Family history and risk of hospital treatment for varicose veins in Sweden
Identifieur interne : 006837 ( Istex/Corpus ); précédent : 006836; suivant : 006838Family history and risk of hospital treatment for varicose veins in Sweden
Auteurs : B. Zöller ; J. Ji ; J. Sundquist ; K. SundquistSource :
- British Journal of Surgery [ 0007-1323 ] ; 2012-07.
Abstract
Family history has been suggested as a risk factor for varicose veins, but recall bias may inflate the familial risks. The aim of this nationwide study was to determine familial risks for hospital treatment for varicose veins.
Url:
DOI: 10.1002/bjs.8779
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Ji</name><affiliation><mods:affiliation>Centre for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Sundquist, J" sort="Sundquist, J" uniqKey="Sundquist J" first="J." last="Sundquist">J. Sundquist</name><affiliation><mods:affiliation>Centre for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California, USA</mods:affiliation></affiliation></author><author><name sortKey="Sundquist, K" sort="Sundquist, K" uniqKey="Sundquist K" first="K." last="Sundquist">K. 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Zöller</name><affiliation><mods:affiliation>Centre for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden</mods:affiliation></affiliation><affiliation><mods:affiliation>Centre for Primary Health Care Research, CRC, Building 28, Floor 11, Entrance 72, Skåne University Hospital, SE‐205 02 Malmö, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Ji, J" sort="Ji, J" uniqKey="Ji J" first="J." last="Ji">J. Ji</name><affiliation><mods:affiliation>Centre for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Sundquist, J" sort="Sundquist, J" uniqKey="Sundquist J" first="J." last="Sundquist">J. 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Background:
<p>Family history has been suggested as a risk factor for varicose veins, but recall bias may inflate the familial risks. The aim of this nationwide study was to determine familial risks for hospital treatment for varicose veins.</p>
Methods:
<p>Data from the Swedish Multi‐Generation Register of people aged 0‐76 years were linked to Hospital Discharge Register data for 1964–2008. Standardized incidence ratios (SIRs) were calculated for individuals whose relatives were treated in hospital for varicose veins and compared with those whose relatives were not. Only main diagnoses of varicose veins were considered.</p>
Results:
<p>A total of 39 396 people had hospital treatment for varicose veins. The familial SIR among offspring with one affected parent was 2·39 (95 per cent confidence interval 2·32 to 2·46). The SIR for those with one affected sibling was 2·86 (2·76 to 2·97). SIRs were increased in both men and women. The SIR for individuals with two or more affected siblings or with two affected parents was 5·88 (5·28 to 6·53) and 5·52 (4·77 to 6·36) respectively. The SIR for the wives of men treated for varicose veins was 1·69 (1·59 to 1·80); that for the husbands of women treated for varicose veins was 1·68 (1·58 to 1·79).</p>
Conclusion:
<p>Using the Swedish Hospital Discharge Register, and thereby eliminating recall bias, family history of hospital treatment for varicose veins was associated with an increased risk of similar treatment among relatives. The increased spousal risk suggests a contribution from non‐genetic factors. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</p></abstract><abstract xml:lang="en" style="short"><p>Can run in families</p></abstract><textClass><classCode scheme="articleCategory">Original Article</classCode><classCode scheme="tocHeading1">Original Articles</classCode></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/DE95DBE0D02455D6C428E490A39A0F6DD0B09D23/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>John Wiley & Sons, Ltd.</publisherName><publisherLoc>Chichester, UK</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1365-2168</doi><issn type="print">0007-1323</issn><issn type="electronic">1365-2168</issn><idGroup><id type="product" value="BJS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="BRITISH JOURNAL OF SURGERY">British Journal of Surgery</title><title type="short">Br J Surg</title></titleGroup></publicationMeta><publicationMeta level="part" position="70"><doi origin="wiley" registered="yes">10.1002/bjs.v99.7</doi><numberingGroup><numbering type="journalVolume" number="99">99</numbering><numbering type="journalIssue">7</numbering></numberingGroup><coverDate startDate="2012-07">July 2012</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="130" status="forIssue"><doi origin="wiley" registered="yes">10.1002/bjs.8779</doi><idGroup><id type="unit" value="BJS8779"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</copyright><eventGroup><event type="manuscriptAccepted" date="2012-03-21"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.1.5 mode:FullText" date="2012-06-22"></event><event type="publishedOnlineEarlyUnpaginated" date="2012-05-04"></event><event type="publishedOnlineFinalForm" date="2012-05-30"></event><event type="firstOnline" date="2012-05-04"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-07"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-24"></event></eventGroup><numberingGroup><numbering type="pageFirst">948</numbering><numbering type="pageLast">953</numbering></numberingGroup><correspondenceTo>Centre for Primary Health Care Research, CRC, Building 28, Floor 11, Entrance 72, Skåne University Hospital, SE‐205 02 Malmö, Sweden.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:BJS.BJS8779.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="5"></count><count type="referenceTotal" number="25"></count></countGroup><titleGroup><title type="main" xml:lang="en">Family history and risk of hospital treatment for varicose veins in Sweden</title><title type="short" xml:lang="en">Family history and varicose veins</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>B.</givenNames><familyName>Zöller</familyName></personName><contactDetails><email>bengt.zoller@med.lu.se</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>J.</givenNames><familyName>Ji</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>J.</givenNames><familyName>Sundquist</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>K.</givenNames><familyName>Sundquist</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="SE" type="organization"><unparsedAffiliation>Centre for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California, USA</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><section xml:id="abs1-1"><title type="main">Background:</title><p>Family history has been suggested as a risk factor for varicose veins, but recall bias may inflate the familial risks. The aim of this nationwide study was to determine familial risks for hospital treatment for varicose veins.</p></section><section xml:id="abs1-2"><title type="main">Methods:</title><p>Data from the Swedish Multi‐Generation Register of people aged 0‐76 years were linked to Hospital Discharge Register data for 1964–2008. Standardized incidence ratios (SIRs) were calculated for individuals whose relatives were treated in hospital for varicose veins and compared with those whose relatives were not. Only main diagnoses of varicose veins were considered.</p></section><section xml:id="abs1-3"><title type="main">Results:</title><p>A total of 39 396 people had hospital treatment for varicose veins. The familial SIR among offspring with one affected parent was 2·39 (95 per cent confidence interval 2·32 to 2·46). The SIR for those with one affected sibling was 2·86 (2·76 to 2·97). SIRs were increased in both men and women. The SIR for individuals with two or more affected siblings or with two affected parents was 5·88 (5·28 to 6·53) and 5·52 (4·77 to 6·36) respectively. The SIR for the wives of men treated for varicose veins was 1·69 (1·59 to 1·80); that for the husbands of women treated for varicose veins was 1·68 (1·58 to 1·79).</p></section><section xml:id="abs1-4"><title type="main">Conclusion:</title><p>Using the Swedish Hospital Discharge Register, and thereby eliminating recall bias, family history of hospital treatment for varicose veins was associated with an increased risk of similar treatment among relatives. The increased spousal risk suggests a contribution from non‐genetic factors. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</p></section></abstract><abstract type="short" xml:lang="en"><p>Can run in families</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Family history and risk of hospital treatment for varicose veins in Sweden</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Family history and varicose veins</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Family history and risk of hospital treatment for varicose veins in Sweden</title></titleInfo><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Zöller</namePart><affiliation>Centre for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden</affiliation><affiliation>Centre for Primary Health Care Research, CRC, Building 28, Floor 11, Entrance 72, Skåne University Hospital, SE‐205 02 Malmö, Sweden.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Ji</namePart><affiliation>Centre for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Sundquist</namePart><affiliation>Centre for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden</affiliation><affiliation>Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, California, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Sundquist</namePart><affiliation>Centre for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Ltd.</publisher><place><placeTerm type="text">Chichester, UK</placeTerm></place><dateIssued encoding="w3cdtf">2012-07</dateIssued><dateValid encoding="w3cdtf">2012-03-21</dateValid><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">5</extent><extent unit="references">25</extent></physicalDescription><abstract>Family history has been suggested as a risk factor for varicose veins, but recall bias may inflate the familial risks. The aim of this nationwide study was to determine familial risks for hospital treatment for varicose veins.</abstract><abstract>Data from the Swedish Multi‐Generation Register of people aged 0‐76 years were linked to Hospital Discharge Register data for 1964–2008. Standardized incidence ratios (SIRs) were calculated for individuals whose relatives were treated in hospital for varicose veins and compared with those whose relatives were not. Only main diagnoses of varicose veins were considered.</abstract><abstract>A total of 39 396 people had hospital treatment for varicose veins. The familial SIR among offspring with one affected parent was 2·39 (95 per cent confidence interval 2·32 to 2·46). The SIR for those with one affected sibling was 2·86 (2·76 to 2·97). SIRs were increased in both men and women. The SIR for individuals with two or more affected siblings or with two affected parents was 5·88 (5·28 to 6·53) and 5·52 (4·77 to 6·36) respectively. The SIR for the wives of men treated for varicose veins was 1·69 (1·59 to 1·80); that for the husbands of women treated for varicose veins was 1·68 (1·58 to 1·79).</abstract><abstract>Using the Swedish Hospital Discharge Register, and thereby eliminating recall bias, family history of hospital treatment for varicose veins was associated with an increased risk of similar treatment among relatives. The increased spousal risk suggests a contribution from non‐genetic factors. Copyright © 2012 British Journal of Surgery Society Ltd. 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