Porokeratosis‐like Changes in Chondrodermatitis Nodularis Helicis:Consequence or Coincidence?
Identifieur interne : 006A95 ( Istex/Corpus ); précédent : 006A94; suivant : 006A96Porokeratosis‐like Changes in Chondrodermatitis Nodularis Helicis:Consequence or Coincidence?
Auteurs : R. N. Page ; R. King ; P. B. GoogeSource :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
Background: Chondrodermatitis nodularis helicis (CNH) is a condition with known predisposing factors, but of unknown etiology. A variety of opinions exist as to the cause of this condition, without consensus. Design: We reviewed 111 cases of CNH from 103 patients at our laboratory. p53 immunohistochemical staining, which is over expressed in basilar epidermal cells of porokeratosis, was performed in a representative sample of CNH cases. Histologic changes characteristic of porokeratosis were qualified as a 1) parakeratotic column of keratinocytes 2) an attenuated to absent granular layer, and 3) adjacent or underlying dyskeratosis of keratinocytes, present in columns or aggregates. Results: Porokeratosis‐like changes were identified in 77 of 111 cases. p53 staining was noncontributory. Conclusion: The presence of these porokeratosis‐like changes in 69% of cases is intriguing. It is not clear whether or not this could possibly represent a causative mechanism or, perhaps, an otherwise coincident histologic change. The presence of porokeratosis‐like changes in CNH provides a possible hypothesis in relationship to its etiology, at the very least, it could provide some histologic clue as to the presence of this deep dermal process in superficial biopsies.
Url:
DOI: 10.1111/j.0303-6987.2005.320ff.x
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ISTEX:E3EC3A9C5BC2EB2CDC1540808E2C0F903DF84D81Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Porokeratosis‐like Changes in Chondrodermatitis Nodularis Helicis:Consequence or Coincidence?</title><author><name sortKey="Page, R N" sort="Page, R N" uniqKey="Page R" first="R. N." last="Page">R. N. Page</name><affiliation><mods:affiliation>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA</mods:affiliation></affiliation></author><author><name sortKey="King, R" sort="King, R" uniqKey="King R" first="R." last="King">R. King</name><affiliation><mods:affiliation>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA</mods:affiliation></affiliation></author><author><name sortKey="Googe, P B" sort="Googe, P B" uniqKey="Googe P" first="P. B." last="Googe">P. B. 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N." last="Page">R. N. Page</name><affiliation><mods:affiliation>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA</mods:affiliation></affiliation></author><author><name sortKey="King, R" sort="King, R" uniqKey="King R" first="R." last="King">R. King</name><affiliation><mods:affiliation>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA</mods:affiliation></affiliation></author><author><name sortKey="Googe, P B" sort="Googe, P B" uniqKey="Googe P" first="P. B." last="Googe">P. B. Googe</name><affiliation><mods:affiliation>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="107">107</biblScope><biblScope unit="page" to="107">107</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Chondrodermatitis nodularis helicis (CNH) is a condition with known predisposing factors, but of unknown etiology. A variety of opinions exist as to the cause of this condition, without consensus. Design: We reviewed 111 cases of CNH from 103 patients at our laboratory. p53 immunohistochemical staining, which is over expressed in basilar epidermal cells of porokeratosis, was performed in a representative sample of CNH cases. Histologic changes characteristic of porokeratosis were qualified as a 1) parakeratotic column of keratinocytes 2) an attenuated to absent granular layer, and 3) adjacent or underlying dyskeratosis of keratinocytes, present in columns or aggregates. Results: Porokeratosis‐like changes were identified in 77 of 111 cases. p53 staining was noncontributory. Conclusion: The presence of these porokeratosis‐like changes in 69% of cases is intriguing. It is not clear whether or not this could possibly represent a causative mechanism or, perhaps, an otherwise coincident histologic change. The presence of porokeratosis‐like changes in CNH provides a possible hypothesis in relationship to its etiology, at the very least, it could provide some histologic clue as to the presence of this deep dermal process in superficial 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Page</name><affiliations><json:string>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA</json:string></affiliations></json:item><json:item><name>R. King</name><affiliations><json:string>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA</json:string></affiliations></json:item><json:item><name>P.B. Googe</name><affiliations><json:string>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA</json:string></affiliations></json:item></author><articleId><json:string>CUP320FF</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>abstract</json:string></originalGenre><abstract>Background: Chondrodermatitis nodularis helicis (CNH) is a condition with known predisposing factors, but of unknown etiology. A variety of opinions exist as to the cause of this condition, without consensus. Design: We reviewed 111 cases of CNH from 103 patients at our laboratory. p53 immunohistochemical staining, which is over expressed in basilar epidermal cells of porokeratosis, was performed in a representative sample of CNH cases. Histologic changes characteristic of porokeratosis were qualified as a 1) parakeratotic column of keratinocytes 2) an attenuated to absent granular layer, and 3) adjacent or underlying dyskeratosis of keratinocytes, present in columns or aggregates. Results: Porokeratosis‐like changes were identified in 77 of 111 cases. p53 staining was noncontributory. Conclusion: The presence of these porokeratosis‐like changes in 69% of cases is intriguing. It is not clear whether or not this could possibly represent a causative mechanism or, perhaps, an otherwise coincident histologic change. The presence of porokeratosis‐like changes in CNH provides a possible hypothesis in relationship to its etiology, at the very least, it could provide some histologic clue as to the presence of this deep dermal process in superficial biopsies.</abstract><qualityIndicators><score>7.22</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595 x 782 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractCharCount>1271</abstractCharCount><pdfWordCount>46669</pdfWordCount><pdfCharCount>312307</pdfCharCount><pdfPageCount>53</pdfPageCount><abstractWordCount>185</abstractWordCount></qualityIndicators><title>Porokeratosis‐like Changes in Chondrodermatitis Nodularis Helicis:Consequence or Coincidence?</title><genre><json:string>abstract</json:string></genre><host><title>Journal of Cutaneous Pathology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0560</json:string></doi><issn><json:string>0303-6987</json:string></issn><eissn><json:string>1600-0560</json:string></eissn><publisherId><json:string>CUP</json:string></publisherId><volume>32</volume><issue>1</issue><pages><first>107</first><last>107</last><total>1</total></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>pathology</json:string><json:string>dermatology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>dermatology & venereal diseases</json:string></scienceMetrix></categories><publicationDate>2005</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1111/j.0303-6987.2005.320ff.x</json:string></doi><id>E3EC3A9C5BC2EB2CDC1540808E2C0F903DF84D81</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/E3EC3A9C5BC2EB2CDC1540808E2C0F903DF84D81/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/E3EC3A9C5BC2EB2CDC1540808E2C0F903DF84D81/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/E3EC3A9C5BC2EB2CDC1540808E2C0F903DF84D81/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Porokeratosis‐like Changes in Chondrodermatitis Nodularis Helicis:Consequence or Coincidence?</title></titleStmt><publicationStmt><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01"></date></publicationStmt><notesStmt><note type="content-type" subtype="abstract" source="abstract" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-HPN7T1Q2-R">abstract</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="abstract"><analytic><title level="a" type="main">Porokeratosis‐like Changes in Chondrodermatitis Nodularis Helicis:Consequence or Coincidence?</title><title level="a" type="short">Abstracts</title><author xml:id="author-0000"><persName><forename type="first">R.N.</forename><surname>Page</surname></persName><affiliation>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">R.</forename><surname>King</surname></persName><affiliation>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">P.B.</forename><surname>Googe</surname></persName><affiliation>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA<address><country key="US"></country></address></affiliation></author><idno type="istex">E3EC3A9C5BC2EB2CDC1540808E2C0F903DF84D81</idno><idno type="DOI">10.1111/j.0303-6987.2005.320ff.x</idno><idno type="unit">CUP320FF</idno><idno type="toTypesetVersion">file:CUP.CUP320ff.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="pISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><idno type="book-DOI">10.1111/(ISSN)1600-0560</idno><idno type="book-part-DOI">10.1111/cup.2005.32.issue-1</idno><idno type="product">CUP</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="107">107</biblScope><biblScope unit="page" to="107">107</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; 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A variety of opinions exist as to the cause of this condition, without consensus. Design: We reviewed 111 cases of CNH from 103 patients at our laboratory. p53 immunohistochemical staining, which is over expressed in basilar epidermal cells of porokeratosis, was performed in a representative sample of CNH cases. Histologic changes characteristic of porokeratosis were qualified as a 1) parakeratotic column of keratinocytes 2) an attenuated to absent granular layer, and 3) adjacent or underlying dyskeratosis of keratinocytes, present in columns or aggregates. Results: Porokeratosis‐like changes were identified in 77 of 111 cases. p53 staining was noncontributory. Conclusion: The presence of these porokeratosis‐like changes in 69% of cases is intriguing. It is not clear whether or not this could possibly represent a causative mechanism or, perhaps, an otherwise coincident histologic change. The presence of porokeratosis‐like changes in CNH provides a possible hypothesis in relationship to its etiology, at the very least, it could provide some histologic clue as to the presence of this deep dermal process in superficial biopsies.</p></abstract><textClass><classCode scheme="tocHeading1">ASOD 41st meeting Abstracts</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/E3EC3A9C5BC2EB2CDC1540808E2C0F903DF84D81/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley component found"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd/Inc.</publisherName><publisherLoc>Oxford, UK; Malden, USA</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0560</doi><issn type="print">0303-6987</issn><issn type="electronic">1600-0560</issn><idGroup><id type="product" value="CUP"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF CUTANEOUS PATHOLOGY">Journal of Cutaneous Pathology</title></titleGroup></publicationMeta><publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/cup.2005.32.issue-1</doi><numberingGroup><numbering type="journalVolume" number="32">32</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2005-01">January 2005</coverDate></publicationMeta><publicationMeta level="unit" type="abstract" position="0010700" status="forIssue"><doi origin="wiley">10.1111/j.0303-6987.2005.320ff.x</doi><idGroup><id type="unit" value="CUP320FF"></id></idGroup><countGroup><count type="pageTotal" number="1"></count></countGroup><titleGroup><title type="tocHeading1">ASOD 41st meeting Abstracts</title></titleGroup><eventGroup><event type="firstOnline" date="2008-06-28"></event><event type="publishedOnlineFinalForm" date="2008-06-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.15 mode:FullText source:Header result:Header" date="2010-07-19"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-16"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="107">107</numbering><numbering type="pageLast" number="107">107</numbering></numberingGroup><linkGroup><link type="toTypesetVersion" href="file:CUP.CUP320ff.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="0"></count><count type="wordTotal" number="1835"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Porokeratosis‐like Changes in Chondrodermatitis Nodularis Helicis:Consequence or Coincidence?</title><title type="shortAuthors"><b>Abstracts</b></title><title type="short"><b>Abstracts</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>R.N.</givenNames><familyName>Page</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>R.</givenNames><familyName>King</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>P.B.</givenNames><familyName>Googe</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Knoxville Dermatopathology Laboratory, University of Tennessee, Graduate School of Medicine, Knoxville, TN, Vanderbilt Medical School, Nashville, TN, USA</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background: </b> Chondrodermatitis nodularis helicis (CNH) is a condition with known predisposing factors, but of unknown etiology. A variety of opinions exist as to the cause of this condition, without consensus. Design: We reviewed 111 cases of CNH from 103 patients at our laboratory. p53 immunohistochemical staining, which is over expressed in basilar epidermal cells of porokeratosis, was performed in a representative sample of CNH cases. Histologic changes characteristic of porokeratosis were qualified as a 1) parakeratotic column of keratinocytes 2) an attenuated to absent granular layer, and 3) adjacent or underlying dyskeratosis of keratinocytes, present in columns or aggregates. Results: Porokeratosis‐like changes were identified in 77 of 111 cases. p53 staining was noncontributory. Conclusion: The presence of these porokeratosis‐like changes in 69% of cases is intriguing. It is not clear whether or not this could possibly represent a causative mechanism or, perhaps, an otherwise coincident histologic change. 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A variety of opinions exist as to the cause of this condition, without consensus. Design: We reviewed 111 cases of CNH from 103 patients at our laboratory. p53 immunohistochemical staining, which is over expressed in basilar epidermal cells of porokeratosis, was performed in a representative sample of CNH cases. Histologic changes characteristic of porokeratosis were qualified as a 1) parakeratotic column of keratinocytes 2) an attenuated to absent granular layer, and 3) adjacent or underlying dyskeratosis of keratinocytes, present in columns or aggregates. Results: Porokeratosis‐like changes were identified in 77 of 111 cases. p53 staining was noncontributory. Conclusion: The presence of these porokeratosis‐like changes in 69% of cases is intriguing. It is not clear whether or not this could possibly represent a causative mechanism or, perhaps, an otherwise coincident histologic change. The presence of porokeratosis‐like changes in CNH provides a possible hypothesis in relationship to its etiology, at the very least, it could provide some histologic clue as to the presence of this deep dermal process in superficial biopsies.</abstract><relatedItem type="host"><titleInfo><title>Journal of Cutaneous Pathology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0303-6987</identifier><identifier type="eISSN">1600-0560</identifier><identifier type="DOI">10.1111/(ISSN)1600-0560</identifier><identifier type="PublisherID">CUP</identifier><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>107</start><end>107</end><total>1</total></extent></part></relatedItem><identifier type="istex">E3EC3A9C5BC2EB2CDC1540808E2C0F903DF84D81</identifier><identifier type="DOI">10.1111/j.0303-6987.2005.320ff.x</identifier><identifier type="ArticleID">CUP320FF</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd/Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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