What doctors and patients think about false-negative sentinel lymph nodes in vulvar cancer.
Identifieur interne : 009948 ( Main/Curation ); précédent : 009947; suivant : 009949What doctors and patients think about false-negative sentinel lymph nodes in vulvar cancer.
Auteurs : J A De Hullu [Pays-Bas] ; A C Ansink ; T. Tymstra ; A G Van Der ZeeSource :
- Journal of psychosomatic obstetrics and gynaecology [ 0167-482X ] ; 2001.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Attitude du personnel soignant, Biopsie de noeud lymphatique sentinelle (psychologie), Complications postopératoires (psychologie), Faux négatifs, Femelle, Humains, Lymphadénectomie (psychologie), Métastase lymphatique, Participation du patient (psychologie), Rôle de malade, Sujet âgé, Tumeurs de la vulve (), Tumeurs de la vulve (anatomopathologie), Tumeurs de la vulve (psychologie).
- MESH :
- anatomopathologie : Tumeurs de la vulve.
- psychologie : Biopsie de noeud lymphatique sentinelle, Complications postopératoires, Lymphadénectomie, Participation du patient, Tumeurs de la vulve.
- Adulte d'âge moyen, Attitude du personnel soignant, Faux négatifs, Femelle, Humains, Métastase lymphatique, Rôle de malade, Sujet âgé, Tumeurs de la vulve.
English descriptors
- KwdEn :
- Aged, Attitude of Health Personnel, False Negative Reactions, Female, Humans, Lymph Node Excision (psychology), Lymphatic Metastasis, Middle Aged, Patient Participation (psychology), Postoperative Complications (psychology), Sentinel Lymph Node Biopsy (psychology), Sick Role, Vulvar Neoplasms (pathology), Vulvar Neoplasms (psychology), Vulvar Neoplasms (surgery).
- MESH :
- pathology : Vulvar Neoplasms.
- psychology : Lymph Node Excision, Patient Participation, Postoperative Complications, Sentinel Lymph Node Biopsy, Vulvar Neoplasms.
- surgery : Vulvar Neoplasms.
- Aged, Attitude of Health Personnel, False Negative Reactions, Female, Humans, Lymphatic Metastasis, Middle Aged, Sick Role.
Abstract
The sentinel lymph node procedure is a relatively new, minimally-invasive method for the assessment of nodal status in malignancies such as breast cancer, cutaneous melanoma and vulvar cancer. Although highly accurate, this new method is inevitably associated with a certain false-negative rate, possibly leading to worse survival in a small subset of patients. The clinical implementation of the sentinel lymph node procedure is therefore a matter of ongoing debate, especially among doctors. The aim of this study was to assess opinions on the acceptable false-negative rate of the sentinel lymph node procedure in patients with vulvar cancer, who in the past had undergone standard routine radical vulvectomy and complete inguinofemoral lymphadenectomy (and frequently experienced complications), and in gynecologists treating patients with vulvar cancer. Structured questionnaires were sent to both patients and gynecologists. The patients had been treated for vulvar cancer between 1985 and 1993, and were all in complete remission with a median follow-up of 118 months (range: 76-185). Questions to the patients dealt with experienced side-effects of the standard treatment and opinion on the acceptable false-negative rate of the sentinel lymph node procedure. The response rate among patients was 91% (106/117). Forty per cent of the patients experienced one or more infections in the legs (cellulitis) and 49% of the patients still experience either severe pain and/or severe lymphedema in the legs. Sixty-six per cent of the patients preferred complete inguinofemoral lymphadenectomy in preference to a 5% false-negative rate of the sentinel lymph node procedure of 5%. Their preference was not related to age or the side-effects they had experienced. The response rate among gynecologists was 80% (80/100), of whom 60% were willing to accept a 5-20% false-negative rate of the sentinel lymph node procedure. While gynecologists may consider the sentinel lymph node procedure to be a promising diagnostic tool, the majority of vulvar cancer patients, who have undergone complete inguinofemoral lymphadenectomy in the past and have frequently experienced complications, would not advise introduction of this technique because they do not want to take any risk of missing a lymph node metastasis.
PubMed: 11840573
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004659
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :004659
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :004659
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000870
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000870
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000870
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :009D44
Links to Exploration step
pubmed:11840573Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">What doctors and patients think about false-negative sentinel lymph nodes in vulvar cancer.</title>
<author><name sortKey="De Hullu, J A" sort="De Hullu, J A" uniqKey="De Hullu J" first="J A" last="De Hullu">J A De Hullu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gynecologic Oncology, Groningen University Hospital, Groningen, Hanzeplein 1, PO Box 30001, 9700RB Groningen, The Netherlands. j.a.de.hull@og.azg.nl</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gynecologic Oncology, Groningen University Hospital, Groningen, Hanzeplein 1, PO Box 30001, 9700RB Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ansink, A C" sort="Ansink, A C" uniqKey="Ansink A" first="A C" last="Ansink">A C Ansink</name>
</author>
<author><name sortKey="Tymstra, T" sort="Tymstra, T" uniqKey="Tymstra T" first="T" last="Tymstra">T. Tymstra</name>
</author>
<author><name sortKey="Van Der Zee, A G" sort="Van Der Zee, A G" uniqKey="Van Der Zee A" first="A G" last="Van Der Zee">A G Van Der Zee</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2001">2001</date>
<idno type="RBID">pubmed:11840573</idno>
<idno type="pmid">11840573</idno>
<idno type="wicri:Area/PubMed/Corpus">004659</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">004659</idno>
<idno type="wicri:Area/PubMed/Curation">004659</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">004659</idno>
<idno type="wicri:Area/PubMed/Checkpoint">004659</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">004659</idno>
<idno type="wicri:Area/Ncbi/Merge">000870</idno>
<idno type="wicri:Area/Ncbi/Curation">000870</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000870</idno>
<idno type="wicri:doubleKey">0167-482X:2001:De Hullu J:what:doctors:and</idno>
<idno type="wicri:Area/Main/Merge">009D44</idno>
<idno type="wicri:Area/Main/Curation">009948</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">What doctors and patients think about false-negative sentinel lymph nodes in vulvar cancer.</title>
<author><name sortKey="De Hullu, J A" sort="De Hullu, J A" uniqKey="De Hullu J" first="J A" last="De Hullu">J A De Hullu</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Gynecologic Oncology, Groningen University Hospital, Groningen, Hanzeplein 1, PO Box 30001, 9700RB Groningen, The Netherlands. j.a.de.hull@og.azg.nl</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gynecologic Oncology, Groningen University Hospital, Groningen, Hanzeplein 1, PO Box 30001, 9700RB Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ansink, A C" sort="Ansink, A C" uniqKey="Ansink A" first="A C" last="Ansink">A C Ansink</name>
</author>
<author><name sortKey="Tymstra, T" sort="Tymstra, T" uniqKey="Tymstra T" first="T" last="Tymstra">T. Tymstra</name>
</author>
<author><name sortKey="Van Der Zee, A G" sort="Van Der Zee, A G" uniqKey="Van Der Zee A" first="A G" last="Van Der Zee">A G Van Der Zee</name>
</author>
</analytic>
<series><title level="j">Journal of psychosomatic obstetrics and gynaecology</title>
<idno type="ISSN">0167-482X</idno>
<imprint><date when="2001" type="published">2001</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Attitude of Health Personnel</term>
<term>False Negative Reactions</term>
<term>Female</term>
<term>Humans</term>
<term>Lymph Node Excision (psychology)</term>
<term>Lymphatic Metastasis</term>
<term>Middle Aged</term>
<term>Patient Participation (psychology)</term>
<term>Postoperative Complications (psychology)</term>
<term>Sentinel Lymph Node Biopsy (psychology)</term>
<term>Sick Role</term>
<term>Vulvar Neoplasms (pathology)</term>
<term>Vulvar Neoplasms (psychology)</term>
<term>Vulvar Neoplasms (surgery)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Attitude du personnel soignant</term>
<term>Biopsie de noeud lymphatique sentinelle (psychologie)</term>
<term>Complications postopératoires (psychologie)</term>
<term>Faux négatifs</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphadénectomie (psychologie)</term>
<term>Métastase lymphatique</term>
<term>Participation du patient (psychologie)</term>
<term>Rôle de malade</term>
<term>Sujet âgé</term>
<term>Tumeurs de la vulve ()</term>
<term>Tumeurs de la vulve (anatomopathologie)</term>
<term>Tumeurs de la vulve (psychologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs de la vulve</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Vulvar Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Biopsie de noeud lymphatique sentinelle</term>
<term>Complications postopératoires</term>
<term>Lymphadénectomie</term>
<term>Participation du patient</term>
<term>Tumeurs de la vulve</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Lymph Node Excision</term>
<term>Patient Participation</term>
<term>Postoperative Complications</term>
<term>Sentinel Lymph Node Biopsy</term>
<term>Vulvar Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Vulvar Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Attitude of Health Personnel</term>
<term>False Negative Reactions</term>
<term>Female</term>
<term>Humans</term>
<term>Lymphatic Metastasis</term>
<term>Middle Aged</term>
<term>Sick Role</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Attitude du personnel soignant</term>
<term>Faux négatifs</term>
<term>Femelle</term>
<term>Humains</term>
<term>Métastase lymphatique</term>
<term>Rôle de malade</term>
<term>Sujet âgé</term>
<term>Tumeurs de la vulve</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The sentinel lymph node procedure is a relatively new, minimally-invasive method for the assessment of nodal status in malignancies such as breast cancer, cutaneous melanoma and vulvar cancer. Although highly accurate, this new method is inevitably associated with a certain false-negative rate, possibly leading to worse survival in a small subset of patients. The clinical implementation of the sentinel lymph node procedure is therefore a matter of ongoing debate, especially among doctors. The aim of this study was to assess opinions on the acceptable false-negative rate of the sentinel lymph node procedure in patients with vulvar cancer, who in the past had undergone standard routine radical vulvectomy and complete inguinofemoral lymphadenectomy (and frequently experienced complications), and in gynecologists treating patients with vulvar cancer. Structured questionnaires were sent to both patients and gynecologists. The patients had been treated for vulvar cancer between 1985 and 1993, and were all in complete remission with a median follow-up of 118 months (range: 76-185). Questions to the patients dealt with experienced side-effects of the standard treatment and opinion on the acceptable false-negative rate of the sentinel lymph node procedure. The response rate among patients was 91% (106/117). Forty per cent of the patients experienced one or more infections in the legs (cellulitis) and 49% of the patients still experience either severe pain and/or severe lymphedema in the legs. Sixty-six per cent of the patients preferred complete inguinofemoral lymphadenectomy in preference to a 5% false-negative rate of the sentinel lymph node procedure of 5%. Their preference was not related to age or the side-effects they had experienced. The response rate among gynecologists was 80% (80/100), of whom 60% were willing to accept a 5-20% false-negative rate of the sentinel lymph node procedure. While gynecologists may consider the sentinel lymph node procedure to be a promising diagnostic tool, the majority of vulvar cancer patients, who have undergone complete inguinofemoral lymphadenectomy in the past and have frequently experienced complications, would not advise introduction of this technique because they do not want to take any risk of missing a lymph node metastasis.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 009948 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 009948 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Curation |type= RBID |clé= pubmed:11840573 |texte= What doctors and patients think about false-negative sentinel lymph nodes in vulvar cancer. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:11840573" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |