Preoperative 5-fluorouracil and radiation therapy for locally advanced breast cancer
Identifieur interne : 006054 ( Istex/Curation ); précédent : 006053; suivant : 006055Preoperative 5-fluorouracil and radiation therapy for locally advanced breast cancer
Auteurs : Kristin A. Skinner [États-Unis] ; Gary Dunnington [États-Unis] ; Howard Silberman [États-Unis] ; Barbara Florentine [États-Unis] ; Darcy Spicer [États-Unis] ; Silvia C. Formenti [États-Unis]Source :
- The American Journal of Surgery [ 0002-9610 ] ; 1997.
Abstract
BackgroundFifteen percent of breast cancer patients present with large tumors involving skin or chest wall. Often, surgery with primary wound closure is impossible. We used neoadjuvant chemoradiation in locally advanced breast cancer patients, in hopes of increasing resectability.MethodsEligible patients had locally advanced breast cancer deemed unresectable with primary wound closure. Patients received 8 weeks of infusional 5-fluorouracil (5-FU) 200 mg/m2 per day and radiation therapy to 50 Gy. Patients rendered resectable underwent modified radical mastectomy (MRM) followed up by chemotherapy.ResultsOf 30 evaluable patients, 73% had an objective clinical response. All were able to undergo MRM with primary wound closure; 63% had residual disease, 20% had minimal microscopic disease, and 17% had complete pathologic response. Treatment-related toxicity was minimal. Surgical morbidity was not increased.ConclusionsInfusional 5-FU with concomitant radiotherapy is well tolerated and effective at producing shrinkage in the majority of patients, converting inoperable breast cancer to easily resectable disease.
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DOI: 10.1016/S0002-9610(97)00198-0
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Skinner</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Dunnington, Gary" sort="Dunnington, Gary" uniqKey="Dunnington G" first="Gary" last="Dunnington">Gary Dunnington</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Silberman, Howard" sort="Silberman, Howard" uniqKey="Silberman H" first="Howard" last="Silberman">Howard Silberman</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Florentine, Barbara" sort="Florentine, Barbara" uniqKey="Florentine B" first="Barbara" last="Florentine">Barbara Florentine</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Pathology, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Pathology, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Spicer, Darcy" sort="Spicer, Darcy" uniqKey="Spicer D" first="Darcy" last="Spicer">Darcy Spicer</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Medical Oncology, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Medical Oncology, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Formenti, Silvia C" sort="Formenti, Silvia C" uniqKey="Formenti S" first="Silvia C." last="Formenti">Silvia C. 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Skinner</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Dunnington, Gary" sort="Dunnington, Gary" uniqKey="Dunnington G" first="Gary" last="Dunnington">Gary Dunnington</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Silberman, Howard" sort="Silberman, Howard" uniqKey="Silberman H" first="Howard" last="Silberman">Howard Silberman</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Surgery, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Florentine, Barbara" sort="Florentine, Barbara" uniqKey="Florentine B" first="Barbara" last="Florentine">Barbara Florentine</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Pathology, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Pathology, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Spicer, Darcy" sort="Spicer, Darcy" uniqKey="Spicer D" first="Darcy" last="Spicer">Darcy Spicer</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Medical Oncology, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Medical Oncology, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author><author><name sortKey="Formenti, Silvia C" sort="Formenti, Silvia C" uniqKey="Formenti S" first="Silvia C." last="Formenti">Silvia C. Formenti</name><affiliation wicri:level="1"><mods:affiliation>From the Department of Radiation Oncology, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>From the Department of Radiation Oncology, University of Southern California School of Medicine and the Kenneth Norn's Comprehensive Cancer Center, Los Angeles, California</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">The American Journal of Surgery</title><title level="j" type="abbrev">AJS</title><idno type="ISSN">0002-9610</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">174</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="705">705</biblScope><biblScope unit="page" to="708">708</biblScope></imprint><idno type="ISSN">0002-9610</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9610</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BackgroundFifteen percent of breast cancer patients present with large tumors involving skin or chest wall. Often, surgery with primary wound closure is impossible. We used neoadjuvant chemoradiation in locally advanced breast cancer patients, in hopes of increasing resectability.MethodsEligible patients had locally advanced breast cancer deemed unresectable with primary wound closure. Patients received 8 weeks of infusional 5-fluorouracil (5-FU) 200 mg/m2 per day and radiation therapy to 50 Gy. Patients rendered resectable underwent modified radical mastectomy (MRM) followed up by chemotherapy.ResultsOf 30 evaluable patients, 73% had an objective clinical response. All were able to undergo MRM with primary wound closure; 63% had residual disease, 20% had minimal microscopic disease, and 17% had complete pathologic response. Treatment-related toxicity was minimal. Surgical morbidity was not increased.ConclusionsInfusional 5-FU with concomitant radiotherapy is well tolerated and effective at producing shrinkage in the majority of patients, converting inoperable breast cancer to easily resectable disease.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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