Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer
Identifieur interne : 007740 ( Istex/Corpus ); précédent : 007739; suivant : 007741Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer
Auteurs : M. R. S. Keshtgar ; D. W. Chicken ; M. R. Austwick ; S. K. Somasundaram ; C. A. Mosse ; Y. Zhu ; I. J. Bigio ; S. G. BownSource :
- British Journal of Surgery [ 0007-1323 ] ; 2010-08.
Abstract
Intraoperative diagnosis of sentinel node metastases enables an immediate decision to proceed to axillary lymph node dissection, avoiding a second operation in node‐positive women with breast cancer.
Url:
DOI: 10.1002/bjs.7095
Links to Exploration step
ISTEX:FE1B6B0309FD81EC635EC32D8091DD1F06A37FCALe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer</title><author><name sortKey="Keshtgar, M R S" sort="Keshtgar, M R S" uniqKey="Keshtgar M" first="M. R. S." last="Keshtgar">M. R. S. Keshtgar</name><affiliation><mods:affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Breast Surgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK</mods:affiliation></affiliation></author><author><name sortKey="Chicken, D W" sort="Chicken, D W" uniqKey="Chicken D" first="D. W." last="Chicken">D. W. Chicken</name><affiliation><mods:affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Austwick, M R" sort="Austwick, M R" uniqKey="Austwick M" first="M. R." last="Austwick">M. R. Austwick</name><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Somasundaram, S K" sort="Somasundaram, S K" uniqKey="Somasundaram S" first="S. K." last="Somasundaram">S. K. Somasundaram</name><affiliation><mods:affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Mosse, C A" sort="Mosse, C A" uniqKey="Mosse C" first="C. A." last="Mosse">C. A. Mosse</name><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Zhu, Y" sort="Zhu, Y" uniqKey="Zhu Y" first="Y." last="Zhu">Y. Zhu</name><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Statistical Science, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Bigio, I J" sort="Bigio, I J" uniqKey="Bigio I" first="I. J." last="Bigio">I. J. Bigio</name><affiliation><mods:affiliation>Departments of Biomedical Engineering and Electrical Engineering, Boston University, Boston, Massachusetts, USA</mods:affiliation></affiliation></author><author><name sortKey="Bown, S G" sort="Bown, S G" uniqKey="Bown S" first="S. G." last="Bown">S. G. Bown</name><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:FE1B6B0309FD81EC635EC32D8091DD1F06A37FCA</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/bjs.7095</idno><idno type="url">https://api.istex.fr/document/FE1B6B0309FD81EC635EC32D8091DD1F06A37FCA/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">007740</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">007740</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer</title><author><name sortKey="Keshtgar, M R S" sort="Keshtgar, M R S" uniqKey="Keshtgar M" first="M. R. S." last="Keshtgar">M. R. S. Keshtgar</name><affiliation><mods:affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Breast Surgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK</mods:affiliation></affiliation></author><author><name sortKey="Chicken, D W" sort="Chicken, D W" uniqKey="Chicken D" first="D. W." last="Chicken">D. W. Chicken</name><affiliation><mods:affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Austwick, M R" sort="Austwick, M R" uniqKey="Austwick M" first="M. R." last="Austwick">M. R. Austwick</name><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Somasundaram, S K" sort="Somasundaram, S K" uniqKey="Somasundaram S" first="S. K." last="Somasundaram">S. K. Somasundaram</name><affiliation><mods:affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Mosse, C A" sort="Mosse, C A" uniqKey="Mosse C" first="C. A." last="Mosse">C. A. Mosse</name><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Zhu, Y" sort="Zhu, Y" uniqKey="Zhu Y" first="Y." last="Zhu">Y. Zhu</name><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Statistical Science, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Bigio, I J" sort="Bigio, I J" uniqKey="Bigio I" first="I. J." last="Bigio">I. J. Bigio</name><affiliation><mods:affiliation>Departments of Biomedical Engineering and Electrical Engineering, Boston University, Boston, Massachusetts, USA</mods:affiliation></affiliation></author><author><name sortKey="Bown, S G" sort="Bown, S G" uniqKey="Bown S" first="S. G." last="Bown">S. G. Bown</name><affiliation><mods:affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">British Journal of Surgery</title><title level="j" type="alt">BRITISH JOURNAL OF SURGERY</title><idno type="ISSN">0007-1323</idno><idno type="eISSN">1365-2168</idno><imprint><biblScope unit="vol">97</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1232">1232</biblScope><biblScope unit="page" to="1239">1239</biblScope><biblScope unit="page-count">8</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2010-08">2010-08</date></imprint><idno type="ISSN">0007-1323</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-1323</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Intraoperative diagnosis of sentinel node metastases enables an immediate decision to proceed to axillary lymph node dissection, avoiding a second operation in node‐positive women with breast cancer.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>node</json:string><json:string>metastasis</json:string><json:string>pixel</json:string><json:string>metastatic</json:string><json:string>british journal</json:string><json:string>breast cancer</json:string><json:string>axillary</json:string><json:string>intraoperative</json:string><json:string>canonical</json:string><json:string>sentinel node metastases</json:string><json:string>scanner</json:string><json:string>john wiley sons</json:string><json:string>micrometastases</json:string><json:string>metastatic nodes</json:string><json:string>surgery society</json:string><json:string>copyright</json:string><json:string>macrometastases</json:string><json:string>discriminant</json:string><json:string>alnd</json:string><json:string>oncol</json:string><json:string>sentinel</json:string><json:string>algorithm</json:string><json:string>canonical scores</json:string><json:string>histology</json:string><json:string>intraoperative diagnosis</json:string><json:string>diagnostic algorithm</json:string><json:string>normal nodes</json:string><json:string>canonical score</json:string><json:string>lymph</json:string><json:string>discriminant algorithm</json:string><json:string>breoptic plate</json:string><json:string>sentinel node</json:string><json:string>sentinel nodes</json:string><json:string>point measurements</json:string><json:string>white light</json:string><json:string>positive pixels</json:string><json:string>false positives</json:string><json:string>clin oncol</json:string><json:string>tumour cells</json:string><json:string>sentinel lymph node biopsy</json:string><json:string>linear discriminant analysis</json:string><json:string>training data</json:string><json:string>biopsy</json:string><json:string>spectroscopy</json:string><json:string>hamamatsu photonics</json:string><json:string>principal components</json:string><json:string>university college london</json:string><json:string>statistical techniques</json:string><json:string>sentinel node biopsy</json:string><json:string>principal component analysis</json:string><json:string>cluster size</json:string><json:string>data points</json:string><json:string>bivalved node</json:string><json:string>short pulses</json:string><json:string>suspicious areas</json:string><json:string>translational research</json:string><json:string>interrogates tissue</json:string><json:string>data reduction</json:string><json:string>second operation</json:string><json:string>surg oncol</json:string><json:string>centre</json:string></teeft></keywords><author><json:item><name>M. R. S. Keshtgar</name><affiliations><json:string>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</json:string><json:string>Department of Breast Surgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK</json:string></affiliations></json:item><json:item><name>D. W. Chicken</name><affiliations><json:string>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</json:string><json:string>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</json:string></affiliations></json:item><json:item><name>M. R. Austwick</name><affiliations><json:string>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</json:string></affiliations></json:item><json:item><name>S. K. Somasundaram</name><affiliations><json:string>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</json:string><json:string>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</json:string></affiliations></json:item><json:item><name>C. A. Mosse</name><affiliations><json:string>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</json:string></affiliations></json:item><json:item><name>Y. Zhu</name><affiliations><json:string>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</json:string><json:string>Department of Statistical Science, Royal Free and University College Medical School, University College London, London, UK</json:string></affiliations></json:item><json:item><name>I. J. Bigio</name><affiliations><json:string>Departments of Biomedical Engineering and Electrical Engineering, Boston University, Boston, Massachusetts, USA</json:string></affiliations></json:item><json:item><name>S. G. Bown</name><affiliations><json:string>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</json:string></affiliations></json:item></author><articleId><json:string>BJS7095</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Shining a light on cancer</abstract><qualityIndicators><score>4.74</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595 x 782 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>199</abstractCharCount><pdfWordCount>4416</pdfWordCount><pdfCharCount>27498</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>27</abstractWordCount></qualityIndicators><title>Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer</title><genre><json:string>article</json:string></genre><host><title>British Journal of Surgery</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1365-2168</json:string></doi><issn><json:string>0007-1323</json:string></issn><eissn><json:string>1365-2168</json:string></eissn><publisherId><json:string>BJS</json:string></publisherId><volume>97</volume><issue>8</issue><pages><first>1232</first><last>1239</last><total>8</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item></subject></host><categories><wos><json:string>science</json:string><json:string>surgery</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>surgery</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1002/bjs.7095</json:string></doi><id>FE1B6B0309FD81EC635EC32D8091DD1F06A37FCA</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/FE1B6B0309FD81EC635EC32D8091DD1F06A37FCA/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/FE1B6B0309FD81EC635EC32D8091DD1F06A37FCA/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/FE1B6B0309FD81EC635EC32D8091DD1F06A37FCA/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer</title></titleStmt><publicationStmt><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><availability><licence>Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</licence></availability><date type="published" when="2010-08"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer</title><title level="a" type="short" xml:lang="en">Intraoperative diagnosis of sentinel node metastases in breast cancer</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">M. R. S.</forename><surname>Keshtgar</surname></persName><email>m.keshtgar@ucl.ac.uk</email><affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK<address><country key="GB"></country></address></affiliation><affiliation>Department of Breast Surgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK</affiliation></author><author xml:id="author-0001"><persName><forename type="first">D. W.</forename><surname>Chicken</surname></persName><affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK<address><country key="GB"></country></address></affiliation><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">M. R.</forename><surname>Austwick</surname></persName><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">S. K.</forename><surname>Somasundaram</surname></persName><affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK<address><country key="GB"></country></address></affiliation><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">C. A.</forename><surname>Mosse</surname></persName><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Y.</forename><surname>Zhu</surname></persName><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK<address><country key="GB"></country></address></affiliation><affiliation>Department of Statistical Science, Royal Free and University College Medical School, University College London, London, UK<address><country key="GB"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">I. J.</forename><surname>Bigio</surname></persName><affiliation>Departments of Biomedical Engineering and Electrical Engineering, Boston University, Boston, Massachusetts, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">S. G.</forename><surname>Bown</surname></persName><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK<address><country key="GB"></country></address></affiliation></author><idno type="istex">FE1B6B0309FD81EC635EC32D8091DD1F06A37FCA</idno><idno type="DOI">10.1002/bjs.7095</idno><idno type="unit">BJS7095</idno><idno type="toTypesetVersion">file:BJS.BJS7095.pdf</idno></analytic><monogr><title level="j" type="main">British Journal of Surgery</title><title level="j" type="alt">BRITISH JOURNAL OF SURGERY</title><idno type="pISSN">0007-1323</idno><idno type="eISSN">1365-2168</idno><idno type="book-DOI">10.1002/(ISSN)1365-2168</idno><idno type="book-part-DOI">10.1002/bjs.v97:8</idno><idno type="product">BJS</idno><imprint><biblScope unit="vol">97</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1232">1232</biblScope><biblScope unit="page" to="1239">1239</biblScope><biblScope unit="page-count">8</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2010-08"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head>
Background:
<p>Intraoperative diagnosis of sentinel node metastases enables an immediate decision to proceed to axillary lymph node dissection, avoiding a second operation in node‐positive women with breast cancer.</p>
Methods:
<p>An optical scanner was developed that interrogated the cut surface of bivalved, but otherwise unprocessed, sentinel lymph nodes with pulses of white light by elastic scattering spectroscopy (ESS). The scattered light underwent spectral analysis, and individual spectra were initially correlated with conventional histology to develop a diagnostic algorithm. This algorithm was used to create false colour‐coded maps of scans from an independent set of nodes, and the optimal criteria for discriminating between normal and cancer spectra were defined statistically.</p>
Results:
<p>The discriminant algorithm was developed from a training set of 2989 spectra obtained from 30 metastatic and 331 normal nodes. Subsequent scans from 129 independent nodes were analysed. The scanner detected macrometastases (larger than 2 mm) with a sensitivity of 76 per cent (69 per cent including micrometastases) and specificity of 96 per cent.</p>
Conclusion:
<p>In this proof‐of‐principle study, the ESS results were comparable with current intraoperative diagnostic techniques of lymph node assessment. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</p></abstract><abstract xml:lang="en" style="short"><p>Shining a light on cancer</p></abstract><textClass><classCode scheme="articleCategory">Original Article</classCode><classCode scheme="tocHeading1">Original Articles</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/FE1B6B0309FD81EC635EC32D8091DD1F06A37FCA/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd.</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1365-2168</doi><issn type="print">0007-1323</issn><issn type="electronic">1365-2168</issn><idGroup><id type="product" value="BJS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="BRITISH JOURNAL OF SURGERY">British Journal of Surgery</title><title type="short">Br J Surg</title></titleGroup></publicationMeta><publicationMeta level="part" position="80"><doi origin="wiley" registered="yes">10.1002/bjs.v97:8</doi><numberingGroup><numbering type="journalVolume" number="97">97</numbering><numbering type="journalIssue">8</numbering></numberingGroup><coverDate startDate="2010-08">August 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="100" status="forIssue"><doi origin="wiley" registered="yes">10.1002/bjs.7095</doi><idGroup><id type="unit" value="BJS7095"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</copyright><eventGroup><event type="manuscriptAccepted" date="2010-02-24"></event><event type="firstOnline" date="2010-06-30"></event><event type="publishedOnlineFinalForm" date="2010-07-05"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2010-06-30"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.27 mode:FullText" date="2010-11-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-07"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-15"></event></eventGroup><numberingGroup><numbering type="pageFirst">1232</numbering><numbering type="pageLast">1239</numbering></numberingGroup><correspondenceTo>Department of Breast Surgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:BJS.BJS7095.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="19"></count></countGroup><titleGroup><title type="main" xml:lang="en">Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer</title><title type="short" xml:lang="en">Intraoperative diagnosis of sentinel node metastases in breast cancer</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>M. R. S.</givenNames><familyName>Keshtgar</familyName></personName><contactDetails><email>m.keshtgar@ucl.ac.uk</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>D. W.</givenNames><familyName>Chicken</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>M. R.</givenNames><familyName>Austwick</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>S. K.</givenNames><familyName>Somasundaram</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>C. A.</givenNames><familyName>Mosse</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Y.</givenNames><familyName>Zhu</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af4"><personName><givenNames>I. J.</givenNames><familyName>Bigio</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af2"><personName><givenNames>S. G.</givenNames><familyName>Bown</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="GB" type="organization"><unparsedAffiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="GB" type="organization"><unparsedAffiliation>Department of Statistical Science, Royal Free and University College Medical School, University College London, London, UK</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Departments of Biomedical Engineering and Electrical Engineering, Boston University, Boston, Massachusetts, USA</unparsedAffiliation></affiliation></affiliationGroup><supportingInformation><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:00071323:media:bjs7095:bjs_7095_sm_suppinfoapp1"></mediaResource><caption>Supporting Information</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Intraoperative diagnosis of sentinel node metastases enables an immediate decision to proceed to axillary lymph node dissection, avoiding a second operation in node‐positive women with breast cancer.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>An optical scanner was developed that interrogated the cut surface of bivalved, but otherwise unprocessed, sentinel lymph nodes with pulses of white light by elastic scattering spectroscopy (ESS). The scattered light underwent spectral analysis, and individual spectra were initially correlated with conventional histology to develop a diagnostic algorithm. This algorithm was used to create false colour‐coded maps of scans from an independent set of nodes, and the optimal criteria for discriminating between normal and cancer spectra were defined statistically.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>The discriminant algorithm was developed from a training set of 2989 spectra obtained from 30 metastatic and 331 normal nodes. Subsequent scans from 129 independent nodes were analysed. The scanner detected macrometastases (larger than 2 mm) with a sensitivity of 76 per cent (69 per cent including micrometastases) and specificity of 96 per cent.</p></section><section xml:id="abs1-4"><title type="main">Conclusion:</title><p>In this proof‐of‐principle study, the ESS results were comparable with current intraoperative diagnostic techniques of lymph node assessment. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</p></section></abstract><abstract type="short" xml:lang="en"><p>Shining a light on cancer</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Intraoperative diagnosis of sentinel node metastases in breast cancer</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer</title></titleInfo><name type="personal"><namePart type="given">M. R. S.</namePart><namePart type="family">Keshtgar</namePart><affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</affiliation><affiliation>Department of Breast Surgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. W.</namePart><namePart type="family">Chicken</namePart><affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</affiliation><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. R.</namePart><namePart type="family">Austwick</namePart><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. K.</namePart><namePart type="family">Somasundaram</namePart><affiliation>Department of Surgery, Royal Free and University College Medical School, University College London, London, UK</affiliation><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. A.</namePart><namePart type="family">Mosse</namePart><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Zhu</namePart><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</affiliation><affiliation>Department of Statistical Science, Royal Free and University College Medical School, University College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. J.</namePart><namePart type="family">Bigio</namePart><affiliation>Departments of Biomedical Engineering and Electrical Engineering, Boston University, Boston, Massachusetts, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. G.</namePart><namePart type="family">Bown</namePart><affiliation>National Medical Laser Centre, Royal Free and University College Medical School, University College London, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-08</dateIssued><dateValid encoding="w3cdtf">2010-02-24</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="tables">2</extent><extent unit="references">19</extent></physicalDescription><abstract>Intraoperative diagnosis of sentinel node metastases enables an immediate decision to proceed to axillary lymph node dissection, avoiding a second operation in node‐positive women with breast cancer.</abstract><abstract>An optical scanner was developed that interrogated the cut surface of bivalved, but otherwise unprocessed, sentinel lymph nodes with pulses of white light by elastic scattering spectroscopy (ESS). The scattered light underwent spectral analysis, and individual spectra were initially correlated with conventional histology to develop a diagnostic algorithm. This algorithm was used to create false colour‐coded maps of scans from an independent set of nodes, and the optimal criteria for discriminating between normal and cancer spectra were defined statistically.</abstract><abstract>The discriminant algorithm was developed from a training set of 2989 spectra obtained from 30 metastatic and 331 normal nodes. Subsequent scans from 129 independent nodes were analysed. The scanner detected macrometastases (larger than 2 mm) with a sensitivity of 76 per cent (69 per cent including micrometastases) and specificity of 96 per cent.</abstract><abstract>In this proof‐of‐principle study, the ESS results were comparable with current intraoperative diagnostic techniques of lymph node assessment. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</abstract><abstract type="short" lang="en">Shining a light on cancer</abstract><note type="additional physical form">Supporting Information</note><relatedItem type="host"><titleInfo><title>British Journal of Surgery</title></titleInfo><titleInfo type="abbreviated"><title>Br J Surg</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic></subject><identifier type="ISSN">0007-1323</identifier><identifier type="eISSN">1365-2168</identifier><identifier type="DOI">10.1002/(ISSN)1365-2168</identifier><identifier type="PublisherID">BJS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>97</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1232</start><end>1239</end><total>8</total></extent></part></relatedItem><identifier type="istex">FE1B6B0309FD81EC635EC32D8091DD1F06A37FCA</identifier><identifier type="DOI">10.1002/bjs.7095</identifier><identifier type="ArticleID">BJS7095</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Ltd.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007740 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 007740 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:FE1B6B0309FD81EC635EC32D8091DD1F06A37FCA
|texte= Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer
}}
| This area was generated with Dilib version V0.6.31. |  |