Lymphatics in Human Lymphatic Filariasis: In Vitro Models of Parasite-Induced Lymphatic Remodeling
Identifieur interne : 006191 ( Main/Curation ); précédent : 006190; suivant : 006192Lymphatics in Human Lymphatic Filariasis: In Vitro Models of Parasite-Induced Lymphatic Remodeling
Auteurs : Sasisekhar Bennuru ; Thomas B. NutmanSource :
- Lymphatic Research and Biology [ 1539-6851 ] ; 2009.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Filariose lymphatique.
- immunologie : Filariose lymphatique.
- parasitologie : Filariose lymphatique.
- physiologie : Système lymphatique.
- Animaux, Humains, Modèles animaux de maladie humaine, Techniques in vitro.
English descriptors
- KwdEn :
- MESH :
- immunology : Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- pathology : Elephantiasis, Filarial.
- physiology : Lymphatic System.
- Animals, Disease Models, Animal, Humans, In Vitro Techniques.
Abstract
Lymphatic filariasis characterized by the dysfunction of the lymphatics can lead to severe (and often) irreversible lymphedema and elephantiasis. Decades of research in the field shows that the establishment of the adult parasites in the lymphatics triggers a cascade of events that ultimately results in tissue scarring and fibrosis. In this minireview, we focus on the studies addressing the mechanisms underlying the parasite-induced lymphatic dilatation that suggests parasite-induced lymphatic remodeling and lymphangiogenesis may be the prelude towards developing chronic and irreversible filarial pathology.
Url:
DOI: 10.1089/lrb.2009.0022
PubMed: 20143920
PubMed Central: 2883472
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PMC:2883472Le document en format XML
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Models of Parasite-Induced Lymphatic Remodeling</title>
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Models of Parasite-Induced Lymphatic Remodeling</title>
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<term>Elephantiasis, Filarial (parasitology)</term>
<term>Elephantiasis, Filarial (pathology)</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Lymphatic System (physiology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Filariose lymphatique (anatomopathologie)</term>
<term>Filariose lymphatique (immunologie)</term>
<term>Filariose lymphatique (parasitologie)</term>
<term>Humains</term>
<term>Modèles animaux de maladie humaine</term>
<term>Système lymphatique (physiologie)</term>
<term>Techniques in vitro</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Système lymphatique</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>Lymphatic filariasis characterized by the dysfunction of the lymphatics can lead to severe (and often) irreversible lymphedema and elephantiasis. Decades of research in the field shows that the establishment of the adult parasites in the lymphatics triggers a cascade of events that ultimately results in tissue scarring and fibrosis. In this minireview, we focus on the studies addressing the mechanisms underlying the parasite-induced lymphatic dilatation that suggests parasite-induced lymphatic remodeling and lymphangiogenesis may be the prelude towards developing chronic and irreversible filarial pathology.</p>
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