Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis
Identifieur interne : 000184 ( Main/Exploration ); précédent : 000183; suivant : 000185Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis
Auteurs : Ghaith Aljayyoussi ; Hayley E. Tyrer ; Louise Ford ; Hanna Sjoberg ; Nicolas Pionnier ; David Waterhouse ; Jill Davies ; Joanne Gamble ; Haelly Metugene [Cameroun] ; Darren A. N. Cook ; Andrew Steven ; Raman Sharma ; Ana F. Guimaraes ; Rachel H. Clare ; Andrew Cassidy ; Kelly L. Johnston ; Laura Myhill ; Laura Hayward ; Samuel Wanji [Cameroun] ; Joseph D. Turner ; Mark J. Taylor ; Stephen A. WardSource :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial curative activity against the filarial nematodes responsible for LF (
Url:
DOI: 10.1038/s41598-017-00322-5
PubMed: 28303006
PubMed Central: 5428297
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000E38
- to stream Pmc, to step Curation: 000E37
- to stream Pmc, to step Checkpoint: 000080
- to stream Ncbi, to step Merge: 008E61
- to stream Ncbi, to step Curation: 008E61
- to stream Ncbi, to step Checkpoint: 008E61
- to stream Main, to step Merge: 000184
- to stream Main, to step Curation: 000184
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Short-Course, High-Dose Rifampicin Achieves <italic>Wolbachia</italic> Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis</title><author><name sortKey="Aljayyoussi, Ghaith" sort="Aljayyoussi, Ghaith" uniqKey="Aljayyoussi G" first="Ghaith" last="Aljayyoussi">Ghaith Aljayyoussi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Tyrer, Hayley E" sort="Tyrer, Hayley E" uniqKey="Tyrer H" first="Hayley E." last="Tyrer">Hayley E. Tyrer</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Ford, Louise" sort="Ford, Louise" uniqKey="Ford L" first="Louise" last="Ford">Louise Ford</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Sjoberg, Hanna" sort="Sjoberg, Hanna" uniqKey="Sjoberg H" first="Hanna" last="Sjoberg">Hanna Sjoberg</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Pionnier, Nicolas" sort="Pionnier, Nicolas" uniqKey="Pionnier N" first="Nicolas" last="Pionnier">Nicolas Pionnier</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Waterhouse, David" sort="Waterhouse, David" uniqKey="Waterhouse D" first="David" last="Waterhouse">David Waterhouse</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Davies, Jill" sort="Davies, Jill" uniqKey="Davies J" first="Jill" last="Davies">Jill Davies</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Gamble, Joanne" sort="Gamble, Joanne" uniqKey="Gamble J" first="Joanne" last="Gamble">Joanne Gamble</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Metugene, Haelly" sort="Metugene, Haelly" uniqKey="Metugene H" first="Haelly" last="Metugene">Haelly Metugene</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Research Foundation in Tropical Medicine and the Environment, Buea, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Research Foundation in Tropical Medicine and the Environment, Buea</wicri:regionArea><wicri:noRegion>Buea</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2288 3199</institution-id><institution-id institution-id-type="GRID">grid.29273.3d</institution-id><institution>Department of Microbiology and Parasitology,</institution><institution>University of Buea,</institution></institution-wrap>Buea, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Buea</wicri:regionArea></affiliation></author><author><name sortKey="Cook, Darren A N" sort="Cook, Darren A N" uniqKey="Cook D" first="Darren A. N." last="Cook">Darren A. N. Cook</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Steven, Andrew" sort="Steven, Andrew" uniqKey="Steven A" first="Andrew" last="Steven">Andrew Steven</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Sharma, Raman" sort="Sharma, Raman" uniqKey="Sharma R" first="Raman" last="Sharma">Raman Sharma</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Guimaraes, Ana F" sort="Guimaraes, Ana F" uniqKey="Guimaraes A" first="Ana F." last="Guimaraes">Ana F. Guimaraes</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Clare, Rachel H" sort="Clare, Rachel H" uniqKey="Clare R" first="Rachel H." last="Clare">Rachel H. Clare</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Cassidy, Andrew" sort="Cassidy, Andrew" uniqKey="Cassidy A" first="Andrew" last="Cassidy">Andrew Cassidy</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Johnston, Kelly L" sort="Johnston, Kelly L" uniqKey="Johnston K" first="Kelly L." last="Johnston">Kelly L. Johnston</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Myhill, Laura" sort="Myhill, Laura" uniqKey="Myhill L" first="Laura" last="Myhill">Laura Myhill</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Hayward, Laura" sort="Hayward, Laura" uniqKey="Hayward L" first="Laura" last="Hayward">Laura Hayward</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Wanji, Samuel" sort="Wanji, Samuel" uniqKey="Wanji S" first="Samuel" last="Wanji">Samuel Wanji</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Research Foundation in Tropical Medicine and the Environment, Buea, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Research Foundation in Tropical Medicine and the Environment, Buea</wicri:regionArea><wicri:noRegion>Buea</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2288 3199</institution-id><institution-id institution-id-type="GRID">grid.29273.3d</institution-id><institution>Department of Microbiology and Parasitology,</institution><institution>University of Buea,</institution></institution-wrap>Buea, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Buea</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Joseph D" sort="Turner, Joseph D" uniqKey="Turner J" first="Joseph D." last="Turner">Joseph D. Turner</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Taylor, Mark J" sort="Taylor, Mark J" uniqKey="Taylor M" first="Mark J." last="Taylor">Mark J. Taylor</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Ward, Stephen A" sort="Ward, Stephen A" uniqKey="Ward S" first="Stephen A." last="Ward">Stephen A. Ward</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28303006</idno><idno type="pmc">5428297</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428297</idno><idno type="RBID">PMC:5428297</idno><idno type="doi">10.1038/s41598-017-00322-5</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000E38</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E38</idno><idno type="wicri:Area/Pmc/Curation">000E37</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E37</idno><idno type="wicri:Area/Pmc/Checkpoint">000080</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000080</idno><idno type="wicri:Area/Ncbi/Merge">008E61</idno><idno type="wicri:Area/Ncbi/Curation">008E61</idno><idno type="wicri:Area/Ncbi/Checkpoint">008E61</idno><idno type="wicri:Area/Main/Merge">000184</idno><idno type="wicri:Area/Main/Curation">000184</idno><idno type="wicri:Area/Main/Exploration">000184</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Short-Course, High-Dose Rifampicin Achieves <italic>Wolbachia</italic> Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis</title><author><name sortKey="Aljayyoussi, Ghaith" sort="Aljayyoussi, Ghaith" uniqKey="Aljayyoussi G" first="Ghaith" last="Aljayyoussi">Ghaith Aljayyoussi</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Tyrer, Hayley E" sort="Tyrer, Hayley E" uniqKey="Tyrer H" first="Hayley E." last="Tyrer">Hayley E. Tyrer</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Ford, Louise" sort="Ford, Louise" uniqKey="Ford L" first="Louise" last="Ford">Louise Ford</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Sjoberg, Hanna" sort="Sjoberg, Hanna" uniqKey="Sjoberg H" first="Hanna" last="Sjoberg">Hanna Sjoberg</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Pionnier, Nicolas" sort="Pionnier, Nicolas" uniqKey="Pionnier N" first="Nicolas" last="Pionnier">Nicolas Pionnier</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Waterhouse, David" sort="Waterhouse, David" uniqKey="Waterhouse D" first="David" last="Waterhouse">David Waterhouse</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Davies, Jill" sort="Davies, Jill" uniqKey="Davies J" first="Jill" last="Davies">Jill Davies</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Gamble, Joanne" sort="Gamble, Joanne" uniqKey="Gamble J" first="Joanne" last="Gamble">Joanne Gamble</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Metugene, Haelly" sort="Metugene, Haelly" uniqKey="Metugene H" first="Haelly" last="Metugene">Haelly Metugene</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Research Foundation in Tropical Medicine and the Environment, Buea, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Research Foundation in Tropical Medicine and the Environment, Buea</wicri:regionArea><wicri:noRegion>Buea</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2288 3199</institution-id><institution-id institution-id-type="GRID">grid.29273.3d</institution-id><institution>Department of Microbiology and Parasitology,</institution><institution>University of Buea,</institution></institution-wrap>Buea, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Buea</wicri:regionArea></affiliation></author><author><name sortKey="Cook, Darren A N" sort="Cook, Darren A N" uniqKey="Cook D" first="Darren A. N." last="Cook">Darren A. N. Cook</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Steven, Andrew" sort="Steven, Andrew" uniqKey="Steven A" first="Andrew" last="Steven">Andrew Steven</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Sharma, Raman" sort="Sharma, Raman" uniqKey="Sharma R" first="Raman" last="Sharma">Raman Sharma</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Guimaraes, Ana F" sort="Guimaraes, Ana F" uniqKey="Guimaraes A" first="Ana F." last="Guimaraes">Ana F. Guimaraes</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Clare, Rachel H" sort="Clare, Rachel H" uniqKey="Clare R" first="Rachel H." last="Clare">Rachel H. Clare</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Cassidy, Andrew" sort="Cassidy, Andrew" uniqKey="Cassidy A" first="Andrew" last="Cassidy">Andrew Cassidy</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Johnston, Kelly L" sort="Johnston, Kelly L" uniqKey="Johnston K" first="Kelly L." last="Johnston">Kelly L. Johnston</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Myhill, Laura" sort="Myhill, Laura" uniqKey="Myhill L" first="Laura" last="Myhill">Laura Myhill</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Hayward, Laura" sort="Hayward, Laura" uniqKey="Hayward L" first="Laura" last="Hayward">Laura Hayward</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Wanji, Samuel" sort="Wanji, Samuel" uniqKey="Wanji S" first="Samuel" last="Wanji">Samuel Wanji</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Research Foundation in Tropical Medicine and the Environment, Buea, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Research Foundation in Tropical Medicine and the Environment, Buea</wicri:regionArea><wicri:noRegion>Buea</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2288 3199</institution-id><institution-id institution-id-type="GRID">grid.29273.3d</institution-id><institution>Department of Microbiology and Parasitology,</institution><institution>University of Buea,</institution></institution-wrap>Buea, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Buea</wicri:regionArea></affiliation></author><author><name sortKey="Turner, Joseph D" sort="Turner, Joseph D" uniqKey="Turner J" first="Joseph D." last="Turner">Joseph D. Turner</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Taylor, Mark J" sort="Taylor, Mark J" uniqKey="Taylor M" first="Mark J." last="Taylor">Mark J. Taylor</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author><author><name sortKey="Ward, Stephen A" sort="Ward, Stephen A" uniqKey="Ward S" first="Stephen A." last="Ward">Stephen A. Ward</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9764</institution-id><institution-id institution-id-type="GRID">grid.48004.38</institution-id><institution>Department of Parasitology,</institution><institution>Liverpool School of Tropical Medicine,</institution></institution-wrap>Pembroke Place, Liverpool L3 5QA UK</nlm:aff><wicri:noCountry code="subfield">Liverpool L3 5QA UK</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial curative activity against the filarial nematodes responsible for LF (<italic>Brugia malayi, Wuchereria bancrofti</italic>) or onchocerciasis (<italic>Onchocerca volvulus</italic>) is doxycycline. The target of doxycycline is the essential endosymbiont, <italic>Wolbachia</italic>. Four to six weeks doxycycline therapy achieves >90% depletion of <italic>Wolbachia</italic> in worm tissues leading to blockade of embryogenesis, adult sterility and premature death 18–24 months post-treatment. Long treatment length and contraindications in children and pregnancy are obstacles to implementing doxycycline as a public health strategy. Here we determine, via preclinical infection models of <italic>Brugia malayi</italic> or <italic>Onchocerca ochengi</italic> that elevated exposures of orally-administered rifampicin can lead to <italic>Wolbachia</italic> depletions from filariae more rapidly than those achieved by doxycycline. Dose escalation of rifampicin achieves >90% <italic>Wolbachia</italic> depletion in time periods of 7 days in <italic>B. malayi</italic> and 14 days in <italic>O. ochengi</italic>. Using pharmacokinetic-pharmacodynamic modelling and mouse-human bridging analysis, we conclude that clinically relevant dose elevations of rifampicin, which have recently been determined as safe in humans, could be administered as short courses to filariasis target populations with potential to reduce anti-<italic>Wolbachia</italic> curative therapy times to between one and two weeks.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bockarie, Mj" uniqKey="Bockarie M">MJ Bockarie</name></author><author><name sortKey="Kelly Hope, La" uniqKey="Kelly Hope L">LA Kelly-Hope</name></author><author><name sortKey="Rebollo, M" uniqKey="Rebollo M">M Rebollo</name></author><author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Bockarie, M" uniqKey="Bockarie M">M Bockarie</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name></author><author><name sortKey="Zagaria, N" uniqKey="Zagaria N">N Zagaria</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Molyneux, Dh" uniqKey="Molyneux D">DH Molyneux</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Kyelem, D" uniqKey="Kyelem D">D Kyelem</name></author><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ottesen, E" uniqKey="Ottesen E">E Ottesen</name></author><author><name sortKey="Duke, B" uniqKey="Duke B">B Duke</name></author><author><name sortKey="Karam, M" uniqKey="Karam M">M Karam</name></author><author><name sortKey="Behbehani, K" uniqKey="Behbehani K">K Behbehani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kale, Oo" uniqKey="Kale O">OO Kale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ichimori, K" uniqKey="Ichimori K">K Ichimori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bockarie, Mj" uniqKey="Bockarie M">MJ Bockarie</name></author><author><name sortKey="Deb, Rm" uniqKey="Deb R">RM Deb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rebollo, Mp" uniqKey="Rebollo M">MP Rebollo</name></author><author><name sortKey="Bockarie, Mj" uniqKey="Bockarie M">MJ Bockarie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gyapong, Jo" uniqKey="Gyapong J">JO Gyapong</name></author><author><name sortKey="Kumaraswami, V" uniqKey="Kumaraswami V">V Kumaraswami</name></author><author><name sortKey="Biswas, G" uniqKey="Biswas G">G Biswas</name></author><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coffeng, Le" uniqKey="Coffeng L">LE Coffeng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Basa Ez, M G" uniqKey="Basa Ez M">M-G Basáñez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sodahlon, Yk" uniqKey="Sodahlon Y">YK Sodahlon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jian, S" uniqKey="De Jian S">S De-jian</name></author><author><name sortKey="Xu Li, D" uniqKey="Xu Li D">D Xu-li</name></author><author><name sortKey="Ji Hui, D" uniqKey="Ji Hui D">D Ji-hui</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cheun, Hi" uniqKey="Cheun H">HI Cheun</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Diawara, L" uniqKey="Diawara L">L Diawara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourguinat, C" uniqKey="Bourguinat C">C Bourguinat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osei Atweneboana, My" uniqKey="Osei Atweneboana M">MY Osei-Atweneboana</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osei Atweneboana, My" uniqKey="Osei Atweneboana M">MY Osei-Atweneboana</name></author><author><name sortKey="Boakye, Da" uniqKey="Boakye D">DA Boakye</name></author><author><name sortKey="Awadzi, K" uniqKey="Awadzi K">K Awadzi</name></author><author><name sortKey="Gyapong, Jo" uniqKey="Gyapong J">JO Gyapong</name></author><author><name sortKey="Prichard, Rk" uniqKey="Prichard R">RK Prichard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gardon, J" uniqKey="Gardon J">J Gardon</name></author><author><name sortKey="Gardon Wendel, N" uniqKey="Gardon Wendel N">N Gardon-Wendel</name></author><author><name sortKey="Kamgno, J" uniqKey="Kamgno J">J Kamgno</name></author><author><name sortKey="Chippaux, J P" uniqKey="Chippaux J">J-P Chippaux</name></author><author><name sortKey="Boussinesq, M" uniqKey="Boussinesq M">M Boussinesq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Townson, S" uniqKey="Townson S">S Townson</name></author><author><name sortKey="Slatko, Be" uniqKey="Slatko B">BE Slatko</name></author><author><name sortKey="Ward, Sa" uniqKey="Ward S">SA Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debrah, Ay" uniqKey="Debrah A">AY Debrah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debrah, Ay" uniqKey="Debrah A">AY Debrah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Supali, T" uniqKey="Supali T">T Supali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mand, S" uniqKey="Mand S">S Mand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gayen, P" uniqKey="Gayen P">P Gayen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Jd" uniqKey="Turner J">JD Turner</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O Adjei</name></author><author><name sortKey="Buttner, Dw" uniqKey="Buttner D">DW Buttner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Albers, A" uniqKey="Albers A">A Albers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volkmann, L" uniqKey="Volkmann L">L Volkmann</name></author><author><name sortKey="Fischer, K" uniqKey="Fischer K">K Fischer</name></author><author><name sortKey="Taylor, M" uniqKey="Taylor M">M Taylor</name></author><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walker, M" uniqKey="Walker M">M Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S Mand</name></author><author><name sortKey="Adjei, O" uniqKey="Adjei O">O Adjei</name></author><author><name sortKey="Fleischer, B" uniqKey="Fleischer B">B Fleischer</name></author><author><name sortKey="Buttner, Dw" uniqKey="Buttner D">DW Buttner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turner, Jd" uniqKey="Turner J">JD Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debrah, Ay" uniqKey="Debrah A">AY Debrah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Czeizel, Ae" uniqKey="Czeizel A">AE Czeizel</name></author><author><name sortKey="Rockenbauer, M" uniqKey="Rockenbauer M">M Rockenbauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halliday, A" uniqKey="Halliday A">A Halliday</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clare, Rh" uniqKey="Clare R">RH Clare</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gilbert, J" uniqKey="Gilbert J">J Gilbert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Makepeace, Bl" uniqKey="Makepeace B">BL Makepeace</name></author><author><name sortKey="Rodgers, L" uniqKey="Rodgers L">L Rodgers</name></author><author><name sortKey="Trees, Aj" uniqKey="Trees A">AJ Trees</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boeree, Mj" uniqKey="Boeree M">MJ Boeree</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnston, Kl" uniqKey="Johnston K">KL Johnston</name></author><author><name sortKey="Ford, L" uniqKey="Ford L">L Ford</name></author><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnston, Kl" uniqKey="Johnston K">KL Johnston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boatin, Ba" uniqKey="Boatin B">BA Boatin</name></author><author><name sortKey="Richards, Fo" uniqKey="Richards F">FO Richards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamgno, J" uniqKey="Kamgno J">J Kamgno</name></author><author><name sortKey="Gardon, J" uniqKey="Gardon J">J Gardon</name></author><author><name sortKey="Gardon Wendel, N" uniqKey="Gardon Wendel N">N Gardon-Wendel</name></author><author><name sortKey="Duke, Bo" uniqKey="Duke B">BO Duke</name></author><author><name sortKey="Boussinesq, M" uniqKey="Boussinesq M">M Boussinesq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoerauf, A" uniqKey="Hoerauf A">A Hoerauf</name></author><author><name sortKey="Pfarr, K" uniqKey="Pfarr K">K Pfarr</name></author><author><name sortKey="Mand, S" uniqKey="Mand S">S Mand</name></author><author><name sortKey="Debrah, A" uniqKey="Debrah A">A Debrah</name></author><author><name sortKey="Specht, S" uniqKey="Specht S">S Specht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgarry, Hf" uniqKey="Mcgarry H">HF McGarry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wanji, S" uniqKey="Wanji S">S Wanji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Specht, S" uniqKey="Specht S">S Specht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richards, Fo" uniqKey="Richards F">FO Richards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Ingen, J" uniqKey="Van Ingen J">J van Ingen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boeree, Mj" uniqKey="Boeree M">MJ Boeree</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Acocella, G" uniqKey="Acocella G">G Acocella</name></author><author><name sortKey="Brumfitt, W" uniqKey="Brumfitt W">W Brumfitt</name></author><author><name sortKey="Hamilton Miller, Jm" uniqKey="Hamilton Miller J">JM Hamilton-Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gruneberg, Rn" uniqKey="Gruneberg R">RN Gruneberg</name></author><author><name sortKey="Emmerson, Am" uniqKey="Emmerson A">AM Emmerson</name></author><author><name sortKey="Cremer, Aw" uniqKey="Cremer A">AW Cremer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baciewicz, Am" uniqKey="Baciewicz A">AM Baciewicz</name></author><author><name sortKey="Chrisman, Cr" uniqKey="Chrisman C">CR Chrisman</name></author><author><name sortKey="Finch, Ck" uniqKey="Finch C">CK Finch</name></author><author><name sortKey="Self, Th" uniqKey="Self T">TH Self</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgarry, Hf" uniqKey="Mcgarry H">HF McGarry</name></author><author><name sortKey="Plant, Ld" uniqKey="Plant L">LD Plant</name></author><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcgarry, Hf" uniqKey="Mcgarry H">HF McGarry</name></author><author><name sortKey="Egerton, Gl" uniqKey="Egerton G">GL Egerton</name></author><author><name sortKey="Taylor, Mj" uniqKey="Taylor M">MJ Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neely, Mn" uniqKey="Neely M">MN Neely</name></author><author><name sortKey="Van Guilder, Mg" uniqKey="Van Guilder M">MG van Guilder</name></author><author><name sortKey="Yamada, Wm" uniqKey="Yamada W">WM Yamada</name></author><author><name sortKey="Schumitzky, A" uniqKey="Schumitzky A">A Schumitzky</name></author><author><name sortKey="Jelliffe, Rw" uniqKey="Jelliffe R">RW Jelliffe</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Cameroun</li></country></list><tree><noCountry><name sortKey="Aljayyoussi, Ghaith" sort="Aljayyoussi, Ghaith" uniqKey="Aljayyoussi G" first="Ghaith" last="Aljayyoussi">Ghaith Aljayyoussi</name><name sortKey="Cassidy, Andrew" sort="Cassidy, Andrew" uniqKey="Cassidy A" first="Andrew" last="Cassidy">Andrew Cassidy</name><name sortKey="Clare, Rachel H" sort="Clare, Rachel H" uniqKey="Clare R" first="Rachel H." last="Clare">Rachel H. Clare</name><name sortKey="Cook, Darren A N" sort="Cook, Darren A N" uniqKey="Cook D" first="Darren A. N." last="Cook">Darren A. N. Cook</name><name sortKey="Davies, Jill" sort="Davies, Jill" uniqKey="Davies J" first="Jill" last="Davies">Jill Davies</name><name sortKey="Ford, Louise" sort="Ford, Louise" uniqKey="Ford L" first="Louise" last="Ford">Louise Ford</name><name sortKey="Gamble, Joanne" sort="Gamble, Joanne" uniqKey="Gamble J" first="Joanne" last="Gamble">Joanne Gamble</name><name sortKey="Guimaraes, Ana F" sort="Guimaraes, Ana F" uniqKey="Guimaraes A" first="Ana F." last="Guimaraes">Ana F. Guimaraes</name><name sortKey="Hayward, Laura" sort="Hayward, Laura" uniqKey="Hayward L" first="Laura" last="Hayward">Laura Hayward</name><name sortKey="Johnston, Kelly L" sort="Johnston, Kelly L" uniqKey="Johnston K" first="Kelly L." last="Johnston">Kelly L. Johnston</name><name sortKey="Myhill, Laura" sort="Myhill, Laura" uniqKey="Myhill L" first="Laura" last="Myhill">Laura Myhill</name><name sortKey="Pionnier, Nicolas" sort="Pionnier, Nicolas" uniqKey="Pionnier N" first="Nicolas" last="Pionnier">Nicolas Pionnier</name><name sortKey="Sharma, Raman" sort="Sharma, Raman" uniqKey="Sharma R" first="Raman" last="Sharma">Raman Sharma</name><name sortKey="Sjoberg, Hanna" sort="Sjoberg, Hanna" uniqKey="Sjoberg H" first="Hanna" last="Sjoberg">Hanna Sjoberg</name><name sortKey="Steven, Andrew" sort="Steven, Andrew" uniqKey="Steven A" first="Andrew" last="Steven">Andrew Steven</name><name sortKey="Taylor, Mark J" sort="Taylor, Mark J" uniqKey="Taylor M" first="Mark J." last="Taylor">Mark J. Taylor</name><name sortKey="Turner, Joseph D" sort="Turner, Joseph D" uniqKey="Turner J" first="Joseph D." last="Turner">Joseph D. Turner</name><name sortKey="Tyrer, Hayley E" sort="Tyrer, Hayley E" uniqKey="Tyrer H" first="Hayley E." last="Tyrer">Hayley E. Tyrer</name><name sortKey="Ward, Stephen A" sort="Ward, Stephen A" uniqKey="Ward S" first="Stephen A." last="Ward">Stephen A. Ward</name><name sortKey="Waterhouse, David" sort="Waterhouse, David" uniqKey="Waterhouse D" first="David" last="Waterhouse">David Waterhouse</name></noCountry><country name="Cameroun"><noRegion><name sortKey="Metugene, Haelly" sort="Metugene, Haelly" uniqKey="Metugene H" first="Haelly" last="Metugene">Haelly Metugene</name></noRegion><name sortKey="Metugene, Haelly" sort="Metugene, Haelly" uniqKey="Metugene H" first="Haelly" last="Metugene">Haelly Metugene</name><name sortKey="Wanji, Samuel" sort="Wanji, Samuel" uniqKey="Wanji S" first="Samuel" last="Wanji">Samuel Wanji</name><name sortKey="Wanji, Samuel" sort="Wanji, Samuel" uniqKey="Wanji S" first="Samuel" last="Wanji">Samuel Wanji</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000184 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000184 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5428297
|texte= Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28303006" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |