Injection of microfilariae induces resistance to Brugia malayi infection in ferrets and accelerates development of lymphostatic disease.
Identifieur interne : 00DA12 ( Main/Curation ); précédent : 00DA11; suivant : 00DA13Injection of microfilariae induces resistance to Brugia malayi infection in ferrets and accelerates development of lymphostatic disease.
Auteurs : R B Crandall ; C A Crandall ; J K NayarSource :
- Parasite immunology [ 0141-9838 ] ; 1990.
Descripteurs français
- KwdFr :
- Animaux, Brugia (immunologie), Brugia (isolement et purification), Femelle, Filariose lymphatique (anatomopathologie), Filariose lymphatique (immunologie), Filarioses (immunologie), Furets, Immunité active, Lymphoedème, Microfilaria (immunologie), Mâle, Système lymphatique (anatomopathologie), Système lymphatique (parasitologie).
- MESH :
- anatomopathologie : Filariose lymphatique, Système lymphatique.
- immunologie : Brugia, Filariose lymphatique, Filarioses, Microfilaria.
- isolement et purification : Brugia.
- parasitologie : Système lymphatique.
- Animaux, Femelle, Furets, Immunité active, Lymphoedème, Mâle.
English descriptors
- KwdEn :
- Animals, Brugia (immunology), Brugia (isolation & purification), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (pathology), Female, Ferrets, Filariasis (immunology), Immunity, Active, Lymphatic System (parasitology), Lymphatic System (pathology), Lymphedema, Male, Microfilariae (immunology).
- MESH :
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Microfilariae.
- isolation & purification : Brugia.
- parasitology : Lymphatic System.
- pathology : Elephantiasis, Filarial, Lymphatic System.
- Animals, Female, Ferrets, Immunity, Active, Lymphedema, Male.
Abstract
Ferrets injected intravenously with living microfilariae or cutaneously with microfilariae followed by intravenous injection developed partial resistance to a challenge infection as measured by recovery of adult filariae from lymphatics. Following a challenge infection, the ferrets injected with microfilariae developed lymphatic pathology characteristic of a chronic infection or that observed following multiple infections. There was disruption of lymphatic drainage of the infected limb and lymphoedema. The results suggest that immune responses to antigens of microfilariae, presumably antigens shared with other developmental stages, effected both increased resistance and enhanced lymphatic pathology.
PubMed: 2320382
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R B Crandall<affiliation><nlm:affiliation>University of Florida College of Medicine, Gainesville 32610.</nlm:affiliation>
<wicri:noCountry code="subField">Gainesville 32610</wicri:noCountry>
</affiliation>
Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Injection of microfilariae induces resistance to Brugia malayi infection in ferrets and accelerates development of lymphostatic disease.</title>
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<series><title level="j">Parasite immunology</title>
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<term>Brugia (immunology)</term>
<term>Brugia (isolation & purification)</term>
<term>Elephantiasis, Filarial (immunology)</term>
<term>Elephantiasis, Filarial (pathology)</term>
<term>Female</term>
<term>Ferrets</term>
<term>Filariasis (immunology)</term>
<term>Immunity, Active</term>
<term>Lymphatic System (parasitology)</term>
<term>Lymphatic System (pathology)</term>
<term>Lymphedema</term>
<term>Male</term>
<term>Microfilariae (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Brugia (immunologie)</term>
<term>Brugia (isolement et purification)</term>
<term>Femelle</term>
<term>Filariose lymphatique (anatomopathologie)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filarioses (immunologie)</term>
<term>Furets</term>
<term>Immunité active</term>
<term>Lymphoedème</term>
<term>Microfilaria (immunologie)</term>
<term>Mâle</term>
<term>Système lymphatique (anatomopathologie)</term>
<term>Système lymphatique (parasitologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Système lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia</term>
<term>Filariose lymphatique</term>
<term>Filarioses</term>
<term>Microfilaria</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia</term>
<term>Elephantiasis, Filarial</term>
<term>Filariasis</term>
<term>Microfilariae</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Brugia</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Brugia</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Système lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Lymphatic System</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term>
<term>Lymphatic System</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Ferrets</term>
<term>Immunity, Active</term>
<term>Lymphedema</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Furets</term>
<term>Immunité active</term>
<term>Lymphoedème</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">Ferrets injected intravenously with living microfilariae or cutaneously with microfilariae followed by intravenous injection developed partial resistance to a challenge infection as measured by recovery of adult filariae from lymphatics. Following a challenge infection, the ferrets injected with microfilariae developed lymphatic pathology characteristic of a chronic infection or that observed following multiple infections. There was disruption of lymphatic drainage of the infected limb and lymphoedema. The results suggest that immune responses to antigens of microfilariae, presumably antigens shared with other developmental stages, effected both increased resistance and enhanced lymphatic pathology.</div>
</front>
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