Tropical pulmonary eosinophilia: analysis of antifilarial antibody localized to the lung.
Identifieur interne : 00DE00 ( Main/Curation ); précédent : 00DD99; suivant : 00DE01Tropical pulmonary eosinophilia: analysis of antifilarial antibody localized to the lung.
Auteurs : T B Nutman [États-Unis] ; V K Vijayan ; P. Pinkston ; V. Kumaraswami ; C. Steel ; R G Crystal ; E A OttesenSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 1989.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Animaux, Anticorps antihelminthe (analyse), Asthme (immunologie), Brugia (immunologie), Femelle, Filarioidea (immunologie), Filariose lymphatique (immunologie), Humains, Immunoglobulines (analyse), Immunotransfert, Liquide de lavage bronchoalvéolaire (immunologie), Maladie aigüe, Mâle, Poumon (immunologie), Poumon éosinophile (immunologie), Spécificité des anticorps, Wuchereria bancrofti (immunologie).
- MESH :
- analyse : Anticorps antihelminthe, Immunoglobulines.
- immunologie : Asthme, Brugia, Filarioidea, Filariose lymphatique, Liquide de lavage bronchoalvéolaire, Poumon, Poumon éosinophile, Wuchereria bancrofti.
- Adolescent, Adulte, Animaux, Femelle, Humains, Immunotransfert, Maladie aigüe, Mâle, Spécificité des anticorps.
English descriptors
- KwdEn :
- Acute Disease, Adolescent, Adult, Animals, Antibodies, Helminth (analysis), Antibody Specificity, Asthma (immunology), Bronchoalveolar Lavage Fluid (immunology), Brugia (immunology), Elephantiasis, Filarial (immunology), Female, Filarioidea (immunology), Humans, Immunoblotting, Immunoglobulins (analysis), Lung (immunology), Male, Pulmonary Eosinophilia (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , analysis : Antibodies, Helminth, Immunoglobulins.
- immunology : Asthma, Bronchoalveolar Lavage Fluid, Brugia, Elephantiasis, Filarial, Filarioidea, Lung, Pulmonary Eosinophilia, Wuchereria bancrofti.
- Acute Disease, Adolescent, Adult, Animals, Antibody Specificity, Female, Humans, Immunoblotting, Male.
Abstract
Acute tropical pulmonary eosinophilia (TPE) is characterized by wheezing, pulmonary infiltrates, marked peripheral blood eosinophilia, and very high serum levels of filaria-specific antibodies. To evaluate the amount and character of the filaria-specific antibodies in the lungs in this disorder, bronchoalveolar lavage was carried out in individuals with acute TPE, in normal subjects, and in patients with elephantiasis or asthma. Striking elevations of total IgE were found in the lower respiratory tract epithelial lining fluid (ELF) of patients with TPE along with high levels of filarial-specific IgG, IgM, and IgE. When patients with acute TPE were treated with diethylcarbamazine and evaluated again 6-14 d later, there was marked reduction in ELF parasite-specific IgG and IgE, which paralleled a rapid clinical response. Immunoblot comparison of the antigen recognition patterns of ELF and serum antibodies demonstrated a general similarity in parasite antigens recognized, but the lung IgE and IgG antibodies appeared to recognize only a certain subset of the parasite antigens recognized by serum antibodies. Thus, a profound antibody response to filarial infection is found in the lungs of patients with TPE, suggesting that these filaria-specific antibodies play an important role in the pathogenesis of this disorder.
PubMed: 2685125
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :005F00
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :005F00
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :005F00
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :007E56
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :007E56
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :007E56
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :00EA17
Links to Exploration step
pubmed:2685125Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tropical pulmonary eosinophilia: analysis of antifilarial antibody localized to the lung.</title><author><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Vijayan, V K" sort="Vijayan, V K" uniqKey="Vijayan V" first="V K" last="Vijayan">V K Vijayan</name></author><author><name sortKey="Pinkston, P" sort="Pinkston, P" uniqKey="Pinkston P" first="P" last="Pinkston">P. Pinkston</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Steel, C" sort="Steel, C" uniqKey="Steel C" first="C" last="Steel">C. Steel</name></author><author><name sortKey="Crystal, R G" sort="Crystal, R G" uniqKey="Crystal R" first="R G" last="Crystal">R G Crystal</name></author><author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2685125</idno><idno type="pmid">2685125</idno><idno type="wicri:Area/PubMed/Corpus">005F00</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005F00</idno><idno type="wicri:Area/PubMed/Curation">005F00</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005F00</idno><idno type="wicri:Area/PubMed/Checkpoint">005F00</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005F00</idno><idno type="wicri:Area/Ncbi/Merge">007E56</idno><idno type="wicri:Area/Ncbi/Curation">007E56</idno><idno type="wicri:Area/Ncbi/Checkpoint">007E56</idno><idno type="wicri:doubleKey">0022-1899:1989:Nutman T:tropical:pulmonary:eosinophilia</idno><idno type="wicri:Area/Main/Merge">00EA17</idno><idno type="wicri:Area/Main/Curation">00DE00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Tropical pulmonary eosinophilia: analysis of antifilarial antibody localized to the lung.</title><author><name sortKey="Nutman, T B" sort="Nutman, T B" uniqKey="Nutman T" first="T B" last="Nutman">T B Nutman</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Vijayan, V K" sort="Vijayan, V K" uniqKey="Vijayan V" first="V K" last="Vijayan">V K Vijayan</name></author><author><name sortKey="Pinkston, P" sort="Pinkston, P" uniqKey="Pinkston P" first="P" last="Pinkston">P. Pinkston</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V" last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Steel, C" sort="Steel, C" uniqKey="Steel C" first="C" last="Steel">C. Steel</name></author><author><name sortKey="Crystal, R G" sort="Crystal, R G" uniqKey="Crystal R" first="R G" last="Crystal">R G Crystal</name></author><author><name sortKey="Ottesen, E A" sort="Ottesen, E A" uniqKey="Ottesen E" first="E A" last="Ottesen">E A Ottesen</name></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="ISSN">0022-1899</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Disease</term><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antibodies, Helminth (analysis)</term><term>Antibody Specificity</term><term>Asthma (immunology)</term><term>Bronchoalveolar Lavage Fluid (immunology)</term><term>Brugia (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Female</term><term>Filarioidea (immunology)</term><term>Humans</term><term>Immunoblotting</term><term>Immunoglobulins (analysis)</term><term>Lung (immunology)</term><term>Male</term><term>Pulmonary Eosinophilia (immunology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Anticorps antihelminthe (analyse)</term><term>Asthme (immunologie)</term><term>Brugia (immunologie)</term><term>Femelle</term><term>Filarioidea (immunologie)</term><term>Filariose lymphatique (immunologie)</term><term>Humains</term><term>Immunoglobulines (analyse)</term><term>Immunotransfert</term><term>Liquide de lavage bronchoalvéolaire (immunologie)</term><term>Maladie aigüe</term><term>Mâle</term><term>Poumon (immunologie)</term><term>Poumon éosinophile (immunologie)</term><term>Spécificité des anticorps</term><term>Wuchereria bancrofti (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobulines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Asthme</term><term>Brugia</term><term>Filarioidea</term><term>Filariose lymphatique</term><term>Liquide de lavage bronchoalvéolaire</term><term>Poumon</term><term>Poumon éosinophile</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Asthma</term><term>Bronchoalveolar Lavage Fluid</term><term>Brugia</term><term>Elephantiasis, Filarial</term><term>Filarioidea</term><term>Lung</term><term>Pulmonary Eosinophilia</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acute Disease</term><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Antibody Specificity</term><term>Female</term><term>Humans</term><term>Immunoblotting</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Immunotransfert</term><term>Maladie aigüe</term><term>Mâle</term><term>Spécificité des anticorps</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acute tropical pulmonary eosinophilia (TPE) is characterized by wheezing, pulmonary infiltrates, marked peripheral blood eosinophilia, and very high serum levels of filaria-specific antibodies. To evaluate the amount and character of the filaria-specific antibodies in the lungs in this disorder, bronchoalveolar lavage was carried out in individuals with acute TPE, in normal subjects, and in patients with elephantiasis or asthma. Striking elevations of total IgE were found in the lower respiratory tract epithelial lining fluid (ELF) of patients with TPE along with high levels of filarial-specific IgG, IgM, and IgE. When patients with acute TPE were treated with diethylcarbamazine and evaluated again 6-14 d later, there was marked reduction in ELF parasite-specific IgG and IgE, which paralleled a rapid clinical response. Immunoblot comparison of the antigen recognition patterns of ELF and serum antibodies demonstrated a general similarity in parasite antigens recognized, but the lung IgE and IgG antibodies appeared to recognize only a certain subset of the parasite antigens recognized by serum antibodies. Thus, a profound antibody response to filarial infection is found in the lungs of patients with TPE, suggesting that these filaria-specific antibodies play an important role in the pathogenesis of this disorder.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00DE00 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 00DE00 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Curation
|type= RBID
|clé= pubmed:2685125
|texte= Tropical pulmonary eosinophilia: analysis of antifilarial antibody localized to the lung.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:2685125" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |