Research Perspectives in Inherited Lymphatic Disease
Identifieur interne : 007764 ( Istex/Corpus ); précédent : 007763; suivant : 007765Research Perspectives in Inherited Lymphatic Disease
Auteurs : Robert E. Ferrell ; David N. FinegoldSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2008-05.
Abstract
Genetic studies of inherited lymphedema have provided the starting point for the molecular dissection of lymphatic development and disease. Here, we update the recent contribution of the study of inherited lymphedema and discuss the parallels between mouse models of lymphedema and inherited lymphedema. That the known mutations leading to lymphatic phenotypes explain fewer than half the cases of lymphedema means that the continued study of these disorders may reveal new pathways in lymphatic biology.
Url:
DOI: 10.1196/annals.1413.012
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Ferrell</name><affiliation><mods:affiliation>Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Finegold, David N" sort="Finegold, David N" uniqKey="Finegold D" first="David N." last="Finegold">David N. 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Here, we update the recent contribution of the study of inherited lymphedema and discuss the parallels between mouse models of lymphedema and inherited lymphedema. That the known mutations leading to lymphatic phenotypes explain fewer than half the cases of lymphedema means that the continued study of these disorders may reveal new pathways in lymphatic biology.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">lymphedema</term><term xml:id="k2">lymphangiogenesis</term><term xml:id="k3">Milroy's disease</term><term xml:id="k4">FOXC2</term></keywords><classCode scheme="tocHeading1">Part II. Biological Principles of the Lymphatic System</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/FE87BC7E2A4941983022635D36F1FDE7BFDD2B70/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Inc</publisherName><publisherLoc>Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1749-6632</doi><issn type="print">0077-8923</issn><issn type="electronic">1749-6632</issn><idGroup><id type="product" value="NYAS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANNALS OF NEW YORK ACADEMY SCIENCES">Annals of the New York Academy of Sciences</title></titleGroup></publicationMeta><publicationMeta level="part" position="05001"><doi origin="wiley">10.1196/nyas.2008.1131.issue-1</doi><titleGroup><title type="main">The Lymphatic Continuum Revisited</title></titleGroup><numberingGroup><numbering type="journalVolume" number="1131">1131</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2008-05">May 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="13" status="forIssue"><doi origin="wiley">10.1196/annals.1413.012</doi><idGroup><id type="unit" value="NYAS1131012"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Part II. Biological Principles of the Lymphatic System</title></titleGroup><copyright>© 2008 New York Academy of Sciences</copyright><eventGroup><event type="firstOnline" date="2008-05-28"></event><event type="publishedOnlineFinalForm" date="2008-05-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.5 mode:FullText source:FullText result:FullText" date="2010-04-07"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="134">134</numbering><numbering type="pageLast" number="139">139</numbering></numberingGroup><correspondenceTo>Address for correspondence: Robert E. Ferrell, Ph.D., Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh PA 15261. Voice: +1‐412‐624‐3018; fax: +1‐412‐624‐3020
<email>rferrell@hgen.pitt.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NYAS.NYAS1131012.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="39"></count><count type="linksCrossRef" number="39"></count></countGroup><titleGroup><title type="main"><i>Research Perspectives in Inherited Lymphatic Disease</i></title><title type="subtitle"><i>An Update</i></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Robert E.</givenNames><familyName>Ferrell</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>David N.</givenNames><familyName>Finegold</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">lymphedema</keyword><keyword xml:id="k2">lymphangiogenesis</keyword><keyword xml:id="k3">Milroy's disease</keyword><keyword xml:id="k4">FOXC2</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Genetic studies of inherited lymphedema have provided the starting point for the molecular dissection of lymphatic development and disease. 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Here, we update the recent contribution of the study of inherited lymphedema and discuss the parallels between mouse models of lymphedema and inherited lymphedema. That the known mutations leading to lymphatic phenotypes explain fewer than half the cases of lymphedema means that the continued study of these disorders may reveal new pathways in lymphatic biology.</abstract><subject lang="en"><genre>keywords</genre><topic>lymphedema</topic><topic>lymphangiogenesis</topic><topic>Milroy's disease</topic><topic>FOXC2</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of Sciences</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0077-8923</identifier><identifier type="eISSN">1749-6632</identifier><identifier type="DOI">10.1111/(ISSN)1749-6632</identifier><identifier type="PublisherID">NYAS</identifier><part><date>2008</date><detail type="title"><title>The Lymphatic Continuum Revisited</title></detail><detail type="volume"><caption>vol.</caption><number>1131</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>134</start><end>139</end><total>5</total></extent></part></relatedItem><identifier type="istex">FE87BC7E2A4941983022635D36F1FDE7BFDD2B70</identifier><identifier type="DOI">10.1196/annals.1413.012</identifier><identifier type="ArticleID">NYAS1131012</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 New York Academy of Sciences</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Inc</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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