Tc-99m-Human Serum Albumin Transit Time as a Measure of Arm Breast Cancer-Related Lymphedema
Identifieur interne : 000131 ( Main/Exploration ); précédent : 000130; suivant : 000132Tc-99m-Human Serum Albumin Transit Time as a Measure of Arm Breast Cancer-Related Lymphedema
Auteurs : Navid M. Toyserkani ; Svend Hvidsten ; Siavosh Tabatabaeifar ; Jane A. Simonsen ; Poul F. H Ilund-Carlsen ; Jens A. S RensenSource :
- Plastic and Reconstructive Surgery Global Open [ 2169-7574 ] ; 2017.
Abstract
Lymphoscintigraphy has often been used for evaluating arm lymphatic dysfunction, but no optimal approach for quantification has so far emerged. We propose a quantifiable measure of lymphatic function that we applied in patients treated for breast cancer.
Eleven patients, aged 34–68 years, with unilateral arm lymphedema following breast cancer treatment underwent bilateral lymphoscintigraphy using intradermal injection in both hands of technetium-99m–labeled human serum albumin and sequential 5 min imaging for 5 hours. The mean transit time (MTT) in the arms was calculated based on time activity curves generated from injection site and arm regions. Visual lymphedema scoring was performed based on dermal backflow and lymph node presence. Excess arm volume was calculated from circumference measurements.
The MTT (mean ± SD) was significantly longer in the lymphedema arm than in the normal arm: 60.1 ± 27.7 versus 5.4 ± 2.5 minutes (mean difference, 54.7 minutes; 95% confidence interval, 36.5–72.9 minutes;
Measurements of MTT were able to discriminate lymphedema from healthy arm and MTT correlated with relevant markers for lymphedema severity. We encourage further research using the MTT approach for monitoring lymphedema and evaluation of treatment response.
Url:
DOI: 10.1097/GOX.0000000000001362
PubMed: 28740776
PubMed Central: 5505837
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 004581
- to stream Pmc, to step Curation: 004580
- to stream Pmc, to step Checkpoint: 000051
- to stream PubMed, to step Corpus: 000093
- to stream PubMed, to step Curation: 000093
- to stream PubMed, to step Checkpoint: 000093
- to stream Ncbi, to step Merge: 009304
- to stream Ncbi, to step Curation: 009304
- to stream Ncbi, to step Checkpoint: 009304
- to stream Main, to step Merge: 000131
- to stream Main, to step Curation: 000131
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tc-99m-Human Serum Albumin Transit Time as a Measure of Arm Breast Cancer-Related Lymphedema</title><author><name sortKey="Toyserkani, Navid M" sort="Toyserkani, Navid M" uniqKey="Toyserkani N" first="Navid M." last="Toyserkani">Navid M. Toyserkani</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hvidsten, Svend" sort="Hvidsten, Svend" uniqKey="Hvidsten S" first="Svend" last="Hvidsten">Svend Hvidsten</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tabatabaeifar, Siavosh" sort="Tabatabaeifar, Siavosh" uniqKey="Tabatabaeifar S" first="Siavosh" last="Tabatabaeifar">Siavosh Tabatabaeifar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Simonsen, Jane A" sort="Simonsen, Jane A" uniqKey="Simonsen J" first="Jane A." last="Simonsen">Jane A. Simonsen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="H Ilund Carlsen, Poul F" sort="H Ilund Carlsen, Poul F" uniqKey="H Ilund Carlsen P" first="Poul F." last="H Ilund-Carlsen">Poul F. H Ilund-Carlsen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="S Rensen, Jens A" sort="S Rensen, Jens A" uniqKey="S Rensen J" first="Jens A." last="S Rensen">Jens A. S Rensen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28740776</idno><idno type="pmc">5505837</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505837</idno><idno type="RBID">PMC:5505837</idno><idno type="doi">10.1097/GOX.0000000000001362</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">004581</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004581</idno><idno type="wicri:Area/Pmc/Curation">004580</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004580</idno><idno type="wicri:Area/Pmc/Checkpoint">000051</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000051</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000093</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000093</idno><idno type="wicri:Area/PubMed/Curation">000093</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000093</idno><idno type="wicri:Area/PubMed/Checkpoint">000093</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000093</idno><idno type="wicri:Area/Ncbi/Merge">009304</idno><idno type="wicri:Area/Ncbi/Curation">009304</idno><idno type="wicri:Area/Ncbi/Checkpoint">009304</idno><idno type="wicri:Area/Main/Merge">000131</idno><idno type="wicri:Area/Main/Curation">000131</idno><idno type="wicri:Area/Main/Exploration">000131</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tc-99m-Human Serum Albumin Transit Time as a Measure of Arm Breast Cancer-Related Lymphedema</title><author><name sortKey="Toyserkani, Navid M" sort="Toyserkani, Navid M" uniqKey="Toyserkani N" first="Navid M." last="Toyserkani">Navid M. Toyserkani</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Hvidsten, Svend" sort="Hvidsten, Svend" uniqKey="Hvidsten S" first="Svend" last="Hvidsten">Svend Hvidsten</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Tabatabaeifar, Siavosh" sort="Tabatabaeifar, Siavosh" uniqKey="Tabatabaeifar S" first="Siavosh" last="Tabatabaeifar">Siavosh Tabatabaeifar</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Simonsen, Jane A" sort="Simonsen, Jane A" uniqKey="Simonsen J" first="Jane A." last="Simonsen">Jane A. Simonsen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="H Ilund Carlsen, Poul F" sort="H Ilund Carlsen, Poul F" uniqKey="H Ilund Carlsen P" first="Poul F." last="H Ilund-Carlsen">Poul F. H Ilund-Carlsen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="S Rensen, Jens A" sort="S Rensen, Jens A" uniqKey="S Rensen J" first="Jens A." last="S Rensen">Jens A. S Rensen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Plastic and Reconstructive Surgery Global Open</title><idno type="eISSN">2169-7574</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Lymphoscintigraphy has often been used for evaluating arm lymphatic dysfunction, but no optimal approach for quantification has so far emerged. We propose a quantifiable measure of lymphatic function that we applied in patients treated for breast cancer.</p></sec><sec><title>Methods:</title><p>Eleven patients, aged 34–68 years, with unilateral arm lymphedema following breast cancer treatment underwent bilateral lymphoscintigraphy using intradermal injection in both hands of technetium-99m–labeled human serum albumin and sequential 5 min imaging for 5 hours. The mean transit time (MTT) in the arms was calculated based on time activity curves generated from injection site and arm regions. Visual lymphedema scoring was performed based on dermal backflow and lymph node presence. Excess arm volume was calculated from circumference measurements.</p></sec><sec><title>Results:</title><p>The MTT (mean ± SD) was significantly longer in the lymphedema arm than in the normal arm: 60.1 ± 27.7 versus 5.4 ± 2.5 minutes (mean difference, 54.7 minutes; 95% confidence interval, 36.5–72.9 minutes; <italic>P</italic> < 0.0001). Patients with previous erysipelas infection had significantly longer MTT than other patients (mean difference, 43.7 minutes; 95% confidence interval, 18.6–68.7 minutes; <italic>P</italic> < 0.001). There was a positive correlation between MTT and excess arm volume (r = 0.64; <italic>P</italic> = 0.04) and number of lymph nodes removed (r = 0.65; <italic>P</italic> = 0.03) but no correlation between visual score and MTT.</p></sec><sec><title>Conclusion:</title><p>Measurements of MTT were able to discriminate lymphedema from healthy arm and MTT correlated with relevant markers for lymphedema severity. We encourage further research using the MTT approach for monitoring lymphedema and evaluation of treatment response.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mcwayne, J" uniqKey="Mcwayne J">J McWayne</name></author><author><name sortKey="Heiney, Sp" uniqKey="Heiney S">SP Heiney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dupuy, A" uniqKey="Dupuy A">A Dupuy</name></author><author><name sortKey="Benchikhi, H" uniqKey="Benchikhi H">H Benchikhi</name></author><author><name sortKey="Roujeau, Jc" uniqKey="Roujeau J">JC Roujeau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Disipio, T" uniqKey="Disipio T">T DiSipio</name></author><author><name sortKey="Rye, S" uniqKey="Rye S">S Rye</name></author><author><name sortKey="Newman, B" uniqKey="Newman B">B Newman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Toyserkani, Nm" uniqKey="Toyserkani N">NM Toyserkani</name></author><author><name sortKey="J Rgensen, Mg" uniqKey="J Rgensen M">MG Jørgensen</name></author><author><name sortKey="Haugaard, K" uniqKey="Haugaard K">K Haugaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szuba, A" uniqKey="Szuba A">A Szuba</name></author><author><name sortKey="Strauss, W" uniqKey="Strauss W">W Strauss</name></author><author><name sortKey="Sirsikar, Sp" uniqKey="Sirsikar S">SP Sirsikar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoo, Jn" uniqKey="Yoo J">JN Yoo</name></author><author><name sortKey="Cheong, Ys" uniqKey="Cheong Y">YS Cheong</name></author><author><name sortKey="Min, Ys" uniqKey="Min Y">YS Min</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossi, M" uniqKey="Rossi M">M Rossi</name></author><author><name sortKey="Grassi, R" uniqKey="Grassi R">R Grassi</name></author><author><name sortKey="Costa, R" uniqKey="Costa R">R Costa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pain, Sj" uniqKey="Pain S">SJ Pain</name></author><author><name sortKey="Barber, Rw" uniqKey="Barber R">RW Barber</name></author><author><name sortKey="Ballinger, Jr" uniqKey="Ballinger J">JR Ballinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lane, Kn" uniqKey="Lane K">KN Lane</name></author><author><name sortKey="Dolan, Lb" uniqKey="Dolan L">LB Dolan</name></author><author><name sortKey="Worsley, D" uniqKey="Worsley D">D Worsley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozturk, Cn" uniqKey="Ozturk C">CN Ozturk</name></author><author><name sortKey="Ozturk, C" uniqKey="Ozturk C">C Ozturk</name></author><author><name sortKey="Glasgow, M" uniqKey="Glasgow M">M Glasgow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Penha, Tr" uniqKey="Penha T">TR Penha</name></author><author><name sortKey="Ijsbrandy, C" uniqKey="Ijsbrandy C">C Ijsbrandy</name></author><author><name sortKey="Hendrix, Na" uniqKey="Hendrix N">NA Hendrix</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brorson, H" uniqKey="Brorson H">H Brorson</name></author><author><name sortKey="Hoijer, P" uniqKey="Hoijer P">P Höijer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hvidsten, S" uniqKey="Hvidsten S">S Hvidsten</name></author><author><name sortKey="Toyserkani, Nm" uniqKey="Toyserkani N">NM Toyserkani</name></author><author><name sortKey="S Rensen, Ja" uniqKey="S Rensen J">JA Sørensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Modi, S" uniqKey="Modi S">S Modi</name></author><author><name sortKey="Stanton, Aw" uniqKey="Stanton A">AW Stanton</name></author><author><name sortKey="Mortimer, Ps" uniqKey="Mortimer P">PS Mortimer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramos, Sm" uniqKey="Ramos S">SM Ramos</name></author><author><name sortKey="O Onnell, Ls" uniqKey="O Onnell L">LS O’Donnell</name></author><author><name sortKey="Knight, G" uniqKey="Knight G">G Knight</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asdourian, Ms" uniqKey="Asdourian M">MS Asdourian</name></author><author><name sortKey="Skolny, Mn" uniqKey="Skolny M">MN Skolny</name></author><author><name sortKey="Brunelle, C" uniqKey="Brunelle C">C Brunelle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pain, Sj" uniqKey="Pain S">SJ Pain</name></author><author><name sortKey="Purushotham, Ad" uniqKey="Purushotham A">AD Purushotham</name></author><author><name sortKey="Barber, Rw" uniqKey="Barber R">RW Barber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Ahony, S" uniqKey="O Ahony S">S O’Mahony</name></author><author><name sortKey="Solanki, Ck" uniqKey="Solanki C">CK Solanki</name></author><author><name sortKey="Barber, Rw" uniqKey="Barber R">RW Barber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Ahony, S" uniqKey="O Ahony S">S O’Mahony</name></author><author><name sortKey="Rose, Sl" uniqKey="Rose S">SL Rose</name></author><author><name sortKey="Chilvers, Aj" uniqKey="Chilvers A">AJ Chilvers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mortimer, Ps" uniqKey="Mortimer P">PS Mortimer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devoogdt, N" uniqKey="Devoogdt N">N Devoogdt</name></author><author><name sortKey="Van Den Wyngaert, T" uniqKey="Van Den Wyngaert T">T Van den Wyngaert</name></author><author><name sortKey="Bourgeois, P" uniqKey="Bourgeois P">P Bourgeois</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="H Ilund Carlsen, Poul F" sort="H Ilund Carlsen, Poul F" uniqKey="H Ilund Carlsen P" first="Poul F." last="H Ilund-Carlsen">Poul F. H Ilund-Carlsen</name><name sortKey="Hvidsten, Svend" sort="Hvidsten, Svend" uniqKey="Hvidsten S" first="Svend" last="Hvidsten">Svend Hvidsten</name><name sortKey="S Rensen, Jens A" sort="S Rensen, Jens A" uniqKey="S Rensen J" first="Jens A." last="S Rensen">Jens A. S Rensen</name><name sortKey="Simonsen, Jane A" sort="Simonsen, Jane A" uniqKey="Simonsen J" first="Jane A." last="Simonsen">Jane A. Simonsen</name><name sortKey="Tabatabaeifar, Siavosh" sort="Tabatabaeifar, Siavosh" uniqKey="Tabatabaeifar S" first="Siavosh" last="Tabatabaeifar">Siavosh Tabatabaeifar</name><name sortKey="Toyserkani, Navid M" sort="Toyserkani, Navid M" uniqKey="Toyserkani N" first="Navid M." last="Toyserkani">Navid M. Toyserkani</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000131 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000131 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5505837
|texte= Tc-99m-Human Serum Albumin Transit Time as a Measure of Arm Breast Cancer-Related Lymphedema
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28740776" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |