G-protein coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases
Identifieur interne : 006272 ( Main/Curation ); précédent : 006271; suivant : 006273G-protein coupled receptors as potential drug targets for lymphangiogenesis and lymphatic vascular diseases
Auteurs : William P. Dunworth [États-Unis] ; Kathleen M. Caron [États-Unis]Source :
- Arteriosclerosis, thrombosis, and vascular biology [ 1079-5642 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Endothélium lymphatique (), Endothélium lymphatique (physiologie), Humains, Lymphangiogenèse (), Lymphangiogenèse (physiologie), Lymphoedème (physiopathologie), Lymphoedème (traitement médicamenteux), Protéine apparentée au récepteur de la calcitonine, Récepteurs aux lysophospholipides (physiologie), Récepteurs couplés aux protéines G (), Récepteurs couplés aux protéines G (physiologie), Récepteurs à la calcitonine (physiologie), Souris, Souris knockout.
- MESH :
- physiologie : Endothélium lymphatique, Lymphangiogenèse, Récepteurs aux lysophospholipides, Récepteurs couplés aux protéines G, Récepteurs à la calcitonine.
- physiopathologie : Lymphoedème.
- traitement médicamenteux : Lymphoedème.
- Animaux, Endothélium lymphatique, Humains, Lymphangiogenèse, Protéine apparentée au récepteur de la calcitonine, Récepteurs couplés aux protéines G, Souris, Souris knockout.
English descriptors
- KwdEn :
- Animals, Calcitonin Receptor-Like Protein, Endothelium, Lymphatic (drug effects), Endothelium, Lymphatic (physiology), Humans, Lymphangiogenesis (drug effects), Lymphangiogenesis (physiology), Lymphedema (drug therapy), Lymphedema (physiopathology), Mice, Mice, Knockout, Receptors, Calcitonin (physiology), Receptors, G-Protein-Coupled (drug effects), Receptors, G-Protein-Coupled (physiology), Receptors, Lysophospholipid (physiology).
- MESH :
- chemical , drug effects : Receptors, G-Protein-Coupled.
- chemical , physiology : Receptors, Calcitonin, Receptors, G-Protein-Coupled, Receptors, Lysophospholipid.
- chemical : Calcitonin Receptor-Like Protein.
- drug effects : Endothelium, Lymphatic, Lymphangiogenesis.
- drug therapy : Lymphedema.
- physiology : Endothelium, Lymphatic, Lymphangiogenesis.
- physiopathology : Lymphedema.
- Animals, Humans, Mice, Mice, Knockout.
Abstract
G-protein coupled receptors (GPCRs) are widely expressed cell surface receptors that have been successfully exploited for the treatment of a variety of human diseases. Recent studies in genetically engineered mouse models have led to the identification of several GPCRs important for lymphatic vascular development and function. The adrenomedullin receptor, which consists of an oligomer between calcitonin receptor-like receptor and receptor activity modifying protein 2, is required for normal lymphatic vascular development and regulates lymphatic capillary permeability in mice. Numerous studies also suggest that lysophospholipid receptors are involved in the development of lymphatic vessels and lymphatic endothelial cell permeability. Given our current lack of pharmacological targets for the treatment of lymphatic vascular diseases like lymphedema, the continued identification and study of GPCRs in lymphatic endothelial cells may eventually lead to major breakthroughs and new pharmacological strategies for the treatment of lymphedema.
Url:
DOI: 10.1161/ATVBAHA.109.185066
PubMed: 19265032
PubMed Central: 2761011
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PMC:2761011Le document en format XML
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<term>Calcitonin Receptor-Like Protein</term>
<term>Endothelium, Lymphatic (drug effects)</term>
<term>Endothelium, Lymphatic (physiology)</term>
<term>Humans</term>
<term>Lymphangiogenesis (drug effects)</term>
<term>Lymphangiogenesis (physiology)</term>
<term>Lymphedema (drug therapy)</term>
<term>Lymphedema (physiopathology)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Receptors, Calcitonin (physiology)</term>
<term>Receptors, G-Protein-Coupled (drug effects)</term>
<term>Receptors, G-Protein-Coupled (physiology)</term>
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<term>Endothélium lymphatique ()</term>
<term>Endothélium lymphatique (physiologie)</term>
<term>Humains</term>
<term>Lymphangiogenèse ()</term>
<term>Lymphangiogenèse (physiologie)</term>
<term>Lymphoedème (physiopathologie)</term>
<term>Lymphoedème (traitement médicamenteux)</term>
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<term>Récepteurs couplés aux protéines G (physiologie)</term>
<term>Récepteurs à la calcitonine (physiologie)</term>
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<term>Souris knockout</term>
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<term>Receptors, G-Protein-Coupled</term>
<term>Receptors, Lysophospholipid</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Calcitonin Receptor-Like Protein</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Endothelium, Lymphatic</term>
<term>Lymphangiogenesis</term>
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<term>Lymphangiogenèse</term>
<term>Récepteurs aux lysophospholipides</term>
<term>Récepteurs couplés aux protéines G</term>
<term>Récepteurs à la calcitonine</term>
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<term>Lymphangiogenesis</term>
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<term>Lymphangiogenèse</term>
<term>Protéine apparentée au récepteur de la calcitonine</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">G-protein coupled receptors (GPCRs) are widely expressed cell surface receptors that have been successfully exploited for the treatment of a variety of human diseases. Recent studies in genetically engineered mouse models have led to the identification of several GPCRs important for lymphatic vascular development and function. The adrenomedullin receptor, which consists of an oligomer between calcitonin receptor-like receptor and receptor activity modifying protein 2, is required for normal lymphatic vascular development and regulates lymphatic capillary permeability in mice. Numerous studies also suggest that lysophospholipid receptors are involved in the development of lymphatic vessels and lymphatic endothelial cell permeability. Given our current lack of pharmacological targets for the treatment of lymphatic vascular diseases like lymphedema, the continued identification and study of GPCRs in lymphatic endothelial cells may eventually lead to major breakthroughs and new pharmacological strategies for the treatment of lymphedema.</p>
</div>
</front>
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