A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Identifieur interne : 008056 ( Main/Curation ); précédent : 008055; suivant : 008057A genetic Xenopus laevis tadpole model to study lymphangiogenesis.
Auteurs : Annelii Ny [Belgique] ; Marta Koch ; Martin Schneider ; Elke Neven ; Ricky T. Tong ; Sunit Maity ; Christian Fischer ; Stephane Plaisance ; Diether Lambrechts ; Christophe Héligon ; Sven Terclavers ; Malgorzata Ciesiolka ; Roland K Lin ; Wing Yan Man ; Irena Senn ; Sabine Wyns ; Florea Lupu ; André Br Ndli ; Kris Vleminckx ; Désiré Collen ; Mieke Dewerchin ; Edward M. Conway ; Lieve Moons ; Rakesh K. Jain ; Peter CarmelietSource :
- Nature medicine [ 1078-8956 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Larve (croissance et développement), Larve (génétique), Lymphangiogenèse (génétique), Lymphangiogenèse (physiologie), Protéines suppresseurs de tumeurs, Protéines à homéodomaine (physiologie), Système lymphatique (anatomie et histologie), Système lymphatique (croissance et développement), Xenopus laevis (croissance et développement), Xenopus laevis (génétique).
- MESH :
- anatomie et histologie : Système lymphatique.
- croissance et développement : Larve, Système lymphatique, Xenopus laevis.
- génétique : Larve, Lymphangiogenèse, Xenopus laevis.
- physiologie : Lymphangiogenèse, Protéines à homéodomaine.
- Animaux, Protéines suppresseurs de tumeurs.
English descriptors
- KwdEn :
- Animals, Homeodomain Proteins (physiology), Larva (genetics), Larva (growth & development), Lymphangiogenesis (genetics), Lymphangiogenesis (physiology), Lymphatic System (anatomy & histology), Lymphatic System (growth & development), Tumor Suppressor Proteins, Xenopus laevis (genetics), Xenopus laevis (growth & development).
- MESH :
- chemical , physiology : Homeodomain Proteins.
- anatomy & histology : Lymphatic System.
- genetics : Larva, Lymphangiogenesis, Xenopus laevis.
- growth & development : Larva, Lymphatic System, Xenopus laevis.
- physiology : Lymphangiogenesis.
- Animals, Tumor Suppressor Proteins.
Abstract
Lymph vessels control fluid homeostasis, immunity and metastasis. Unraveling the molecular basis of lymphangiogenesis has been hampered by the lack of a small animal model that can be genetically manipulated. Here, we show that Xenopus tadpoles develop lymph vessels from lymphangioblasts or, through transdifferentiation, from venous endothelial cells. Lymphangiography showed that these lymph vessels drain lymph, through the lymph heart, to the venous circulation. Morpholino-mediated knockdown of the lymphangiogenic factor Prox1 caused lymph vessel defects and lymphedema by impairing lymphatic commitment. Knockdown of vascular endothelial growth factor C (VEGF-C) also induced lymph vessel defects and lymphedema, but primarily by affecting migration of lymphatic endothelial cells. Knockdown of VEGF-C also resulted in aberrant blood vessel formation in tadpoles. This tadpole model offers opportunities for the discovery of new regulators of lymphangiogenesis.
DOI: 10.1038/nm1285
PubMed: 16116431
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Tong</name></author><author><name sortKey="Maity, Sunit" sort="Maity, Sunit" uniqKey="Maity S" first="Sunit" last="Maity">Sunit Maity</name></author><author><name sortKey="Fischer, Christian" sort="Fischer, Christian" uniqKey="Fischer C" first="Christian" last="Fischer">Christian Fischer</name></author><author><name sortKey="Plaisance, Stephane" sort="Plaisance, Stephane" uniqKey="Plaisance S" first="Stephane" last="Plaisance">Stephane Plaisance</name></author><author><name sortKey="Lambrechts, Diether" sort="Lambrechts, Diether" uniqKey="Lambrechts D" first="Diether" last="Lambrechts">Diether Lambrechts</name></author><author><name sortKey="Heligon, Christophe" sort="Heligon, Christophe" uniqKey="Heligon C" first="Christophe" last="Héligon">Christophe Héligon</name></author><author><name sortKey="Terclavers, Sven" sort="Terclavers, Sven" uniqKey="Terclavers S" first="Sven" last="Terclavers">Sven Terclavers</name></author><author><name sortKey="Ciesiolka, Malgorzata" sort="Ciesiolka, Malgorzata" uniqKey="Ciesiolka M" first="Malgorzata" last="Ciesiolka">Malgorzata Ciesiolka</name></author><author><name sortKey="K Lin, Roland" sort="K Lin, Roland" uniqKey="K Lin R" first="Roland" last="K Lin">Roland K Lin</name></author><author><name sortKey="Man, Wing Yan" sort="Man, Wing Yan" uniqKey="Man W" first="Wing Yan" last="Man">Wing Yan Man</name></author><author><name sortKey="Senn, Irena" sort="Senn, Irena" uniqKey="Senn I" first="Irena" last="Senn">Irena Senn</name></author><author><name sortKey="Wyns, Sabine" sort="Wyns, Sabine" uniqKey="Wyns S" first="Sabine" last="Wyns">Sabine Wyns</name></author><author><name sortKey="Lupu, Florea" sort="Lupu, Florea" uniqKey="Lupu F" first="Florea" last="Lupu">Florea Lupu</name></author><author><name sortKey="Br Ndli, Andre" sort="Br Ndli, Andre" uniqKey="Br Ndli A" first="André" last="Br Ndli">André Br Ndli</name></author><author><name sortKey="Vleminckx, Kris" sort="Vleminckx, Kris" uniqKey="Vleminckx K" first="Kris" last="Vleminckx">Kris Vleminckx</name></author><author><name sortKey="Collen, Desire" sort="Collen, Desire" uniqKey="Collen D" first="Désiré" last="Collen">Désiré Collen</name></author><author><name sortKey="Dewerchin, Mieke" sort="Dewerchin, Mieke" uniqKey="Dewerchin M" first="Mieke" last="Dewerchin">Mieke Dewerchin</name></author><author><name sortKey="Conway, Edward M" sort="Conway, Edward M" uniqKey="Conway E" first="Edward M" last="Conway">Edward M. Conway</name></author><author><name sortKey="Moons, Lieve" sort="Moons, Lieve" uniqKey="Moons L" first="Lieve" last="Moons">Lieve Moons</name></author><author><name sortKey="Jain, Rakesh K" sort="Jain, Rakesh K" uniqKey="Jain R" first="Rakesh K" last="Jain">Rakesh K. Jain</name></author><author><name sortKey="Carmeliet, Peter" sort="Carmeliet, Peter" uniqKey="Carmeliet P" first="Peter" last="Carmeliet">Peter Carmeliet</name></author></analytic><series><title level="j">Nature medicine</title><idno type="ISSN">1078-8956</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Homeodomain Proteins (physiology)</term><term>Larva (genetics)</term><term>Larva (growth & development)</term><term>Lymphangiogenesis (genetics)</term><term>Lymphangiogenesis (physiology)</term><term>Lymphatic System (anatomy & histology)</term><term>Lymphatic System (growth & development)</term><term>Tumor Suppressor Proteins</term><term>Xenopus laevis (genetics)</term><term>Xenopus laevis (growth & development)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Larve (croissance et développement)</term><term>Larve (génétique)</term><term>Lymphangiogenèse (génétique)</term><term>Lymphangiogenèse (physiologie)</term><term>Protéines suppresseurs de tumeurs</term><term>Protéines à homéodomaine (physiologie)</term><term>Système lymphatique (anatomie et histologie)</term><term>Système lymphatique (croissance et développement)</term><term>Xenopus laevis (croissance et développement)</term><term>Xenopus laevis (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Homeodomain Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomie et histologie" xml:lang="fr"><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Larve</term><term>Système lymphatique</term><term>Xenopus laevis</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Larva</term><term>Lymphangiogenesis</term><term>Xenopus laevis</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Larva</term><term>Lymphatic System</term><term>Xenopus laevis</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Larve</term><term>Lymphangiogenèse</term><term>Xenopus laevis</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Lymphangiogenèse</term><term>Protéines à homéodomaine</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Tumor Suppressor Proteins</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Protéines suppresseurs de tumeurs</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymph vessels control fluid homeostasis, immunity and metastasis. Unraveling the molecular basis of lymphangiogenesis has been hampered by the lack of a small animal model that can be genetically manipulated. Here, we show that Xenopus tadpoles develop lymph vessels from lymphangioblasts or, through transdifferentiation, from venous endothelial cells. Lymphangiography showed that these lymph vessels drain lymph, through the lymph heart, to the venous circulation. Morpholino-mediated knockdown of the lymphangiogenic factor Prox1 caused lymph vessel defects and lymphedema by impairing lymphatic commitment. Knockdown of vascular endothelial growth factor C (VEGF-C) also induced lymph vessel defects and lymphedema, but primarily by affecting migration of lymphatic endothelial cells. Knockdown of VEGF-C also resulted in aberrant blood vessel formation in tadpoles. This tadpole model offers opportunities for the discovery of new regulators of lymphangiogenesis.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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