The alarmin HMGB‐1 influences healing outcomes in fetal skin wounds
Identifieur interne : 004F70 ( Istex/Curation ); précédent : 004F69; suivant : 004F71The alarmin HMGB‐1 influences healing outcomes in fetal skin wounds
Auteurs : Adrienne D. Dardenne ; Brian C. Wulff ; Traci A. Wilgus [États-Unis]Source :
- Wound Repair and Regeneration [ 1067-1927 ] ; 2013-03.
Abstract
In mice, cutaneous wounds generated early in development (embryonic day 15, E15) heal scarlessly, while wounds generated late in gestation (embryonic day 18, E18) heal with scar formation. Even though both types of wounds are generated in the same sterile uterine environment, scarless fetal wounds heal without inflammation, but a strong inflammatory response is observed in scar‐forming fetal wounds. We hypothesized that altered release of alarmins, endogenous molecules that trigger inflammation in response to damage, may be responsible for the age‐related changes in inflammation and healing outcomes in fetal skin. The purpose of this study was to determine whether the alarmin high‐mobility group box‐1 (HMGB‐1) is involved in fetal wound repair. Immunohistochemical analysis showed that in unwounded skin, E18 keratinocytes expressed higher levels of HMGB‐1 compared with E15 keratinocytes. After injury, HMGB‐1 was released to a greater extent from keratinocytes at the margin of scar‐forming E18 wounds, compared with scarless E15 wounds. Furthermore, instead of healing scarlessly, E15 wounds healed with scars when treated with HMGB‐1. HMGB‐1‐injected wounds also had more fibroblasts, blood vessels, and macrophages compared with control wounds. Together, these data suggest that extracellular HMGB‐1 levels influence the quality of healing in cutaneous wounds.
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DOI: 10.1111/wrr.12028
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Adrienne D. Dardenne<affiliation><mods:affiliation>Department of Veterinary Preventive Medicine, University Laboratory Animal Resources, The Ohio State University, Ohio, Columbus</mods:affiliation><wicri:noCountry code="subField">Columbus</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Pathology, The Ohio State University, Ohio, Columbus</mods:affiliation><wicri:noCountry code="subField">Columbus</wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The alarmin HMGB‐1 influences healing outcomes in fetal skin wounds</title><author><name sortKey="Dardenne, Adrienne D" sort="Dardenne, Adrienne D" uniqKey="Dardenne A" first="Adrienne D." last="Dardenne">Adrienne D. Dardenne</name><affiliation><mods:affiliation>Department of Veterinary Preventive Medicine, University Laboratory Animal Resources, The Ohio State University, Ohio, Columbus</mods:affiliation><wicri:noCountry code="subField">Columbus</wicri:noCountry></affiliation></author><author><name sortKey="Wulff, Brian C" sort="Wulff, Brian C" uniqKey="Wulff B" first="Brian C." last="Wulff">Brian C. Wulff</name><affiliation><mods:affiliation>Department of Pathology, The Ohio State University, Ohio, Columbus</mods:affiliation><wicri:noCountry code="subField">Columbus</wicri:noCountry></affiliation></author><author><name sortKey="Wilgus, Traci A" sort="Wilgus, Traci A" uniqKey="Wilgus T" first="Traci A." last="Wilgus">Traci A. Wilgus</name><affiliation><mods:affiliation>Department of Pathology, The Ohio State University, Ohio, Columbus</mods:affiliation><wicri:noCountry code="subField">Columbus</wicri:noCountry></affiliation><affiliation><mods:affiliation>Dr. Traci A. Wilgus, PhD, Department of Pathology, The Ohio State University, 129 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA.Tel: 614 366‐8526;Fax: 614 366‐9389;Email:</mods:affiliation><wicri:noCountry code="subField">366‐9389;Email:</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: traci.wilgus@osumc.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A96DCA10748A4825D1C6355B871575F1BF94F146</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1111/wrr.12028</idno><idno type="url">https://api.istex.fr/document/A96DCA10748A4825D1C6355B871575F1BF94F146/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004F70</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">004F70</idno><idno type="wicri:Area/Istex/Curation">004F70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">The alarmin <hi rend="fc">HMGB</hi>‐1 influences healing outcomes in fetal skin wounds</title><author><name sortKey="Dardenne, Adrienne D" sort="Dardenne, Adrienne D" uniqKey="Dardenne A" first="Adrienne D." last="Dardenne">Adrienne D. Dardenne</name><affiliation><mods:affiliation>Department of Veterinary Preventive Medicine, University Laboratory Animal Resources, The Ohio State University, Ohio, Columbus</mods:affiliation><wicri:noCountry code="subField">Columbus</wicri:noCountry></affiliation></author><author><name sortKey="Wulff, Brian C" sort="Wulff, Brian C" uniqKey="Wulff B" first="Brian C." last="Wulff">Brian C. Wulff</name><affiliation><mods:affiliation>Department of Pathology, The Ohio State University, Ohio, Columbus</mods:affiliation><wicri:noCountry code="subField">Columbus</wicri:noCountry></affiliation></author><author><name sortKey="Wilgus, Traci A" sort="Wilgus, Traci A" uniqKey="Wilgus T" first="Traci A." last="Wilgus">Traci A. Wilgus</name><affiliation><mods:affiliation>Department of Pathology, The Ohio State University, Ohio, Columbus</mods:affiliation></affiliation><affiliation><mods:affiliation>Dr. Traci A. Wilgus, PhD, Department of Pathology, The Ohio State University, 129 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA.Tel: 614 366‐8526;Fax: 614 366‐9389;Email:</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: traci.wilgus@osumc.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Wound Repair and Regeneration</title><title level="j" type="alt">WOUND REPAIR AND REGENERATION</title><idno type="ISSN">1067-1927</idno><idno type="eISSN">1524-475X</idno><imprint><biblScope unit="vol">21</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="282">282</biblScope><biblScope unit="page" to="291">291</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2013-03">2013-03</date></imprint><idno type="ISSN">1067-1927</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1067-1927</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">In mice, cutaneous wounds generated early in development (embryonic day 15, E15) heal scarlessly, while wounds generated late in gestation (embryonic day 18, E18) heal with scar formation. Even though both types of wounds are generated in the same sterile uterine environment, scarless fetal wounds heal without inflammation, but a strong inflammatory response is observed in scar‐forming fetal wounds. We hypothesized that altered release of alarmins, endogenous molecules that trigger inflammation in response to damage, may be responsible for the age‐related changes in inflammation and healing outcomes in fetal skin. The purpose of this study was to determine whether the alarmin high‐mobility group box‐1 (HMGB‐1) is involved in fetal wound repair. Immunohistochemical analysis showed that in unwounded skin, E18 keratinocytes expressed higher levels of HMGB‐1 compared with E15 keratinocytes. After injury, HMGB‐1 was released to a greater extent from keratinocytes at the margin of scar‐forming E18 wounds, compared with scarless E15 wounds. Furthermore, instead of healing scarlessly, E15 wounds healed with scars when treated with HMGB‐1. HMGB‐1‐injected wounds also had more fibroblasts, blood vessels, and macrophages compared with control wounds. Together, these data suggest that extracellular HMGB‐1 levels influence the quality of healing in cutaneous wounds.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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