Single institution's initial experience with sentinel lymph node biopsy in breast cancer patients
Identifieur interne : 006C44 ( Istex/Corpus ); précédent : 006C43; suivant : 006C45Single institution's initial experience with sentinel lymph node biopsy in breast cancer patients
Auteurs : W. S. Yong ; C. Y. Wong ; J. S. Y. Lee ; K. C. Soo ; P. H. Tan ; A. S. W. GohSource :
- ANZ Journal of Surgery [ 1445-1433 ] ; 2003-06.
Abstract
Background: The sentinel lymph node is the first draining node from a cancer‐bearing area and is therefore the first to manifest metastasis. In breast cancer it has been shown to predict the axillary status. Axillary dissection provides information determining prognosis and need for adjuvant therapy but carries a certain morbidity. Our aim was to determine the feasibility of detecting the sentinel node in a teaching hospital and whether the sentinel node accurately predicts the axillary status.
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DOI: 10.1046/j.1445-2197.2003.t01-1-02632.x
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Soo</name><affiliation><mods:affiliation>Departments of Surgery,</mods:affiliation></affiliation></author><author><name sortKey="Tan, P H" sort="Tan, P H" uniqKey="Tan P" first="P. H." last="Tan">P. H. Tan</name><affiliation><mods:affiliation>Pathology and</mods:affiliation></affiliation></author><author><name sortKey="Goh, A S W" sort="Goh, A S W" uniqKey="Goh A" first="A. S. W." last="Goh">A. S. W. 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Yong</name><affiliation><mods:affiliation>Departments of Surgery,</mods:affiliation></affiliation></author><author><name sortKey="Wong, C Y" sort="Wong, C Y" uniqKey="Wong C" first="C. Y." last="Wong">C. Y. Wong</name><affiliation><mods:affiliation>Departments of Surgery,</mods:affiliation></affiliation></author><author><name sortKey="Lee, J S Y" sort="Lee, J S Y" uniqKey="Lee J" first="J. S. Y." last="Lee">J. S. Y. Lee</name><affiliation><mods:affiliation>Departments of Surgery,</mods:affiliation></affiliation></author><author><name sortKey="Soo, K C" sort="Soo, K C" uniqKey="Soo K" first="K. C." last="Soo">K. C. Soo</name><affiliation><mods:affiliation>Departments of Surgery,</mods:affiliation></affiliation></author><author><name sortKey="Tan, P H" sort="Tan, P H" uniqKey="Tan P" first="P. H." last="Tan">P. H. Tan</name><affiliation><mods:affiliation>Pathology and</mods:affiliation></affiliation></author><author><name sortKey="Goh, A S W" sort="Goh, A S W" uniqKey="Goh A" first="A. S. W." last="Goh">A. S. W. Goh</name><affiliation><mods:affiliation>Nuclear Medicine, Singapore General Hospital, Singapore</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">ANZ Journal of Surgery</title><title level="j" type="alt">ANZ JOURNAL SURGERY</title><idno type="ISSN">1445-1433</idno><idno type="eISSN">1445-2197</idno><imprint><biblScope unit="vol">73</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="416">416</biblScope><biblScope unit="page" to="421">421</biblScope><publisher>Blackwell Science Pty</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2003-06">2003-06</date></imprint><idno type="ISSN">1445-1433</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1445-1433</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: The sentinel lymph node is the first draining node from a cancer‐bearing area and is therefore the first to manifest metastasis. In breast cancer it has been shown to predict the axillary status. Axillary dissection provides information determining prognosis and need for adjuvant therapy but carries a certain morbidity. Our aim was to determine the feasibility of detecting the sentinel node in a teaching hospital and whether the sentinel node accurately predicts the axillary status.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>node</json:string><json:string>axillary</json:string><json:string>tumour</json:string><json:string>sentinel lymph node</json:string><json:string>breast cancer</json:string><json:string>axilla</json:string><json:string>lymph</json:string><json:string>sentinel</json:string><json:string>sentinel node</json:string><json:string>sentinel lymph node biopsy</json:string><json:string>excision</json:string><json:string>surg</json:string><json:string>medial</json:string><json:string>lymphatic</json:string><json:string>adjuvant</json:string><json:string>sentinel lymph nodes</json:string><json:string>nodal</json:string><json:string>biopsy</json:string><json:string>gamma probe</json:string><json:string>lymph nodes</json:string><json:string>axillary dissection</json:string><json:string>axillary lymph nodes</json:string><json:string>tumour size</json:string><json:string>detection rate</json:string><json:string>axillary clearance</json:string><json:string>histology</json:string><json:string>axillary nodes</json:string><json:string>adjuvant therapy</json:string><json:string>axillary status</json:string><json:string>medial tumours</json:string><json:string>lymphatic mapping</json:string><json:string>excision biopsy</json:string><json:string>breast cancer patients</json:string><json:string>preoperative lymphoscintigram</json:string><json:string>carcinoma</json:string></teeft></keywords><author><json:item><name>W. S. Yong</name><affiliations><json:string>Departments of Surgery,</json:string></affiliations></json:item><json:item><name>C. Y. Wong</name><affiliations><json:string>Departments of Surgery,</json:string></affiliations></json:item><json:item><name>J. S. Y. Lee</name><affiliations><json:string>Departments of Surgery,</json:string></affiliations></json:item><json:item><name>K. C. Soo</name><affiliations><json:string>Departments of Surgery,</json:string></affiliations></json:item><json:item><name>P. H. Tan</name><affiliations><json:string>Pathology and</json:string></affiliations></json:item><json:item><name>A. S. W. 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S.</forename><surname>Yong</surname></persName><affiliation>Departments of Surgery,</affiliation></author><author xml:id="author-0001"><persName><forename type="first">C. Y.</forename><surname>Wong</surname></persName><affiliation>Departments of Surgery,</affiliation></author><author xml:id="author-0002"><persName><forename type="first">J. S. Y.</forename><surname>Lee</surname></persName><affiliation>Departments of Surgery,</affiliation></author><author xml:id="author-0003"><persName><forename type="first">K. C.</forename><surname>Soo</surname></persName><affiliation>Departments of Surgery,</affiliation></author><author xml:id="author-0004"><persName><forename type="first">P. H.</forename><surname>Tan</surname></persName><affiliation>Pathology and</affiliation></author><author xml:id="author-0005"><persName><forename type="first">A. S. W.</forename><surname>Goh</surname></persName><affiliation>Nuclear Medicine, Singapore General Hospital, Singapore<address><country key="SG"></country></address></affiliation></author><idno type="istex">E702F3484A38723465DB1B77F14DB1A2B695A663</idno><idno type="DOI">10.1046/j.1445-2197.2003.t01-1-02632.x</idno><idno type="unit">ANS2632</idno><idno type="toTypesetVersion">file:ANS.ANS2632.pdf</idno></analytic><monogr><title level="j" type="main">ANZ Journal of Surgery</title><title level="j" type="alt">ANZ JOURNAL SURGERY</title><idno type="pISSN">1445-1433</idno><idno type="eISSN">1445-2197</idno><idno type="book-DOI">10.1111/(ISSN)1445-2197</idno><idno type="book-part-DOI">10.1111/ans.2003.73.issue-6</idno><idno type="product">ANS</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">73</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="416">416</biblScope><biblScope unit="page" to="421">421</biblScope><publisher>Blackwell Science Pty</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2003-06"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Background: </hi> The sentinel lymph node is the first draining node from a cancer‐bearing area and is therefore the first to manifest metastasis. In breast cancer it has been shown to predict the axillary status. Axillary dissection provides information determining prognosis and need for adjuvant therapy but carries a certain morbidity. Our aim was to determine the feasibility of detecting the sentinel node in a teaching hospital and whether the sentinel node accurately predicts the axillary status.</p><p><hi rend="bold">Methods: </hi> All patients with stage I and II breast cancer and non‐palpable axillary nodes were eligible, including those with previous excision biopsy. We excluded pregnant women, those with previous axillary surgery and women with advanced breast cancer with enlarged axillary nodes. The sentinel node was detected with technetium‐99<hi rend="italic">m</hi>‐labelled tin colloid and vital blue dye and removed, and axillary clearance was performed.</p><p><hi rend="bold">Results: </hi> A total of 312 patients were examined from August 1996 to December 1998. The mean age was 53 years (range 28−83) and mean tumour size 2.6 cm (range 0.2−9.0). The detection rate of the sentinel node was 86%. The sentinel lymph node predicted the axillary status with a sensitivity of 83% and specificity of 100%. The false‐negative rate was 16.7%.</p><p><hi rend="bold">Conclusions: </hi> Detection of the sentinel lymph node is feasible and it can accurately predict the nodal status of the axilla. However, the high false‐negative rate precludes as yet the use of sentinel lymph node biopsy in replacing axillary clearance as the standard of care for breast cancer.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">accuracy</term><term xml:id="k2">axillary clearance</term><term xml:id="k3">breast cancer</term><term xml:id="k4">detection rate</term><term xml:id="k5">false negative</term><term xml:id="k6">sensitivity</term><term xml:id="k7">sentinel lymph node biopsy</term><term xml:id="k8">standard of care</term></keywords><classCode scheme="tocHeading1">ORIGINAL ARTICLES</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/E702F3484A38723465DB1B77F14DB1A2B695A663/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science Pty</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1445-2197</doi><issn type="print">1445-1433</issn><issn type="electronic">1445-2197</issn><idGroup><id type="product" value="ANS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANZ JOURNAL SURGERY">ANZ Journal of Surgery</title></titleGroup></publicationMeta><publicationMeta level="part" position="06006"><doi origin="wiley">10.1111/ans.2003.73.issue-6</doi><numberingGroup><numbering type="journalVolume" number="73">73</numbering><numbering type="journalIssue" number="6">6</numbering></numberingGroup><coverDate startDate="2003-06">June 2003</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0041600" status="forIssue"><doi origin="wiley">10.1046/j.1445-2197.2003.t01-1-02632.x</doi><idGroup><id type="unit" value="ANS2632"></id></idGroup><titleGroup><title type="tocHeading1">ORIGINAL ARTICLES</title></titleGroup><eventGroup><event type="firstOnline" date="2003-06-19"></event><event type="publishedOnlineFinalForm" date="2003-06-19"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.4 mode:FullText source:FullText result:FullText" date="2010-03-30"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-04"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="416">416</numbering><numbering type="pageLast" number="421">421</numbering></numberingGroup><correspondenceTo> Dr W. S. Yong, Department of Surgery, Singapore General Hospital, Outram Road, Singapore 169608, Republic of Singapore.
Email: <email>gsuyws@sgh.com.sg</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ANS.ANS2632.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 6 February 2003.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="23"></count><count type="wordTotal" number="3883"></count><count type="linksPubMed" number="23"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Single institution's initial experience with sentinel lymph node biopsy in breast cancer patients</title><title type="shortAuthors">Yong <i>et al.</i></title><title type="short">Sentinel lymph node biopsy for breast cancer</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>W. S.</givenNames><familyName>Yong</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>C. Y.</givenNames><familyName>Wong</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>J. S. Y.</givenNames><familyName>Lee</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>K. C.</givenNames><familyName>Soo</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>P. H.</givenNames><familyName>Tan</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a3"><personName><givenNames>A. S. W.</givenNames><familyName>Goh</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Departments of Surgery,</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Pathology and</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="SG"><unparsedAffiliation>Nuclear Medicine, Singapore General Hospital, Singapore</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">accuracy</keyword><keyword xml:id="k2">axillary clearance</keyword><keyword xml:id="k3">breast cancer</keyword><keyword xml:id="k4">detection rate</keyword><keyword xml:id="k5">false negative</keyword><keyword xml:id="k6">sensitivity</keyword><keyword xml:id="k7">sentinel lymph node biopsy</keyword><keyword xml:id="k8">standard of care</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background: </b> The sentinel lymph node is the first draining node from a cancer‐bearing area and is therefore the first to manifest metastasis. In breast cancer it has been shown to predict the axillary status. Axillary dissection provides information determining prognosis and need for adjuvant therapy but carries a certain morbidity. Our aim was to determine the feasibility of detecting the sentinel node in a teaching hospital and whether the sentinel node accurately predicts the axillary status.</p><p><b>Methods: </b> All patients with stage I and II breast cancer and non‐palpable axillary nodes were eligible, including those with previous excision biopsy. We excluded pregnant women, those with previous axillary surgery and women with advanced breast cancer with enlarged axillary nodes. The sentinel node was detected with technetium‐99<i>m</i>‐labelled tin colloid and vital blue dye and removed, and axillary clearance was performed.</p><p><b>Results: </b> A total of 312 patients were examined from August 1996 to December 1998. The mean age was 53 years (range 28−83) and mean tumour size 2.6 cm (range 0.2−9.0). The detection rate of the sentinel node was 86%. The sentinel lymph node predicted the axillary status with a sensitivity of 83% and specificity of 100%. The false‐negative rate was 16.7%.</p><p><b>Conclusions: </b> Detection of the sentinel lymph node is feasible and it can accurately predict the nodal status of the axilla. However, the high false‐negative rate precludes as yet the use of sentinel lymph node biopsy in replacing axillary clearance as the standard of care for breast cancer.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Single institution's initial experience with sentinel lymph node biopsy in breast cancer patients</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Sentinel lymph node biopsy for breast cancer</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Single institution's initial experience with sentinel lymph node biopsy in breast cancer patients</title></titleInfo><name type="personal"><namePart type="given">W. S.</namePart><namePart type="family">Yong</namePart><affiliation>Departments of Surgery,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. Y.</namePart><namePart type="family">Wong</namePart><affiliation>Departments of Surgery,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. S. Y.</namePart><namePart type="family">Lee</namePart><affiliation>Departments of Surgery,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. C.</namePart><namePart type="family">Soo</namePart><affiliation>Departments of Surgery,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. H.</namePart><namePart type="family">Tan</namePart><affiliation>Pathology and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. S. W.</namePart><namePart type="family">Goh</namePart><affiliation>Nuclear Medicine, Singapore General Hospital, Singapore</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Science Pty</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2003-06</dateIssued><edition>Accepted for publication 6 February 2003.</edition><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">1</extent><extent unit="references">23</extent><extent unit="words">3883</extent></physicalDescription><abstract>Background: The sentinel lymph node is the first draining node from a cancer‐bearing area and is therefore the first to manifest metastasis. In breast cancer it has been shown to predict the axillary status. Axillary dissection provides information determining prognosis and need for adjuvant therapy but carries a certain morbidity. Our aim was to determine the feasibility of detecting the sentinel node in a teaching hospital and whether the sentinel node accurately predicts the axillary status.</abstract><abstract>Methods: All patients with stage I and II breast cancer and non‐palpable axillary nodes were eligible, including those with previous excision biopsy. We excluded pregnant women, those with previous axillary surgery and women with advanced breast cancer with enlarged axillary nodes. The sentinel node was detected with technetium‐99m‐labelled tin colloid and vital blue dye and removed, and axillary clearance was performed.</abstract><abstract>Results: A total of 312 patients were examined from August 1996 to December 1998. The mean age was 53 years (range 28−83) and mean tumour size 2.6 cm (range 0.2−9.0). The detection rate of the sentinel node was 86%. The sentinel lymph node predicted the axillary status with a sensitivity of 83% and specificity of 100%. The false‐negative rate was 16.7%.</abstract><abstract>Conclusions: Detection of the sentinel lymph node is feasible and it can accurately predict the nodal status of the axilla. However, the high false‐negative rate precludes as yet the use of sentinel lymph node biopsy in replacing axillary clearance as the standard of care for breast cancer.</abstract><subject lang="en"><genre>keywords</genre><topic>accuracy</topic><topic>axillary clearance</topic><topic>breast cancer</topic><topic>detection rate</topic><topic>false negative</topic><topic>sensitivity</topic><topic>sentinel lymph node biopsy</topic><topic>standard of care</topic></subject><relatedItem type="host"><titleInfo><title>ANZ Journal of Surgery</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1445-1433</identifier><identifier type="eISSN">1445-2197</identifier><identifier type="DOI">10.1111/(ISSN)1445-2197</identifier><identifier type="PublisherID">ANS</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>416</start><end>421</end></extent></part></relatedItem><identifier type="istex">E702F3484A38723465DB1B77F14DB1A2B695A663</identifier><identifier type="DOI">10.1046/j.1445-2197.2003.t01-1-02632.x</identifier><identifier type="ArticleID">ANS2632</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Science Pty</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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