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Dermatopathology of the foreskin: an institutional experience of over 400 cases

Identifieur interne : 007357 ( Istex/Corpus ); précédent : 007356; suivant : 007358

Dermatopathology of the foreskin: an institutional experience of over 400 cases

Auteurs : Dava S. West ; John A. Papalas ; Maria A. Selim ; Robin T. Vollmer

Source :

RBID : ISTEX:F6843AB5BE8D87A5EAD99FAEEE8AF582BA3D7793

Abstract

Diseases of the foreskin may manifest with an array of pathologic findings, including potentially under‐recognized dermatologic conditions. Herein, we summarize an institutional experience in foreskin dermatopathology.

Url:
DOI: 10.1111/cup.12032

Links to Exploration step

ISTEX:F6843AB5BE8D87A5EAD99FAEEE8AF582BA3D7793

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<abstract style="main"> Background
<p>Diseases of the foreskin may manifest with an array of pathologic findings, including potentially under‐recognized dermatologic conditions. Herein, we summarize an institutional experience in foreskin dermatopathology.</p>
Methods
<p>Diagnoses rendered on foreskin specimens between 1982 and April 2009 were obtained through a computer‐based keyword search. Cases given normal, non‐specific or descriptive diagnoses were reviewed by a dermatopathologist.</p>
Results
<p>Keyword search yielded 414 foreskin diagnoses. Interpretations included normal foreskin (n = 131), benign lesions (n = 262) and malignant/dysplastic entities (n = 21). Of 353 cases given normal, descriptive or non‐specific diagnoses, 334 were reviewed. Of reviewed cases, 209 (63%) were given more specific diagnoses [e.g. spongiotic dermatitis (n = 115), lichen sclerosus et atrophicus (
<hi rend="fc">LSA</hi>
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Conclusions
<p>This study shows benign inflammatory lesions represent the most frequent foreskin pathology. When possible, specific diagnoses should be rendered, as accurate classification may be of clinical importance. There is an abundance of recent literature on the role of circumcision in disease prevention, and this topic is explored. We discuss the theoretical possibility that foreskin inflammation compromises the mucosal/epithelial barrier, thus playing a role in disease transmission.</p>
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<personName>
<givenNames>Dava S.</givenNames>
<familyName>West</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cup12032-cr-0002" affiliationRef="#cup12032-aff-0001">
<personName>
<givenNames>John A.</givenNames>
<familyName>Papalas</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cup12032-cr-0003" affiliationRef="#cup12032-aff-0001">
<personName>
<givenNames>Maria A.</givenNames>
<familyName>Selim</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cup12032-cr-0004" affiliationRef="#cup12032-aff-0002" corresponding="yes">
<personName>
<givenNames>Robin T.</givenNames>
<familyName>Vollmer</familyName>
</personName>
</creator>
</creators>
<affiliationGroup>
<affiliation countryCode="US" type="organization" xml:id="cup12032-aff-0001">
<orgName>Department of Pathology, Duke University Medical Center</orgName>
<address>
<city>Durham</city>
<countryPart>NC</countryPart>
<country>USA</country>
</address>
</affiliation>
<affiliation countryCode="US" type="organization" xml:id="cup12032-aff-0002">
<orgName>Department of Pathology, Veterans Affairs Medical Center</orgName>
<address>
<city>Durham</city>
<countryPart>NC</countryPart>
<country>USA</country>
</address>
</affiliation>
</affiliationGroup>
<keywordGroup type="author">
<keyword xml:id="cup12032-kwd-0001">circumcision</keyword>
<keyword xml:id="cup12032-kwd-0002">dermatopathology</keyword>
<keyword xml:id="cup12032-kwd-0003">foreskin</keyword>
<keyword xml:id="cup12032-kwd-0004">penis</keyword>
<keyword xml:id="cup12032-kwd-0005">prepuce</keyword>
</keywordGroup>
<abstractGroup>
<abstract type="main">
<section xml:id="cup12032-sec-0001">
<title type="main">Background</title>
<p>Diseases of the foreskin may manifest with an array of pathologic findings, including potentially under‐recognized dermatologic conditions. Herein, we summarize an institutional experience in foreskin dermatopathology.</p>
</section>
<section xml:id="cup12032-sec-0002">
<title type="main">Methods</title>
<p>Diagnoses rendered on foreskin specimens between 1982 and April 2009 were obtained through a computer‐based keyword search. Cases given normal, non‐specific or descriptive diagnoses were reviewed by a dermatopathologist.</p>
</section>
<section xml:id="cup12032-sec-0003">
<title type="main">Results</title>
<p>Keyword search yielded 414 foreskin diagnoses. Interpretations included normal foreskin (n = 131), benign lesions (n = 262) and malignant/dysplastic entities (n = 21). Of 353 cases given normal, descriptive or non‐specific diagnoses, 334 were reviewed. Of reviewed cases, 209 (63%) were given more specific diagnoses [e.g. spongiotic dermatitis (n = 115), lichen sclerosus et atrophicus (
<fc>LSA</fc>
; n = 41), interface/lichenoid dermatitis (n = 26), psoriasiform dermatitis (n = 7)]. Discrepancy between the clinical and pathologic impression was frequently noted (n = 77).</p>
</section>
<section xml:id="cup12032-sec-0004">
<title type="main">Conclusions</title>
<p>This study shows benign inflammatory lesions represent the most frequent foreskin pathology. When possible, specific diagnoses should be rendered, as accurate classification may be of clinical importance. There is an abundance of recent literature on the role of circumcision in disease prevention, and this topic is explored. We discuss the theoretical possibility that foreskin inflammation compromises the mucosal/epithelial barrier, thus playing a role in disease transmission.</p>
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<title>Dermatopathology of the foreskin: an institutional experience of over 400 cases</title>
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<title>Dermatopathology of the foreskin</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en">
<title>Dermatopathology of the foreskin: an institutional experience of over 400 cases</title>
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<name type="personal">
<namePart type="given">Dava S.</namePart>
<namePart type="family">West</namePart>
<affiliation>Department of Pathology, Duke University Medical Center, NC, Durham, USA</affiliation>
<role>
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<name type="personal">
<namePart type="given">John A.</namePart>
<namePart type="family">Papalas</namePart>
<affiliation>Department of Pathology, Duke University Medical Center, NC, Durham, USA</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
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<name type="personal">
<namePart type="given">Maria A.</namePart>
<namePart type="family">Selim</namePart>
<affiliation>Department of Pathology, Duke University Medical Center, NC, Durham, USA</affiliation>
<role>
<roleTerm type="text">author</roleTerm>
</role>
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<name type="personal">
<namePart type="given">Robin T.</namePart>
<namePart type="family">Vollmer</namePart>
<affiliation>Department of Pathology, Veterans Affairs Medical Center, NC, Durham, USA</affiliation>
<affiliation>Robin T. Vollmer, MD,Department of Pathology, Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USATel: +919 286 0411Fax: +919 286 6818e‐mail:</affiliation>
<affiliation>E-mail: robin.vollmer@va.gov</affiliation>
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<dateIssued encoding="w3cdtf">2013-01</dateIssued>
<dateCreated encoding="w3cdtf">2012-09-28</dateCreated>
<dateValid encoding="w3cdtf">2012-05-06</dateValid>
<edition>West DS, Papalas JA, Selim MA, Vollmer RT. Dermatopathology of the foreskin: an institutional experience of over 400 cases.</edition>
<copyrightDate encoding="w3cdtf">2013</copyrightDate>
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<abstract>Diseases of the foreskin may manifest with an array of pathologic findings, including potentially under‐recognized dermatologic conditions. Herein, we summarize an institutional experience in foreskin dermatopathology.</abstract>
<abstract>Diagnoses rendered on foreskin specimens between 1982 and April 2009 were obtained through a computer‐based keyword search. Cases given normal, non‐specific or descriptive diagnoses were reviewed by a dermatopathologist.</abstract>
<abstract>Keyword search yielded 414 foreskin diagnoses. Interpretations included normal foreskin (n = 131), benign lesions (n = 262) and malignant/dysplastic entities (n = 21). Of 353 cases given normal, descriptive or non‐specific diagnoses, 334 were reviewed. Of reviewed cases, 209 (63%) were given more specific diagnoses [e.g. spongiotic dermatitis (n = 115), lichen sclerosus et atrophicus (LSA; n = 41), interface/lichenoid dermatitis (n = 26), psoriasiform dermatitis (n = 7)]. Discrepancy between the clinical and pathologic impression was frequently noted (n = 77).</abstract>
<abstract>This study shows benign inflammatory lesions represent the most frequent foreskin pathology. When possible, specific diagnoses should be rendered, as accurate classification may be of clinical importance. There is an abundance of recent literature on the role of circumcision in disease prevention, and this topic is explored. We discuss the theoretical possibility that foreskin inflammation compromises the mucosal/epithelial barrier, thus playing a role in disease transmission.</abstract>
<subject>
<genre>keywords</genre>
<topic>circumcision</topic>
<topic>dermatopathology</topic>
<topic>foreskin</topic>
<topic>penis</topic>
<topic>prepuce</topic>
</subject>
<relatedItem type="host">
<titleInfo>
<title>Journal of Cutaneous Pathology</title>
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<titleInfo type="abbreviated">
<title>J Cutan Pathol</title>
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<genre type="journal">journal</genre>
<subject>
<genre>article-category</genre>
<topic>Original Article</topic>
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<identifier type="ISSN">0303-6987</identifier>
<identifier type="eISSN">1600-0560</identifier>
<identifier type="DOI">10.1111/(ISSN)1600-0560</identifier>
<identifier type="PublisherID">CUP</identifier>
<part>
<date>2013</date>
<detail type="volume">
<caption>vol.</caption>
<number>40</number>
</detail>
<detail type="issue">
<caption>no.</caption>
<number>1</number>
</detail>
<extent unit="pages">
<start>11</start>
<end>18</end>
<total>8</total>
</extent>
</part>
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<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2013 John Wiley & Sons A/SCopyright © 2012 John Wiley & Sons A/S</accessCondition>
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<recordOrigin>Blackwell Publishing Ltd</recordOrigin>
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