1033 The effects of primary chemotherapy on the complexity of breast cancer surgical treatment
Identifieur interne : 005518 ( Istex/Curation ); précédent : 005517; suivant : 0055191033 The effects of primary chemotherapy on the complexity of breast cancer surgical treatment
Auteurs : R. Hegg ; C. A. Ruiz ; W. W. Rezende ; L. C. Teixeira ; A. C. S. D. Barros ; A. C. T. Nisida ; J. A. Pinotti ; I. F. AguiarSource :
- European Journal of Cancer [ 0959-8049 ] ; 1995.
Abstract
The goal of this trial is to analyse the effect of primary chemotherapy on the complexity of the surgical treatment of breast cancer. From Feb 1990 through Oct 1994, 233 patients with palpable early stage breast cancer (stages I, II and III UICC/AJC) diagnosed through needle biopsy, received pre-operative chemotherapy with Epirrubicin (50mg/m2), Cyclophosphamide (500mg/m2) and 5-Fluouracil (500mg/m2) administered by IV infusion for 3 courses on 21 days cycles. The mean age of the group was 50.6years (2669). The response regarding clinical stage is summarized below.ClinicalStageNumber ofPatients (%)Clinical responseCR (%)PR (%)SD or PD (%)I27(12)12(44)11(41)4(15)II98(42)13(13)56(58)29(29)III108(46)7(7)81(75)20(18)With these results, 57 of the patients underwent less extent surgical treatment (41% QUART instead of radical mastectomy and 16% TART instead of QUART). No life-threatening complications were seen due to chemotherapy. The data demonstrate the feasibility of primary chemotherapy is early stage breast cancer, providing significant reduction in the extent of surgical treatment.
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DOI: 10.1016/0959-8049(95)96281-H
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