The effects of 5,6-benzo-[a]-pyrone (coumarin) and DEC on filaritic lymphoedema and elephantiasis in India: preliminary results
Identifieur interne : 00E132 ( Main/Curation ); précédent : 00E131; suivant : 00E133The effects of 5,6-benzo-[a]-pyrone (coumarin) and DEC on filaritic lymphoedema and elephantiasis in India: preliminary results
Auteurs : S. Jamal ; J. R. Casley-Smith ; J. R. Casley-SmithSource :
- Annals of tropical Medicine and Parasitology [ 0003-4983 ] ; 1989.
Descripteurs français
- KwdFr :
- Analyse de régression, Analyse de variance, Coumarines (usage thérapeutique), Diéthylcarbamazine (usage thérapeutique), Essais contrôlés randomisés comme sujet, Filariose lymphatique (traitement médicamenteux), Filarioses (traitement médicamenteux), Humains, Inde, Lymphoedème (traitement médicamenteux), Méthode en double aveugle.
- MESH :
- traitement médicamenteux : Filariose lymphatique, Filarioses, Lymphoedème.
- usage thérapeutique : Coumarines, Diéthylcarbamazine.
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Analysis of Variance, Chemotherapy, Coumarin, Coumarins (therapeutic use), Diethylcarbamazine (therapeutic use), Double-Blind Method, Elephantiasis, Elephantiasis, Filarial (drug therapy), Filariasis (drug therapy), Filariosis, Human, Humans, India, Lymphatic system, Lymphedema, Lymphedema (drug therapy), Randomized Controlled Trials as Topic, Regression Analysis, Treatment.
- MESH :
- chemical , therapeutic use : Coumarins, Diethylcarbamazine.
- geographic : India.
- drug therapy : Elephantiasis, Filarial, Filariasis, Lymphedema.
- Analysis of Variance, Double-Blind Method, Humans, Randomized Controlled Trials as Topic, Regression Analysis.
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Jamal</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name></author></analytic><series><title level="j" type="main">Annals of tropical Medicine and Parasitology</title><title level="j" type="abbreviated">Ann. Trop. Med. Parasitol.</title><idno type="ISSN">0003-4983</idno><imprint><date when="1989">1989</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Annals of tropical Medicine and Parasitology</title><title level="j" type="abbreviated">Ann. Trop. Med. 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Jamal</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. 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Jamal</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J. R." last="Casley-Smith">J. R. Casley-Smith</name></author></analytic><series><title level="j" type="main">Annals of tropical Medicine and Parasitology</title><title level="j" type="abbreviated">Ann. Trop. Med. Parasitol.</title><idno type="ISSN">0003-4983</idno><imprint><date when="1989">1989</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Annals of tropical Medicine and Parasitology</title><title level="j" type="abbreviated">Ann. Trop. Med. Parasitol.</title><idno type="ISSN">0003-4983</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chemotherapy</term><term>Coumarin</term><term>Elephantiasis</term><term>Filariosis</term><term>Human</term><term>India</term><term>Lymphatic system</term><term>Lymphedema</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Eléphantiasis</term><term>Lymphoedème</term><term>Filariose</term><term>Système lymphatique</term><term>Chimiothérapie</term><term>Coumarine</term><term>Diéthylcarbamazine</term><term>Traitement</term><term>Inde</term><term>Homme</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader></TEI></INIST><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effects of 5,6 benzo-[a]-pyrone (coumarin) and DEC on filaritic lymphoedema and elephantiasis in India. Preliminary results.</title><author><name sortKey="Jamal, S" sort="Jamal, S" uniqKey="Jamal S" first="S" last="Jamal">S. Jamal</name><affiliation wicri:level="1"><nlm:affiliation>Department Plastic Surgery, Madras Medical College, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department Plastic Surgery, Madras Medical College</wicri:regionArea><wicri:noRegion>Madras Medical College</wicri:noRegion></affiliation></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2690762</idno><idno type="pmid">2690762</idno><idno type="wicri:Area/PubMed/Corpus">005F85</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005F85</idno><idno type="wicri:Area/PubMed/Curation">005F85</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005F85</idno><idno type="wicri:Area/PubMed/Checkpoint">005F85</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005F85</idno><idno type="wicri:Area/Ncbi/Merge">007F23</idno><idno type="wicri:Area/Ncbi/Curation">007F23</idno><idno type="wicri:Area/Ncbi/Checkpoint">007F23</idno><idno type="wicri:doubleKey">0003-4983:1989:Jamal S:the:effects:of</idno><idno type="wicri:Area/Main/Merge">00EA27</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effects of 5,6 benzo-[a]-pyrone (coumarin) and DEC on filaritic lymphoedema and elephantiasis in India. Preliminary results.</title><author><name sortKey="Jamal, S" sort="Jamal, S" uniqKey="Jamal S" first="S" last="Jamal">S. Jamal</name><affiliation wicri:level="1"><nlm:affiliation>Department Plastic Surgery, Madras Medical College, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department Plastic Surgery, Madras Medical College</wicri:regionArea><wicri:noRegion>Madras Medical College</wicri:noRegion></affiliation></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></author></analytic><series><title level="j">Annals of tropical medicine and parasitology</title><idno type="ISSN">0003-4983</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Coumarins (therapeutic use)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Double-Blind Method</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Filariasis (drug therapy)</term><term>Humans</term><term>India</term><term>Lymphedema (drug therapy)</term><term>Randomized Controlled Trials as Topic</term><term>Regression Analysis</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de régression</term><term>Analyse de variance</term><term>Coumarines (usage thérapeutique)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Essais contrôlés randomisés comme sujet</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filarioses (traitement médicamenteux)</term><term>Humains</term><term>Inde</term><term>Lymphoedème (traitement médicamenteux)</term><term>Méthode en double aveugle</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Coumarins</term><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>India</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Coumarines</term><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Double-Blind Method</term><term>Humans</term><term>Randomized Controlled Trials as Topic</term><term>Regression Analysis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de régression</term><term>Analyse de variance</term><term>Essais contrôlés randomisés comme sujet</term><term>Humains</term><term>Inde</term><term>Méthode en double aveugle</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A randomized double-blind, placebo-controlled, trial of 5,6 benzo-[alpha]-pyrone (coumarin, '56 BaP') and of diethylcarbamazine (DEC) is being performed on patients with filaritic lymphoedema and elephantiasis over two years, using matched groups. In 169 patients there were significant (1% level) reductions in the amounts of oedema for the patients taking 56 BaP. The excess limb volumes were reduced from 40 to 25% over two years. A similar, but less significant (5% level), improvement was found for the circumference measurements. The rate of reduction was increased when the initial amount of oedema was greater. This therapy, while much slower than many other methods of treatment, does convert a slowly worsening condition into a slowly improving one. There were no significant reductions in the amount of oedema following DEC treatment.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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