Activation of P44/42 Map Kinases within Human Epidermal Neoplasia.
Identifieur interne : 005240 ( Istex/Curation ); précédent : 005239; suivant : 005241Activation of P44/42 Map Kinases within Human Epidermal Neoplasia.
Auteurs : Bryon Jackson ; Rosalie Elenitsas ; John. T. SeykoraSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
Squamous cell carcinoma (SCC) arises from a series of genetic changes that form a clone of keratinocytes with enhanced growth characteristics. The p44/42 Map kinase pathway is a highly conserved growth regulatory pathway that helps relay critical signals from the cell membrane to the nucleus. Evidence demonstrating activation of the p44/42 pathway in the human cutaneous SCC has not been established. This study examined if p44/42 MAP kinase is activated in lesions of keratinocytic neoplasia. Lesions from the defined stages of keratinocytic neoplasia, normal skin, actinic keratoses, squamous cell carcinoma in situ, and squamous cell carcinoma, were randomly selected from archived material and studied. Antibodies that detect human p44/42 (phosphorylated and unphosphorylated) and only phosphorylated, activated, human p44/42 were used. The intensity and prevalence of cytoplasmic and nuclear staining was evaluated in the lesional cells. The results suggest that there is a not a simple linear relationship between the amount of nuclear staining and the type of lesion. The results show that there was a significant increase in the level of nuclear phosphorylated p44/42 staining progressing from an actinic keratoses to a sqaumous cell carcinoma in situ. These findings suggest that p44/42 MAP kinases are activated in keratinocytic neoplasia.
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DOI: 10.1111/j.0303-6987.2005.320de.x
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Bryon Jackson<affiliation><mods:affiliation>Department of Dermatology, University of Pennsylvania Medical School</mods:affiliation><wicri:noCountry code="subField">School</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Dermatology, University of Pennsylvania Medical School</mods:affiliation><wicri:noCountry code="subField">School</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Dermatology, University of Pennsylvania Medical School</mods:affiliation><wicri:noCountry code="subField">School</wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Activation of P44/42 Map Kinases within Human Epidermal Neoplasia.</title><author><name sortKey="Jackson, Bryon" sort="Jackson, Bryon" uniqKey="Jackson B" first="Bryon" last="Jackson">Bryon Jackson</name><affiliation><mods:affiliation>Department of Dermatology, University of Pennsylvania Medical School</mods:affiliation><wicri:noCountry code="subField">School</wicri:noCountry></affiliation></author><author><name sortKey="Elenitsas, Rosalie" sort="Elenitsas, Rosalie" uniqKey="Elenitsas R" first="Rosalie" last="Elenitsas">Rosalie Elenitsas</name><affiliation><mods:affiliation>Department of Dermatology, University of Pennsylvania Medical School</mods:affiliation><wicri:noCountry code="subField">School</wicri:noCountry></affiliation></author><author><name sortKey="Seykora, John T" sort="Seykora, John T" uniqKey="Seykora J" first="John. T" last="Seykora">John. T. Seykora</name><affiliation><mods:affiliation>Department of Dermatology, University of Pennsylvania Medical School</mods:affiliation><wicri:noCountry code="subField">School</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AF856211F5C76C2B1DC4755E17CACCDF80753F1E</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.0303-6987.2005.320de.x</idno><idno type="url">https://api.istex.fr/document/AF856211F5C76C2B1DC4755E17CACCDF80753F1E/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">005240</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">005240</idno><idno type="wicri:Area/Istex/Curation">005240</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Activation of P44/42 Map Kinases within Human Epidermal Neoplasia.</title><author><name sortKey="Jackson, Bryon" sort="Jackson, Bryon" uniqKey="Jackson B" first="Bryon" last="Jackson">Bryon Jackson</name><affiliation><mods:affiliation>Department of Dermatology, University of Pennsylvania Medical School</mods:affiliation><wicri:noCountry code="subField">School</wicri:noCountry></affiliation></author><author><name sortKey="Elenitsas, Rosalie" sort="Elenitsas, Rosalie" uniqKey="Elenitsas R" first="Rosalie" last="Elenitsas">Rosalie Elenitsas</name><affiliation><mods:affiliation>Department of Dermatology, University of Pennsylvania Medical School</mods:affiliation><wicri:noCountry code="subField">School</wicri:noCountry></affiliation></author><author><name sortKey="Seykora, John T" sort="Seykora, John T" uniqKey="Seykora J" first="John. T" last="Seykora">John. T. Seykora</name><affiliation><mods:affiliation>Department of Dermatology, University of Pennsylvania Medical School</mods:affiliation><wicri:noCountry code="subField">School</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="95">95</biblScope><biblScope unit="page" to="95">95</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Squamous cell carcinoma (SCC) arises from a series of genetic changes that form a clone of keratinocytes with enhanced growth characteristics. The p44/42 Map kinase pathway is a highly conserved growth regulatory pathway that helps relay critical signals from the cell membrane to the nucleus. Evidence demonstrating activation of the p44/42 pathway in the human cutaneous SCC has not been established. This study examined if p44/42 MAP kinase is activated in lesions of keratinocytic neoplasia. Lesions from the defined stages of keratinocytic neoplasia, normal skin, actinic keratoses, squamous cell carcinoma in situ, and squamous cell carcinoma, were randomly selected from archived material and studied. Antibodies that detect human p44/42 (phosphorylated and unphosphorylated) and only phosphorylated, activated, human p44/42 were used. The intensity and prevalence of cytoplasmic and nuclear staining was evaluated in the lesional cells. The results suggest that there is a not a simple linear relationship between the amount of nuclear staining and the type of lesion. The results show that there was a significant increase in the level of nuclear phosphorylated p44/42 staining progressing from an actinic keratoses to a sqaumous cell carcinoma in situ. These findings suggest that p44/42 MAP kinases are activated in keratinocytic neoplasia.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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