P‐50 Clinical, histological and immunological characteristics of Neumann‐type pemphigus vegetans in a dog
Identifieur interne : 008A18 ( Main/Curation ); précédent : 008A17; suivant : 008A19P‐50 Clinical, histological and immunological characteristics of Neumann‐type pemphigus vegetans in a dog
Auteurs : M. Heimann [États-Unis] ; L. Beco [États-Unis] ; M. Petein [États-Unis] ; V. Rademaeker [États-Unis] ; T. Olivry [États-Unis]Source :
- Veterinary Dermatology [ 0959-4493 ] ; 2004-08.
Abstract
Pemphigus vegetans is a very rare cutaneous autoimmune blistering acantholytic disease of humans that combines features of both pemphigus foliaceus and mucosal lesions of pemphigus vulgaris. We report here the clinical, histopathological and immunological findings in a dog whose lesions resembled those of pemphigus vegetans of humans. A 4‐year old, greater Swiss mountain dog was presented with verrucous papules and crusts on the axillae and inguinal region. Within 3 months, lesions progressed to involve the thorax and ear pinnae, and then became generalized. Ulcers were observed in the oral cavity, anus and prepuce. Microscopic examination of mucosal and cutaneous biopsy specimens revealed a mixed pattern of deep intraepidermal neutrophilic and eosinophilic pustules with isolated and clustered acantholytic keratinocytes, along with suprabasal epidermal clefts leaving rounded basal keratinocytes at the bottom of the vesicles. These dual changes were also observed within the hair follicle epithelium. Dermal inflammation was mixed and perivascular. Direct immunofluorescence revealed IgG deposited around epidermal keratinocytes. Indirect immunofluorescence performed on normal canine gingival substrate uncovered antikeratinocyte IgG autoantibodies with a serum titre of 1:2500. Immunoblotting confirmed that circulating IgG autoantibodies recognized the extracellular segment of canine desmoglein‐1 and human desmoglein‐3. Treatment with azathioprine and oral glucocorticoids resulted in long‐lasting complete remission. In this dog, clinical signs, microscopic skin lesions and immunological findings were deemed analogous to those of human Neumann‐type pemphigus vegetans. Funding: Self‐funded.
Url:
DOI: 10.1111/j.1365-3164.2004.00414_50.x
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Clinical, histological and immunological characteristics of Neumann‐type pemphigus vegetans in a dog</title><author><name sortKey="Heimann, M" sort="Heimann, M" uniqKey="Heimann M" first="M." last="Heimann">M. Heimann</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut de Pathologie et Genetique, Loverval, Belgium; Cabinet Veterinaire Reine Astrid, Spa, Belgium; Cabinet Vétérinaire, Montzen, Belgium; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Beco, L" sort="Beco, L" uniqKey="Beco L" first="L." last="Beco">L. Beco</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut de Pathologie et Genetique, Loverval, Belgium; Cabinet Veterinaire Reine Astrid, Spa, Belgium; Cabinet Vétérinaire, Montzen, Belgium; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Petein, M" sort="Petein, M" uniqKey="Petein M" first="M." last="Petein">M. Petein</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut de Pathologie et Genetique, Loverval, Belgium; Cabinet Veterinaire Reine Astrid, Spa, Belgium; Cabinet Vétérinaire, Montzen, Belgium; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Rademaeker, V" sort="Rademaeker, V" uniqKey="Rademaeker V" first="V." last="Rademaeker">V. Rademaeker</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut de Pathologie et Genetique, Loverval, Belgium; Cabinet Veterinaire Reine Astrid, Spa, Belgium; Cabinet Vétérinaire, Montzen, Belgium; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Olivry, T" sort="Olivry, T" uniqKey="Olivry T" first="T." last="Olivry">T. Olivry</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institut de Pathologie et Genetique, Loverval, Belgium; Cabinet Veterinaire Reine Astrid, Spa, Belgium; Cabinet Vétérinaire, Montzen, Belgium; College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Veterinary Dermatology</title><title level="j" type="alt">VETERINARY DERMATOLOGY</title><idno type="ISSN">0959-4493</idno><idno type="eISSN">1365-3164</idno><imprint><biblScope unit="vol">15</biblScope><biblScope unit="page" from="57">57</biblScope><biblScope unit="page" to="57">57</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-08">2004-08</date></imprint><idno type="ISSN">0959-4493</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0959-4493</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pemphigus vegetans is a very rare cutaneous autoimmune blistering acantholytic disease of humans that combines features of both pemphigus foliaceus and mucosal lesions of pemphigus vulgaris. We report here the clinical, histopathological and immunological findings in a dog whose lesions resembled those of pemphigus vegetans of humans. A 4‐year old, greater Swiss mountain dog was presented with verrucous papules and crusts on the axillae and inguinal region. Within 3 months, lesions progressed to involve the thorax and ear pinnae, and then became generalized. Ulcers were observed in the oral cavity, anus and prepuce. Microscopic examination of mucosal and cutaneous biopsy specimens revealed a mixed pattern of deep intraepidermal neutrophilic and eosinophilic pustules with isolated and clustered acantholytic keratinocytes, along with suprabasal epidermal clefts leaving rounded basal keratinocytes at the bottom of the vesicles. These dual changes were also observed within the hair follicle epithelium. Dermal inflammation was mixed and perivascular. Direct immunofluorescence revealed IgG deposited around epidermal keratinocytes. Indirect immunofluorescence performed on normal canine gingival substrate uncovered antikeratinocyte IgG autoantibodies with a serum titre of 1:2500. Immunoblotting confirmed that circulating IgG autoantibodies recognized the extracellular segment of canine desmoglein‐1 and human desmoglein‐3. Treatment with azathioprine and oral glucocorticoids resulted in long‐lasting complete remission. In this dog, clinical signs, microscopic skin lesions and immunological findings were deemed analogous to those of human Neumann‐type pemphigus vegetans. Funding: Self‐funded.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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