LymphedemaV1, Main, Curation, bibRecord, 001928

Radiotherapy of the Lymphatic Pathways in Early Breast Cancer

Identifieur interne : 001928 ( Main/Curation ); précédent : 001927; suivant : 001929

Radiotherapy of the Lymphatic Pathways in Early Breast Cancer

Auteurs : Marie-Luise Sautter-Bihl [Allemagne] ; Felix Sedlmayer [Autriche]

Source :

Breast Care [ 1661-3791 ] ; 2015.

RBID : PMC:4608631

Abstract

Summary

International guidelines reveal substantial differences regarding indications for regional nodal irradiation (RNI). Recently, several randomized studies provided new insights and these are discussed here. Patients with 1-3 positive nodes seem to profit from RNI compared to whole-breast (WBI) or chest-wall irradiation (CWI) alone, both with regard to locoregional control and disease-free survival. Irradiation of the regional lymphatics including axillary, supraclavicular and internal mammary nodes provided a small but significant survival benefit in recent randomized trials and 1 meta-analysis. Lymph node irradiation yields comparable tumor control in comparison to axillary lymph node dissection while reducing the rate of lymph edema. Data concerning the impact of 1-2 macroscopically affected sentinel nodes or microscopic metastases on prognosis are equivocal. Recent data suggest that the current restrictive use of RNI should be scrutinized, as the hazard-benefit relation appears to shift towards an improvement of outcome.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608631

DOI: 10.1159/000438662
PubMed: 26600761
PubMed Central: 4608631

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PMC:4608631

Le document en format XML

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<affiliation wicri:level="1"><nlm:aff id="aff1">Klinik für Radioonkologie und Strahlentherapie, Städtisches Klinikum Karlsruhe, Germany</nlm:aff>
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<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Radiotherapy and Radiation Oncology, LKH Salzburg, Paracelsus Medical University Hospital, Salzburg, Austria</nlm:aff>
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<p>International guidelines reveal substantial differences regarding indications for regional nodal irradiation (RNI). Recently, several randomized studies provided new insights and these are discussed here. Patients with 1-3 positive nodes seem to profit from RNI compared to whole-breast (WBI) or chest-wall irradiation (CWI) alone, both with regard to locoregional control and disease-free survival. Irradiation of the regional lymphatics including axillary, supraclavicular and internal mammary nodes provided a small but significant survival benefit in recent randomized trials and 1 meta-analysis. Lymph node irradiation yields comparable tumor control in comparison to axillary lymph node dissection while reducing the rate of lymph edema. Data concerning the impact of 1-2 macroscopically affected sentinel nodes or microscopic metastases on prognosis are equivocal. Recent data suggest that the current restrictive use of RNI should be scrutinized, as the hazard-benefit relation appears to shift towards an improvement of outcome.</p>
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Radiotherapy of the Lymphatic Pathways in Early Breast Cancer

Radiotherapy of the Lymphatic Pathways in Early Breast Cancer

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki