Near Infrared Photoacoustic Detection of Sentinel Lymph Nodes with Gold Nanobeacons
Identifieur interne : 005741 ( Main/Curation ); précédent : 005740; suivant : 005742Near Infrared Photoacoustic Detection of Sentinel Lymph Nodes with Gold Nanobeacons
Auteurs : Dipanjan Pan [États-Unis] ; Manojit Pramanik [États-Unis] ; Angana Senpan [États-Unis] ; Soumojit Ghosh [États-Unis] ; Samuel A. Wickline [États-Unis] ; Lihong V. Wang [États-Unis] ; Gregory M. Lanza [États-Unis]Source :
- Biomaterials [ 0142-9612 ] ; 2010.
Abstract
Detection of sentinel lymph node (SLN) using photoacoustic imaging is an emerging technique for noninvasive axillary staging of breast cancer. Due to the absence of intrinsic contrast inside the lymph nodes, exogenous contrast agents are used for photoacoustic detection. In this work, we have demonstrated near infrared detection of SLN with gold nanobeacons (GNB) providing the photoacoustic contrast in a rodent model. We found that size dictates the
Url:
DOI: 10.1016/j.biomaterials.2010.01.136
PubMed: 20172607
PubMed Central: 2874457
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002871
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :002870
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003313
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003925
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :003925
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003925
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :005790
Links to Exploration step
PMC:2874457Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Near Infrared Photoacoustic Detection of Sentinel Lymph Nodes with Gold Nanobeacons</title>
<author><name sortKey="Pan, Dipanjan" sort="Pan, Dipanjan" uniqKey="Pan D" first="Dipanjan" last="Pan">Dipanjan Pan</name>
<affiliation wicri:level="4"><nlm:aff id="A1">C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pramanik, Manojit" sort="Pramanik, Manojit" uniqKey="Pramanik M" first="Manojit" last="Pramanik">Manojit Pramanik</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130</wicri:regionArea>
<orgName type="university">Université Washington de Saint-Louis</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Senpan, Angana" sort="Senpan, Angana" uniqKey="Senpan A" first="Angana" last="Senpan">Angana Senpan</name>
<affiliation wicri:level="4"><nlm:aff id="A1">C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ghosh, Soumojit" sort="Ghosh, Soumojit" uniqKey="Ghosh S" first="Soumojit" last="Ghosh">Soumojit Ghosh</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130</wicri:regionArea>
<orgName type="university">Université Washington de Saint-Louis</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wickline, Samuel A" sort="Wickline, Samuel A" uniqKey="Wickline S" first="Samuel A." last="Wickline">Samuel A. Wickline</name>
<affiliation wicri:level="4"><nlm:aff id="A1">C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Lihong V" sort="Wang, Lihong V" uniqKey="Wang L" first="Lihong V." last="Wang">Lihong V. Wang</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130</wicri:regionArea>
<orgName type="university">Université Washington de Saint-Louis</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lanza, Gregory M" sort="Lanza, Gregory M" uniqKey="Lanza G" first="Gregory M." last="Lanza">Gregory M. Lanza</name>
<affiliation wicri:level="4"><nlm:aff id="A1">C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20172607</idno>
<idno type="pmc">2874457</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874457</idno>
<idno type="RBID">PMC:2874457</idno>
<idno type="doi">10.1016/j.biomaterials.2010.01.136</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">002871</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002871</idno>
<idno type="wicri:Area/Pmc/Curation">002870</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002870</idno>
<idno type="wicri:Area/Pmc/Checkpoint">003313</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003313</idno>
<idno type="wicri:Area/Ncbi/Merge">003925</idno>
<idno type="wicri:Area/Ncbi/Curation">003925</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003925</idno>
<idno type="wicri:doubleKey">0142-9612:2010:Pan D:near:infrared:photoacoustic</idno>
<idno type="wicri:Area/Main/Merge">005790</idno>
<idno type="wicri:Area/Main/Curation">005741</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Near Infrared Photoacoustic Detection of Sentinel Lymph Nodes with Gold Nanobeacons</title>
<author><name sortKey="Pan, Dipanjan" sort="Pan, Dipanjan" uniqKey="Pan D" first="Dipanjan" last="Pan">Dipanjan Pan</name>
<affiliation wicri:level="4"><nlm:aff id="A1">C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pramanik, Manojit" sort="Pramanik, Manojit" uniqKey="Pramanik M" first="Manojit" last="Pramanik">Manojit Pramanik</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130</wicri:regionArea>
<orgName type="university">Université Washington de Saint-Louis</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Senpan, Angana" sort="Senpan, Angana" uniqKey="Senpan A" first="Angana" last="Senpan">Angana Senpan</name>
<affiliation wicri:level="4"><nlm:aff id="A1">C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ghosh, Soumojit" sort="Ghosh, Soumojit" uniqKey="Ghosh S" first="Soumojit" last="Ghosh">Soumojit Ghosh</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130</wicri:regionArea>
<orgName type="university">Université Washington de Saint-Louis</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wickline, Samuel A" sort="Wickline, Samuel A" uniqKey="Wickline S" first="Samuel A." last="Wickline">Samuel A. Wickline</name>
<affiliation wicri:level="4"><nlm:aff id="A1">C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Lihong V" sort="Wang, Lihong V" uniqKey="Wang L" first="Lihong V." last="Wang">Lihong V. Wang</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130</wicri:regionArea>
<orgName type="university">Université Washington de Saint-Louis</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lanza, Gregory M" sort="Lanza, Gregory M" uniqKey="Lanza G" first="Gregory M." last="Lanza">Gregory M. Lanza</name>
<affiliation wicri:level="4"><nlm:aff id="A1">C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Biomaterials</title>
<idno type="ISSN">0142-9612</idno>
<idno type="eISSN">1878-5905</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">Detection of sentinel lymph node (SLN) using photoacoustic imaging is an emerging technique for noninvasive axillary staging of breast cancer. Due to the absence of intrinsic contrast inside the lymph nodes, exogenous contrast agents are used for photoacoustic detection. In this work, we have demonstrated near infrared detection of SLN with gold nanobeacons (GNB) providing the photoacoustic contrast in a rodent model. We found that size dictates the <italic>in vivo</italic>
characteristics of these nanoparticles in SLN imaging. Larger nanobeacons with high pay loads of gold were not as efficient as smaller size nanobeacons with lower pay loads for this purpose. Colloidal GNBs were designed as a nanomedicine platform with “soft” nature that is amenable to bio-elimination, an essential feature for <italic>in vivo</italic>
efficacy and safety. The GNBs were synthesized as lipid- or polymer-encapsulated colloidal particles incorporating tiny gold nanoparticles (2–4 nm) in three tunable sizes (90 nm, 150 nm and 290 nm). Smaller GNBs were noted trafficking through the lymphatic system and accumulating more efficiently in the lymph nodes in comparison to the bigger nanoagents. At 20 min, the GNBs reached the SLN and were no longer observed within the draining lymphatic vessel. Within one hour post injection, the contrast ratio of the lymphnodes with the surrounding blood vessels was 9:1. These findings were also supported by analytical measurements of the <italic>ex vivo</italic>
tissue samples. Results indicate that cumulative nanoparticle deposition in lymph nodes is size dependent and that high payloads of gold, although offering greater contrast <italic>in vitro</italic>
, may yield nanoagents with poor intradermal migration and lymphatic transport characteristics.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005741 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 005741 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:2874457 |texte= Near Infrared Photoacoustic Detection of Sentinel Lymph Nodes with Gold Nanobeacons }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:20172607" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |