Comparison of high dose ivermectin and diethylcarbamazine for activity against bancroftian filariasis in Haiti.
Identifieur interne : 00D574 ( Main/Curation ); précédent : 00D573; suivant : 00D575Comparison of high dose ivermectin and diethylcarbamazine for activity against bancroftian filariasis in Haiti.
Auteurs : F O Richards [États-Unis] ; M L Eberhard ; R T Bryan ; D F Mcneeley ; P J Lammie ; M B Mcneeley ; Y. Bernard ; A W Hightower ; H C SpencerSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1991.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Diéthylcarbamazine (usage thérapeutique), Femelle, Filariose lymphatique (sang), Filariose lymphatique (traitement médicamenteux), Haïti, Humains, Ivermectine (usage thérapeutique), Microfilaria (), Microfilaria (croissance et développement), Mâle, Méthode en double aveugle, Tolérance aux médicaments, Wuchereria bancrofti (), Wuchereria bancrofti (croissance et développement), Études de suivi.
- MESH :
- croissance et développement : Microfilaria, Wuchereria bancrofti.
- sang : Filariose lymphatique.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Diéthylcarbamazine, Ivermectine.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Femelle, Haïti, Humains, Microfilaria, Mâle, Méthode en double aveugle, Tolérance aux médicaments, Wuchereria bancrofti, Études de suivi.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Diethylcarbamazine (therapeutic use), Double-Blind Method, Drug Tolerance, Elephantiasis, Filarial (blood), Elephantiasis, Filarial (drug therapy), Female, Follow-Up Studies, Haiti, Humans, Ivermectin (therapeutic use), Male, Microfilariae (drug effects), Microfilariae (growth & development), Middle Aged, Wuchereria bancrofti (drug effects), Wuchereria bancrofti (growth & development).
- MESH :
- chemical , therapeutic use : Diethylcarbamazine, Ivermectin.
- blood : Elephantiasis, Filarial.
- drug effects : Microfilariae, Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial.
- growth & development : Microfilariae, Wuchereria bancrofti.
- Adolescent, Adult, Animals, Double-Blind Method, Drug Tolerance, Female, Follow-Up Studies, Haiti, Humans, Male, Middle Aged.
Abstract
This three-phase study was designed to compare high dose ivermectin with a standard diethylcarbamazine (DEC) regimen for patient tolerability, potential to kill adult filaria, and duration of microfilarial suppression in 30 Haitian subjects with Wuchereria bancrofti microfilaremia. All were first given a 1-mg oral dose of ivermectin (phase 1) to reduce microfilaria densities. Participants were randomized into three groups: Group 1 received DEC (6mg/kg per day for 12 days), Group 2 received 200 mcg/kg of ivermectin, and Group 3 received 400 mcg/kg of ivermectin (200 mcg/kg per day for 2 days). All drug regimens were well tolerated with few adverse reactions. Most reactions occurred during phase I and consisted primarily of headache, fever, and myalgia. At the end of phase 1, 27 of 30 (90%) patients were microfilaria negative. During phase 2, four of the six men receiving DEC developed scrotal reactions suggesting killing adult worms; no such reactions were noted in 10 men receiving ivermectin (p less than 0.05). At one-year follow up (phase 3), all treatment groups had less than 10% return to pretreatment microfilaria levels. The mean percent of baseline microfilaria counts were for Group 1, 0.9% (range 0-5%); Group 2, 8.2% (range 0-31%); and Group 3, 3.8% (range 0-25%). Seven individuals in Group 1 were microfilaria-negative, while only one and three individuals were microfilaria-negative in Groups 2 and 3, respectively. These results suggest that DEC causes more damage to the adult worms and greater reduction in microfilaria densities than ivermectin, but that high doses of ivermectin may suppress microfilaremia in lymphatic filariasis for periods much longer than previously reported.
PubMed: 1996738
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :005C07
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :005C07
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :005C07
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003786
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :003786
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003786
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :00E116
Links to Exploration step
pubmed:1996738Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of high dose ivermectin and diethylcarbamazine for activity against bancroftian filariasis in Haiti.</title><author><name sortKey="Richards, F O" sort="Richards, F O" uniqKey="Richards F" first="F O" last="Richards">F O Richards</name><affiliation wicri:level="2"><nlm:affiliation>Division of Parasitic Diseases, Centers for Disease Control, US Department of Health and Human Services, Atlanta, GA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Division of Parasitic Diseases, Centers for Disease Control, US Department of Health and Human Services, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name></author><author><name sortKey="Bryan, R T" sort="Bryan, R T" uniqKey="Bryan R" first="R T" last="Bryan">R T Bryan</name></author><author><name sortKey="Mcneeley, D F" sort="Mcneeley, D F" uniqKey="Mcneeley D" first="D F" last="Mcneeley">D F Mcneeley</name></author><author><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name></author><author><name sortKey="Mcneeley, M B" sort="Mcneeley, M B" uniqKey="Mcneeley M" first="M B" last="Mcneeley">M B Mcneeley</name></author><author><name sortKey="Bernard, Y" sort="Bernard, Y" uniqKey="Bernard Y" first="Y" last="Bernard">Y. Bernard</name></author><author><name sortKey="Hightower, A W" sort="Hightower, A W" uniqKey="Hightower A" first="A W" last="Hightower">A W Hightower</name></author><author><name sortKey="Spencer, H C" sort="Spencer, H C" uniqKey="Spencer H" first="H C" last="Spencer">H C Spencer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1996738</idno><idno type="pmid">1996738</idno><idno type="wicri:Area/PubMed/Corpus">005C07</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005C07</idno><idno type="wicri:Area/PubMed/Curation">005C07</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005C07</idno><idno type="wicri:Area/PubMed/Checkpoint">005C07</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005C07</idno><idno type="wicri:Area/Ncbi/Merge">003786</idno><idno type="wicri:Area/Ncbi/Curation">003786</idno><idno type="wicri:Area/Ncbi/Checkpoint">003786</idno><idno type="wicri:doubleKey">0002-9637:1991:Richards F:comparison:of:high</idno><idno type="wicri:Area/Main/Merge">00E116</idno><idno type="wicri:Area/Main/Curation">00D574</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparison of high dose ivermectin and diethylcarbamazine for activity against bancroftian filariasis in Haiti.</title><author><name sortKey="Richards, F O" sort="Richards, F O" uniqKey="Richards F" first="F O" last="Richards">F O Richards</name><affiliation wicri:level="2"><nlm:affiliation>Division of Parasitic Diseases, Centers for Disease Control, US Department of Health and Human Services, Atlanta, GA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Division of Parasitic Diseases, Centers for Disease Control, US Department of Health and Human Services, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Eberhard, M L" sort="Eberhard, M L" uniqKey="Eberhard M" first="M L" last="Eberhard">M L Eberhard</name></author><author><name sortKey="Bryan, R T" sort="Bryan, R T" uniqKey="Bryan R" first="R T" last="Bryan">R T Bryan</name></author><author><name sortKey="Mcneeley, D F" sort="Mcneeley, D F" uniqKey="Mcneeley D" first="D F" last="Mcneeley">D F Mcneeley</name></author><author><name sortKey="Lammie, P J" sort="Lammie, P J" uniqKey="Lammie P" first="P J" last="Lammie">P J Lammie</name></author><author><name sortKey="Mcneeley, M B" sort="Mcneeley, M B" uniqKey="Mcneeley M" first="M B" last="Mcneeley">M B Mcneeley</name></author><author><name sortKey="Bernard, Y" sort="Bernard, Y" uniqKey="Bernard Y" first="Y" last="Bernard">Y. Bernard</name></author><author><name sortKey="Hightower, A W" sort="Hightower, A W" uniqKey="Hightower A" first="A W" last="Hightower">A W Hightower</name></author><author><name sortKey="Spencer, H C" sort="Spencer, H C" uniqKey="Spencer H" first="H C" last="Spencer">H C Spencer</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Diethylcarbamazine (therapeutic use)</term><term>Double-Blind Method</term><term>Drug Tolerance</term><term>Elephantiasis, Filarial (blood)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Female</term><term>Follow-Up Studies</term><term>Haiti</term><term>Humans</term><term>Ivermectin (therapeutic use)</term><term>Male</term><term>Microfilariae (drug effects)</term><term>Microfilariae (growth & development)</term><term>Middle Aged</term><term>Wuchereria bancrofti (drug effects)</term><term>Wuchereria bancrofti (growth & development)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Femelle</term><term>Filariose lymphatique (sang)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Haïti</term><term>Humains</term><term>Ivermectine (usage thérapeutique)</term><term>Microfilaria ()</term><term>Microfilaria (croissance et développement)</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Tolérance aux médicaments</term><term>Wuchereria bancrofti ()</term><term>Wuchereria bancrofti (croissance et développement)</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term><term>Ivermectin</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Microfilaria</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Microfilariae</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Ivermectine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Double-Blind Method</term><term>Drug Tolerance</term><term>Female</term><term>Follow-Up Studies</term><term>Haiti</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Haïti</term><term>Humains</term><term>Microfilaria</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Tolérance aux médicaments</term><term>Wuchereria bancrofti</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This three-phase study was designed to compare high dose ivermectin with a standard diethylcarbamazine (DEC) regimen for patient tolerability, potential to kill adult filaria, and duration of microfilarial suppression in 30 Haitian subjects with Wuchereria bancrofti microfilaremia. All were first given a 1-mg oral dose of ivermectin (phase 1) to reduce microfilaria densities. Participants were randomized into three groups: Group 1 received DEC (6mg/kg per day for 12 days), Group 2 received 200 mcg/kg of ivermectin, and Group 3 received 400 mcg/kg of ivermectin (200 mcg/kg per day for 2 days). All drug regimens were well tolerated with few adverse reactions. Most reactions occurred during phase I and consisted primarily of headache, fever, and myalgia. At the end of phase 1, 27 of 30 (90%) patients were microfilaria negative. During phase 2, four of the six men receiving DEC developed scrotal reactions suggesting killing adult worms; no such reactions were noted in 10 men receiving ivermectin (p less than 0.05). At one-year follow up (phase 3), all treatment groups had less than 10% return to pretreatment microfilaria levels. The mean percent of baseline microfilaria counts were for Group 1, 0.9% (range 0-5%); Group 2, 8.2% (range 0-31%); and Group 3, 3.8% (range 0-25%). Seven individuals in Group 1 were microfilaria-negative, while only one and three individuals were microfilaria-negative in Groups 2 and 3, respectively. These results suggest that DEC causes more damage to the adult worms and greater reduction in microfilaria densities than ivermectin, but that high doses of ivermectin may suppress microfilaremia in lymphatic filariasis for periods much longer than previously reported.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00D574 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 00D574 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Curation
|type= RBID
|clé= pubmed:1996738
|texte= Comparison of high dose ivermectin and diethylcarbamazine for activity against bancroftian filariasis in Haiti.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:1996738" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |