Lymphoedema of the lower extremities – background, pathophysiology and diagnostic considerations
Identifieur interne : 004B40 ( Istex/Curation ); précédent : 004B39; suivant : 004B41Lymphoedema of the lower extremities – background, pathophysiology and diagnostic considerations
Auteurs : Mads R. Jensen [Danemark] ; Lene Simonsen [Danemark] ; Tonny Karlsmark [Danemark] ; Jens Bülow [Danemark]Source :
- Clinical Physiology and Functional Imaging [ 1475-0961 ] ; 2010-11.
Abstract
Lymphoedema of the lower extremities is a chronic debilitating disease that is often underdiagnosed. Early diagnosis and treatment is paramount in reducing the risk of progression and complications. Lymphoedema has traditionally been defined as interstitial oedema and protein accumulation because of a defect in the lymphatic drainage; however, some findings suggest that the interstitial protein concentration may be low in some types of lymphoedema. Primary lymphoedema is caused by an inherent defect in the lymphatic vessels or lymph nodes. Secondary lymphoedema is caused by damages to the lymphatic system most often caused by cancer or its treatment. Many of the underlying pathophysiological mechanisms have yet to be elucidated. Many methods have been developed for examination of the lymphatic system. Lymphoscintigraphy is presently the preferred diagnostic modality. Lack of consensus regarding protocol and qualitative interpretation criteria results in a too observer dependent outcome. Methods for objectifying the scintigraphy through quantification have been criticized. Depot clearance rates are an alternative method of quantification of lymphatic drainage capacity. This method however has mostly been applied on upper extremity lymphoedema. The aim of this review is to provide a literature‐based overview of the aetiology and pathophysiology of lower extremity lymphoedema and to summarize the current knowledge about lymphoscintigraphy and depot clearance techniques. The abundance of factors influencing the outcome of the examination stresses the need for consensus regarding examination protocols and interpretation. Further studies are needed to improve diagnostic performance and understanding of pathophysiological mechanisms.
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DOI: 10.1111/j.1475-097X.2010.00969.x
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Jensen</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV, Denmark</mods:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV</wicri:regionArea></affiliation></author><author><name sortKey="Simonsen, Lene" sort="Simonsen, Lene" uniqKey="Simonsen L" first="Lene" last="Simonsen">Lene Simonsen</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV, Denmark</mods:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV</wicri:regionArea></affiliation></author><author><name sortKey="Karlsmark, Tonny" sort="Karlsmark, Tonny" uniqKey="Karlsmark T" first="Tonny" last="Karlsmark">Tonny Karlsmark</name><affiliation wicri:level="1"><mods:affiliation>Department of Dermatology and Venerology, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV, Denmark</mods:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Dermatology and Venerology, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV</wicri:regionArea></affiliation></author><author><name sortKey="Bulow, Jens" sort="Bulow, Jens" uniqKey="Bulow J" first="Jens" last="Bülow">Jens Bülow</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV, Denmark</mods:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A039E56F0658B2455EA19FF1D9C08040508CBA10</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1475-097X.2010.00969.x</idno><idno type="url">https://api.istex.fr/document/A039E56F0658B2455EA19FF1D9C08040508CBA10/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004B40</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">004B40</idno><idno type="wicri:Area/Istex/Curation">004B40</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Lymphoedema of the lower extremities – background, pathophysiology and diagnostic considerations</title><author><name sortKey="Jensen, Mads R" sort="Jensen, Mads R" uniqKey="Jensen M" first="Mads R." last="Jensen">Mads R. Jensen</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV, Denmark</mods:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV</wicri:regionArea></affiliation></author><author><name sortKey="Simonsen, Lene" sort="Simonsen, Lene" uniqKey="Simonsen L" first="Lene" last="Simonsen">Lene Simonsen</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV, Denmark</mods:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV</wicri:regionArea></affiliation></author><author><name sortKey="Karlsmark, Tonny" sort="Karlsmark, Tonny" uniqKey="Karlsmark T" first="Tonny" last="Karlsmark">Tonny Karlsmark</name><affiliation wicri:level="1"><mods:affiliation>Department of Dermatology and Venerology, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV, Denmark</mods:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Dermatology and Venerology, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV</wicri:regionArea></affiliation></author><author><name sortKey="Bulow, Jens" sort="Bulow, Jens" uniqKey="Bulow J" first="Jens" last="Bülow">Jens Bülow</name><affiliation wicri:level="1"><mods:affiliation>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV, Denmark</mods:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen NV</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Physiology and Functional Imaging</title><title level="j" type="alt">CLINICAL PHYSIOLOGY FUNCTIONAL IMAGING</title><idno type="ISSN">1475-0961</idno><idno type="eISSN">1475-097X</idno><imprint><biblScope unit="vol">30</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="389">389</biblScope><biblScope unit="page" to="398">398</biblScope><biblScope unit="page-count">10</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-11">2010-11</date></imprint><idno type="ISSN">1475-0961</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1475-0961</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphoedema of the lower extremities is a chronic debilitating disease that is often underdiagnosed. Early diagnosis and treatment is paramount in reducing the risk of progression and complications. Lymphoedema has traditionally been defined as interstitial oedema and protein accumulation because of a defect in the lymphatic drainage; however, some findings suggest that the interstitial protein concentration may be low in some types of lymphoedema. Primary lymphoedema is caused by an inherent defect in the lymphatic vessels or lymph nodes. Secondary lymphoedema is caused by damages to the lymphatic system most often caused by cancer or its treatment. Many of the underlying pathophysiological mechanisms have yet to be elucidated. Many methods have been developed for examination of the lymphatic system. Lymphoscintigraphy is presently the preferred diagnostic modality. Lack of consensus regarding protocol and qualitative interpretation criteria results in a too observer dependent outcome. Methods for objectifying the scintigraphy through quantification have been criticized. Depot clearance rates are an alternative method of quantification of lymphatic drainage capacity. This method however has mostly been applied on upper extremity lymphoedema. The aim of this review is to provide a literature‐based overview of the aetiology and pathophysiology of lower extremity lymphoedema and to summarize the current knowledge about lymphoscintigraphy and depot clearance techniques. The abundance of factors influencing the outcome of the examination stresses the need for consensus regarding examination protocols and interpretation. Further studies are needed to improve diagnostic performance and understanding of pathophysiological mechanisms.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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