Characterization of immunosuppressive proteins of Brugia malayi microfilariae.
Identifieur interne : 00E669 ( Main/Curation ); précédent : 00E668; suivant : 00E670Characterization of immunosuppressive proteins of Brugia malayi microfilariae.
Auteurs : A A Wadee [États-Unis] ; A C Vickery ; W F PiessensSource :
- Acta tropica [ 0001-706X ] ; 1987.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Animaux, Brugia (immunologie), Concanavaline A, Filariose lymphatique (immunologie), Filarioses (immunologie), Gerbillinae, Humains, Interleukine-2 (biosynthèse), Microfilaria (immunologie), Protéines (immunologie), Protéines (isolement et purification), Souris, Souris de lignée C3H, Tolérance immunitaire, Électrophorèse sur gel de polyacrylamide.
- MESH :
- biosynthèse : Interleukine-2.
- immunologie : Brugia, Filariose lymphatique, Filarioses, Microfilaria, Protéines.
- isolement et purification : Protéines.
- Activation des lymphocytes, Animaux, Concanavaline A, Gerbillinae, Humains, Souris, Souris de lignée C3H, Tolérance immunitaire, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Animals, Brugia (immunology), Concanavalin A, Electrophoresis, Polyacrylamide Gel, Elephantiasis, Filarial (immunology), Filariasis (immunology), Gerbillinae, Humans, Immune Tolerance, Interleukin-2 (biosynthesis), Lymphocyte Activation, Mice, Mice, Inbred C3H, Microfilariae (immunology), Proteins (immunology), Proteins (isolation & purification).
- MESH :
- chemical , biosynthesis : Interleukin-2.
- chemical , immunology : Proteins.
- chemical , isolation & purification : Proteins.
- chemical : Concanavalin A.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Microfilariae.
- Animals, Electrophoresis, Polyacrylamide Gel, Gerbillinae, Humans, Immune Tolerance, Lymphocyte Activation, Mice, Mice, Inbred C3H.
Abstract
Inhibition of Concanavalin A-induced lymphocyte proliferation was used to monitor the partial purification and characterization of suppressor molecules from microfilariae of Brugia malayi. Suppressor activity was present in high molecular weight fractions of microfilarial extracts (Mr greater than 50 kd on SDS-PAGE) and was protease-sensitive but resisted treatment with sodium periodate, indicating that it is associated with parasite proteins. Suppressor activity was released by microfilariae cultured in vitro and could be detected in peritoneal exudates of intraperitoneally-infected jirds and in lymph and sera from athymic C3H/HeN mice with patent B. malayi infections. These findings indicate that immune unresponsiveness during patent filarial infections may result from the in vivo release by microfilariae of high molecular weight proteins that suppress host immune responses.
PubMed: 2892371
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pubmed:2892371Le document en format XML
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<term>Brugia (immunology)</term>
<term>Concanavalin A</term>
<term>Electrophoresis, Polyacrylamide Gel</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Filariasis (immunology)</term>
<term>Gerbillinae</term>
<term>Humans</term>
<term>Immune Tolerance</term>
<term>Interleukin-2 (biosynthesis)</term>
<term>Lymphocyte Activation</term>
<term>Mice</term>
<term>Mice, Inbred C3H</term>
<term>Microfilariae (immunology)</term>
<term>Proteins (immunology)</term>
<term>Proteins (isolation & purification)</term>
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<term>Animaux</term>
<term>Brugia (immunologie)</term>
<term>Concanavaline A</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filarioses (immunologie)</term>
<term>Gerbillinae</term>
<term>Humains</term>
<term>Interleukine-2 (biosynthèse)</term>
<term>Microfilaria (immunologie)</term>
<term>Protéines (immunologie)</term>
<term>Protéines (isolement et purification)</term>
<term>Souris</term>
<term>Souris de lignée C3H</term>
<term>Tolérance immunitaire</term>
<term>Électrophorèse sur gel de polyacrylamide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interleukin-2</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Proteins</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Concanavalin A</term>
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<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interleukine-2</term>
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<term>Filariose lymphatique</term>
<term>Filarioses</term>
<term>Microfilaria</term>
<term>Protéines</term>
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<term>Elephantiasis, Filarial</term>
<term>Filariasis</term>
<term>Microfilariae</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Protéines</term>
</keywords>
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<term>Electrophoresis, Polyacrylamide Gel</term>
<term>Gerbillinae</term>
<term>Humans</term>
<term>Immune Tolerance</term>
<term>Lymphocyte Activation</term>
<term>Mice</term>
<term>Mice, Inbred C3H</term>
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<term>Animaux</term>
<term>Concanavaline A</term>
<term>Gerbillinae</term>
<term>Humains</term>
<term>Souris</term>
<term>Souris de lignée C3H</term>
<term>Tolérance immunitaire</term>
<term>Électrophorèse sur gel de polyacrylamide</term>
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<front><div type="abstract" xml:lang="en">Inhibition of Concanavalin A-induced lymphocyte proliferation was used to monitor the partial purification and characterization of suppressor molecules from microfilariae of Brugia malayi. Suppressor activity was present in high molecular weight fractions of microfilarial extracts (Mr greater than 50 kd on SDS-PAGE) and was protease-sensitive but resisted treatment with sodium periodate, indicating that it is associated with parasite proteins. Suppressor activity was released by microfilariae cultured in vitro and could be detected in peritoneal exudates of intraperitoneally-infected jirds and in lymph and sera from athymic C3H/HeN mice with patent B. malayi infections. These findings indicate that immune unresponsiveness during patent filarial infections may result from the in vivo release by microfilariae of high molecular weight proteins that suppress host immune responses.</div>
</front>
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