High frequency of MYC gene amplification is a common feature of radiation‐induced sarcomas. Further results from EORTC STBSG TL 01/01
Identifieur interne : 001D25 ( Istex/Curation ); précédent : 001D24; suivant : 001D26High frequency of MYC gene amplification is a common feature of radiation‐induced sarcomas. Further results from EORTC STBSG TL 01/01
Auteurs : Christoph K Cker [Allemagne] ; Alexander Marx [Allemagne] ; Katharina Mössinger [Allemagne] ; Frederike Svehla [Allemagne] ; Ulrike Schneider [Allemagne] ; Pancras Cornelis Wilhelmus Hogendoorn [Pays-Bas, Allemagne] ; Ole Steen Nielsen [Danemark, Allemagne] ; Stefan Küffer [Allemagne] ; Christian Sauer [Allemagne] ; Cyril Fisher [Royaume-Uni, Allemagne] ; Christian Hallermann [Allemagne] ; Jörg Thomas Hartmann [Allemagne] ; Jean-Yves Blay [France, Allemagne] ; Gunhild Mechtersheimer [Allemagne] ; Peter Hohenberger [Allemagne] ; Philipp Ströbel [Allemagne]Source :
- Genes, Chromosomes and Cancer [ 1045-2257 ] ; 2013-01.
Abstract
Irradiation is a major causative factor among the small subgroup of sarcomas with a known etiology. The prognosis of radiation‐induced sarcomas (RIS) is significantly worse than that of their spontaneous counterparts. The most frequent histological subtypes include undifferentiated pleomorphic sarcomas, angiosarcomas, and leiomyosarcomas. A high frequency of MYC amplifications in radiation‐induced angiosarcomas, but not in primary angiosarcomas, has recently been described. To investigate whether MYC amplifications are also frequent in RIS other than angiosarcomas, we analyzed the MYC amplification status of 83 RIS and 192 sporadic sarcomas by fluorescence in situ hybridization. We found significantly higher numbers of MYC amplifications in RIS than in sporadic sarcomas (P < 0.0001), especially in angiosarcomas, undifferentiated pleomorphic sarcomas, and leiomyosarcomas. Angiosarcomas were special in that MYC amplifications were particularly frequent and always high level, while other RIS showed low‐level amplifications. We conclude that MYC amplifications are a frequent feature of RIS as a group and may contribute to the biology of these tumors. © 2012 Wiley Periodicals, Inc.
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DOI: 10.1002/gcc.22009
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xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Mannheim, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Göttingen, University of Göttingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Göttingen, University of Göttingen</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Göttingen, Robert‐Koch‐Str. 40, 37075 Göttingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Göttingen, Robert‐Koch‐Str. 40, 37075 Göttingen</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3FBCB282B381187920EDAFB9160E19595D9AA358</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1002/gcc.22009</idno><idno type="url">https://api.istex.fr/document/3FBCB282B381187920EDAFB9160E19595D9AA358/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001D25</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001D25</idno><idno type="wicri:Area/Istex/Curation">001D25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">High frequency of <hi rend="italic">MYC</hi> gene amplification is a common feature of radiation‐induced sarcomas. Further results from EORTC STBSG TL 01/01</title><author><name sortKey="K Cker, Christoph" sort="K Cker, Christoph" uniqKey="K Cker C" first="Christoph" last="K Cker">Christoph K Cker</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Mannheim, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Mannheim, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Mossinger, Katharina" sort="Mossinger, Katharina" uniqKey="Mossinger K" first="Katharina" last="Mössinger">Katharina Mössinger</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Mannheim, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Svehla, Frederike" sort="Svehla, Frederike" uniqKey="Svehla F" first="Frederike" last="Svehla">Frederike Svehla</name><affiliation wicri:level="1"><mods:affiliation>Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Center Mannheim, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Schneider, Ulrike" sort="Schneider, Ulrike" uniqKey="Schneider U" first="Ulrike" last="Schneider">Ulrike Schneider</name><affiliation wicri:level="1"><mods:affiliation>Pathology Laboratory, Robert Roessle Hospital and Tumor Institute, Charité University Hospital, Berlin, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Pathology Laboratory, Robert Roessle Hospital and Tumor Institute, Charité University Hospital, Berlin</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Hogendoorn, Pancras Cornelis Wilhelmus" sort="Hogendoorn, Pancras Cornelis Wilhelmus" uniqKey="Hogendoorn P" first="Pancras Cornelis Wilhelmus" last="Hogendoorn">Pancras Cornelis Wilhelmus Hogendoorn</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, Leiden University Medical Center, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Leiden University Medical Center</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Nielsen, Ole Steen" sort="Nielsen, Ole Steen" uniqKey="Nielsen O" first="Ole Steen" last="Nielsen">Ole Steen Nielsen</name><affiliation wicri:level="1"><mods:affiliation>Department of Oncology, Aarhus University Hospital, Denmark</mods:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Oncology, Aarhus University Hospital</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Kuffer, Stefan" sort="Kuffer, Stefan" uniqKey="Kuffer S" first="Stefan" last="Küffer">Stefan Küffer</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Mannheim, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Sauer, Christian" sort="Sauer, Christian" uniqKey="Sauer C" first="Christian" last="Sauer">Christian Sauer</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Mannheim, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Fisher, Cyril" sort="Fisher, Cyril" uniqKey="Fisher C" first="Cyril" last="Fisher">Cyril Fisher</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, The Royal Marsden Hospital, London, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pathology, The Royal Marsden Hospital, London</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name><affiliation wicri:level="1"><mods:affiliation>Department of Dermatology, Fachklinik Hornheide, Münster, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, Fachklinik Hornheide, Münster</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Hartmann, Jorg Thomas" sort="Hartmann, Jorg Thomas" uniqKey="Hartmann J" first="Jörg Thomas" last="Hartmann">Jörg Thomas Hartmann</name><affiliation wicri:level="1"><mods:affiliation>Clinic of Internal Medicine II, University of Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic of Internal Medicine II, University of Kiel</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Blay, Jean Ves" sort="Blay, Jean Ves" uniqKey="Blay J" first="Jean-Yves" last="Blay">Jean-Yves Blay</name><affiliation wicri:level="1"><mods:affiliation>Department of Medicine, Centre Léon Bérard, University Claude Bernard Lyon I, Lyon, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medicine, Centre Léon Bérard, University Claude Bernard Lyon I, Lyon</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Mechtersheimer, Gunhild" sort="Mechtersheimer, Gunhild" uniqKey="Mechtersheimer G" first="Gunhild" last="Mechtersheimer">Gunhild Mechtersheimer</name><affiliation wicri:level="1"><mods:affiliation>Clinic of Internal Medicine II, University of Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic of Internal Medicine II, University of Kiel</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name><affiliation wicri:level="1"><mods:affiliation>Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Center Mannheim, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Mannheim, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Mannheim, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Göttingen, University of Göttingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Göttingen, University of Göttingen</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University of Heidelberg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University of Heidelberg</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Pathology, University Medical Center Göttingen, Robert‐Koch‐Str. 40, 37075 Göttingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Pathology, University Medical Center Göttingen, Robert‐Koch‐Str. 40, 37075 Göttingen</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Genes, Chromosomes and Cancer</title><title level="j" type="alt">GENES, CHROMOSOMES AND CANCER</title><idno type="ISSN">1045-2257</idno><idno type="eISSN">1098-2264</idno><imprint><biblScope unit="vol">52</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="93">93</biblScope><biblScope unit="page" to="98">98</biblScope><biblScope unit="page-count">6</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-01">2013-01</date></imprint><idno type="ISSN">1045-2257</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1045-2257</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Irradiation is a major causative factor among the small subgroup of sarcomas with a known etiology. The prognosis of radiation‐induced sarcomas (RIS) is significantly worse than that of their spontaneous counterparts. The most frequent histological subtypes include undifferentiated pleomorphic sarcomas, angiosarcomas, and leiomyosarcomas. A high frequency of MYC amplifications in radiation‐induced angiosarcomas, but not in primary angiosarcomas, has recently been described. To investigate whether MYC amplifications are also frequent in RIS other than angiosarcomas, we analyzed the MYC amplification status of 83 RIS and 192 sporadic sarcomas by fluorescence in situ hybridization. We found significantly higher numbers of MYC amplifications in RIS than in sporadic sarcomas (P < 0.0001), especially in angiosarcomas, undifferentiated pleomorphic sarcomas, and leiomyosarcomas. Angiosarcomas were special in that MYC amplifications were particularly frequent and always high level, while other RIS showed low‐level amplifications. We conclude that MYC amplifications are a frequent feature of RIS as a group and may contribute to the biology of these tumors. © 2012 Wiley Periodicals, Inc.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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