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Recent advances in the chemotherapy of lymphatic filariasis.

Identifieur interne : 00CC22 ( Main/Curation ); précédent : 00CC21; suivant : 00CC23

Recent advances in the chemotherapy of lymphatic filariasis.

Auteurs : V. Navaratnam

Source :

The Southeast Asian journal of tropical medicine and public health [ 0125-1562 ] ; 1993.

RBID : pubmed:7973948

Descripteurs français

KwdFr :
- Benzimidazoles (usage thérapeutique), Benzothiazoles, Diéthylcarbamazine (usage thérapeutique), Filaricides (effets indésirables), Filaricides (pharmacocinétique), Filaricides (pharmacologie), Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Humains, Ivermectine (usage thérapeutique), Thiazoles (usage thérapeutique), Tiabendazol (usage thérapeutique).
MESH :
- effets indésirables : Filaricides.
- pharmacocinétique : Filaricides.
- pharmacologie : Filaricides.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Benzimidazoles, Diéthylcarbamazine, Filaricides, Ivermectine, Thiazoles, Tiabendazol.
- Benzothiazoles, Humains.

English descriptors

KwdEn :
- Benzimidazoles (therapeutic use), Benzothiazoles, Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Filaricides (adverse effects), Filaricides (pharmacokinetics), Filaricides (pharmacology), Filaricides (therapeutic use), Humans, Ivermectin (therapeutic use), Thiabendazole (therapeutic use), Thiazoles (therapeutic use).
MESH :
- chemical , adverse effects : Filaricides.
- chemical , pharmacokinetics : Filaricides.
- chemical , pharmacology : Filaricides.
- chemical , therapeutic use : Benzimidazoles, Diethylcarbamazine, Filaricides, Ivermectin, Thiabendazole, Thiazoles.
- chemical : Benzothiazoles.
- drug therapy : Elephantiasis, Filarial.
- Humans.

Abstract

Lymphatic filariasis is the most widespread of human filarial infections, a group of vector-borne infestations. After the discovery of diethylcarbamazine (DEC), little advance was made in the development of new chemotherapeutic agents for the treatment of lymphatic filariasis until 1985. Since then, several new initiatives have occurred as the result of a global effort by the World Bank/UNDP/WHO Special Programme on Tropical Diseases and the Onchocerciasis Control Programme. Some of these global research initiatives are reviewed in this paper. Recent observations throw a new light on the rational use of DEC including its deployment as a medicated salt. Ivermectin, an established drug for the treatment of river-blindness is examined for its potential use in the treatment of lymphatic filariasis. Experimental results from two novel compounds out of several being developed by the WHO/OCP Macrofil project are considered in respect to their potential macrofilaricidal activity, particularly in relation to lymphatic filarial infections.

PubMed: 7973948

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V. Navaratnam

<affiliation><nlm:affiliation>Center for Drug Research, Universiti Sains Malaysia, Penang.</nlm:affiliation>
<wicri:noCountry code="subField">Penang</wicri:noCountry>
</affiliation>

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Recent advances in the chemotherapy of lymphatic filariasis.</title>
<author><name sortKey="Navaratnam, V" sort="Navaratnam, V" uniqKey="Navaratnam V" first="V" last="Navaratnam">V. Navaratnam</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Benzimidazoles (therapeutic use)</term>
<term>Benzothiazoles</term>
<term>Diethylcarbamazine (therapeutic use)</term>
<term>Elephantiasis, Filarial (drug therapy)</term>
<term>Filaricides (adverse effects)</term>
<term>Filaricides (pharmacokinetics)</term>
<term>Filaricides (pharmacology)</term>
<term>Filaricides (therapeutic use)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Benzimidazoles (usage thérapeutique)</term>
<term>Benzothiazoles</term>
<term>Diéthylcarbamazine (usage thérapeutique)</term>
<term>Filaricides (effets indésirables)</term>
<term>Filaricides (pharmacocinétique)</term>
<term>Filaricides (pharmacologie)</term>
<term>Filaricides (usage thérapeutique)</term>
<term>Filariose lymphatique (traitement médicamenteux)</term>
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<term>Ivermectine (usage thérapeutique)</term>
<term>Thiazoles (usage thérapeutique)</term>
<term>Tiabendazol (usage thérapeutique)</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Filaricides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Filaricides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Benzimidazoles</term>
<term>Diethylcarbamazine</term>
<term>Filaricides</term>
<term>Ivermectin</term>
<term>Thiabendazole</term>
<term>Thiazoles</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Benzothiazoles</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Filaricides</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Filaricides</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Filaricides</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Benzimidazoles</term>
<term>Diéthylcarbamazine</term>
<term>Filaricides</term>
<term>Ivermectine</term>
<term>Thiazoles</term>
<term>Tiabendazol</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Benzothiazoles</term>
<term>Humains</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Lymphatic filariasis is the most widespread of human filarial infections, a group of vector-borne infestations. After the discovery of diethylcarbamazine (DEC), little advance was made in the development of new chemotherapeutic agents for the treatment of lymphatic filariasis until 1985. Since then, several new initiatives have occurred as the result of a global effort by the World Bank/UNDP/WHO Special Programme on Tropical Diseases and the Onchocerciasis Control Programme. Some of these global research initiatives are reviewed in this paper. Recent observations throw a new light on the rational use of DEC including its deployment as a medicated salt. Ivermectin, an established drug for the treatment of river-blindness is examined for its potential use in the treatment of lymphatic filariasis. Experimental results from two novel compounds out of several being developed by the WHO/OCP Macrofil project are considered in respect to their potential macrofilaricidal activity, particularly in relation to lymphatic filarial infections.</div>
</front>
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Recent advances in the chemotherapy of lymphatic filariasis.

Recent advances in the chemotherapy of lymphatic filariasis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Curation

No country items

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki