Mutagenic and cytotoxic activity of an isocoumarin (paepalantine) isolated from Paepalanthus vellozioides
Identifieur interne : 001600 ( Istex/Curation ); précédent : 001599; suivant : 001601Mutagenic and cytotoxic activity of an isocoumarin (paepalantine) isolated from Paepalanthus vellozioides
Auteurs : Eliana Aparecida Varanda [Brésil] ; Maria Stella Gonçalves Raddi [Brésil] ; Francisca De Luz Dias [Brésil] ; Maria Cristina P. Araújo [Brésil] ; Solange Cardoso Alvares Gibran [Brésil] ; Catarina S. Takahashi [Brésil] ; Wagner Vilegas [Brésil]Source :
- Teratogenesis, Carcinogenesis, and Mutagenesis [ 0270-3211 ] ; 1997.
Abstract
A new isocoumarin with antimicrobial activity was isolated from Paepalanthus vellozioides (a native Brazilian plant) and called paepalantine. This study was carried out to assess the mutagenic activity of this new agent in assays with Salmonella typhimurium TA100, TA98, and TA102 and in Chinese hamster ovary (CHO) cell cultures, as well as cytotoxicity to McCoy cells. Paepalantine caused a significant dose‐dependent increase in the frequency of revertants in the three strains used in the assay, both with and without S9 mix, in concentrations varying from 2 to 128 μg/plate. The mutagenicity was confirmed in assays with CHO cells treated in the G1, S, and G2 phases of the cell cycle. There was an increase in the chromosomal aberration frequency, mainly in the G2 phase. Furthermore, the mitotic index of the treated cultures (40, 80, and 160 μg/ml) was significantly lower, indicating cytotoxicity. The midpoint cytotoxicity values to McCoy cells by the neutral red (NR) and microculture tetrazolium (MTT) techniques resulted in a NR50 and MTT50 of 30 and 38 μg/ml, respectively. Alterations to the paepalantine structure are suggested to reduce its mutagenic and cytotoxic activity in investigations for its antineoplasic potential. Teratogenesis Carcinog. Mutagen. 17:85–95, 1997. © 1997 Wiley‐Liss, Inc.
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DOI: 10.1002/(SICI)1520-6866(1997)17:2<85::AID-TCM4>3.0.CO;2-A
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Araújo</name><affiliation wicri:level="1"><mods:affiliation>Faculty of Medicine of Ribeirão Preto, São Paulo University, São Paulo, Brazil</mods:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Faculty of Medicine of Ribeirão Preto, São Paulo University, São Paulo</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Genetics, Federal University of Pernambuco, Pernambuco, Brazil</mods:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Genetics, Federal University of Pernambuco, Pernambuco</wicri:regionArea></affiliation></author><author><name sortKey="Gibran, Solange Cardoso Alvares" sort="Gibran, Solange Cardoso Alvares" uniqKey="Gibran S" first="Solange Cardoso Alvares" last="Gibran">Solange Cardoso Alvares Gibran</name><affiliation wicri:level="1"><mods:affiliation>Faculty of Pharmaceutical Sciences of Araraquara, Estadual Paulist University, São Paulo, Brazil</mods:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Faculty of Pharmaceutical Sciences of Araraquara, Estadual Paulist University, São Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Takahashi, Catarina S" sort="Takahashi, Catarina S" uniqKey="Takahashi C" first="Catarina S." last="Takahashi">Catarina S. Takahashi</name><affiliation wicri:level="1"><mods:affiliation>Faculty of Medicine of Ribeirão Preto, São Paulo University, São Paulo, Brazil</mods:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Faculty of Medicine of Ribeirão Preto, São Paulo University, São Paulo</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Faculty of Philosophy, Sciences, and Letters of Ribeirão Preto, São Paulo University, São Paulo, Brazil</mods:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Faculty of Philosophy, Sciences, and Letters of Ribeirão Preto, São Paulo University, São Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Vilegas, Wagner" sort="Vilegas, Wagner" uniqKey="Vilegas W" first="Wagner" last="Vilegas">Wagner Vilegas</name><affiliation wicri:level="1"><mods:affiliation>Chemical Institute of Araraquara, Estadual Paulist University, São Paulo, Brazil</mods:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Chemical Institute of Araraquara, Estadual Paulist University, São Paulo</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Teratogenesis, Carcinogenesis, and Mutagenesis</title><title level="j" type="alt">TERATOGENESIS, CARCINOGENESIS, AND MUTAGENESIS</title><idno type="ISSN">0270-3211</idno><idno type="eISSN">1520-6866</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="85">85</biblScope><biblScope unit="page" to="95">95</biblScope><biblScope unit="page-count">11</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="1997">1997</date></imprint><idno type="ISSN">0270-3211</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0270-3211</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new isocoumarin with antimicrobial activity was isolated from Paepalanthus vellozioides (a native Brazilian plant) and called paepalantine. This study was carried out to assess the mutagenic activity of this new agent in assays with Salmonella typhimurium TA100, TA98, and TA102 and in Chinese hamster ovary (CHO) cell cultures, as well as cytotoxicity to McCoy cells. Paepalantine caused a significant dose‐dependent increase in the frequency of revertants in the three strains used in the assay, both with and without S9 mix, in concentrations varying from 2 to 128 μg/plate. The mutagenicity was confirmed in assays with CHO cells treated in the G1, S, and G2 phases of the cell cycle. There was an increase in the chromosomal aberration frequency, mainly in the G2 phase. Furthermore, the mitotic index of the treated cultures (40, 80, and 160 μg/ml) was significantly lower, indicating cytotoxicity. The midpoint cytotoxicity values to McCoy cells by the neutral red (NR) and microculture tetrazolium (MTT) techniques resulted in a NR50 and MTT50 of 30 and 38 μg/ml, respectively. Alterations to the paepalantine structure are suggested to reduce its mutagenic and cytotoxic activity in investigations for its antineoplasic potential. Teratogenesis Carcinog. Mutagen. 17:85–95, 1997. © 1997 Wiley‐Liss, Inc.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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