Combined radiation and surgical treatment of Stages IB and IIA and B carcinoma of the cervix
Identifieur interne : 004D11 ( Istex/Curation ); précédent : 004D10; suivant : 004D12Combined radiation and surgical treatment of Stages IB and IIA and B carcinoma of the cervix
Auteurs : P. Marziale [Italie] ; G. Atlante [Italie] ; V. Le Pera [Italie] ; T. Marino [Italie] ; M. Pozzi [Italie] ; A. Iacovelli [Italie]Source :
- Gynecologic Oncology [ 0090-8258 ] ; 1981.
Abstract
From 1 February 1965 to 31 December 1979, 757 patients suffering from Stage IB and Stage IIA and B carcinoma of the cervix were treated at the Regina Elena Cancer Institute in Rome with the combined use of irradiation and surgery. The procedure followed consists of four main steps: (i) staging; (ii) preoperative radiotherapy; (iii) radical hysterectomy three to four weeks later, according to Wertheim-Meigs; (iv) telecobalt therapy if positive lymph nodes are found after lymphadenectomy. This therapy, considered ideal, was not always carried out because of general clinical and local conditions unfavorable for radical surgical treatment. For the survival rates only the 526 patients treated up to the end of 1975 are considered. The patients who received the ideal therapy had the best survival rates: Stage IB,37/39 patients (94.8%); Stage IIA,54/65 patients (83.1%); Stage IIB,140/238 patients (58.8%). The superiority of this ideal therapy is further confirmed when the survival rates are considered in relation to the type of therapy and to the lymph node metastases. Sterilization of the primary neoplastic lesion was obtained in 63% of the patients treated with preoperative radium therapy. Survival depends to a great extent on whether the lymph nodes are positive or negative. In addition, the best results are obtained when the primary lesion becomes negative after irradiation (86.8% against 54.2%).
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DOI: 10.1016/S0090-8258(81)80005-4
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The procedure followed consists of four main steps: (i) staging; (ii) preoperative radiotherapy; (iii) radical hysterectomy three to four weeks later, according to Wertheim-Meigs; (iv) telecobalt therapy if positive lymph nodes are found after lymphadenectomy. This therapy, considered ideal, was not always carried out because of general clinical and local conditions unfavorable for radical surgical treatment. For the survival rates only the 526 patients treated up to the end of 1975 are considered. The patients who received the ideal therapy had the best survival rates: Stage IB,37/39 patients (94.8%); Stage IIA,54/65 patients (83.1%); Stage IIB,140/238 patients (58.8%). The superiority of this ideal therapy is further confirmed when the survival rates are considered in relation to the type of therapy and to the lymph node metastases. Sterilization of the primary neoplastic lesion was obtained in 63% of the patients treated with preoperative radium therapy. Survival depends to a great extent on whether the lymph nodes are positive or negative. In addition, the best results are obtained when the primary lesion becomes negative after irradiation (86.8% against 54.2%).</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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