Angiosarcoma with dermal melanocytosis
Identifieur interne : 006B60 ( Istex/Corpus ); précédent : 006B59; suivant : 006B61Angiosarcoma with dermal melanocytosis
Auteurs : M. Akiyama ; W. Naka ; T. Harada ; T. NishikawaSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 1989-06.
Abstract
We report a case of angiosarcoma and dermal melanocytosis occurring simultaneously in the same lesion. We examined the primary and 2 metastatic lesions. Histopathologically, the anaplastic angiosarcoma cells had a tendency to form irregularly shaped small cavities. Immunohistochemically, they were strongly reactive with Ulex europaeus agglutinin (UEAI) stain. The mid and deep dermis of the same lesion had spindle or elongated slender melanocytes containing melanin granules. The melanocytes were positive with S‐100 protein stain. Ultrastructurally, pinocytotic vesicles, fine filaments, and Weibel‐Palade body‐like dense granules were observed in the cytoplasm of angiosarcoma cells. Dermal melanocytes had external lamina and melanosomes in various stages. The melanocytes showed no similarity to the neoplastic tumor cells and there was no apparent intermediate form between the 2 kinds of cells. The etiological implications of dermal melanocytosis with a tumor of vascular origin are discussed.
Url:
DOI: 10.1111/j.1600-0560.1989.tb00030.x
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Naka</name><affiliation><mods:affiliation>Department of Dermatology, Keio University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Harada, T" sort="Harada, T" uniqKey="Harada T" first="T." last="Harada">T. Harada</name><affiliation><mods:affiliation>Department of Dermatology, Keio University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Nishikawa, T" sort="Nishikawa, T" uniqKey="Nishikawa T" first="T." last="Nishikawa">T. 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Akiyama</name><affiliation><mods:affiliation>Department of Dermatology, Keio University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pathology, Keio University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Dr. M. Akiyama, Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku‐ku, Tokyo 160, Japan.</mods:affiliation></affiliation></author><author><name sortKey="Naka, W" sort="Naka, W" uniqKey="Naka W" first="W." last="Naka">W. Naka</name><affiliation><mods:affiliation>Department of Dermatology, Keio University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Harada, T" sort="Harada, T" uniqKey="Harada T" first="T." last="Harada">T. Harada</name><affiliation><mods:affiliation>Department of Dermatology, Keio University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author><author><name sortKey="Nishikawa, T" sort="Nishikawa, T" uniqKey="Nishikawa T" first="T." last="Nishikawa">T. Nishikawa</name><affiliation><mods:affiliation>Department of Dermatology, Keio University School of Medicine, Tokyo, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">16</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="149">149</biblScope><biblScope unit="page" to="153">153</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1989-06">1989-06</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report a case of angiosarcoma and dermal melanocytosis occurring simultaneously in the same lesion. We examined the primary and 2 metastatic lesions. Histopathologically, the anaplastic angiosarcoma cells had a tendency to form irregularly shaped small cavities. Immunohistochemically, they were strongly reactive with Ulex europaeus agglutinin (UEAI) stain. The mid and deep dermis of the same lesion had spindle or elongated slender melanocytes containing melanin granules. The melanocytes were positive with S‐100 protein stain. Ultrastructurally, pinocytotic vesicles, fine filaments, and Weibel‐Palade body‐like dense granules were observed in the cytoplasm of angiosarcoma cells. Dermal melanocytes had external lamina and melanosomes in various stages. The melanocytes showed no similarity to the neoplastic tumor cells and there was no apparent intermediate form between the 2 kinds of cells. The etiological implications of dermal melanocytosis with a tumor of vascular origin are discussed.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>dermal</json:string><json:string>melanocyte</json:string><json:string>melanocytosis</json:string><json:string>dermal melanocytosis</json:string><json:string>angiosarcoma</json:string><json:string>tumor cells</json:string><json:string>nevus</json:string><json:string>primary lesion</json:string><json:string>dermatol</json:string><json:string>right foot</json:string><json:string>dermal melanocytes</json:string><json:string>metastatic</json:string><json:string>akiyama</json:string><json:string>granule</json:string><json:string>neoplastic</json:string><json:string>eruptive</json:string><json:string>metastatic lesions</json:string><json:string>dermis</json:string><json:string>lesion</json:string><json:string>electron microscopy</json:string><json:string>anaplastic</json:string><json:string>lymphedema</json:string><json:string>subcutaneous</json:string><json:string>basal</json:string><json:string>melanoeyte</json:string><json:string>pathol</json:string><json:string>subcutaneous nodules</json:string><json:string>vascular origin</json:string><json:string>neoplastic tumor cells</json:string><json:string>deep dermis</json:string><json:string>keio university school</json:string><json:string>ulex europaeus agglutinin</json:string><json:string>rabbit antiserum</json:string><json:string>same lesion</json:string><json:string>anaplastic tumor cells</json:string><json:string>skin tumors</json:string><json:string>case report</json:string><json:string>irregular cavities</json:string><json:string>right thigh</json:string><json:string>present case</json:string><json:string>dermal meianocytosis</json:string><json:string>blue nevi</json:string><json:string>small cavities</json:string><json:string>dermal melanoeyte</json:string><json:string>melanoeyte proliferation</json:string><json:string>etiological implications</json:string><json:string>basal eell epithelioma</json:string><json:string>external lamina</json:string><json:string>arch dermatol</json:string><json:string>protein stain</json:string><json:string>cutan pathol</json:string><json:string>eruptive nevoeytie nevi</json:string><json:string>blue nevus</json:string></teeft></keywords><author><json:item><name>M. 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We examined the primary and 2 metastatic lesions. Histopathologically, the anaplastic angiosarcoma cells had a tendency to form irregularly shaped small cavities. Immunohistochemically, they were strongly reactive with Ulex europaeus agglutinin (UEAI) stain. The mid and deep dermis of the same lesion had spindle or elongated slender melanocytes containing melanin granules. The melanocytes were positive with S‐100 protein stain. Ultrastructurally, pinocytotic vesicles, fine filaments, and Weibel‐Palade body‐like dense granules were observed in the cytoplasm of angiosarcoma cells. Dermal melanocytes had external lamina and melanosomes in various stages. The melanocytes showed no similarity to the neoplastic tumor cells and there was no apparent intermediate form between the 2 kinds of cells. 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