system infections, and gastrointestinal infections. In each case, the specific viral infections may drive a diagnostic evaluation that is specific for that type of virus. This review also discusses the management of these infections, which can become problematic in patients with PIDDs.
Url:
DOI: 10.3389/fimmu.2017.00665
PubMed: 28674531
PubMed Central: 5474473
Affiliations:
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Ruffner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>The Children’s Hospital of Philadelphia</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sullivan, Kathleen E" sort="Sullivan, Kathleen E" uniqKey="Sullivan K" first="Kathleen E." last="Sullivan">Kathleen E. Sullivan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>The Children’s Hospital of Philadelphia</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Henrickson, Sarah E" sort="Henrickson, Sarah E" uniqKey="Henrickson S" first="Sarah E." last="Henrickson">Sarah E. Henrickson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>The Children’s Hospital of Philadelphia</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Viral infections are commonplace and often innocuous. Nevertheless, within the population of patients with primary immunodeficiencies (PIDDs), viral infections can be the feature that drives a diagnostic evaluation or can be the most significant morbidity for the patient. This review is focused on the viral complications of PIDDs. It will focus on respiratory viruses, the most common type of viral infection in the general population. Children and adults with an increased frequency or severity of respiratory viral infections are often referred for an immunologic evaluation. The classic teaching is to investigate humoral function in people with recurrent sinopulmonary infections, but this is often interpreted to mean recurrent bacterial infections. Recurrent or very severe viral infections may also be a harbinger of a primary immunodeficiency as well. This review will also cover persistent cutaneous viral infections, systemic infections, central nervous system infections, and gastrointestinal infections. In each case, the specific viral infections may drive a diagnostic evaluation that is specific for that type of virus. This review also discusses the management of these infections, which can become problematic in patients with PIDDs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Campbell, H" uniqKey="Campbell H">H Campbell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gruber, C" uniqKey="Gruber C">C Gruber</name></author><author><name sortKey="Keil, T" uniqKey="Keil T">T Keil</name></author><author><name sortKey="Kulig, M" uniqKey="Kulig M">M Kulig</name></author><author><name sortKey="Roll, S" uniqKey="Roll S">S Roll</name></author><author><name sortKey="Wahn, U" uniqKey="Wahn U">U Wahn</name></author><author><name sortKey="Wahn, V" uniqKey="Wahn V">V Wahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monto, As" uniqKey="Monto A">AS Monto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aligne, Ca" uniqKey="Aligne C">CA 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J" uniqKey="Iber J">J Iber</name></author><author><name sortKey="Sutter, Rw" uniqKey="Sutter R">RW Sutter</name></author><author><name sortKey="Wassilak, Sg" uniqKey="Wassilak S">SG Wassilak</name></author><author><name sortKey="Burns, Cc" uniqKey="Burns C">CC Burns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, J" uniqKey="Guo J">J Guo</name></author><author><name sortKey="Bolivar Wagers, S" uniqKey="Bolivar Wagers S">S Bolivar-Wagers</name></author><author><name sortKey="Srinivas, N" uniqKey="Srinivas N">N Srinivas</name></author><author><name sortKey="Holubar, M" uniqKey="Holubar M">M Holubar</name></author><author><name sortKey="Maldonado, Y" uniqKey="Maldonado Y">Y Maldonado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wintergerst, U" uniqKey="Wintergerst U">U Wintergerst</name></author><author><name sortKey="Belohradsky, Bh" uniqKey="Belohradsky B">BH Belohradsky</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Ruffner, Melanie A" sort="Ruffner, Melanie A" uniqKey="Ruffner M" first="Melanie A." last="Ruffner">Melanie A. Ruffner</name></noRegion><name sortKey="Henrickson, Sarah E" sort="Henrickson, Sarah E" uniqKey="Henrickson S" first="Sarah E." last="Henrickson">Sarah E. Henrickson</name><name sortKey="Sullivan, Kathleen E" sort="Sullivan, Kathleen E" uniqKey="Sullivan K" first="Kathleen E." last="Sullivan">Kathleen E. Sullivan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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