Vulval squamous cell carcinoma arising in chronic hidradenitis suppurativa
Identifieur interne : 006750 ( Istex/Corpus ); précédent : 006749; suivant : 006751Vulval squamous cell carcinoma arising in chronic hidradenitis suppurativa
Auteurs : K. A. Short ; G. Kalu ; P. S. Mortimer ; E. M. HigginsSource :
- Clinical and Experimental Dermatology [ 0307-6938 ] ; 2005-09.
Abstract
We report a case of vulval squamous cell carcinoma (SCC) arising in chronic hidradenitis suppurativa (HS). The patient had a complex medical history including a 25‐year‐history of Crohn's disease. In addition she had recently received immunosuppressive therapy for nephrotic syndrome secondary to membranous glomerulonephritis. A painful nodule was noted on the vulva that was clinically very suspicious of SCC. An excision biopsy confirmed the diagnosis. There are few publications in the English literature citing association between HS and the development of SCC. The first report in the English literature of vulval SCC arising in chronic HS was published in 1999. We wish to draw attention to the possibility that patients with HS may develop SCC in lesional skin. A painful lump or ulcer could easily be mistaken for an inflammatory lesion and a low threshold for biopsy is warranted. We suggest constant vigilance with regard to malignant change in ano‐genital HS as the diagnosis can be difficult.
Url:
DOI: 10.1111/j.1365-2230.2005.01875.x
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Short</name><affiliation><mods:affiliation>Department of Dermatology, King's College Hospital, London, Department of Gynaecology, The Princess Royal Hospital, West Sussex</mods:affiliation></affiliation></author><author><name sortKey="Kalu, G" sort="Kalu, G" uniqKey="Kalu G" first="G." last="Kalu">G. Kalu</name><affiliation><mods:affiliation>Department of Dermatology, King's College Hospital, London, Department of Gynaecology, The Princess Royal Hospital, West Sussex</mods:affiliation></affiliation></author><author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P. S." last="Mortimer">P. S. Mortimer</name><affiliation><mods:affiliation>Department of Dermatology, St George's Hospital, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Higgins, E M" sort="Higgins, E M" uniqKey="Higgins E" first="E. M." last="Higgins">E. M. 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The patient had a complex medical history including a 25‐year‐history of Crohn's disease. In addition she had recently received immunosuppressive therapy for nephrotic syndrome secondary to membranous glomerulonephritis. A painful nodule was noted on the vulva that was clinically very suspicious of SCC. An excision biopsy confirmed the diagnosis. There are few publications in the English literature citing association between HS and the development of SCC. The first report in the English literature of vulval SCC arising in chronic HS was published in 1999. We wish to draw attention to the possibility that patients with HS may develop SCC in lesional skin. A painful lump or ulcer could easily be mistaken for an inflammatory lesion and a low threshold for biopsy is warranted. We suggest constant vigilance with regard to malignant change in ano‐genital HS as the diagnosis can be difficult.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>vulval</json:string><json:string>dermatology</json:string><json:string>suppurativa</json:string><json:string>hidradenitis</json:string><json:string>lymphoedema</json:string><json:string>squamous</json:string><json:string>excision</json:string><json:string>nodule</json:string><json:string>invasive</json:string><json:string>hidradenitis suppurativa</json:string><json:string>vulva</json:string><json:string>english literature</json:string><json:string>carcinoma</json:string><json:string>blackwell publishing</json:string><json:string>experimental dermatology</json:string><json:string>squamous cell carcinoma</json:string><json:string>chronic hidradenitis suppurativa</json:string><json:string>cell carcinoma</json:string><json:string>recurrence</json:string><json:string>painful nodule</json:string><json:string>constant vigilance</json:string><json:string>hyperkeratotic nodule</json:string><json:string>central crater</json:string><json:string>superior aspect</json:string><json:string>right labium minora</json:string><json:string>lesional skin</json:string><json:string>excision biopsy</json:string><json:string>malignant change</json:string><json:string>membranous glomerulonephritis</json:string><json:string>full thickness dysplasia</json:string><json:string>surgical margin</json:string><json:string>nephrotic syndrome</json:string><json:string>conservative management</json:string><json:string>immunosuppressive therapy</json:string><json:string>college hospital</json:string><json:string>painful lump</json:string></teeft></keywords><author><json:item><name>K. 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The patient had a complex medical history including a 25‐year‐history of Crohn's disease. In addition she had recently received immunosuppressive therapy for nephrotic syndrome secondary to membranous glomerulonephritis. A painful nodule was noted on the vulva that was clinically very suspicious of SCC. An excision biopsy confirmed the diagnosis. There are few publications in the English literature citing association between HS and the development of SCC. The first report in the English literature of vulval SCC arising in chronic HS was published in 1999. We wish to draw attention to the possibility that patients with HS may develop SCC in lesional skin. A painful lump or ulcer could easily be mistaken for an inflammatory lesion and a low threshold for biopsy is warranted. 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An excision biopsy confirmed the diagnosis. There are few publications in the English literature citing association between HS and the development of SCC. The first report in the English literature of vulval SCC arising in chronic HS was published in 1999. We wish to draw attention to the possibility that patients with HS may develop SCC in lesional skin. A painful lump or ulcer could easily be mistaken for an inflammatory lesion and a low threshold for biopsy is warranted. 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