Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature
Identifieur interne : 002146 ( Main/Curation ); précédent : 002145; suivant : 002147Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature
Auteurs : Lifang Cui ; Jixin Zhang [République populaire de Chine] ; Xinmin Zhang [États-Unis] ; Hong Chang ; Congling Qu ; Jiangying Zhang ; Dingrong Zhong [République populaire de Chine]Source :
- International Journal of Clinical and Experimental Pathology [ 1936-2625 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Biopsie, Détection précoce de cancer, Facteurs de risque, Facteurs temps, Femelle, Humains, Hémangiosarcome (), Hémangiosarcome (diagnostic), Hémangiosarcome (étiologie), Immunohistochimie, Issue fatale, Lymphangiosarcome (), Lymphangiosarcome (diagnostic), Lymphangiosarcome (étiologie), Marqueurs biologiques tumoraux (analyse), Mastectomie (effets indésirables), Radiothérapie adjuvante (effets indésirables), Résultat thérapeutique, Sujet âgé, Tumeurs du sein (), Tumeurs du sein (radiothérapie), Tumeurs radio-induites (), Tumeurs radio-induites (diagnostic), Tumeurs radio-induites (étiologie), Valeur prédictive des tests, Études rétrospectives.
- MESH :
- analyse : Marqueurs biologiques tumoraux.
- diagnostic : Hémangiosarcome, Lymphangiosarcome, Tumeurs radio-induites.
- effets indésirables : Mastectomie, Radiothérapie adjuvante.
- radiothérapie : Tumeurs du sein.
- étiologie : Hémangiosarcome, Lymphangiosarcome, Tumeurs radio-induites.
- Adulte, Adulte d'âge moyen, Biopsie, Détection précoce de cancer, Facteurs de risque, Facteurs temps, Femelle, Humains, Hémangiosarcome, Immunohistochimie, Issue fatale, Lymphangiosarcome, Résultat thérapeutique, Sujet âgé, Tumeurs du sein, Tumeurs radio-induites, Valeur prédictive des tests, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Biomarkers, Tumor (analysis), Biopsy, Breast Neoplasms (radiotherapy), Breast Neoplasms (surgery), Early Detection of Cancer, Fatal Outcome, Female, Hemangiosarcoma (chemistry), Hemangiosarcoma (diagnosis), Hemangiosarcoma (etiology), Hemangiosarcoma (therapy), Humans, Immunohistochemistry, Lymphangiosarcoma (chemistry), Lymphangiosarcoma (diagnosis), Lymphangiosarcoma (etiology), Lymphangiosarcoma (therapy), Mastectomy (adverse effects), Middle Aged, Neoplasms, Radiation-Induced (chemistry), Neoplasms, Radiation-Induced (diagnosis), Neoplasms, Radiation-Induced (etiology), Neoplasms, Radiation-Induced (therapy), Predictive Value of Tests, Radiotherapy, Adjuvant (adverse effects), Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome.
- MESH :
- chemical , analysis : Biomarkers, Tumor.
- adverse effects : Mastectomy, Radiotherapy, Adjuvant.
- chemistry : Hemangiosarcoma, Lymphangiosarcoma, Neoplasms, Radiation-Induced.
- diagnosis : Hemangiosarcoma, Lymphangiosarcoma, Neoplasms, Radiation-Induced.
- etiology : Hemangiosarcoma, Lymphangiosarcoma, Neoplasms, Radiation-Induced.
- radiotherapy : Breast Neoplasms.
- surgery : Breast Neoplasms.
- therapy : Hemangiosarcoma, Lymphangiosarcoma, Neoplasms, Radiation-Induced.
- Adult, Aged, Biopsy, Early Detection of Cancer, Fatal Outcome, Female, Humans, Immunohistochemistry, Middle Aged, Predictive Value of Tests, Retrospective Studies, Risk Factors, Time Factors, Treatment Outcome.
Abstract
Aims: To study the clinicopathologic features of Stewart-Treves syndrome (STS) in postmastectomy patients including the epidemiology, presentation, morphology, differentiation, pathogenesis and therapeutic options. Methods and results: Ten cases of STS in postmastectomy patients were retrospectively identified in our archives, and immunohistochemistry for CD34, CD31, D2-40, HHV-8, CK, EMA and Ki-67 was performed. All ten patients presented with lymphedema after mastectomy as the first sign. Physical examination revealed multiple raised, pinkish-red papulo-vesicular lesions or ulceration as the early evidence of tumor in the field where radiation therapy was introduced. Microscopic examination revealed infiltrative proliferation of vessels and the heteromorphic tumor cells expressed CD34, CD31 and D2-40. Despite the various treatment modalities, 5 patients died in an average of 19 months, 4 patients survived to the last follow-up (9-31 months), and 1 patient got lost. Conclusions: STS is a fatal complication of postmastectomy lymphedema. Patients with STS have very poor prognosis. The key to improve patient’s survival is the early diagnosis through a high alert of this disease by primary care physicians and comprehensive physical examination of patients with pertinent history and suspicious clinical presentations followed by prompt biopsy for definitive diagnosis.
Url:
PubMed: 26617830
PubMed Central: 4637645
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000275
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000275
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001511
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000B19
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000B19
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000B19
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :007B76
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :007B76
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :007B76
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002149
Links to Exploration step
PMC:4637645Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature</title><author><name sortKey="Cui, Lifang" sort="Cui, Lifang" uniqKey="Cui L" first="Lifang" last="Cui">Lifang Cui</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Beijing Shijitan Hospital, Capital Medical University</institution><addr-line>China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhang, Jixin" sort="Zhang, Jixin" uniqKey="Zhang J" first="Jixin" last="Zhang">Jixin Zhang</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pathology, Peking University First Hospital</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Xinmin" sort="Zhang, Xinmin" uniqKey="Zhang X" first="Xinmin" last="Zhang">Xinmin Zhang</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Department of Pathology and Laboratory Medicine, Temple University Hospital</institution><addr-line>Philadelphia, PA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Philadelphia, PA</wicri:regionArea><wicri:noRegion>PA</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Hong" sort="Chang, Hong" uniqKey="Chang H" first="Hong" last="Chang">Hong Chang</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Beijing Shijitan Hospital, Capital Medical University</institution><addr-line>China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Qu, Congling" sort="Qu, Congling" uniqKey="Qu C" first="Congling" last="Qu">Congling Qu</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Beijing Shijitan Hospital, Capital Medical University</institution><addr-line>China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhang, Jiangying" sort="Zhang, Jiangying" uniqKey="Zhang J" first="Jiangying" last="Zhang">Jiangying Zhang</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Beijing Shijitan Hospital, Capital Medical University</institution><addr-line>China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhong, Dingrong" sort="Zhong, Dingrong" uniqKey="Zhong D" first="Dingrong" last="Zhong">Dingrong Zhong</name><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College</institution><addr-line>Beijing 100730, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing 100730</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26617830</idno><idno type="pmc">4637645</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637645</idno><idno type="RBID">PMC:4637645</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000275</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000275</idno><idno type="wicri:Area/Pmc/Curation">000275</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000275</idno><idno type="wicri:Area/Pmc/Checkpoint">001511</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001511</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000B19</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B19</idno><idno type="wicri:Area/PubMed/Curation">000B19</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B19</idno><idno type="wicri:Area/PubMed/Checkpoint">000B19</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B19</idno><idno type="wicri:Area/Ncbi/Merge">007B76</idno><idno type="wicri:Area/Ncbi/Curation">007B76</idno><idno type="wicri:Area/Ncbi/Checkpoint">007B76</idno><idno type="wicri:Area/Main/Merge">002149</idno><idno type="wicri:Area/Main/Curation">002146</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature</title><author><name sortKey="Cui, Lifang" sort="Cui, Lifang" uniqKey="Cui L" first="Lifang" last="Cui">Lifang Cui</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Beijing Shijitan Hospital, Capital Medical University</institution><addr-line>China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhang, Jixin" sort="Zhang, Jixin" uniqKey="Zhang J" first="Jixin" last="Zhang">Jixin Zhang</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Department of Pathology, Peking University First Hospital</institution><addr-line>Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Xinmin" sort="Zhang, Xinmin" uniqKey="Zhang X" first="Xinmin" last="Zhang">Xinmin Zhang</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Department of Pathology and Laboratory Medicine, Temple University Hospital</institution><addr-line>Philadelphia, PA, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Philadelphia, PA</wicri:regionArea><wicri:noRegion>PA</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Hong" sort="Chang, Hong" uniqKey="Chang H" first="Hong" last="Chang">Hong Chang</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Beijing Shijitan Hospital, Capital Medical University</institution><addr-line>China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Qu, Congling" sort="Qu, Congling" uniqKey="Qu C" first="Congling" last="Qu">Congling Qu</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Beijing Shijitan Hospital, Capital Medical University</institution><addr-line>China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhang, Jiangying" sort="Zhang, Jiangying" uniqKey="Zhang J" first="Jiangying" last="Zhang">Jiangying Zhang</name><affiliation><nlm:aff id="au1"><institution>Department of Pathology, Beijing Shijitan Hospital, Capital Medical University</institution><addr-line>China</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhong, Dingrong" sort="Zhong, Dingrong" uniqKey="Zhong D" first="Dingrong" last="Zhong">Dingrong Zhong</name><affiliation wicri:level="1"><nlm:aff id="au4"><institution>Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College</institution><addr-line>Beijing 100730, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Beijing 100730</wicri:regionArea></affiliation></author></analytic><series><title level="j">International Journal of Clinical and Experimental Pathology</title><idno type="eISSN">1936-2625</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biomarkers, Tumor (analysis)</term><term>Biopsy</term><term>Breast Neoplasms (radiotherapy)</term><term>Breast Neoplasms (surgery)</term><term>Early Detection of Cancer</term><term>Fatal Outcome</term><term>Female</term><term>Hemangiosarcoma (chemistry)</term><term>Hemangiosarcoma (diagnosis)</term><term>Hemangiosarcoma (etiology)</term><term>Hemangiosarcoma (therapy)</term><term>Humans</term><term>Immunohistochemistry</term><term>Lymphangiosarcoma (chemistry)</term><term>Lymphangiosarcoma (diagnosis)</term><term>Lymphangiosarcoma (etiology)</term><term>Lymphangiosarcoma (therapy)</term><term>Mastectomy (adverse effects)</term><term>Middle Aged</term><term>Neoplasms, Radiation-Induced (chemistry)</term><term>Neoplasms, Radiation-Induced (diagnosis)</term><term>Neoplasms, Radiation-Induced (etiology)</term><term>Neoplasms, Radiation-Induced (therapy)</term><term>Predictive Value of Tests</term><term>Radiotherapy, Adjuvant (adverse effects)</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Biopsie</term><term>Détection précoce de cancer</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Hémangiosarcome ()</term><term>Hémangiosarcome (diagnostic)</term><term>Hémangiosarcome (étiologie)</term><term>Immunohistochimie</term><term>Issue fatale</term><term>Lymphangiosarcome ()</term><term>Lymphangiosarcome (diagnostic)</term><term>Lymphangiosarcome (étiologie)</term><term>Marqueurs biologiques tumoraux (analyse)</term><term>Mastectomie (effets indésirables)</term><term>Radiothérapie adjuvante (effets indésirables)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (radiothérapie)</term><term>Tumeurs radio-induites ()</term><term>Tumeurs radio-induites (diagnostic)</term><term>Tumeurs radio-induites (étiologie)</term><term>Valeur prédictive des tests</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers, Tumor</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Mastectomy</term><term>Radiotherapy, Adjuvant</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Marqueurs biologiques tumoraux</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hemangiosarcoma</term><term>Lymphangiosarcoma</term><term>Neoplasms, Radiation-Induced</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hemangiosarcoma</term><term>Lymphangiosarcoma</term><term>Neoplasms, Radiation-Induced</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hémangiosarcome</term><term>Lymphangiosarcome</term><term>Tumeurs radio-induites</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Mastectomie</term><term>Radiothérapie adjuvante</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hemangiosarcoma</term><term>Lymphangiosarcoma</term><term>Neoplasms, Radiation-Induced</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hemangiosarcoma</term><term>Lymphangiosarcoma</term><term>Neoplasms, Radiation-Induced</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hémangiosarcome</term><term>Lymphangiosarcome</term><term>Tumeurs radio-induites</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biopsy</term><term>Early Detection of Cancer</term><term>Fatal Outcome</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Biopsie</term><term>Détection précoce de cancer</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Hémangiosarcome</term><term>Immunohistochimie</term><term>Issue fatale</term><term>Lymphangiosarcome</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Tumeurs du sein</term><term>Tumeurs radio-induites</term><term>Valeur prédictive des tests</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Aims: To study the clinicopathologic features of Stewart-Treves syndrome (STS) in postmastectomy patients including the epidemiology, presentation, morphology, differentiation, pathogenesis and therapeutic options. Methods and results: Ten cases of STS in postmastectomy patients were retrospectively identified in our archives, and immunohistochemistry for CD34, CD31, D2-40, HHV-8, CK, EMA and Ki-67 was performed. All ten patients presented with lymphedema after mastectomy as the first sign. Physical examination revealed multiple raised, pinkish-red papulo-vesicular lesions or ulceration as the early evidence of tumor in the field where radiation therapy was introduced. Microscopic examination revealed infiltrative proliferation of vessels and the heteromorphic tumor cells expressed CD34, CD31 and D2-40. Despite the various treatment modalities, 5 patients died in an average of 19 months, 4 patients survived to the last follow-up (9-31 months), and 1 patient got lost. Conclusions: STS is a fatal complication of postmastectomy lymphedema. Patients with STS have very poor prognosis. The key to improve patient’s survival is the early diagnosis through a high alert of this disease by primary care physicians and comprehensive physical examination of patients with pertinent history and suspicious clinical presentations followed by prompt biopsy for definitive diagnosis.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002146 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002146 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Curation
|type= RBID
|clé= PMC:4637645
|texte= Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:26617830" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |