Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles
Identifieur interne : 004D67 ( Main/Curation ); précédent : 004D66; suivant : 004D68Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles
Auteurs : Shuang Cai [États-Unis] ; Qiuhong Zhang [États-Unis] ; Taryn Bagby [États-Unis] ; M. Laird Forrest [États-Unis]Source :
- Advanced drug delivery reviews [ 0169-409X ] ; 2011.
Abstract
The lymphatic system plays a crucial role in the immune system’s recognition and response to disease, and most solid cancers initially spread from the primary site via the tumor’s surrounding lymphatics before hematological dissemination. Hence, the lymphatic system is an important target for developing new vaccines, cancer treatments, and diagnostic agents. Targeting the lymphatic system by subcutaneous, intestinal, and pulmonary routes has been evaluated and subsequently utilized to improve lymphatic penetration and retention of drug molecules, reduce drug-related systemic toxicities, and enhance bioavailability of poorly soluble and unstable drugs. Lymphatic imaging is an essential tool for the detection and staging of cancer. New nano-based technologies offer improved detection and characterization of the nodal diseases, while new delivery devices can better target and confine treatments to tumors within the nodal space while sparing healthy tissues. This manuscript reviews recent advances in the field of lymphatic drug delivery and imaging and focuses specifically on the development ofliposomes and solid lipid nanoparticles for lymphatic introduction via the subcutaneous, intestinal, and pulmonary routes.
Url:
DOI: 10.1016/j.addr.2011.05.017
PubMed: 21712055
PubMed Central: 3164476
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002A21
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :002A20
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002E81
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :004476
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :004476
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :004476
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004E03
Links to Exploration step
PMC:3164476Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles</title>
<author><name sortKey="Cai, Shuang" sort="Cai, Shuang" uniqKey="Cai S" first="Shuang" last="Cai">Shuang Cai</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Pharmaceutical Chemistry, University of Kansas</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Lawrence (Kansas)</settlement>
<region type="state">Kansas</region>
</placeName>
<orgName type="university">Université du Kansas</orgName>
</affiliation>
</author>
<author><name sortKey="Zhang, Qiuhong" sort="Zhang, Qiuhong" uniqKey="Zhang Q" first="Qiuhong" last="Zhang">Qiuhong Zhang</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Pharmaceutical Chemistry, University of Kansas</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Lawrence (Kansas)</settlement>
<region type="state">Kansas</region>
</placeName>
<orgName type="university">Université du Kansas</orgName>
</affiliation>
</author>
<author><name sortKey="Bagby, Taryn" sort="Bagby, Taryn" uniqKey="Bagby T" first="Taryn" last="Bagby">Taryn Bagby</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Pharmaceutical Chemistry, University of Kansas</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Lawrence (Kansas)</settlement>
<region type="state">Kansas</region>
</placeName>
<orgName type="university">Université du Kansas</orgName>
</affiliation>
</author>
<author><name sortKey="Forrest, M Laird" sort="Forrest, M Laird" uniqKey="Forrest M" first="M. Laird" last="Forrest">M. Laird Forrest</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Pharmaceutical Chemistry, University of Kansas</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Lawrence (Kansas)</settlement>
<region type="state">Kansas</region>
</placeName>
<orgName type="university">Université du Kansas</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21712055</idno>
<idno type="pmc">3164476</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164476</idno>
<idno type="RBID">PMC:3164476</idno>
<idno type="doi">10.1016/j.addr.2011.05.017</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">002A21</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002A21</idno>
<idno type="wicri:Area/Pmc/Curation">002A20</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A20</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002E81</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002E81</idno>
<idno type="wicri:Area/Ncbi/Merge">004476</idno>
<idno type="wicri:Area/Ncbi/Curation">004476</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004476</idno>
<idno type="wicri:doubleKey">0169-409X:2011:Cai S:lymphatic:drug:delivery</idno>
<idno type="wicri:Area/Main/Merge">004E03</idno>
<idno type="wicri:Area/Main/Curation">004D67</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles</title>
<author><name sortKey="Cai, Shuang" sort="Cai, Shuang" uniqKey="Cai S" first="Shuang" last="Cai">Shuang Cai</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Pharmaceutical Chemistry, University of Kansas</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Lawrence (Kansas)</settlement>
<region type="state">Kansas</region>
</placeName>
<orgName type="university">Université du Kansas</orgName>
</affiliation>
</author>
<author><name sortKey="Zhang, Qiuhong" sort="Zhang, Qiuhong" uniqKey="Zhang Q" first="Qiuhong" last="Zhang">Qiuhong Zhang</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Pharmaceutical Chemistry, University of Kansas</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Lawrence (Kansas)</settlement>
<region type="state">Kansas</region>
</placeName>
<orgName type="university">Université du Kansas</orgName>
</affiliation>
</author>
<author><name sortKey="Bagby, Taryn" sort="Bagby, Taryn" uniqKey="Bagby T" first="Taryn" last="Bagby">Taryn Bagby</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Pharmaceutical Chemistry, University of Kansas</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Lawrence (Kansas)</settlement>
<region type="state">Kansas</region>
</placeName>
<orgName type="university">Université du Kansas</orgName>
</affiliation>
</author>
<author><name sortKey="Forrest, M Laird" sort="Forrest, M Laird" uniqKey="Forrest M" first="M. Laird" last="Forrest">M. Laird Forrest</name>
<affiliation wicri:level="4"><nlm:aff id="A1"> Department of Pharmaceutical Chemistry, University of Kansas</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Lawrence (Kansas)</settlement>
<region type="state">Kansas</region>
</placeName>
<orgName type="university">Université du Kansas</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Advanced drug delivery reviews</title>
<idno type="ISSN">0169-409X</idno>
<idno type="eISSN">1872-8294</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The lymphatic system plays a crucial role in the immune system’s recognition and response to disease, and most solid cancers initially spread from the primary site via the tumor’s surrounding lymphatics before hematological dissemination. Hence, the lymphatic system is an important target for developing new vaccines, cancer treatments, and diagnostic agents. Targeting the lymphatic system by subcutaneous, intestinal, and pulmonary routes has been evaluated and subsequently utilized to improve lymphatic penetration and retention of drug molecules, reduce drug-related systemic toxicities, and enhance bioavailability of poorly soluble and unstable drugs. Lymphatic imaging is an essential tool for the detection and staging of cancer. New nano-based technologies offer improved detection and characterization of the nodal diseases, while new delivery devices can better target and confine treatments to tumors within the nodal space while sparing healthy tissues. This manuscript reviews recent advances in the field of lymphatic drug delivery and imaging and focuses specifically on the development ofliposomes and solid lipid nanoparticles for lymphatic introduction via the subcutaneous, intestinal, and pulmonary routes.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004D67 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 004D67 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:3164476 |texte= Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:21712055" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |