Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature
Identifieur interne : 002146 ( Main/Curation ); précédent : 002145; suivant : 002147Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature
Auteurs : Lifang Cui ; Jixin Zhang [République populaire de Chine] ; Xinmin Zhang [États-Unis] ; Hong Chang ; Congling Qu ; Jiangying Zhang ; Dingrong Zhong [République populaire de Chine]Source :
- International Journal of Clinical and Experimental Pathology [ 1936-2625 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Biopsie, Détection précoce de cancer, Facteurs de risque, Facteurs temps, Femelle, Humains, Hémangiosarcome (), Hémangiosarcome (diagnostic), Hémangiosarcome (étiologie), Immunohistochimie, Issue fatale, Lymphangiosarcome (), Lymphangiosarcome (diagnostic), Lymphangiosarcome (étiologie), Marqueurs biologiques tumoraux (analyse), Mastectomie (effets indésirables), Radiothérapie adjuvante (effets indésirables), Résultat thérapeutique, Sujet âgé, Tumeurs du sein (), Tumeurs du sein (radiothérapie), Tumeurs radio-induites (), Tumeurs radio-induites (diagnostic), Tumeurs radio-induites (étiologie), Valeur prédictive des tests, Études rétrospectives.
- MESH :
- analyse : Marqueurs biologiques tumoraux.
- diagnostic : Hémangiosarcome, Lymphangiosarcome, Tumeurs radio-induites.
- effets indésirables : Mastectomie, Radiothérapie adjuvante.
- radiothérapie : Tumeurs du sein.
- étiologie : Hémangiosarcome, Lymphangiosarcome, Tumeurs radio-induites.
- Adulte, Adulte d'âge moyen, Biopsie, Détection précoce de cancer, Facteurs de risque, Facteurs temps, Femelle, Humains, Hémangiosarcome, Immunohistochimie, Issue fatale, Lymphangiosarcome, Résultat thérapeutique, Sujet âgé, Tumeurs du sein, Tumeurs radio-induites, Valeur prédictive des tests, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Biomarkers, Tumor (analysis), Biopsy, Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Early Detection of Cancer, Fatal Outcome, Female, Hemangiosarcoma (chemistry), Hemangiosarcoma (diagnosis), Hemangiosarcoma (etiology), Hemangiosarcoma (therapy), Humans, Immunohistochemistry, Lymphangiosarcoma (chemistry), Lymphangiosarcoma (diagnosis), Lymphangiosarcoma (etiology), Lymphangiosarcoma (therapy), Mastectomy (adverse effects), Middle Aged, Neoplasms, Radiation-Induced (chemistry), Neoplasms, Radiation-Induced (diagnosis), Neoplasms, Radiation-Induced (etiology), Neoplasms, Radiation-Induced (therapy), Predictive Value of Tests, Radiotherapy, Adjuvant (adverse effects), Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome.
- MESH :
- chemical , analysis : Biomarkers, Tumor.
- adverse effects : Mastectomy, Radiotherapy, Adjuvant.
- chemistry : Hemangiosarcoma, Lymphangiosarcoma, Neoplasms, Radiation-Induced.
- diagnosis : Hemangiosarcoma, Lymphangiosarcoma, Neoplasms, Radiation-Induced.
- etiology : Hemangiosarcoma, Lymphangiosarcoma, Neoplasms, Radiation-Induced.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- therapy : Hemangiosarcoma, Lymphangiosarcoma, Neoplasms, Radiation-Induced.
- Adult, Aged, Biopsy, Early Detection of Cancer, Fatal Outcome, Female, Humans, Immunohistochemistry, Middle Aged, Predictive Value of Tests, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome.
Abstract
Aims: To study the clinicopathologic features of Stewart-Treves syndrome (STS) in postmastectomy patients including the epidemiology, presentation, morphology, differentiation, pathogenesis and therapeutic options. Methods and results: Ten cases of STS in postmastectomy patients were retrospectively identified in our archives, and immunohistochemistry for CD34, CD31, D2-40, HHV-8, CK, EMA and Ki-67 was performed. All ten patients presented with lymphedema after mastectomy as the first sign. Physical examination revealed multiple raised, pinkish-red papulo-vesicular lesions or ulceration as the early evidence of tumor in the field where radiation therapy was introduced. Microscopic examination revealed infiltrative proliferation of vessels and the heteromorphic tumor cells expressed CD34, CD31 and D2-40. Despite the various treatment modalities, 5 patients died in an average of 19 months, 4 patients survived to the last follow-up (9-31 months), and 1 patient got lost. Conclusions: STS is a fatal complication of postmastectomy lymphedema. Patients with STS have very poor prognosis. The key to improve patient’s survival is the early diagnosis through a high alert of this disease by primary care physicians and comprehensive physical examination of patients with pertinent history and suspicious clinical presentations followed by prompt biopsy for definitive diagnosis.
Url:
PubMed: 26617830
PubMed Central: 4637645
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<term>Aged</term>
<term>Biomarkers, Tumor (analysis)</term>
<term>Biopsy</term>
<term>Breast Neoplasms (radiotherapy)</term>
<term>Breast Neoplasms (surgery)</term>
<term>Early Detection of Cancer</term>
<term>Fatal Outcome</term>
<term>Female</term>
<term>Hemangiosarcoma (chemistry)</term>
<term>Hemangiosarcoma (diagnosis)</term>
<term>Hemangiosarcoma (etiology)</term>
<term>Hemangiosarcoma (therapy)</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Lymphangiosarcoma (chemistry)</term>
<term>Lymphangiosarcoma (diagnosis)</term>
<term>Lymphangiosarcoma (etiology)</term>
<term>Lymphangiosarcoma (therapy)</term>
<term>Mastectomy (adverse effects)</term>
<term>Middle Aged</term>
<term>Neoplasms, Radiation-Induced (chemistry)</term>
<term>Neoplasms, Radiation-Induced (diagnosis)</term>
<term>Neoplasms, Radiation-Induced (etiology)</term>
<term>Neoplasms, Radiation-Induced (therapy)</term>
<term>Predictive Value of Tests</term>
<term>Radiotherapy, Adjuvant (adverse effects)</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Détection précoce de cancer</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémangiosarcome ()</term>
<term>Hémangiosarcome (diagnostic)</term>
<term>Hémangiosarcome (étiologie)</term>
<term>Immunohistochimie</term>
<term>Issue fatale</term>
<term>Lymphangiosarcome ()</term>
<term>Lymphangiosarcome (diagnostic)</term>
<term>Lymphangiosarcome (étiologie)</term>
<term>Marqueurs biologiques tumoraux (analyse)</term>
<term>Mastectomie (effets indésirables)</term>
<term>Radiothérapie adjuvante (effets indésirables)</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Tumeurs du sein ()</term>
<term>Tumeurs du sein (radiothérapie)</term>
<term>Tumeurs radio-induites ()</term>
<term>Tumeurs radio-induites (diagnostic)</term>
<term>Tumeurs radio-induites (étiologie)</term>
<term>Valeur prédictive des tests</term>
<term>Études rétrospectives</term>
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</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Mastectomy</term>
<term>Radiotherapy, Adjuvant</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Marqueurs biologiques tumoraux</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hemangiosarcoma</term>
<term>Lymphangiosarcoma</term>
<term>Neoplasms, Radiation-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hemangiosarcoma</term>
<term>Lymphangiosarcoma</term>
<term>Neoplasms, Radiation-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hémangiosarcome</term>
<term>Lymphangiosarcome</term>
<term>Tumeurs radio-induites</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Mastectomie</term>
<term>Radiothérapie adjuvante</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hemangiosarcoma</term>
<term>Lymphangiosarcoma</term>
<term>Neoplasms, Radiation-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hemangiosarcoma</term>
<term>Lymphangiosarcoma</term>
<term>Neoplasms, Radiation-Induced</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hémangiosarcome</term>
<term>Lymphangiosarcome</term>
<term>Tumeurs radio-induites</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Biopsy</term>
<term>Early Detection of Cancer</term>
<term>Fatal Outcome</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Middle Aged</term>
<term>Predictive Value of Tests</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Détection précoce de cancer</term>
<term>Facteurs de risque</term>
<term>Facteurs temps</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hémangiosarcome</term>
<term>Immunohistochimie</term>
<term>Issue fatale</term>
<term>Lymphangiosarcome</term>
<term>Résultat thérapeutique</term>
<term>Sujet âgé</term>
<term>Tumeurs du sein</term>
<term>Tumeurs radio-induites</term>
<term>Valeur prédictive des tests</term>
<term>Études rétrospectives</term>
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<front><div type="abstract" xml:lang="en"><p>Aims: To study the clinicopathologic features of Stewart-Treves syndrome (STS) in postmastectomy patients including the epidemiology, presentation, morphology, differentiation, pathogenesis and therapeutic options. Methods and results: Ten cases of STS in postmastectomy patients were retrospectively identified in our archives, and immunohistochemistry for CD34, CD31, D2-40, HHV-8, CK, EMA and Ki-67 was performed. All ten patients presented with lymphedema after mastectomy as the first sign. Physical examination revealed multiple raised, pinkish-red papulo-vesicular lesions or ulceration as the early evidence of tumor in the field where radiation therapy was introduced. Microscopic examination revealed infiltrative proliferation of vessels and the heteromorphic tumor cells expressed CD34, CD31 and D2-40. Despite the various treatment modalities, 5 patients died in an average of 19 months, 4 patients survived to the last follow-up (9-31 months), and 1 patient got lost. Conclusions: STS is a fatal complication of postmastectomy lymphedema. Patients with STS have very poor prognosis. The key to improve patient’s survival is the early diagnosis through a high alert of this disease by primary care physicians and comprehensive physical examination of patients with pertinent history and suspicious clinical presentations followed by prompt biopsy for definitive diagnosis.</p>
</div>
</front>
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