D2‐40 Immunohistochemical Assessment of Lymphangiogenesis in Normal and Edematous Sinus Mucosa and Nasal Polyp
Identifieur interne : 007492 ( Istex/Corpus ); précédent : 007491; suivant : 007493D2‐40 Immunohistochemical Assessment of Lymphangiogenesis in Normal and Edematous Sinus Mucosa and Nasal Polyp
Auteurs : Tae Hoon Kim ; Sang Hag Lee ; Heung Man Lee ; Seung Hoon Lee ; Hak Hyun Jung ; Woo Sung Cho ; Young Gi Cinn ; Hwan Choe ; Moo Pil Kim ; Ik One Yoo ; Ho Yeon HwangSource :
- The Laryngoscope [ 0023-852X ] ; 2007-03.
Abstract
Objective: The lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, which facilitates interstitial protein transport. Until recently, the lymphatic system of the sinonasal mucosa has been relatively poorly studied. The authors aimed to investigate the distributional and quantitative changes of the lymphatic vessels in inflammatory sinus mucosa and nasal polyps in comparison with healthy sinus mucosa using D2‐40 antibody.
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DOI: 10.1097/MLG.0b013e31802c93b2
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">D2‐40 Immunohistochemical Assessment of Lymphangiogenesis in Normal and Edematous Sinus Mucosa and Nasal Polyp</title><author><name sortKey="Kim, Tae Hoon" sort="Kim, Tae Hoon" uniqKey="Kim T" first="Tae Hoon" last="Kim">Tae Hoon Kim</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Lee, Sang Hag" sort="Lee, Sang Hag" uniqKey="Lee S" first="Sang Hag" last="Lee">Sang Hag Lee</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation><affiliation><mods:affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Lee, Heung Man" sort="Lee, Heung Man" uniqKey="Lee H" first="Heung Man" last="Lee">Heung Man Lee</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation><affiliation><mods:affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Lee, Seung Hoon" sort="Lee, Seung Hoon" uniqKey="Lee S" first="Seung Hoon" last="Lee">Seung Hoon Lee</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation><affiliation><mods:affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Jung, Hak Hyun" sort="Jung, Hak Hyun" uniqKey="Jung H" first="Hak Hyun" last="Jung">Hak Hyun Jung</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Cho, Woo Sung" sort="Cho, Woo Sung" uniqKey="Cho W" first="Woo Sung" last="Cho">Woo Sung Cho</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Cinn, Young Gi" sort="Cinn, Young Gi" uniqKey="Cinn Y" first="Young Gi" last="Cinn">Young Gi Cinn</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Choe, Hwan" sort="Choe, Hwan" uniqKey="Choe H" first="Hwan" last="Choe">Hwan Choe</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Kim, Moo Pil" sort="Kim, Moo Pil" uniqKey="Kim M" first="Moo Pil" last="Kim">Moo Pil Kim</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Yoo, Ik One" sort="Yoo, Ik One" uniqKey="Yoo I" first="Ik One" last="Yoo">Ik One Yoo</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Hwang, Ho Yeon" sort="Hwang, Ho Yeon" uniqKey="Hwang H" first="Ho Yeon" last="Hwang">Ho Yeon Hwang</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F907C12E84C332890F9C1D68841528B717BDB54D</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1097/MLG.0b013e31802c93b2</idno><idno type="url">https://api.istex.fr/document/F907C12E84C332890F9C1D68841528B717BDB54D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">007492</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">007492</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">D2‐40 Immunohistochemical Assessment of Lymphangiogenesis in Normal and Edematous Sinus Mucosa and Nasal Polyp<ref type="note" target="#fn1"></ref></title><author><name sortKey="Kim, Tae Hoon" sort="Kim, Tae Hoon" uniqKey="Kim T" first="Tae Hoon" last="Kim">Tae Hoon Kim</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Lee, Sang Hag" sort="Lee, Sang Hag" uniqKey="Lee S" first="Sang Hag" last="Lee">Sang Hag Lee</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation><affiliation><mods:affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Lee, Heung Man" sort="Lee, Heung Man" uniqKey="Lee H" first="Heung Man" last="Lee">Heung Man Lee</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation><affiliation><mods:affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Lee, Seung Hoon" sort="Lee, Seung Hoon" uniqKey="Lee S" first="Seung Hoon" last="Lee">Seung Hoon Lee</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation><affiliation><mods:affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Jung, Hak Hyun" sort="Jung, Hak Hyun" uniqKey="Jung H" first="Hak Hyun" last="Jung">Hak Hyun Jung</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Cho, Woo Sung" sort="Cho, Woo Sung" uniqKey="Cho W" first="Woo Sung" last="Cho">Woo Sung Cho</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Cinn, Young Gi" sort="Cinn, Young Gi" uniqKey="Cinn Y" first="Young Gi" last="Cinn">Young Gi Cinn</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Choe, Hwan" sort="Choe, Hwan" uniqKey="Choe H" first="Hwan" last="Choe">Hwan Choe</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Kim, Moo Pil" sort="Kim, Moo Pil" uniqKey="Kim M" first="Moo Pil" last="Kim">Moo Pil Kim</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Yoo, Ik One" sort="Yoo, Ik One" uniqKey="Yoo I" first="Ik One" last="Yoo">Ik One Yoo</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author><author><name sortKey="Hwang, Ho Yeon" sort="Hwang, Ho Yeon" uniqKey="Hwang H" first="Ho Yeon" last="Hwang">Ho Yeon Hwang</name><affiliation><mods:affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Laryngoscope</title><title level="j" type="alt">LARYNGOSCOPE</title><idno type="ISSN">0023-852X</idno><idno type="eISSN">1531-4995</idno><imprint><biblScope unit="vol">117</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="442">442</biblScope><biblScope unit="page" to="446">446</biblScope><biblScope unit="page-count">5</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>Hoboken, NJ</pubPlace><date type="published" when="2007-03">2007-03</date></imprint><idno type="ISSN">0023-852X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0023-852X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Objective: The lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, which facilitates interstitial protein transport. Until recently, the lymphatic system of the sinonasal mucosa has been relatively poorly studied. The authors aimed to investigate the distributional and quantitative changes of the lymphatic vessels in inflammatory sinus mucosa and nasal polyps in comparison with healthy sinus mucosa using D2‐40 antibody.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>lymphatic</json:string><json:string>lymphatic vessels</json:string><json:string>ethmoid</json:string><json:string>sinus</json:string><json:string>polyp</json:string><json:string>lymphangiogenesis</json:string><json:string>edematous ethmoid sinus mucosa</json:string><json:string>edematous</json:string><json:string>nasal polyps</json:string><json:string>sinus mucosa</json:string><json:string>edematous sinus mucosa</json:string><json:string>lymphatics</json:string><json:string>distributional</json:string><json:string>ethmoid sinus mucosa</json:string><json:string>laryngoscope</json:string><json:string>immunohistochemical</json:string><json:string>mucosa</json:string><json:string>epithelial</json:string><json:string>nasal polyp</json:string><json:string>mucosal</json:string><json:string>length density</json:string><json:string>nasal</json:string><json:string>distributional patterns</json:string><json:string>important role</json:string><json:string>present study</json:string><json:string>lamina propria</json:string><json:string>inflammation</json:string><json:string>chronic inflammation</json:string><json:string>lymphatic system</json:string><json:string>inflammatory</json:string><json:string>perimeter</json:string><json:string>western blot</json:string><json:string>immunohistochemical staining</json:string><json:string>mucosal edema</json:string><json:string>epithelial basement membrane</json:string><json:string>korea university</json:string><json:string>subepithelial layer</json:string><json:string>lymphatic vessel</json:string><json:string>tissue sections</json:string><json:string>normal ethmoid sinus mucosa</json:string><json:string>epithelial layer</json:string><json:string>distributional characteristics</json:string></teeft></keywords><author><json:item><name>Tae Hoon Kim MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string></affiliations></json:item><json:item><name>Sang Hag Lee MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string><json:string>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</json:string></affiliations></json:item><json:item><name>Heung Man Lee MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string><json:string>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</json:string></affiliations></json:item><json:item><name>Seung Hoon Lee MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string><json:string>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</json:string></affiliations></json:item><json:item><name>Hak Hyun Jung MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string></affiliations></json:item><json:item><name>Woo Sung Cho MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string></affiliations></json:item><json:item><name>Young Gi Cinn MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string></affiliations></json:item><json:item><name>Hwan Choe MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string></affiliations></json:item><json:item><name>Moo Pil Kim MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string></affiliations></json:item><json:item><name>Ik One Yoo MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string></affiliations></json:item><json:item><name>Ho Yeon Hwang MD</name><affiliations><json:string>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>D2‐40</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>lymphangiogenesis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>ethmoid sinus mucosa</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>nasal polyp</value></json:item></subject><articleId><json:string>LARY5541170309</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><qualityIndicators><score>4.085</score><pdfVersion>1.3</pdfVersion><pdfPageSize>585 x 783 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>460</abstractCharCount><pdfWordCount>3317</pdfWordCount><pdfCharCount>21691</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>64</abstractWordCount></qualityIndicators><title>D2‐40 Immunohistochemical Assessment of Lymphangiogenesis in Normal and Edematous Sinus Mucosa and Nasal Polyp</title><genre><json:string>article</json:string></genre><host><title>The 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and Nasal Polyp<ref type="note" target="#fn1"></ref></title></titleStmt><publicationStmt><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>Hoboken, NJ</pubPlace><availability><licence>Copyright © 2007 The Triological Society</licence></availability><date type="published" when="2007-03"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">D2‐40 Immunohistochemical Assessment of Lymphangiogenesis in Normal and Edematous Sinus Mucosa and Nasal Polyp<ref type="note" target="#fn1"></ref></title><title level="a" type="short" xml:lang="en">Lymphangiogenesis in Sinus Mucosa</title><author xml:id="author-0000"><persName><forename type="first">Tae Hoon</forename><surname>Kim</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation></author><author xml:id="author-0001" role="corresp"><persName><forename type="first">Sang Hag</forename><surname>Lee</surname><roleName type="degree">MD</roleName></persName><email>sanghag@kumc.or.kr</email><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation><affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</affiliation></author><author xml:id="author-0002" role="corresp"><persName><forename type="first">Heung Man</forename><surname>Lee</surname><roleName type="degree">MD</roleName></persName><email>sanghag@kumc.or.kr</email><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation><affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</affiliation></author><author xml:id="author-0003" role="corresp"><persName><forename type="first">Seung Hoon</forename><surname>Lee</surname><roleName type="degree">MD</roleName></persName><email>sanghag@kumc.or.kr</email><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation><affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Hak Hyun</forename><surname>Jung</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Woo Sung</forename><surname>Cho</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Young Gi</forename><surname>Cinn</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Hwan</forename><surname>Choe</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Moo Pil</forename><surname>Kim</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Ik One</forename><surname>Yoo</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation></author><author xml:id="author-0010"><persName><forename type="first">Ho Yeon</forename><surname>Hwang</surname><roleName type="degree">MD</roleName></persName><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.<address><country key="KP"></country></address></affiliation></author><idno type="istex">F907C12E84C332890F9C1D68841528B717BDB54D</idno><idno type="DOI">10.1097/MLG.0b013e31802c93b2</idno><idno type="unit">LARY5541170309</idno><idno type="toTypesetVersion">file:LARY.LARY5541170309.pdf</idno></analytic><monogr><title level="j" type="main">The Laryngoscope</title><title level="j" type="alt">LARYNGOSCOPE</title><idno type="pISSN">0023-852X</idno><idno type="eISSN">1531-4995</idno><idno type="book-DOI">10.1002/(ISSN)1531-4995</idno><idno type="book-part-DOI">10.1002/lary.v117:3</idno><idno type="product">LARY</idno><imprint><biblScope unit="vol">117</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="442">442</biblScope><biblScope unit="page" to="446">446</biblScope><biblScope unit="page-count">5</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>Hoboken, NJ</pubPlace><date type="published" when="2007-03"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p><hi rend="bold">Objective:</hi> The lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, which facilitates interstitial protein transport. Until recently, the lymphatic system of the sinonasal mucosa has been relatively poorly studied. The authors aimed to investigate the distributional and quantitative changes of the lymphatic vessels in inflammatory sinus mucosa and nasal polyps in comparison with healthy sinus mucosa using D2‐40 antibody.</p><p><hi rend="bold">Methods:</hi> Immunohistochemistry and Western blotting with D2‐40 antibody were applied to normal and edematous ethmoid sinus mucosa and nasal polyps. The number, size, and length densities of lymphatic vessels were evaluated using tissue sections and whole mount preparations.</p><p><hi rend="bold">Results:</hi> Most lymphatic vessels in normal and edematous ethmoid sinus mucosa were distributed in the subepithelial layer. Some of these vessels were dilated, whereas others were compressed and had a slit‐like lumen. No D2‐40 positive vessels were found in samples of nasal polyps. Lymphatic vessels showed no statistically significant difference in their number, size, or length density between normal and edematous ethmoid sinus mucosa. Western blot also showed no differences in their expression levels.</p><p><hi rend="bold">Conclusion:</hi> These findings indicate that lymphangiogenesis does not occur in edematous ethmoid sinus mucosa, which may not reuptake interstitial fluid efficiently in inflammatory conditions, resulting in the formation of mucosal edema in chronic inflammation.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">D2‐40</term><term xml:id="kwd2">lymphangiogenesis</term><term xml:id="kwd3">ethmoid sinus mucosa</term><term xml:id="kwd4">nasal polyp</term></keywords><classCode scheme="articleCategory">Article</classCode><classCode scheme="tocHeading1">Articles</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/F907C12E84C332890F9C1D68841528B717BDB54D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Inc.</publisherName><publisherLoc>Hoboken, NJ</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-4995</doi><issn type="print">0023-852X</issn><issn type="electronic">1531-4995</issn><idGroup><id type="product" value="LARY"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="LARYNGOSCOPE">The Laryngoscope</title><title type="short">The Laryngoscope</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="no">10.1002/lary.v117:3</doi><numberingGroup><numbering type="journalVolume" number="117">117</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2007-03">March 2007</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="9" status="forIssue"><doi origin="wiley" registered="yes">10.1097/MLG.0b013e31802c93b2</doi><idGroup><id type="unit" value="LARY5541170309"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2007 The Triological Society</copyright><eventGroup><event type="manuscriptAccepted" date="2006-10-23"></event><event type="firstOnline" date="2009-01-02"></event><event type="publishedOnlineFinalForm" date="2009-01-02"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.1 mode:FullText source:FullText result:FullText" date="2010-02-23"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-01"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst">442</numbering><numbering type="pageLast">446</numbering></numberingGroup><correspondenceTo>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:LARY.LARY5541170309.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="17"></count></countGroup><titleGroup><title type="main" xml:lang="en">D2‐40 Immunohistochemical Assessment of Lymphangiogenesis in Normal and Edematous Sinus Mucosa and Nasal Polyp<link href="#fn1"></link></title><title type="short" xml:lang="en">Lymphangiogenesis in Sinus Mucosa</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Tae Hoon</givenNames><familyName>Kim</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Sang Hag</givenNames><familyName>Lee</familyName><degrees>MD</degrees></personName><contactDetails><email>sanghag@kumc.or.kr</email></contactDetails></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Heung Man</givenNames><familyName>Lee</familyName><degrees>MD</degrees></personName><contactDetails><email>sanghag@kumc.or.kr</email></contactDetails></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Seung Hoon</givenNames><familyName>Lee</familyName><degrees>MD</degrees></personName><contactDetails><email>sanghag@kumc.or.kr</email></contactDetails></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Hak Hyun</givenNames><familyName>Jung</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Woo Sung</givenNames><familyName>Cho</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Young Gi</givenNames><familyName>Cinn</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Hwan</givenNames><familyName>Choe</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Moo Pil</givenNames><familyName>Kim</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Ik One</givenNames><familyName>Yoo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Ho Yeon</givenNames><familyName>Hwang</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="KP" type="organization"><unparsedAffiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">D2‐40</keyword><keyword xml:id="kwd2">lymphangiogenesis</keyword><keyword xml:id="kwd3">ethmoid sinus mucosa</keyword><keyword xml:id="kwd4">nasal polyp</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><b>Objective:</b> The lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, which facilitates interstitial protein transport. Until recently, the lymphatic system of the sinonasal mucosa has been relatively poorly studied. The authors aimed to investigate the distributional and quantitative changes of the lymphatic vessels in inflammatory sinus mucosa and nasal polyps in comparison with healthy sinus mucosa using D2‐40 antibody.</p><p><b>Methods:</b> Immunohistochemistry and Western blotting with D2‐40 antibody were applied to normal and edematous ethmoid sinus mucosa and nasal polyps. The number, size, and length densities of lymphatic vessels were evaluated using tissue sections and whole mount preparations.</p><p><b>Results:</b> Most lymphatic vessels in normal and edematous ethmoid sinus mucosa were distributed in the subepithelial layer. Some of these vessels were dilated, whereas others were compressed and had a slit‐like lumen. No D2‐40 positive vessels were found in samples of nasal polyps. Lymphatic vessels showed no statistically significant difference in their number, size, or length density between normal and edematous ethmoid sinus mucosa. Western blot also showed no differences in their expression levels.</p><p><b>Conclusion:</b> These findings indicate that lymphangiogenesis does not occur in edematous ethmoid sinus mucosa, which may not reuptake interstitial fluid efficiently in inflammatory conditions, resulting in the formation of mucosal edema in chronic inflammation.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>This work was supported by a Grant‐in‐Aid for Scientific Research from the Communication Disorders Center, Korea University, Korea.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>D2‐40 Immunohistochemical Assessment of Lymphangiogenesis in Normal and Edematous Sinus Mucosa and Nasal Polyp</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Lymphangiogenesis in Sinus Mucosa</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>D2‐40 Immunohistochemical Assessment of Lymphangiogenesis in Normal and Edematous Sinus Mucosa and Nasal Polyp</title></titleInfo><name type="personal"><namePart type="given">Tae Hoon</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sang Hag</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Heung Man</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Seung Hoon</namePart><namePart type="family">Lee</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><affiliation>Dr. Sang Hag Lee, Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, 126‐1, 5 Ka, Anam‐Dong, SungBuk‐Ku, Seoul, 136‐705, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hak Hyun</namePart><namePart type="family">Jung</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Woo Sung</namePart><namePart type="family">Cho</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Young Gi</namePart><namePart type="family">Cinn</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hwan</namePart><namePart type="family">Choe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Moo Pil</namePart><namePart type="family">Kim</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ik One</namePart><namePart type="family">Yoo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ho Yeon</namePart><namePart type="family">Hwang</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Otorhinolaryngology‐Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">Hoboken, NJ</placeTerm></place><dateIssued encoding="w3cdtf">2007-03</dateIssued><dateValid encoding="w3cdtf">2006-10-23</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">5</extent><extent unit="references">17</extent></physicalDescription><abstract>Objective: The lymphatic system plays an important role in the maintenance of tissue fluid homeostasis, which facilitates interstitial protein transport. Until recently, the lymphatic system of the sinonasal mucosa has been relatively poorly studied. The authors aimed to investigate the distributional and quantitative changes of the lymphatic vessels in inflammatory sinus mucosa and nasal polyps in comparison with healthy sinus mucosa using D2‐40 antibody.</abstract><abstract>Methods: Immunohistochemistry and Western blotting with D2‐40 antibody were applied to normal and edematous ethmoid sinus mucosa and nasal polyps. The number, size, and length densities of lymphatic vessels were evaluated using tissue sections and whole mount preparations.</abstract><abstract>Results: Most lymphatic vessels in normal and edematous ethmoid sinus mucosa were distributed in the subepithelial layer. Some of these vessels were dilated, whereas others were compressed and had a slit‐like lumen. No D2‐40 positive vessels were found in samples of nasal polyps. Lymphatic vessels showed no statistically significant difference in their number, size, or length density between normal and edematous ethmoid sinus mucosa. Western blot also showed no differences in their expression levels.</abstract><abstract>Conclusion: These findings indicate that lymphangiogenesis does not occur in edematous ethmoid sinus mucosa, which may not reuptake interstitial fluid efficiently in inflammatory conditions, resulting in the formation of mucosal edema in chronic inflammation.</abstract><note type="content">*This work was supported by a Grant‐in‐Aid for Scientific Research from the Communication Disorders Center, Korea University, Korea.</note><subject lang="en"><genre>keywords</genre><topic>D2‐40</topic><topic>lymphangiogenesis</topic><topic>ethmoid sinus mucosa</topic><topic>nasal polyp</topic></subject><relatedItem type="host"><titleInfo><title>The Laryngoscope</title></titleInfo><titleInfo type="abbreviated"><title>The Laryngoscope</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Article</topic></subject><identifier type="ISSN">0023-852X</identifier><identifier type="eISSN">1531-4995</identifier><identifier type="DOI">10.1002/(ISSN)1531-4995</identifier><identifier type="PublisherID">LARY</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>117</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>442</start><end>446</end><total>5</total></extent></part></relatedItem><identifier type="istex">F907C12E84C332890F9C1D68841528B717BDB54D</identifier><identifier type="DOI">10.1097/MLG.0b013e31802c93b2</identifier><identifier type="ArticleID">LARY5541170309</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 The Triological Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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