Ras/MAPK Signaling Modulates VEGFR-3 Expression through Ets-Mediated p300 Recruitment and Histone Acetylation on the Vegfr3 Gene in Lymphatic Endothelial Cells
Identifieur interne : 003F46 ( Main/Curation ); précédent : 003F45; suivant : 003F47Ras/MAPK Signaling Modulates VEGFR-3 Expression through Ets-Mediated p300 Recruitment and Histone Acetylation on the Vegfr3 Gene in Lymphatic Endothelial Cells
Auteurs : Taeko Ichise ; Nobuaki Yoshida ; Hirotake IchiseSource :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Modulation of VEGFR-3 expression is important for altering lymphatic endothelial cell (LEC) characteristics during the lymphangiogenic processes that occur under developmental, physiological, and pathological conditions. However, the mechanisms underlying the modulation of
Url:
DOI: 10.1371/journal.pone.0051639
PubMed: 23284731
PubMed Central: 3524184
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ras/MAPK Signaling Modulates VEGFR-3 Expression through Ets-Mediated p300 Recruitment and Histone Acetylation on the <italic>Vegfr3</italic> Gene in Lymphatic Endothelial Cells</title><author><name sortKey="Ichise, Taeko" sort="Ichise, Taeko" uniqKey="Ichise T" first="Taeko" last="Ichise">Taeko Ichise</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yoshida, Nobuaki" sort="Yoshida, Nobuaki" uniqKey="Yoshida N" first="Nobuaki" last="Yoshida">Nobuaki Yoshida</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ichise, Hirotake" sort="Ichise, Hirotake" uniqKey="Ichise H" first="Hirotake" last="Ichise">Hirotake Ichise</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23284731</idno><idno type="pmc">3524184</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524184</idno><idno type="RBID">PMC:3524184</idno><idno type="doi">10.1371/journal.pone.0051639</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">004461</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004461</idno><idno type="wicri:Area/Pmc/Curation">004460</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004460</idno><idno type="wicri:Area/Pmc/Checkpoint">002761</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002761</idno><idno type="wicri:Area/Ncbi/Merge">005483</idno><idno type="wicri:Area/Ncbi/Curation">005483</idno><idno type="wicri:Area/Ncbi/Checkpoint">005483</idno><idno type="wicri:Area/Main/Merge">003F60</idno><idno type="wicri:Area/Main/Curation">003F46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ras/MAPK Signaling Modulates VEGFR-3 Expression through Ets-Mediated p300 Recruitment and Histone Acetylation on the <italic>Vegfr3</italic> Gene in Lymphatic Endothelial Cells</title><author><name sortKey="Ichise, Taeko" sort="Ichise, Taeko" uniqKey="Ichise T" first="Taeko" last="Ichise">Taeko Ichise</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yoshida, Nobuaki" sort="Yoshida, Nobuaki" uniqKey="Yoshida N" first="Nobuaki" last="Yoshida">Nobuaki Yoshida</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ichise, Hirotake" sort="Ichise, Hirotake" uniqKey="Ichise H" first="Hirotake" last="Ichise">Hirotake Ichise</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Modulation of VEGFR-3 expression is important for altering lymphatic endothelial cell (LEC) characteristics during the lymphangiogenic processes that occur under developmental, physiological, and pathological conditions. However, the mechanisms underlying the modulation of <italic>Vegfr3</italic> gene expression remain largely unknown. Using genetically engineered mice and LECs, we demonstrated previously that Ras signaling is involved not only in VEGFR-3-induced signal transduction but also in <italic>Vegfr3</italic> gene expression. Here, we investigated the roles of the transcription factor Ets and the histone acetyltransferase p300 in LECs in Ras-mediated transcriptional regulation of <italic>Vegfr3</italic>. Ras activates Ets proteins via MAPK-induced phosphorylation. Ets knockdown, similar to Ras knockdown, resulted in a decrease in both <italic>Vegfr3</italic> transcript levels and acetylated histone H3 on the <italic>Vegfr3</italic> gene. <italic>Vegfr3</italic> knockdown results in altered LEC phenotypes, such as aberrant cell proliferation and network formation, and Ets knockdown led to milder but similar phenotypic changes. We identified evolutionarily conserved, non-coding regulatory elements within the <italic>Vegfr3</italic> gene that harbor Ets-binding motifs and have enhancer activities in LECs. Chromatin immunoprecipitation (ChIP) assays revealed that acetylated histone H3 on the regulatory elements of the <italic>Vegfr3</italic> gene was decreased following Ras and Ets knockdown, and that activated Ets proteins, together with p300, were associated with these regulatory elements, consistent with a reduction in <italic>Vegfr3</italic> gene expression in p300-knockdown LECs. Our findings demonstrate a link between Ras signaling and Ets- and p300-mediated transcriptional regulation of <italic>Vegfr3</italic>, and provide a potential mechanism by which VEGFR-3 expression levels may be modulated during lymphangiogenesis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name></author><author><name sortKey="Ferrell, Re" uniqKey="Ferrell R">RE Ferrell</name></author><author><name sortKey="Lawrence, Ec" uniqKey="Lawrence E">EC Lawrence</name></author><author><name sortKey="Kimak, Ma" uniqKey="Kimak M">MA Kimak</name></author><author><name sortKey="Levinson, Kl" uniqKey="Levinson K">KL Levinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name></author><author><name sortKey="Saaristo, A" uniqKey="Saaristo A">A Saaristo</name></author><author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name></author><author><name sortKey="Karila, Ka" uniqKey="Karila K">KA Karila</name></author><author><name sortKey="Lawrence, Ec" uniqKey="Lawrence E">EC Lawrence</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haiko, P" uniqKey="Haiko P">P Haiko</name></author><author><name sortKey="Makinen, T" uniqKey="Makinen T">T Makinen</name></author><author><name sortKey="Keskitalo, S" uniqKey="Keskitalo S">S Keskitalo</name></author><author><name sortKey="Taipale, J" uniqKey="Taipale J">J Taipale</name></author><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Zhou, F" uniqKey="Zhou F">F Zhou</name></author><author><name sortKey="Han, W" uniqKey="Han W">W Han</name></author><author><name sortKey="Shen, B" uniqKey="Shen B">B Shen</name></author><author><name sortKey="Luo, J" uniqKey="Luo J">J Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dumont, Dj" uniqKey="Dumont D">DJ Dumont</name></author><author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name></author><author><name sortKey="Taipale, J" uniqKey="Taipale J">J Taipale</name></author><author><name sortKey="Lymboussaki, A" uniqKey="Lymboussaki A">A Lymboussaki</name></author><author><name sortKey="Mustonen, T" uniqKey="Mustonen T">T Mustonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name></author><author><name sortKey="Haiko, P" uniqKey="Haiko P">P Haiko</name></author><author><name sortKey="Sainio, K" uniqKey="Sainio K">K Sainio</name></author><author><name sortKey="Partanen, J" uniqKey="Partanen J">J Partanen</name></author><author><name sortKey="Taipale, J" uniqKey="Taipale J">J Taipale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Kozaki, K" uniqKey="Kozaki K">K Kozaki</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Koshikawa, K" uniqKey="Koshikawa K">K Koshikawa</name></author><author><name sortKey="Yla Herttuala, S" uniqKey="Yla Herttuala S">S Yla-Herttuala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pytowski, B" uniqKey="Pytowski B">B Pytowski</name></author><author><name sortKey="Goldman, J" uniqKey="Goldman J">J Goldman</name></author><author><name sortKey="Persaud, K" uniqKey="Persaud K">K Persaud</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Witte, L" uniqKey="Witte L">L Witte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baluk, P" uniqKey="Baluk P">P Baluk</name></author><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Ator, E" uniqKey="Ator E">E Ator</name></author><author><name sortKey="Lyubynska, N" uniqKey="Lyubynska N">N Lyubynska</name></author><author><name sortKey="Achen, Mg" uniqKey="Achen M">MG Achen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flister, Mj" uniqKey="Flister M">MJ Flister</name></author><author><name sortKey="Wilber, A" uniqKey="Wilber A">A Wilber</name></author><author><name sortKey="Hall, Kl" uniqKey="Hall K">KL Hall</name></author><author><name sortKey="Iwata, C" uniqKey="Iwata C">C Iwata</name></author><author><name sortKey="Miyazono, K" uniqKey="Miyazono K">K Miyazono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huggenberger, R" uniqKey="Huggenberger R">R Huggenberger</name></author><author><name sortKey="Siddiqui, Ss" uniqKey="Siddiqui S">SS Siddiqui</name></author><author><name sortKey="Brander, D" uniqKey="Brander D">D Brander</name></author><author><name sortKey="Ullmann, S" uniqKey="Ullmann S">S Ullmann</name></author><author><name sortKey="Zimmermann, K" uniqKey="Zimmermann K">K Zimmermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshimatsu, Y" uniqKey="Yoshimatsu Y">Y Yoshimatsu</name></author><author><name sortKey="Yamazaki, T" uniqKey="Yamazaki T">T Yamazaki</name></author><author><name sortKey="Mihira, H" uniqKey="Mihira H">H Mihira</name></author><author><name sortKey="Itoh, T" uniqKey="Itoh T">T Itoh</name></author><author><name sortKey="Suehiro, J" uniqKey="Suehiro J">J Suehiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, D" uniqKey="Jones D">D Jones</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Hy" uniqKey="Huang H">HY Huang</name></author><author><name sortKey="Ho, Cc" uniqKey="Ho C">CC Ho</name></author><author><name sortKey="Huang, Ph" uniqKey="Huang P">PH Huang</name></author><author><name sortKey="Hsu, Sm" uniqKey="Hsu S">SM Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Yk" uniqKey="Hong Y">YK Hong</name></author><author><name sortKey="Foreman, K" uniqKey="Foreman K">K Foreman</name></author><author><name sortKey="Shin, Jw" uniqKey="Shin J">JW Shin</name></author><author><name sortKey="Hirakawa, S" uniqKey="Hirakawa S">S Hirakawa</name></author><author><name sortKey="Curry, Cl" uniqKey="Curry C">CL Curry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Hw" uniqKey="Wang H">HW Wang</name></author><author><name sortKey="Trotter, Mw" uniqKey="Trotter M">MW Trotter</name></author><author><name sortKey="Lagos, D" uniqKey="Lagos D">D Lagos</name></author><author><name sortKey="Bourboulia, D" uniqKey="Bourboulia D">D Bourboulia</name></author><author><name sortKey="Henderson, S" uniqKey="Henderson S">S Henderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iljin, K" uniqKey="Iljin K">K Iljin</name></author><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name></author><author><name sortKey="Lawrence, Ec" uniqKey="Lawrence E">EC Lawrence</name></author><author><name sortKey="Kimak, Ma" uniqKey="Kimak M">MA Kimak</name></author><author><name sortKey="Uutela, M" uniqKey="Uutela M">M Uutela</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shawber, Cj" uniqKey="Shawber C">CJ Shawber</name></author><author><name sortKey="Funahashi, Y" uniqKey="Funahashi Y">Y Funahashi</name></author><author><name sortKey="Francisco, E" uniqKey="Francisco E">E Francisco</name></author><author><name sortKey="Vorontchikhina, M" uniqKey="Vorontchikhina M">M Vorontchikhina</name></author><author><name sortKey="Kitamura, Y" uniqKey="Kitamura Y">Y Kitamura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Yk" uniqKey="Hong Y">YK Hong</name></author><author><name sortKey="Harvey, N" uniqKey="Harvey N">N Harvey</name></author><author><name sortKey="Noh, Yh" uniqKey="Noh Y">YH Noh</name></author><author><name sortKey="Schacht, V" uniqKey="Schacht V">V Schacht</name></author><author><name sortKey="Hirakawa, S" uniqKey="Hirakawa S">S Hirakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petrova, Tv" uniqKey="Petrova T">TV Petrova</name></author><author><name sortKey="Makinen, T" uniqKey="Makinen T">T Makinen</name></author><author><name sortKey="Makela, Tp" uniqKey="Makela T">TP Makela</name></author><author><name sortKey="Saarela, J" uniqKey="Saarela J">J Saarela</name></author><author><name sortKey="Virtanen, I" uniqKey="Virtanen I">I Virtanen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mishima, K" uniqKey="Mishima K">K Mishima</name></author><author><name sortKey="Watabe, T" uniqKey="Watabe T">T Watabe</name></author><author><name sortKey="Saito, A" uniqKey="Saito A">A Saito</name></author><author><name sortKey="Yoshimatsu, Y" uniqKey="Yoshimatsu Y">Y Yoshimatsu</name></author><author><name sortKey="Imaizumi, N" uniqKey="Imaizumi N">N Imaizumi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, Mr" uniqKey="Pan M">MR Pan</name></author><author><name sortKey="Chang, Tm" uniqKey="Chang T">TM Chang</name></author><author><name sortKey="Chang, Hc" uniqKey="Chang H">HC Chang</name></author><author><name sortKey="Su, Jl" uniqKey="Su J">JL Su</name></author><author><name sortKey="Wang, Hw" uniqKey="Wang H">HW Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name></author><author><name sortKey="Kang, J" uniqKey="Kang J">J Kang</name></author><author><name sortKey="Yoo, J" uniqKey="Yoo J">J Yoo</name></author><author><name sortKey="Ganesan, Sk" uniqKey="Ganesan S">SK Ganesan</name></author><author><name sortKey="Cook, Sc" uniqKey="Cook S">SC Cook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Mupo, A" uniqKey="Mupo A">A Mupo</name></author><author><name sortKey="Huynh, T" uniqKey="Huynh T">T Huynh</name></author><author><name sortKey="Cioffi, S" uniqKey="Cioffi S">S Cioffi</name></author><author><name sortKey="Woods, M" uniqKey="Woods M">M Woods</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ichise, T" uniqKey="Ichise T">T Ichise</name></author><author><name sortKey="Yoshida, N" uniqKey="Yoshida N">N Yoshida</name></author><author><name sortKey="Ichise, H" uniqKey="Ichise H">H Ichise</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hollenhorst, Pc" uniqKey="Hollenhorst P">PC Hollenhorst</name></author><author><name sortKey="Mcintosh, Lp" uniqKey="Mcintosh L">LP McIntosh</name></author><author><name sortKey="Graves, Bj" uniqKey="Graves B">BJ Graves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunner, D" uniqKey="Brunner D">D Brunner</name></author><author><name sortKey="Ducker, K" uniqKey="Ducker K">K Ducker</name></author><author><name sortKey="Oellers, N" uniqKey="Oellers N">N Oellers</name></author><author><name sortKey="Hafen, E" uniqKey="Hafen E">E Hafen</name></author><author><name sortKey="Scholz, H" uniqKey="Scholz H">H Scholz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Eill, Em" uniqKey="O Eill E">EM O’Neill</name></author><author><name sortKey="Rebay, I" uniqKey="Rebay I">I Rebay</name></author><author><name sortKey="Tjian, R" uniqKey="Tjian R">R Tjian</name></author><author><name sortKey="Rubin, Gm" uniqKey="Rubin G">GM Rubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Bs" uniqKey="Yang B">BS Yang</name></author><author><name sortKey="Hauser, Ca" uniqKey="Hauser C">CA Hauser</name></author><author><name sortKey="Henkel, G" uniqKey="Henkel G">G Henkel</name></author><author><name sortKey="Colman, Ms" uniqKey="Colman M">MS Colman</name></author><author><name sortKey="Van Beveren, C" uniqKey="Van Beveren C">C Van Beveren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wasylyk, C" uniqKey="Wasylyk C">C Wasylyk</name></author><author><name sortKey="Bradford, Ap" uniqKey="Bradford A">AP Bradford</name></author><author><name sortKey="Gutierrez Hartmann, A" uniqKey="Gutierrez Hartmann A">A Gutierrez-Hartmann</name></author><author><name sortKey="Wasylyk, B" uniqKey="Wasylyk B">B Wasylyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Val, S" uniqKey="De Val S">S De Val</name></author><author><name sortKey="Black, Bl" uniqKey="Black B">BL Black</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meadows, Sm" uniqKey="Meadows S">SM Meadows</name></author><author><name sortKey="Myers, Ct" uniqKey="Myers C">CT Myers</name></author><author><name sortKey="Krieg, Pa" uniqKey="Krieg P">PA Krieg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Val, S" uniqKey="De Val S">S De Val</name></author><author><name sortKey="Chi, Nc" uniqKey="Chi N">NC Chi</name></author><author><name sortKey="Meadows, Sm" uniqKey="Meadows S">SM Meadows</name></author><author><name sortKey="Minovitsky, S" uniqKey="Minovitsky S">S Minovitsky</name></author><author><name sortKey="Anderson, Jp" uniqKey="Anderson J">JP Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bedford, Dc" uniqKey="Bedford D">DC Bedford</name></author><author><name sortKey="Kasper, Lh" uniqKey="Kasper L">LH Kasper</name></author><author><name sortKey="Fukuyama, T" uniqKey="Fukuyama T">T Fukuyama</name></author><author><name sortKey="Brindle, Pk" uniqKey="Brindle P">PK Brindle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Foulds, Ce" uniqKey="Foulds C">CE Foulds</name></author><author><name sortKey="Nelson, Ml" uniqKey="Nelson M">ML Nelson</name></author><author><name sortKey="Blaszczak, Ag" uniqKey="Blaszczak A">AG Blaszczak</name></author><author><name sortKey="Graves, Bj" uniqKey="Graves B">BJ Graves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, Ml" uniqKey="Nelson M">ML Nelson</name></author><author><name sortKey="Kang, Hs" uniqKey="Kang H">HS Kang</name></author><author><name sortKey="Lee, Gm" uniqKey="Lee G">GM Lee</name></author><author><name sortKey="Blaszczak, Ag" uniqKey="Blaszczak A">AG Blaszczak</name></author><author><name sortKey="Lau, Dk" uniqKey="Lau D">DK Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, G" uniqKey="Wei G">G Wei</name></author><author><name sortKey="Srinivasan, R" uniqKey="Srinivasan R">R Srinivasan</name></author><author><name sortKey="Cantemir Stone, Cz" uniqKey="Cantemir Stone C">CZ Cantemir-Stone</name></author><author><name sortKey="Sharma, Sm" uniqKey="Sharma S">SM Sharma</name></author><author><name sortKey="Santhanam, R" uniqKey="Santhanam R">R Santhanam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lapinski, Pe" uniqKey="Lapinski P">PE Lapinski</name></author><author><name sortKey="Kwon, S" uniqKey="Kwon S">S Kwon</name></author><author><name sortKey="Lubeck, Ba" uniqKey="Lubeck B">BA Lubeck</name></author><author><name sortKey="Wilkinson, Je" uniqKey="Wilkinson J">JE Wilkinson</name></author><author><name sortKey="Srinivasan, Rs" uniqKey="Srinivasan R">RS Srinivasan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Zarkada, G" uniqKey="Zarkada G">G Zarkada</name></author><author><name sortKey="Wallgard, E" uniqKey="Wallgard E">E Wallgard</name></author><author><name sortKey="Murtomaki, A" uniqKey="Murtomaki A">A Murtomaki</name></author><author><name sortKey="Suchting, S" uniqKey="Suchting S">S Suchting</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shikama, N" uniqKey="Shikama N">N Shikama</name></author><author><name sortKey="Lutz, W" uniqKey="Lutz W">W Lutz</name></author><author><name sortKey="Kretzschmar, R" uniqKey="Kretzschmar R">R Kretzschmar</name></author><author><name sortKey="Sauter, N" uniqKey="Sauter N">N Sauter</name></author><author><name sortKey="Roth, Jf" uniqKey="Roth J">JF Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamaguchi, T" uniqKey="Yamaguchi T">T Yamaguchi</name></author><author><name sortKey="Ichise, T" uniqKey="Ichise T">T Ichise</name></author><author><name sortKey="Iwata, O" uniqKey="Iwata O">O Iwata</name></author><author><name sortKey="Hori, A" uniqKey="Hori A">A Hori</name></author><author><name sortKey="Adachi, T" uniqKey="Adachi T">T Adachi</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003F46 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 003F46 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Curation
|type= RBID
|clé= PMC:3524184
|texte= Ras/MAPK Signaling Modulates VEGFR-3 Expression through Ets-Mediated p300 Recruitment and Histone Acetylation on the Vegfr3 Gene in Lymphatic Endothelial Cells
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:23284731" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |